The network for 'regulation of kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of kinase activity

Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
GRB2 growth factor receptor-bound protein 2 1.000
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 1.000
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 1.000
RB1 retinoblastoma 1 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
FYN FYN oncogene related to SRC, FGR, YES 1.000
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.000
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.999
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.998
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.998
MAPK14 mitogen-activated protein kinase 14 0.998
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.998
JUN jun proto-oncogene 0.998
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.996
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.996
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.996
BCAR1 breast cancer anti-estrogen resistance 1 0.996
TRAF6 TNF receptor-associated factor 6 0.994
TP53 tumor protein p53 0.994
SH3KBP1 SH3-domain kinase binding protein 1 0.992
PLCG1 phospholipase C, gamma 1 0.991
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.991
MAPK8 mitogen-activated protein kinase 8 0.990
SNX9 sorting nexin 9 0.990
PRKCZ protein kinase C, zeta 0.987
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.982
FGFR2 fibroblast growth factor receptor 2 0.976
UBC ubiquitin C 0.976
FGFR1 fibroblast growth factor receptor 1 0.974
FOS FBJ murine osteosarcoma viral oncogene homolog 0.974
CCNE1 cyclin E1 0.973
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.972
PTK2 PTK2 protein tyrosine kinase 2 0.971
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.969
MET met proto-oncogene (hepatocyte growth factor receptor) 0.969
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.967
DUSP1 dual specificity phosphatase 1 0.961
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.960
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.957
GAB1 GRB2-associated binding protein 1 0.956
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.953
ARRB1 arrestin, beta 1 0.947
IGF1R insulin-like growth factor 1 receptor 0.945
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.944
MAPK1 mitogen-activated protein kinase 1 0.942
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.937
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.936
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.931
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.928
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.927
BBS10 Bardet-Biedl syndrome 10 0.924
CAV1 caveolin 1, caveolae protein, 22kDa 0.911
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.908
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.905
MAP2K4 mitogen-activated protein kinase kinase 4 0.901
TNK2 tyrosine kinase, non-receptor, 2 0.891
TSC2 tuberous sclerosis 2 0.884
ESR1 estrogen receptor 1 0.883
TRAF1 TNF receptor-associated factor 1 0.878
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.875
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.875
GRB7 growth factor receptor-bound protein 7 0.874
FGF1 fibroblast growth factor 1 (acidic) 0.874
PDPK1 3-phosphoinositide dependent protein kinase-1 0.870
YAP1 Yes-associated protein 1 0.864
LRRK2 leucine-rich repeat kinase 2 0.863
TOLLIP toll interacting protein 0.863
GSK3B glycogen synthase kinase 3 beta 0.861
CDK2 cyclin-dependent kinase 2 0.854
ABI1 abl-interactor 1 0.853
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.850
IRAK2 interleukin-1 receptor-associated kinase 2 0.849
BRCA1 breast cancer 1, early onset 0.844
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.843
SOCS1 suppressor of cytokine signaling 1 0.842
CDK14 cyclin-dependent kinase 14 0.839
BIRC2 baculoviral IAP repeat containing 2 0.828
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.828
AXL AXL receptor tyrosine kinase 0.825
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.820
SOS1 son of sevenless homolog 1 (Drosophila) 0.820
ZNF43 zinc finger protein 43 0.817
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.817
SMAD3 SMAD family member 3 0.813
ATF3 activating transcription factor 3 0.810
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.809
STK11 serine/threonine kinase 11 0.803
C1QA complement component 1, q subcomponent, A chain 0.798
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.796
CCND1 cyclin D1 0.794
GRB10 growth factor receptor-bound protein 10 0.790
ADAM15 ADAM metallopeptidase domain 15 0.781
SMAD7 SMAD family member 7 0.774
MYD88 myeloid differentiation primary response gene (88) 0.768
CYR61 cysteine-rich, angiogenic inducer, 61 0.764
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
bar-1 Protein BAR-1 0.085
nlg-1 Protein NLG-1 0.075
eps-8 Protein EPS-8 0.074
glp-1 Protein GLP-1 0.072
mec-2 Protein MEC-2 0.067
M01A8.2 Protein M01A8.2 0.063
daf-6 Protein DAF-6 0.063
sur-2 Protein SUR-2 0.063
xpo-1 Protein XPO-1 0.049
K10D6.4 Protein K10D6.4 0.044
pig-1 Protein PIG-1 0.043
pry-1 Protein PRY-1 0.041
sma-1 Protein SMA-1 0.039
plc-1 Protein PLC-1 0.038
C48B4.7 Protein C48B4.7 0.035
mel-26 Protein MEL-26 0.033
CELE_Y57A10A.8 Protein Y57A10A.8 0.033
K08E3.5 Protein K08E3.5 0.032
sma-6 Protein SMA-6 0.032
F10D7.5 Protein F10D7.5 0.031
mes-3 Protein MES-3 0.030
acs-4 Protein ACS-4 0.030
let-756 Protein LET-756 0.030
vab-3 Protein VAB-3 0.029
unc-7 Protein UNC-7 0.029
magi-1 Protein MAGI-1 0.028
unc-73 Protein UNC-73 0.028
mek-2 Protein MEK-2 0.028
rskn-1 Protein RSKN-1 0.027
daf-1 Protein DAF-1 0.027
inx-15 Protein INX-15 0.027
CELE_Y57G11C.22 Protein Y57G11C.22 0.027
dep-1 Protein DEP-1 0.026
mef-2 Protein MEF-2 0.026
pcaf-1 Protein PCAF-1 0.026
ZC449.5 Protein ZC449.5 0.025
daf-3 Protein DAF-3 0.025
sli-1 Protein SLI-1 0.025
hmg-1.2 Protein HMG-1.2 0.025
ptr-2 Protein PTR-2 0.025
par-3 Protein PAR-3 0.024
chd-7 Protein CHD-7 0.024
egl-8 Protein EGL-8 0.024
lin-53 Protein LIN-53 0.023
rsa-1 Protein RSA-1 0.023
kgb-1 Protein KGB-1 0.023
let-60 Protein LET-60 0.023
nhr-6 Protein NHR-6 0.022
spc-1 Protein SPC-1 0.022
unc-53 Protein UNC-53 0.022
R166.2 Protein R166.2 0.022
F14B8.6 Protein F14B8.6 0.022
unc-70 Protein UNC-70 0.022
unc-57 Protein UNC-57 0.021
lin-25 Protein LIN-25 0.021
age-1 Protein AGE-1 0.021
mom-4 Protein MOM-4 0.021
nra-3 Protein NRA-3 0.021
atg-2 Protein ATG-2 0.021
alg-1 Protein ALG-1 0.020
akt-2 Protein AKT-2 0.020
glr-5 Protein GLR-5 0.020
lin-36 Protein LIN-36 0.020
efn-2 Protein EFN-2 0.020
mec-4 Protein MEC-4 0.020
imb-2 Protein IMB-2 0.019
pat-3 Protein PAT-3 0.019
obr-3 Protein OBR-3 0.019
mbk-2 Protein MBK-2 0.019
nipi-3 Protein NIPI-3 0.019
dlg-1 Protein DLG-1 0.019
exc-5 Protein EXC-5 0.019
sto-4 Protein STO-4 0.019
afd-1 Protein AFD-1 0.019
nth-1 Protein NTH-1 0.019
cks-1 Protein CKS-1 0.019
F09A5.4 Protein F09A5.4 0.018
gei-18 Protein GEI-18 0.018
CELE_C18C4.5 Protein C18C4.5 0.018
dli-1 Protein DLI-1 0.018
egl-15 Protein EGL-15 0.018
gsk-3 Protein GSK-3 0.018
dsh-2 Protein DSH-2 0.018
svh-2 Protein SVH-2 0.018
dao-5 Protein DAO-5 0.018
lin-45 Protein LIN-45 0.017
zag-1 Protein ZAG-1 0.017
unc-64 Protein UNC-64 0.017
pkc-3 Protein PKC-3 0.017
dnj-19 Protein DNJ-19 0.017
egl-27 Protein EGL-27 0.017
rhgf-2 Protein RHGF-2 0.017
ric-3 Protein RIC-3 0.017
C16A3.6 Protein C16A3.6 0.017
apl-1 Protein APL-1 0.017
B0035.6 Protein B0035.6 0.017
ncam-1 Protein NCAM-1 0.017
rps-2 Protein RPS-2 0.017
eor-1 Protein EOR-1 0.016
ttr-35 Protein TTR-35 0.016
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
wnt1 wingless-type MMTV integration site family, member 1 0.423
flh floating head 0.195
pea3 ETS-domain transcription factor pea3 0.190
crip2 cysteine-rich protein 2 0.149
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.144
dag1 dystroglycan 1 0.119
sfrp1a secreted frizzled-related protein 1a 0.107
fzd7a frizzled homolog 7a 0.096
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.096
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.089
dusp6 dual specificity phosphatase 6 0.088
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.086
psen1 presenilin 1 0.086
dkk1b dickkopf 1b 0.081
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.078
robo3 roundabout homolog 3 0.074
pdgfaa platelet-derived growth factor alpha a 0.063
zbtb4 zinc finger and BTB domain containing 4 0.060
rnd3a Rho family GTPase 3a 0.060
igf1ra insulin-like growth factor 1a receptor 0.057
epha4a eph receptor A4a 0.053
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.052
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.051
btg2 B-cell translocation gene 2 0.051
epas1b endothelial PAS domain protein 1b 0.051
dlc deltaC 0.050
wnt10a wingless-type MMTV integration site family, member 10a 0.050
smad9 MAD homolog 9 (Drosophila) 0.049
spry4 sprouty (Drosophila) homolog 4 0.047
axin2 axin 2 (conductin, axil) 0.046
igf1rb insulin-like growth factor 1b receptor 0.045
ved ventrally expressed dharma/bozozok antagonist 0.045
fgf3 fibroblast growth factor 3 0.044
ccnb1 cyclin B1 0.043
si:dkey-8l13.4 si:dkey-8l13.4 0.041
foxa2 forkhead box A2 0.041
rhoab ras homolog gene family, member Ab 0.038
cdc25 cell division cycle 25 homolog 0.038
pak2a p21 (CDKN1A)-activated kinase 2a 0.038
arl4ab ADP-ribosylation factor-like 4ab 0.038
shha sonic hedgehog a 0.038
dab1b disabled homolog 1b (Drosophila) 0.037
il17rd interleukin 17 receptor D 0.036
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.036
gro2 groucho 2 0.036
igf2b insulin-like growth factor 2b 0.035
ptpra protein tyrosine phosphatase, receptor type, A 0.034
ptena phosphatase and tensin homolog A 0.034
tlr3 toll-like receptor 3 0.034
socs1 suppressor of cytokine signaling 1 0.034
gadd45bb growth arrest and DNA-damage-inducible, beta b 0.034
nf1a neurofibromin 1a 0.034
wls wntless homolog (Drosophila) 0.034
neo1 neogenin 1 0.033
mpped2 metallophosphoesterase domain containing 2 0.033
vegfaa vascular endothelial growth factor Aa 0.032
foxi1 forkhead box I1 0.032
fgf17 fibroblast growth factor 17 0.032
LOC566708 FL cytokine receptor-like 0.031
socs3a suppressor of cytokine signaling 3a 0.030
sox11a SRY-box containing gene 11a 0.030
gro1 groucho 1 0.030
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.029
cd63 Cd63 antigen 0.029
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.029
tgfb3 transforming growth factor, beta 3 0.029
wnt8b wingless-type MMTV integration site family, member 8b 0.029
ccna2 cyclin A2 0.028
jag2 jagged 2 0.027
hspa4a heat shock protein 4a 0.026
rap1a RAP1A, member of RAS oncogene family 0.026
pak1 p21/Cdc42/Rac1-activated kinase 1 0.026
mt2 metallothionein 2 0.026
mapk14a mitogen-activated protein kinase 14a 0.026
frzb frizzled-related protein 0.026
egr2b early growth response 2b 0.026
sox2 SRY-box containing gene 2 0.026
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.025
pth2 parathyroid hormone 2 0.025
nsa2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.025
mbtps1 membrane-bound transcription factor protease, site 1 0.024
ndrg1 N-myc downstream regulated gene 1 0.024
nppa natriuretic peptide precursor A 0.023
mmp9 matrix metalloproteinase 9 0.023
kirrel3l kin of IRRE like 3 like 0.023
sgk1 serum/glucocorticoid regulated kinase 1 0.023
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.023
id1 inhibitor of DNA binding 1 0.023
ccnd1 cyclin D1 0.023
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.022
ghra growth hormone receptor a 0.022
rarab retinoic acid receptor, alpha b 0.022
wt1b wilms tumor 1b 0.022
fgf20a fibroblast growth factor 20a 0.022
lama5 laminin, alpha 5 0.022
sp2 sp2 transcription factor 0.021
bmp2b bone morphogenetic protein 2b 0.021
msi1 musashi homolog 1 (Drosophila) 0.021
bnc2 basonuclin 2 0.021
her6 hairy-related 6 0.021
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.991
Akt1 CG4006 gene product from transcript CG4006-RA 0.909
rl rolled 0.892
drk downstream of receptor kinase 0.739
kay kayak 0.696
Sin3A CG8815 gene product from transcript CG8815-RC 0.686
Atg1 Autophagy-specific gene 1 0.664
dap dacapo 0.652
G-oalpha47A G protein oalpha 47A 0.650
bsk basket 0.628
Pten CG5671 gene product from transcript CG5671-RB 0.621
Egfr Epidermal growth factor receptor 0.567
par-1 CG8201 gene product from transcript CG8201-RA 0.565
Rab11 Rab-protein 11 0.564
InR Insulin-like receptor 0.538
yki yorkie 0.437
puc puckered 0.426
ovo CG6824 gene product from transcript CG6824-RE 0.418
CaMKII Calcium/calmodulin-dependent protein kinase II 0.416
phl pole hole 0.403
Mad Mothers against dpp 0.402
chico CG5686 gene product from transcript CG5686-RB 0.384
shi shibire 0.349
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.338
Su(H) Suppressor of Hairless 0.291
tws twins 0.279
Rho1 CG8416 gene product from transcript CG8416-RB 0.273
Jra Jun-related antigen 0.267
CkIIalpha Casein kinase II alpha subunit 0.226
shn schnurri 0.224
stck steamer duck 0.212
krz kurtz 0.210
Stat92E Signal-transducer and activator of transcription protein at 92E 0.207
HLHm7 E(spl) region transcript m7 0.203
eIF-4E Eukaryotic initiation factor 4E 0.194
Src42A Src oncogene at 42A 0.186
stg string 0.186
rok Rho-kinase 0.185
Dad Daughters against dpp 0.181
p38b CG7393 gene product from transcript CG7393-RA 0.177
Rab5 Rab-protein 5 0.177
neur neuralized 0.171
scb scab 0.171
Rac2 CG8556 gene product from transcript CG8556-RA 0.166
Tak1 TGF-beta activated kinase 1 0.161
Pka-C1 cAMP-dependent protein kinase 1 0.157
jeb jelly belly 0.156
spas spastin 0.151
ena enabled 0.151
csw corkscrew 0.149
Tl Toll 0.138
rap retina aberrant in pattern 0.138
HLHmdelta E(spl) region transcript mdelta 0.136
rhea CG6831 gene product from transcript CG6831-RA 0.129
ash2 absent, small, or homeotic discs 2 0.125
mbc myoblast city 0.123
HLHmgamma E(spl) region transcript mgamma 0.112
Fmr1 CG6203 gene product from transcript CG6203-RC 0.112
msps mini spindles 0.112
Cip4 CG15015 gene product from transcript CG15015-RA 0.106
nej nejire 0.103
E(spl) Enhancer of split 0.103
dm diminutive 0.102
debcl death executioner Bcl-2 homologue 0.097
Rbf Retinoblastoma-family protein 0.097
HLHm5 E(spl) region transcript m5 0.096
Socs36E Suppressor of cytokine signaling at 36E 0.090
hipk homeodomain interacting protein kinase 0.087
Sara Smad anchor for receptor activation 0.086
pnt pointed 0.086
ben bendless 0.083
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.080
trc tricornered 0.080
Smox Smad on X 0.080
Alk CG8250 gene product from transcript CG8250-RA 0.079
CG13253 CG13253 gene product from transcript CG13253-RB 0.079
Tbh Tyramine beta hydroxylase 0.075
slmb supernumerary limbs 0.074
Sra-1 specifically Rac1-associated protein 1 0.073
Tsp Thrombospondin 0.072
aop anterior open 0.072
ttk tramtrack 0.071
Cdk4 Cyclin-dependent kinase 4 0.070
Abl Abl tyrosine kinase 0.068
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.067
emc extra macrochaetae 0.067
Sema-1a CG18405 gene product from transcript CG18405-RD 0.066
dsh dishevelled 0.066
dia diaphanous 0.066
MP1 Melanization Protease 1 0.065
gus gustavus 0.065
Rac1 CG2248 gene product from transcript CG2248-RA 0.063
ebi CG4063 gene product from transcript CG4063-RA 0.062
drongo CG3365 gene product from transcript CG3365-RH 0.062
tefu telomere fusion 0.062
nbs CG6754 gene product from transcript CG6754-RC 0.062
HLHmbeta E(spl) region transcript mbeta 0.061
sbb scribbler 0.060
pan pangolin 0.060
Dcr-1 Dicer-1 0.060
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 1.000
Pten phosphatase and tensin homolog 1.000
Apc adenomatosis polyposis coli 1.000
Lepr leptin receptor 0.999
Trp53 transformation related protein 53 0.999
Grb2 growth factor receptor bound protein 2 0.999
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.998
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.995
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.994
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.994
Egfr epidermal growth factor receptor 0.994
Src Rous sarcoma oncogene 0.993
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.991
Rb1 retinoblastoma 1 0.987
Apoe apolipoprotein E 0.985
Inpp5d inositol polyphosphate-5-phosphatase D 0.984
Cbl Casitas B-lineage lymphoma 0.984
Stat3 signal transducer and activator of transcription 3 0.982
Csf1 colony stimulating factor 1 (macrophage) 0.981
Cd40 CD40 antigen 0.977
Traf6 TNF receptor-associated factor 6 0.975
Dok1 docking protein 1 0.975
Socs1 suppressor of cytokine signaling 1 0.960
Nf1 neurofibromatosis 1 0.955
Gsk3b glycogen synthase kinase 3 beta 0.950
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.950
Nos1 nitric oxide synthase 1, neuronal 0.944
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.939
Dab1 disabled homolog 1 (Drosophila) 0.938
Insr insulin receptor 0.935
Kit kit oncogene 0.934
Efnb2 ephrin B2 0.929
Prkce protein kinase C, epsilon 0.928
Plcg1 phospholipase C, gamma 1 0.926
Tgfbr2 transforming growth factor, beta receptor II 0.923
Bdnf brain derived neurotrophic factor 0.916
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.915
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.915
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.914
Pparg peroxisome proliferator activated receptor gamma 0.911
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.904
Tnf tumor necrosis factor 0.903
Ephb2 Eph receptor B2 0.900
Tgfb2 transforming growth factor, beta 2 0.893
Jag1 jagged 1 0.891
Smad3 MAD homolog 3 (Drosophila) 0.878
Cd44 CD44 antigen 0.877
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.875
Hif1a hypoxia inducible factor 1, alpha subunit 0.874
Ret ret proto-oncogene 0.872
Esr1 estrogen receptor 1 (alpha) 0.870
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.859
Jak2 Janus kinase 2 0.852
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.851
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.849
Prnp prion protein 0.848
Notch2 Notch gene homolog 2 (Drosophila) 0.841
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.839
Mapk8 mitogen-activated protein kinase 8 0.836
Shc3 src homology 2 domain-containing transforming protein C3 0.835
Irs1 insulin receptor substrate 1 0.835
Ptch1 patched homolog 1 0.829
Gli3 GLI-Kruppel family member GLI3 0.821
Fyn Fyn proto-oncogene 0.818
Mdm2 transformed mouse 3T3 cell double minute 2 0.808
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.803
Wnt5a wingless-related MMTV integration site 5A 0.803
Onecut1 one cut domain, family member 1 0.798
Dok2 docking protein 2 0.798
Ptk7 PTK7 protein tyrosine kinase 7 0.797
App amyloid beta (A4) precursor protein 0.793
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.785
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.785
Braf Braf transforming gene 0.784
Klf3 Kruppel-like factor 3 (basic) 0.778
Fgfr2 fibroblast growth factor receptor 2 0.772
Nos3 nitric oxide synthase 3, endothelial cell 0.772
Gab1 growth factor receptor bound protein 2-associated protein 1 0.769
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.767
2210010C04Rik RIKEN cDNA 2210010C04 gene 0.763
Adam17 a disintegrin and metallopeptidase domain 17 0.761
Fos FBJ osteosarcoma oncogene 0.761
Pnpla2 patatin-like phospholipase domain containing 2 0.757
Psen1 presenilin 1 0.756
Adrb1 adrenergic receptor, beta 1 0.749
Cd22 CD22 antigen 0.744
Sykb spleen tyrosine kinase 0.742
Crhr1 corticotropin releasing hormone receptor 1 0.740
Tgfb1 transforming growth factor, beta 1 0.734
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.731
Clock circadian locomotor output cycles kaput 0.728
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.717
Ikzf1 IKAROS family zinc finger 1 0.715
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.708
Eln elastin 0.706
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.698
Klf7 Kruppel-like factor 7 (ubiquitous) 0.694
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.691
Klk1b5 kallikrein 1-related peptidase b5 0.688
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Junb jun B proto-oncogene 0.340
Itgam integrin, alpha M 0.324
Mgat5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.303
Grb2 growth factor receptor bound protein 2 0.299
Prkcd protein kinase C, delta 0.279
Sirpa signal-regulatory protein alpha 0.277
Fgfr2 fibroblast growth factor receptor 2 0.271
Cmklr1 chemokine-like receptor 1 0.264
Jun Jun oncogene 0.255
Trhr thyrotropin releasing hormone receptor 0.251
Fosl1 fos-like antigen 1 0.238
Klf6 Kruppel-like factor 6 0.237
Ptpn7 protein tyrosine phosphatase, non-receptor type 7 0.223
Jak2 Janus kinase 2 0.223
Il1r1 interleukin 1 receptor, type I 0.221
Itm2b integral membrane protein 2B 0.217
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.214
Hsp90b1 heat shock protein 90, beta, member 1 0.209
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.204
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.203
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.198
Ncan neurocan 0.196
Rnf4 ring finger protein 4 0.195
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.194
Fkbp1a FK506 binding protein 1a 0.186
Dusp1 dual specificity phosphatase 1 0.182
Epas1 endothelial PAS domain protein 1 0.180
Utrn utrophin 0.169
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.166
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.164
Cd4 Cd4 molecule 0.154
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.154
Cd37 CD37 molecule 0.152
Errfi1 ERBB receptor feedback inhibitor 1 0.152
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.149
Hsph1 heat shock 105/110 protein 1 0.148
Gnrhr gonadotropin releasing hormone receptor 0.148
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.147
Prdm2 PR domain containing 2, with ZNF domain 0.147
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.146
Il1rn interleukin 1 receptor antagonist 0.145
RGD1564664 similar to LOC387763 protein 0.143
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.143
Mapk9 mitogen-activated protein kinase 9 0.142
Tacr1 tachykinin receptor 1 0.142
Acmsd aminocarboxymuconate semialdehyde decarboxylase 0.141
Cd38 CD38 molecule 0.140
Ptprc protein tyrosine phosphatase, receptor type, C 0.138
Myo1e myosin IE 0.132
Fgfr1 Fibroblast growth factor receptor 1 0.129
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.129
Mapk1 mitogen activated protein kinase 1 0.127
Hk1 hexokinase 1 0.125
Coro1b coronin, actin-binding protein, 1B 0.125
Prl3d4 prolactin family 3, subfamily d, member 4 0.125
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.124
Necab1 N-terminal EF-hand calcium binding protein 1 0.124
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.123
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.122
Acr acrosin 0.121
Cd3g CD3 molecule, gamma 0.119
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.119
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.119
Pou2f2 POU class 2 homeobox 2 0.118
Hfe hemochromatosis 0.118
Inpp5d inositol polyphosphate-5-phosphatase D 0.117
Jak1 Janus kinase 1 0.117
Lepr leptin receptor 0.116
Hck hemopoietic cell kinase 0.114
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.112
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.112
Olr416 olfactory receptor 416 0.111
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.111
RT1-Da RT1 class II, locus Da 0.110
Stk10 serine/threonine kinase 10 0.108
Hras Harvey rat sarcoma virus oncogene 0.108
P2ry2 purinergic receptor P2Y, G-protein coupled, 2 0.107
Irs1 insulin receptor substrate 1 0.107
Vav1 vav 1 guanine nucleotide exchange factor 0.106
Clic4 chloride intracellular channel 4 0.105
Btg2 BTG family, member 2 0.104
Srd5a2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.104
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.104
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.103
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.103
Tcrb T-cell receptor beta chain 0.103
Cbl Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.103
Ddr1 discoidin domain receptor tyrosine kinase 1 0.102
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.102
Atxn1 ataxin 1 0.102
Gria1 glutamate receptor, ionotropic, AMPA 1 0.102
Uhmk1 U2AF homology motif (UHM) kinase 1 0.101
Bcan brevican 0.101
LOC60591 calcium-activated potassium channel beta subunit 0.100
Ccl4 chemokine (C-C motif) ligand 4 0.100
Trib1 tribbles homolog 1 (Drosophila) 0.099
Actr2 ARP2 actin-related protein 2 homolog (yeast) 0.098
Runx1 runt-related transcription factor 1 0.098
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.098
Hpca hippocalcin 0.097
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
NBP2 Nbp2p 0.983
PIL1 Pil1p 0.965
ROM2 Rom2p 0.880
CKS1 Cks1p 0.875
BMH1 Bmh1p 0.857
CDC28 Cdc28p 0.853
SIC1 Sic1p 0.799
CLN2 Cln2p 0.721
BCK1 Bck1p 0.700
CLB3 Clb3p 0.674
SSK2 Ssk2p 0.670
SNF1 Snf1p 0.667
PBS2 Pbs2p 0.601
SSK1 Ssk1p 0.578
CLN1 Cln1p 0.505
MSG5 Msg5p 0.466
CDC12 Cdc12p 0.452
SIP1 Sip1p 0.402
PCL9 Pcl9p 0.359
EDE1 Ede1p 0.328
PHO85 Pho85p 0.327
CLB2 Clb2p 0.318
BCK2 Bck2p 0.301
BNI1 Bni1p 0.294
SLT2 Slt2p 0.271
PPH21 Pph21p 0.257
CLB6 Clb6p 0.248
HSL1 Hsl1p 0.242
DBF2 Dbf2p 0.240
FAR1 Far1p 0.234
SSK22 Ssk22p 0.219
SPC110 Spc110p 0.218
PSK1 Psk1p 0.215
STE11 Ste11p 0.214
SAP185 Sap185p 0.210
STE4 Ste4p 0.209
BFR1 Bfr1p 0.203
STE20 Ste20p 0.199
MAK5 Mak5p 0.171
SWE1 Swe1p 0.163
MRP8 Mrp8p 0.161
FUS3 Fus3p 0.159
YPD1 Ypd1p 0.149
PHO81 Pho81p 0.149
SWI5 Swi5p 0.138
IKI1 Iki1p 0.135
PTC3 Ptc3p 0.135
RAD53 Rad53p 0.134
PCL1 Pcl1p 0.121
PIN4 Pin4p 0.121
CLB5 Clb5p 0.119
VMA13 Vma13p 0.116
PTC2 Ptc2p 0.115
MKK1 Mkk1p 0.115
TPK2 Tpk2p 0.113
PCL2 Pcl2p 0.111
SCJ1 Scj1p 0.108
CDC53 Cdc53p 0.107
YDR348C hypothetical protein 0.107
MYO5 Myo5p 0.106
RPP1B Rpp1bp 0.104
CRZ1 Crz1p 0.104
CDC37 Cdc37p 0.101
BOI1 Boi1p 0.100
SUS1 Sus1p 0.100
HKR1 Hkr1p 0.099
SIP2 Sip2p 0.094
ZDS1 Zds1p 0.093
PAM1 Pam1p 0.093
CAK1 Cak1p 0.091
CDC6 Cdc6p 0.090
RLM1 Rlm1p 0.089
GAL83 Gal83p 0.087
RPP2B Rpp2bp 0.087
RGC1 Rgc1p 0.087
FKH1 Fkh1p 0.086
MIG1 Mig1p 0.085
YLR257W hypothetical protein 0.083
REG1 Reg1p 0.083
TED1 Ted1p 0.081
RPT6 Rpt6p 0.079
KIC1 Kic1p 0.079
MKS1 Mks1p 0.078
RAD9 Rad9p 0.075
PCL10 Pcl10p 0.074
RPP2A Rpp2ap 0.073
MOB2 Mob2p 0.072
SSN8 Ssn8p 0.072
SPC29 Spc29p 0.071
RPP0 Rpp0p 0.070
ITT1 Itt1p 0.070
KEL3 Kel3p 0.068
CHS1 Chs1p 0.067
SOG2 Sog2p 0.067
PTP2 Ptp2p 0.066
ELP6 Elp6p 0.066
RAS2 Ras2p 0.065
SEC39 Sec39p 0.063
LHS1 Lhs1p 0.061
CLA4 Cla4p 0.061