The network for 'myeloid leukocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

myeloid leukocyte activation

A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.

Mus musculus
Name Description Probability Func Analog Organism
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.999
Lyz2 lysozyme 2 0.999
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.998
Ikzf1 IKAROS family zinc finger 1 0.996
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.995
Tnf tumor necrosis factor 0.995
Ifng interferon gamma 0.992
Il1r1 interleukin 1 receptor, type I 0.972
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.969
Irf5 interferon regulatory factor 5 0.951
Mmp9 matrix metallopeptidase 9 0.950
Csf1 colony stimulating factor 1 (macrophage) 0.947
Cd247 CD247 antigen 0.931
Notch1 Notch gene homolog 1 (Drosophila) 0.929
Fas Fas (TNF receptor superfamily member 6) 0.923
Cd40 CD40 antigen 0.915
Esr1 estrogen receptor 1 (alpha) 0.901
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.901
Sfpi1 SFFV proviral integration 1 0.897
Bcl3 B-cell leukemia/lymphoma 3 0.889
Ptprc protein tyrosine phosphatase, receptor type, C 0.876
Il4 interleukin 4 0.876
Ccr1 chemokine (C-C motif) receptor 1 0.874
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.868
Runx1 runt related transcription factor 1 0.864
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.860
Nos3 nitric oxide synthase 3, endothelial cell 0.859
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.835
Ccr2 chemokine (C-C motif) receptor 2 0.825
Inpp5d inositol polyphosphate-5-phosphatase D 0.812
Ctnnb1 catenin (cadherin associated protein), beta 1 0.808
Nlrp3 NLR family, pyrin domain containing 3 0.798
Tcra T-cell receptor alpha chain 0.795
Igh immunoglobulin heavy chain complex 0.785
Apoe apolipoprotein E 0.783
Tgfbr2 transforming growth factor, beta receptor II 0.773
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.750
Fyn Fyn proto-oncogene 0.736
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.732
Mefv Mediterranean fever 0.731
Rag1 recombination activating gene 1 0.722
Ccl2 chemokine (C-C motif) ligand 2 0.708
Il10ra interleukin 10 receptor, alpha 0.705
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.700
Ptf1a pancreas specific transcription factor, 1a 0.697
Selp selectin, platelet 0.691
Cd44 CD44 antigen 0.691
Notch2 Notch gene homolog 2 (Drosophila) 0.682
Ifngr1 interferon gamma receptor 1 0.661
Stat6 signal transducer and activator of transcription 6 0.661
Birc3 baculoviral IAP repeat-containing 3 0.660
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.659
Grap2 GRB2-related adaptor protein 2 0.628
Fst follistatin 0.628
Myd88 myeloid differentiation primary response gene 88 0.624
Stat3 signal transducer and activator of transcription 3 0.622
Ccr6 chemokine (C-C motif) receptor 6 0.617
Ltbr lymphotoxin B receptor 0.614
Lat linker for activation of T cells 0.613
Tgfb1 transforming growth factor, beta 1 0.608
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.596
Il2rb interleukin 2 receptor, beta chain 0.586
Prkce protein kinase C, epsilon 0.575
Itgb2 integrin beta 2 0.571
Itgal integrin alpha L 0.564
Cd14 CD14 antigen 0.562
Il4ra interleukin 4 receptor, alpha 0.559
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.551
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.530
Ncf1 neutrophil cytosolic factor 1 0.525
Efna1 ephrin A1 0.525
Csf1r colony stimulating factor 1 receptor 0.523
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.502
Lair1 leukocyte-associated Ig-like receptor 1 0.501
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.495
Clec4n C-type lectin domain family 4, member n 0.488
Snai1 snail homolog 1 (Drosophila) 0.483
Rgs14 regulator of G-protein signaling 14 0.472
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.462
Dok3 docking protein 3 0.458
Ldb3 LIM domain binding 3 0.457
Nos2 nitric oxide synthase 2, inducible 0.456
Il1rl1 interleukin 1 receptor-like 1 0.447
Grb2 growth factor receptor bound protein 2 0.438
Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide 0.427
Il2 interleukin 2 0.426
Itgax integrin alpha X 0.422
Icos inducible T-cell co-stimulator 0.416
C3 complement component 3 0.410
Il6 interleukin 6 0.409
Acvr1 activin A receptor, type 1 0.409
Bdkrb1 bradykinin receptor, beta 1 0.407
Il2rg interleukin 2 receptor, gamma chain 0.404
Fyb FYN binding protein 0.404
Cbl Casitas B-lineage lymphoma 0.401
Pik3cg phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.396
Ciita class II transactivator 0.393
Jak3 Janus kinase 3 0.387
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.381
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.379
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SYK spleen tyrosine kinase 0.996
CCR5 chemokine (C-C motif) receptor 5 0.978
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.904
CCL5 chemokine (C-C motif) ligand 5 0.756
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.691
CXCL9 chemokine (C-X-C motif) ligand 9 0.660
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.589
PRKCZ protein kinase C, zeta 0.568
LCK lymphocyte-specific protein tyrosine kinase 0.559
CCL4 chemokine (C-C motif) ligand 4 0.539
BLNK B-cell linker 0.482
NLRC4 NLR family, CARD domain containing 4 0.480
CCL22 chemokine (C-C motif) ligand 22 0.471
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.414
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.409
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.408
CCR7 chemokine (C-C motif) receptor 7 0.406
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.394
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.382
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.378
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.375
ENG endoglin 0.373
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.355
SNAP23 synaptosomal-associated protein, 23kDa 0.323
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.320
SH2D1A SH2 domain containing 1A 0.318
IFNG interferon, gamma 0.300
APP amyloid beta (A4) precursor protein 0.296
CCL2 chemokine (C-C motif) ligand 2 0.293
FYN FYN oncogene related to SRC, FGR, YES 0.273
CCR2 chemokine (C-C motif) receptor 2 0.256
IL8 interleukin 8 0.235
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.231
BCL3 B-cell CLL/lymphoma 3 0.229
MAPT microtubule-associated protein tau 0.226
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.217
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.213
CD80 CD80 molecule 0.202
TFF1 trefoil factor 1 0.201
IL2RB interleukin 2 receptor, beta 0.195
IL10 interleukin 10 0.190
MYD88 myeloid differentiation primary response gene (88) 0.185
NOTCH1 notch 1 0.179
C19orf50 chromosome 19 open reading frame 50 0.178
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.169
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.166
IRF4 interferon regulatory factor 4 0.165
CCL3 chemokine (C-C motif) ligand 3 0.164
TICAM2 toll-like receptor adaptor molecule 2 0.163
CCL8 chemokine (C-C motif) ligand 8 0.159
ABI2 abl-interactor 2 0.158
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.157
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.157
JAG1 jagged 1 0.156
EGFR epidermal growth factor receptor 0.155
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.154
CCR1 chemokine (C-C motif) receptor 1 0.152
PLAU plasminogen activator, urokinase 0.150
FASLG Fas ligand (TNF superfamily, member 6) 0.150
IL10RA interleukin 10 receptor, alpha 0.150
NRP1 neuropilin 1 0.149
TLR2 toll-like receptor 2 0.148
CXCL10 chemokine (C-X-C motif) ligand 10 0.147
CCL19 chemokine (C-C motif) ligand 19 0.144
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.142
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.141
CAV1 caveolin 1, caveolae protein, 22kDa 0.138
CD2 CD2 molecule 0.137
UBASH3B ubiquitin associated and SH3 domain containing B 0.135
SOS1 son of sevenless homolog 1 (Drosophila) 0.133
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.132
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.128
IL2RG interleukin 2 receptor, gamma 0.127
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.127
BCL2L1 BCL2-like 1 0.127
CCL7 chemokine (C-C motif) ligand 7 0.125
CDH5 cadherin 5, type 2 (vascular endothelium) 0.122
IL1B interleukin 1, beta 0.120
SLA Src-like-adaptor 0.118
CXCL13 chemokine (C-X-C motif) ligand 13 0.117
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.115
CD33 CD33 molecule 0.114
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.110
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.105
PLEK pleckstrin 0.102
IL21R interleukin 21 receptor 0.098
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.096
JUNB jun B proto-oncogene 0.095
PPL periplakin 0.094
IGSF6 immunoglobulin superfamily, member 6 0.089
CXCR6 chemokine (C-X-C motif) receptor 6 0.088
PVRL3 poliovirus receptor-related 3 0.086
SH3KBP1 SH3-domain kinase binding protein 1 0.076
ICAM1 intercellular adhesion molecule 1 0.073
TNF tumor necrosis factor 0.073
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.072
CCR4 chemokine (C-C motif) receptor 4 0.069
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.069
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.068
PDGFC platelet derived growth factor C 0.068
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Rattus norvegicus
Name Description Probability Func Analog Organism
Casp1 caspase 1 0.618
Tlr4 toll-like receptor 4 0.452
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.398
Il2rb interleukin 2 receptor, beta 0.390
Igsf6 immunoglobulin superfamily, member 6 0.302
Atf3 activating transcription factor 3 0.297
Cd37 CD37 molecule 0.225
Bak1 BCL2-antagonist/killer 1 0.200
Igh-6 immunoglobulin heavy chain 6 0.199
Cd86 CD86 molecule 0.197
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.196
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.177
Cd8a CD8a molecule 0.172
Cd38 CD38 molecule 0.169
Oprk1 opioid receptor, kappa 1 0.167
Arl11 ADP-ribosylation factor-like 11 0.163
RT1-A3 RT1 class I, locus A3 0.158
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.152
Neurl3 neuralized homolog 3 (Drosophila) 0.149
Ptprc protein tyrosine phosphatase, receptor type, C 0.148
Myl7 myosin, light chain 7, regulatory 0.144
Sirpa signal-regulatory protein alpha 0.138
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.136
Il2rg interleukin 2 receptor, gamma 0.131
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.129
Casp8 caspase 8 0.121
Ciita class II, major histocompatibility complex, transactivator 0.120
Calm2 calmodulin 2 0.120
Gja1 gap junction protein, alpha 1 0.114
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.113
Cxcr3 chemokine (C-X-C motif) receptor 3 0.110
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.105
Iapp islet amyloid polypeptide 0.103
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.103
Adora2a adenosine A2a receptor 0.103
Sell selectin L 0.101
Calm1 calmodulin 1 0.101
Gzmk granzyme K 0.099
Dnase1l3 deoxyribonuclease 1-like 3 0.096
Il1b interleukin 1 beta 0.095
Calcrl calcitonin receptor-like 0.091
Ifi204 interferon activated gene 204 0.090
Nat1 N-acetyltransferase 1 0.088
Psd4 pleckstrin and Sec7 domain containing 4 0.087
Cst7 cystatin F (leukocystatin) 0.085
Hck hemopoietic cell kinase 0.085
Inpp5d inositol polyphosphate-5-phosphatase D 0.084
Ly86 lymphocyte antigen 86 0.084
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.082
Klra17 killer cell lectin-like receptor, subfamily A, member 17 0.081
Apobec1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 0.080
Tgfb1 transforming growth factor, beta 1 0.079
Cybb cytochrome b-245, beta polypeptide 0.077
Faslg Fas ligand (TNF superfamily, member 6) 0.077
Klrc2 killer cell lectin-like receptor subfamily C, member 2 0.076
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.075
Il13ra2 interleukin 13 receptor, alpha 2 0.073
Fcnb ficolin B 0.072
Dchs1 dachsous 1 (Drosophila) 0.071
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.071
Scn11a sodium channel, voltage-gated, type XI, alpha 0.070
Mmp12 matrix metallopeptidase 12 0.069
Gimap4 GTPase, IMAP family member 4 0.069
Plau plasminogen activator, urokinase 0.069
Csf1 colony stimulating factor 1 (macrophage) 0.068
Fam26f family with sequence similarity 26, member F 0.067
Tlr7 toll-like receptor 7 0.064
C5ar1 complement component 5a receptor 1 0.062
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.062
Cd69 Cd69 molecule 0.061
Itgam integrin, alpha M 0.060
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.060
Skap2 src kinase associated phosphoprotein 2 0.059
Alox5ap arachidonate 5-lipoxygenase activating protein 0.059
Slc22a25 solute carrier family 22, member 25 0.058
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.056
Ccr5 chemokine (C-C motif) receptor 5 0.055
RGD1310262 hypothetical LOC304650 0.053
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.053
Prl3d4 prolactin family 3, subfamily d, member 4 0.052
C3ar1 complement component 3a receptor 1 0.052
Kcnab3 potassium voltage-gated channel, shaker-related subfamily, beta member 3 0.052
Ctsc cathepsin C 0.051
Ptpre protein tyrosine phosphatase, receptor type, E 0.051
Reg3b regenerating islet-derived 3 beta 0.051
Pdcl phosducin-like 0.050
Padi3 peptidyl arginine deiminase, type III 0.050
Rhoh ras homolog gene family, member H 0.049
Vom2r27 vomeronasal 2 receptor, 27 0.048
RT1-Ba RT1 class II, locus Ba 0.048
Mrgprf MAS-related GPR, member F 0.048
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.047
Bcl3 B-cell CLL/lymphoma 3 0.047
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.047
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.047
Adam10 ADAM metallopeptidase domain 10 0.047
Pgam1 phosphoglycerate mutase 1 (brain) 0.046
Tcf21 transcription factor 21 0.045
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.044
Prkcb protein kinase C, beta 0.043
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism