The network for 'regulation of b cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of b cell differentiation

Any process that modulates the frequency, rate or extent of B cell differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Ikzf1 IKAROS family zinc finger 1 1.000
Igh immunoglobulin heavy chain complex 1.000
Fyn Fyn proto-oncogene 0.999
Tcra T-cell receptor alpha chain 0.994
Foxp3 forkhead box P3 0.992
Cd19 CD19 antigen 0.984
Pten phosphatase and tensin homolog 0.980
Trp53 transformation related protein 53 0.979
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.964
Kdr kinase insert domain protein receptor 0.963
Rag2 recombination activating gene 2 0.962
Stat5a signal transducer and activator of transcription 5A 0.958
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.953
Cbl Casitas B-lineage lymphoma 0.952
Stat5b signal transducer and activator of transcription 5B 0.948
Id1 inhibitor of DNA binding 1 0.943
Grb2 growth factor receptor bound protein 2 0.930
Inpp5d inositol polyphosphate-5-phosphatase D 0.916
Id3 inhibitor of DNA binding 3 0.890
Rag1 recombination activating gene 1 0.856
Tcf3 transcription factor 3 0.848
Btk Bruton agammaglobulinemia tyrosine kinase 0.843
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.825
Kit kit oncogene 0.824
Irf9 interferon regulatory factor 9 0.811
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.802
Shc1 src homology 2 domain-containing transforming protein C1 0.766
Fas Fas (TNF receptor superfamily member 6) 0.756
Stat3 signal transducer and activator of transcription 3 0.745
Pnp2 purine-nucleoside phosphorylase 2 0.706
Sfrp2 secreted frizzled-related protein 2 0.673
Cd22 CD22 antigen 0.615
Lyz2 lysozyme 2 0.563
Prf1 perforin 1 (pore forming protein) 0.529
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.498
Lck lymphocyte protein tyrosine kinase 0.487
Il2 interleukin 2 0.477
Cd247 CD247 antigen 0.442
Lat linker for activation of T cells 0.438
Blnk B-cell linker 0.423
Ttc7 tetratricopeptide repeat domain 7 0.420
Irf8 interferon regulatory factor 8 0.404
Ctnnb1 catenin (cadherin associated protein), beta 1 0.387
Sfpi1 SFFV proviral integration 1 0.386
Tnf tumor necrosis factor 0.353
Tgfbr2 transforming growth factor, beta receptor II 0.332
Il6st interleukin 6 signal transducer 0.315
Vegfa vascular endothelial growth factor A 0.314
Sh3kbp1 SH3-domain kinase binding protein 1 0.312
Csf1 colony stimulating factor 1 (macrophage) 0.308
Nckap1l NCK associated protein 1 like 0.294
Plcg2 phospholipase C, gamma 2 0.288
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.287
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.273
Cd28 CD28 antigen 0.265
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.238
Tgfb1 transforming growth factor, beta 1 0.226
Lyst lysosomal trafficking regulator 0.216
Tcrd T-cell receptor delta chain 0.183
Nos3 nitric oxide synthase 3, endothelial cell 0.178
Ets1 E26 avian leukemia oncogene 1, 5' domain 0.175
Tcf4 transcription factor 4 0.159
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.155
Lta lymphotoxin A 0.152
Il2rg interleukin 2 receptor, gamma chain 0.144
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.141
Zap70 zeta-chain (TCR) associated protein kinase 0.141
Ldlr low density lipoprotein receptor 0.137
Ank1 ankyrin 1, erythroid 0.135
Ltb lymphotoxin B 0.132
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.132
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.126
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.126
Kitl kit ligand 0.118
Il4 interleukin 4 0.114
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.114
Sfrp1 secreted frizzled-related protein 1 0.113
Cxcl12 chemokine (C-X-C motif) ligand 12 0.112
Traf3ip2 TRAF3 interacting protein 2 0.110
Ptma prothymosin alpha 0.109
Spna1 spectrin alpha 1 0.109
Plcg1 phospholipase C, gamma 1 0.109
Stat2 signal transducer and activator of transcription 2 0.105
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.104
Il4ra interleukin 4 receptor, alpha 0.099
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.099
Cxcr4 chemokine (C-X-C motif) receptor 4 0.099
Jak2 Janus kinase 2 0.097
Vav1 vav 1 oncogene 0.096
Col1a1 collagen, type I, alpha 1 0.095
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.095
Ifnar2 interferon (alpha and beta) receptor 2 0.092
Tcrb T-cell receptor beta chain 0.091
Huwe1 HECT, UBA and WWE domain containing 1 0.088
2010106G01Rik RIKEN cDNA 2010106G01 gene 0.087
Zeb1 zinc finger E-box binding homeobox 1 0.087
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.087
Foxc1 forkhead box C1 0.084
Card11 caspase recruitment domain family, member 11 0.084
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.078
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.828
BCL10 B-cell CLL/lymphoma 10 0.545
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.509
EPOR erythropoietin receptor 0.399
IL4R interleukin 4 receptor 0.319
CSNK1G1 casein kinase 1, gamma 1 0.224
IL2RB interleukin 2 receptor, beta 0.207
INSR insulin receptor 0.201
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.189
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.188
STAP2 signal transducing adaptor family member 2 0.129
CD22 CD22 molecule 0.121
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.113
JAK2 Janus kinase 2 0.113
SH3KBP1 SH3-domain kinase binding protein 1 0.100
PIAS1 protein inhibitor of activated STAT, 1 0.091
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.073
CTBP1 C-terminal binding protein 1 0.073
CD2 CD2 molecule 0.068
UBASH3B ubiquitin associated and SH3 domain containing B 0.060
IRS1 insulin receptor substrate 1 0.060
ZHX1 zinc fingers and homeoboxes 1 0.057
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.056
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.046
LAT linker for activation of T cells 0.037
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.035
SYK spleen tyrosine kinase 0.033
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.032
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.031
CD33 CD33 molecule 0.030
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.030
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.029
VAV1 vav 1 guanine nucleotide exchange factor 0.029
SH2D2A SH2 domain containing 2A 0.029
IL4 interleukin 4 0.029
SOCS3 suppressor of cytokine signaling 3 0.028
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.028
STAT5A signal transducer and activator of transcription 5A 0.027
PRKCQ protein kinase C, theta 0.026
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 0.024
PDPK1 3-phosphoinositide dependent protein kinase-1 0.024
BTK Bruton agammaglobulinemia tyrosine kinase 0.023
GHR growth hormone receptor 0.022
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.021
BLNK B-cell linker 0.021
TXN thioredoxin 0.020
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.020
GLA galactosidase, alpha 0.019
CD247 CD247 molecule 0.019
MTA3 metastasis associated 1 family, member 3 0.019
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.019
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.019
DOK3 docking protein 3 0.018
HIPK2 homeodomain interacting protein kinase 2 0.018
PRKCB protein kinase C, beta 0.018
MBD1 methyl-CpG binding domain protein 1 0.018
C10orf46 chromosome 10 open reading frame 46 0.017
BCL3 B-cell CLL/lymphoma 3 0.016
SMAD7 SMAD family member 7 0.016
MANF mesencephalic astrocyte-derived neurotrophic factor 0.016
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.015
SOCS2 suppressor of cytokine signaling 2 0.015
LRMP lymphoid-restricted membrane protein 0.014
CAV1 caveolin 1, caveolae protein, 22kDa 0.014
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.014
GFER growth factor, augmenter of liver regeneration 0.014
SLAMF1 signaling lymphocytic activation molecule family member 1 0.014
PRTFDC1 phosphoribosyl transferase domain containing 1 0.013
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.013
GRB10 growth factor receptor-bound protein 10 0.012
SH2B1 SH2B adaptor protein 1 0.012
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.012
SELL selectin L 0.012
GRIP1 glutamate receptor interacting protein 1 0.012
PILRA paired immunoglobin-like type 2 receptor alpha 0.011
PPIF peptidylprolyl isomerase F 0.011
MET met proto-oncogene (hepatocyte growth factor receptor) 0.011
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.011
SATB1 SATB homeobox 1 0.011
JAK3 Janus kinase 3 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hck hemopoietic cell kinase 0.504
Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.281
Cybb cytochrome b-245, beta polypeptide 0.262
Laptm5 lysosomal protein transmembrane 5 0.241
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.229
Lcp1 lymphocyte cytosolic protein 1 0.221
Ly86 lymphocyte antigen 86 0.211
Ctse cathepsin E 0.179
Myo1f myosin IF 0.176
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.170
Cd37 CD37 molecule 0.165
Vav1 vav 1 guanine nucleotide exchange factor 0.152
C5ar1 complement component 5a receptor 1 0.150
Cd4 Cd4 molecule 0.128
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.118
Pld4 phospholipase D family, member 4 0.117
Klhl6 kelch-like 6 (Drosophila) 0.103
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.101
Cfp complement factor properdin 0.091
Sla src-like adaptor 0.091
Nos3 nitric oxide synthase 3, endothelial cell 0.088
Igsf6 immunoglobulin superfamily, member 6 0.087
Bin2 bridging integrator 2 0.082
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.080
Sirpa signal-regulatory protein alpha 0.074
Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.073
Ddr2 discoidin domain receptor tyrosine kinase 2 0.066
Stk10 serine/threonine kinase 10 0.065
Utrn utrophin 0.059
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.057
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.056
Srpr signal recognition particle receptor ('docking protein') 0.056
Crbn cereblon 0.055
Gpsm3 G-protein signaling modulator 3 (AGS3-like, C. elegans) 0.055
Vwf von Willebrand factor 0.053
Arhgap25 Rho GTPase activating protein 25 0.053
Hdac7 histone deacetylase 7 0.053
Evi2a ecotropic viral integration site 2A 0.051
Inpp5d inositol polyphosphate-5-phosphatase D 0.051
Clic4 chloride intracellular channel 4 0.049
Cyb5r4 cytochrome b5 reductase 4 0.049
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.049
Cd53 Cd53 molecule 0.049
Plac8 placenta-specific 8 0.048
Ltbp3 latent transforming growth factor beta binding protein 3 0.048
Il2rg interleukin 2 receptor, gamma 0.047
Dhx40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.046
C1qc complement component 1, q subcomponent, C chain 0.046
Anpep alanyl (membrane) aminopeptidase 0.045
F13a1 coagulation factor XIII, A1 polypeptide 0.045
Acacb acetyl-Coenzyme A carboxylase beta 0.043
Glipr1 GLI pathogenesis-related 1 0.043
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.042
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.042
Calcrl calcitonin receptor-like 0.042
Tlr7 toll-like receptor 7 0.042
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.040
Cd8a CD8a molecule 0.040
Arl11 ADP-ribosylation factor-like 11 0.038
Nras neuroblastoma ras oncogene 0.038
Ptprc protein tyrosine phosphatase, receptor type, C 0.036
Igfbp5 insulin-like growth factor binding protein 5 0.034
Apol3 apolipoprotein L, 3 0.033
Wipf1 WAS/WASL interacting protein family, member 1 0.032
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.032
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.032
Tyrobp Tyro protein tyrosine kinase binding protein 0.031
Lamc1 laminin, gamma 1 0.031
Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.031
Lcp2 lymphocyte cytosolic protein 2 0.031
Lama2 laminin, alpha 2 0.030
Cd2 Cd2 molecule 0.029
Bmp6 bone morphogenetic protein 6 0.029
Spn sialophorin 0.028
Podxl podocalyxin-like 0.028
Ptpn7 protein tyrosine phosphatase, non-receptor type 7 0.027
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.027
Csf1r colony stimulating factor 1 receptor 0.026
Arhgap4 Rho GTPase activating protein 4 0.026
Ccr5 chemokine (C-C motif) receptor 5 0.026
Gja4 gap junction protein, alpha 4 0.026
Slc24a6 solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 0.026
Cd83 CD83 molecule 0.026
Dock8 dedicator of cytokinesis 8 0.026
Il1r1 interleukin 1 receptor, type I 0.025
Cd3g CD3 molecule, gamma 0.025
Gas7 growth arrest specific 7 0.025
Syt9 synaptotagmin IX 0.025
Igh-6 immunoglobulin heavy chain 6 0.025
Nckap1l NCK associated protein 1 like 0.025
Plvap plasmalemma vesicle associated protein 0.024
Cpz carboxypeptidase Z 0.024
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.024
Cmtm3 CKLF-like MARVEL transmembrane domain containing 3 0.023
Col5a1 collagen, type V, alpha 1 0.023
Abcc9 ATP-binding cassette, subfamily C (CFTR/MRP), member 9 0.023
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.023
Bcl2 B-cell CLL/lymphoma 2 0.023
Itpr1 inositol 1,4,5-triphosphate receptor, type 1 0.023
Surf4 surfeit 4 0.023
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism