IMP

Process View

Mus musculus

21 genes annotated in mouse

cellular response to interleukin 4

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to interleukin 4"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to interleukin 4" (in gray)

Name	Description	Probability	Func Analog Organism
Stat3	signal transducer and activator of transcription 3	0.993	Mouse
Eef1a1	eukaryotic translation elongation factor 1 alpha 1	0.972
Ccl2	chemokine (C-C motif) ligand 2	0.960
Stat5b	signal transducer and activator of transcription 5B	0.947	Mouse
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.929
Tubb5	tubulin, beta 5	0.912
Rpl6	ribosomal protein L6	0.866
Hspa8	heat shock protein 8	0.849
Rpl7a	ribosomal protein L7A	0.816
Hsp90b1	heat shock protein 90, beta (Grp94), member 1	0.786
Rplp0	ribosomal protein, large, P0	0.782
Foxp3	forkhead box P3	0.757
Tnf	tumor necrosis factor	0.729
Lef1	lymphoid enhancer binding factor 1	0.717	Human
Rps2	ribosomal protein S2	0.668
Gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1	0.641
Ccl12	chemokine (C-C motif) ligand 12	0.640	Mouse
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.626
Stat5a	signal transducer and activator of transcription 5A	0.622	Mouse
Lyz2	lysozyme 2	0.617
Hspa5	heat shock protein 5	0.561
Manf	mesencephalic astrocyte-derived neurotrophic factor	0.536
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.535
Tlr4	toll-like receptor 4	0.464
Il1r1	interleukin 1 receptor, type I	0.462
Rpl8	ribosomal protein L8	0.460
Irf9	interferon regulatory factor 9	0.446
Gata6	GATA binding protein 6	0.442	Mouse
Ccr1	chemokine (C-C motif) receptor 1	0.428
Creld2	cysteine-rich with EGF-like domains 2	0.401
Myd88	myeloid differentiation primary response gene 88	0.384
Il6	interleukin 6	0.361
Tcf7	transcription factor 7, T-cell specific	0.340	Human
Ppia	peptidylprolyl isomerase A	0.298
Tuba1b	tubulin, alpha 1B	0.273
Rps3	ribosomal protein S3	0.270
Rpgrip1l	Rpgrip1-like	0.263
Pdia6	protein disulfide isomerase associated 6	0.261
Rpl4	ribosomal protein L4	0.257
Stat6	signal transducer and activator of transcription 6	0.247
Actg1	actin, gamma, cytoplasmic 1	0.237
Hsph1	heat shock 105kDa/110kDa protein 1	0.234
Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.231
Iqcb1	IQ calmodulin-binding motif containing 1	0.224
Socs1	suppressor of cytokine signaling 1	0.221
Ccl8	chemokine (C-C motif) ligand 8	0.221
Skil	SKI-like	0.216
Tkt	transketolase	0.206
Ccl3	chemokine (C-C motif) ligand 3	0.202	Mouse
Ccl6	chemokine (C-C motif) ligand 6	0.194	Mouse
Zfpm2	zinc finger protein, multitype 2	0.194
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.180
Akt1	thymoma viral proto-oncogene 1	0.178
Il4ra	interleukin 4 receptor, alpha	0.174
Ccl7	chemokine (C-C motif) ligand 7	0.169	Mouse
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.167	Mouse
Daxx	Fas death domain-associated protein	0.161
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.157
Ccl9	chemokine (C-C motif) ligand 9	0.155	Mouse
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.134
Il10	interleukin 10	0.132
Jak2	Janus kinase 2	0.127
Ccr2	chemokine (C-C motif) receptor 2	0.119
Socs3	suppressor of cytokine signaling 3	0.118
Mmp12	matrix metallopeptidase 12	0.117
Cxcl2	chemokine (C-X-C motif) ligand 2	0.110
Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	0.107
Ptma	prothymosin alpha	0.106
Rps5	ribosomal protein S5	0.106
Ch25h	cholesterol 25-hydroxylase	0.105
Mcm5	minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)	0.104
Rpl10	ribosomal protein 10	0.103
Sdf2l1	stromal cell-derived factor 2-like 1	0.095
Sqstm1	sequestosome 1	0.089
Tgfb1	transforming growth factor, beta 1	0.089
Pparg	peroxisome proliferator activated receptor gamma	0.087
Nckap1l	NCK associated protein 1 like	0.085
C1qc	complement component 1, q subcomponent, C chain	0.085
C3ar1	complement component 3a receptor 1	0.082
Arid1b	AT rich interactive domain 1B (SWI-like)	0.081
Folr2	folate receptor 2 (fetal)	0.078
Gata4	GATA binding protein 4	0.078	Mouse
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.077
Ccr5	chemokine (C-C motif) receptor 5	0.075
Ccl22	chemokine (C-C motif) ligand 22	0.074
Ahi1	Abelson helper integration site 1	0.072
Srebf1	sterol regulatory element binding transcription factor 1	0.070
Cxcl1	chemokine (C-X-C motif) ligand 1	0.070
Tal1	T-cell acute lymphocytic leukemia 1	0.070
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.067
Nfil3	nuclear factor, interleukin 3, regulated	0.066
Cfp	complement factor properdin	0.065
Nphp1	nephronophthisis 1 (juvenile) homolog (human)	0.065
Stat1	signal transducer and activator of transcription 1	0.064	Mouse
Runx1	runt related transcription factor 1	0.063
Snai1	snail homolog 1 (Drosophila)	0.062
Smad3	MAD homolog 3 (Drosophila)	0.062
Actb	actin, beta	0.058
Gfpt2	glutamine fructose-6-phosphate transaminase 2	0.058
Fcgr1	Fc receptor, IgG, high affinity I	0.057
Il6st	interleukin 6 signal transducer	0.057
Clec4d	C-type lectin domain family 4, member d	0.056
Ccl4	chemokine (C-C motif) ligand 4	0.054	Mouse
Tbx3	T-box 3	0.054
Tuba1a	tubulin, alpha 1A	0.053
Kit	kit oncogene	0.053
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.053
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.049
Eef2	eukaryotic translation elongation factor 2	0.047
Dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.046
Cct3	chaperonin containing Tcp1, subunit 3 (gamma)	0.046
Stat2	signal transducer and activator of transcription 2	0.046	Mouse
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.046
Dbnl	drebrin-like	0.046
Myb	myeloblastosis oncogene	0.045
Hspd1	heat shock protein 1 (chaperonin)	0.043
Pdia3	protein disulfide isomerase associated 3	0.042
Cfl1	cofilin 1, non-muscle	0.041
Mmp3	matrix metallopeptidase 3	0.041
Fas	Fas (TNF receptor superfamily member 6)	0.041
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.040
Axin2	axin2	0.040
Pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.039
Adrbk1	adrenergic receptor kinase, beta 1	0.039
Lgals9	lectin, galactose binding, soluble 9	0.039
Msr1	macrophage scavenger receptor 1	0.038
Rps3a	ribosomal protein S3A	0.038
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.038
Rpl3	ribosomal protein L3	0.036
Il1b	interleukin 1 beta	0.036
Lyz1	lysozyme 1	0.036
Selp	selectin, platelet	0.036
Ccl11	chemokine (C-C motif) ligand 11	0.035	Mouse
Agap2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.035
Rplp1	ribosomal protein, large, P1	0.034
Adar	adenosine deaminase, RNA-specific	0.034
Tuba3b	tubulin, alpha 3B	0.034	Mouse
Jak1	Janus kinase 1	0.034
Mx2	myxovirus (influenza virus) resistance 2	0.034
Shank3	SH3/ankyrin domain gene 3	0.034
Irf1	interferon regulatory factor 1	0.033
Gm13654	predicted gene 13654	0.033
Stip1	stress-induced phosphoprotein 1	0.032
Pdia4	protein disulfide isomerase associated 4	0.032
Cd7	CD7 antigen	0.032
Flii	flightless I homolog (Drosophila)	0.032
Fasl	Fas ligand (TNF superfamily, member 6)	0.031
Nsf	N-ethylmaleimide sensitive fusion protein	0.031
Bcl3	B-cell leukemia/lymphoma 3	0.031
Tyrobp	TYRO protein tyrosine kinase binding protein	0.029
Pabpc1	poly(A) binding protein, cytoplasmic 1	0.029
Irg1	immunoresponsive gene 1	0.029
Vcam1	vascular cell adhesion molecule 1	0.028
Mgat2	mannoside acetylglucosaminyltransferase 2	0.028
Tubb2c	tubulin, beta 2C	0.028
Batf	basic leucine zipper transcription factor, ATF-like	0.028
Rpl15	ribosomal protein L15	0.028
Ar	androgen receptor	0.028
Ikzf1	IKAROS family zinc finger 1	0.028
Saa3	serum amyloid A 3	0.028
Cxcl10	chemokine (C-X-C motif) ligand 10	0.027
Ccl17	chemokine (C-C motif) ligand 17	0.027	Mouse
F13a1	coagulation factor XIII, A1 subunit	0.027
Il2	interleukin 2	0.026
Slc25a1	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	0.026
Tubb6	tubulin, beta 6	0.025
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.025
Cd40	CD40 antigen	0.025
Ccnd1	cyclin D1	0.025
Hic1	hypermethylated in cancer 1	0.025
Tuba8	tubulin, alpha 8	0.025	Mouse
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.025
Spcs2	signal peptidase complex subunit 2 homolog (S. cerevisiae)	0.025
Sele	selectin, endothelial cell	0.024
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.024
Il2rb	interleukin 2 receptor, beta chain	0.024
Fcna	ficolin A	0.024
Aacs	acetoacetyl-CoA synthetase	0.024
Rpn1	ribophorin I	0.024
C1qb	complement component 1, q subcomponent, beta polypeptide	0.023
Gja4	gap junction protein, alpha 4	0.023
Gzmb	granzyme B	0.023
Zfpm1	zinc finger protein, multitype 1	0.023
Prlr	prolactin receptor	0.023
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.023
Gdf15	growth differentiation factor 15	0.023
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.022
Gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.022
Ifnar2	interferon (alpha and beta) receptor 2	0.021
Rxra	retinoid X receptor alpha	0.021
Nos3	nitric oxide synthase 3, endothelial cell	0.021
Eef1g	eukaryotic translation elongation factor 1 gamma	0.021
Serpina3g	serine (or cysteine) peptidase inhibitor, clade A, member 3G	0.021
Cpa3	carboxypeptidase A3, mast cell	0.021
Rpl19	ribosomal protein L19	0.020
Hcls1	hematopoietic cell specific Lyn substrate 1	0.020
Gfi1	growth factor independent 1	0.020
Adcy4	adenylate cyclase 4	0.020
Lepr	leptin receptor	0.020
Lyve1	lymphatic vessel endothelial hyaluronan receptor 1	0.020
Shh	sonic hedgehog	0.020
Tubb3	tubulin, beta 3	0.019
Arhgef1	Rho guanine nucleotide exchange factor (GEF) 1	0.019
Vcp	valosin containing protein	0.019
Tbx21	T-box 21	0.019
Dynll1	dynein light chain LC8-type 1	0.019
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.019
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.019
Meox1	mesenchyme homeobox 1	0.019
Ctsw	cathepsin W	0.019
Myl7	myosin, light polypeptide 7, regulatory	0.019
Gata1	GATA binding protein 1	0.019	Mouse
S1pr3	sphingosine-1-phosphate receptor 3	0.019
Alox15	arachidonate 15-lipoxygenase	0.018
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.018
Ahr	aryl-hydrocarbon receptor	0.018
Tssk1	testis-specific serine kinase 1	0.018
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.018
Tuba4a	tubulin, alpha 4A	0.018	Mouse
Anapc5	anaphase-promoting complex subunit 5	0.018
Edem1	ER degradation enhancer, mannosidase alpha-like 1	0.018
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.018
Ptgs2	prostaglandin-endoperoxide synthase 2	0.018
Canx	calnexin	0.017
Mmp8	matrix metallopeptidase 8	0.017
Tbx2	T-box 2	0.017
Tuba3a	tubulin, alpha 3A	0.017	Mouse
St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.017
Cd14	CD14 antigen	0.017
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.017
Sox7	SRY-box containing gene 7	0.017
Itgb2	integrin beta 2	0.017
Dnaja1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.017
Eed	embryonic ectoderm development	0.017
Rnh1	ribonuclease/angiogenin inhibitor 1	0.017
Aif1	allograft inflammatory factor 1	0.016
Calr	calreticulin	0.016
Acat2	acetyl-Coenzyme A acetyltransferase 2	0.016
Ogfr	opioid growth factor receptor	0.016
Icam1	intercellular adhesion molecule 1	0.016
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.016
Cxcl5	chemokine (C-X-C motif) ligand 5	0.016
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.016
Cd163	CD163 antigen	0.015
Ubc	ubiquitin C	0.015
Slc10a6	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	0.015
Inhba	inhibin beta-A	0.015
Hn1	hematological and neurological expressed sequence 1	0.015
Ctps	cytidine 5'-triphosphate synthase	0.015
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.015
Ly86	lymphocyte antigen 86	0.015
Il10ra	interleukin 10 receptor, alpha	0.015
Pf4	platelet factor 4	0.015
Cdk6	cyclin-dependent kinase 6	0.015
Pgf	placental growth factor	0.015
Selplg	selectin, platelet (p-selectin) ligand	0.015
Acly	ATP citrate lyase	0.015
Slfn1	schlafen 1	0.015
Sfpi1	SFFV proviral integration 1	0.015
a	nonagouti	0.015
Trim21	tripartite motif-containing 21	0.015
Gm11428	predicted gene 11428	0.015
Prf1	perforin 1 (pore forming protein)	0.014
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.014
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.014
Retnla	resistin like alpha	0.014
Has1	hyaluronan synthase1	0.014
Cd27	CD27 antigen	0.014
Ncr1	natural cytotoxicity triggering receptor 1	0.014
Marcksl1	MARCKS-like 1	0.014
Mmp13	matrix metallopeptidase 13	0.014
Tgif2	TGFB-induced factor homeobox 2	0.014
Cd28	CD28 antigen	0.014
Atf3	activating transcription factor 3	0.014
Pax2	paired box gene 2	0.014
Tbx5	T-box 5	0.013
Dusp2	dual specificity phosphatase 2	0.013
Il1rn	interleukin 1 receptor antagonist	0.013
Ctss	cathepsin S	0.013
AI607873	expressed sequence AI607873	0.013
Itgax	integrin alpha X	0.013
Rpl13	ribosomal protein L13	0.013
Csf2ra	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.013
Trim28	tripartite motif-containing 28	0.013
S1pr2	sphingosine-1-phosphate receptor 2	0.013
Hck	hemopoietic cell kinase	0.013
Cxcl9	chemokine (C-X-C motif) ligand 9	0.013
Mecom	MDS1 and EVI1 complex locus	0.013
Dnajb9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.013
Atp5b	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	0.013
Basp1	brain abundant, membrane attached signal protein 1	0.012
Arhgap1	Rho GTPase activating protein 1	0.012
Hmgn1	high mobility group nucleosomal binding domain 1	0.012
Ear11	eosinophil-associated, ribonuclease A family, member 11	0.012
Xbp1	X-box binding protein 1	0.012
Junb	Jun-B oncogene	0.012
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.012
Ftsjd2	FtsJ methyltransferase domain containing 2	0.012
Rc3h1	RING CCCH (C3H) domains 1	0.012
Fcrls	Fc receptor-like S, scavenger receptor	0.012
Rangap1	RAN GTPase activating protein 1	0.012
Dhh	desert hedgehog	0.012
Traf1	TNF receptor-associated factor 1	0.012
Jph2	junctophilin 2	0.012
Cd96	CD96 antigen	0.012
Rasal3	RAS protein activator like 3	0.012
Cd8a	CD8 antigen, alpha chain	0.012
Tbxas1	thromboxane A synthase 1, platelet	0.012
Gp49a	glycoprotein 49 A	0.012
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.012
AF251705	cDNA sequence AF251705	0.012
Egr2	early growth response 2	0.012
Il17ra	interleukin 17 receptor A	0.012
Clec4n	C-type lectin domain family 4, member n	0.012
Lcp2	lymphocyte cytosolic protein 2	0.012
Rfc5	replication factor C (activator 1) 5	0.012
Pim1	proviral integration site 1	0.012
Hspb1	heat shock protein 1	0.012
Rhog	ras homolog gene family, member G	0.011
Cd244	CD244 natural killer cell receptor 2B4	0.011
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.011
Dhcr7	7-dehydrocholesterol reductase	0.011
Notch1	Notch gene homolog 1 (Drosophila)	0.011
Cdh2	cadherin 2	0.011
Gata3	GATA binding protein 3	0.011
Tuba1c	tubulin, alpha 1C	0.011	Mouse
Mcm7	minichromosome maintenance deficient 7 (S. cerevisiae)	0.011
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.011
Cd44	CD44 antigen	0.011
Mapk3	mitogen-activated protein kinase 3	0.011
Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	0.011
Cep290	centrosomal protein 290	0.011
Bag2	BCL2-associated athanogene 2	0.011
Pole	polymerase (DNA directed), epsilon	0.011
Gata2	GATA binding protein 2	0.011	Mouse
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.011
Slamf9	SLAM family member 9	0.011
Dll4	delta-like 4 (Drosophila)	0.011
Rnf19b	ring finger protein 19B	0.011
Apeh	acylpeptide hydrolase	0.011
Tbx4	T-box 4	0.011
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.011
Numb	numb gene homolog (Drosophila)	0.011
Dab2	disabled homolog 2 (Drosophila)	0.011
Endou	endonuclease, polyU-specific	0.011
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.011
Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	0.010
Ralgds	ral guanine nucleotide dissociation stimulator	0.010
Acaa2	acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)	0.010
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.010
Clec4e	C-type lectin domain family 4, member e	0.010
Capn1	calpain 1	0.010
C5ar1	complement component 5a receptor 1	0.010
Foxf1a	forkhead box F1a	0.010
Nckap5l	NCK-associated protein 5-like	0.010
Serp1	stress-associated endoplasmic reticulum protein 1	0.010
Chd7	chromodomain helicase DNA binding protein 7	0.010
Rpl18a	ribosomal protein L18A	0.010
Wisp2	WNT1 inducible signaling pathway protein 2	0.010
Osmr	oncostatin M receptor	0.010
AW112010	expressed sequence AW112010	0.010