The network for 'somatic diversification of immune receptors' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

somatic diversification of immune receptors

The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Igh immunoglobulin heavy chain complex 0.998
Il10 interleukin 10 0.998
Ifng interferon gamma 0.996
Ikzf1 IKAROS family zinc finger 1 0.996
Atm ataxia telangiectasia mutated homolog (human) 0.996
Rag2 recombination activating gene 2 0.989
Il4 interleukin 4 0.986
Foxp3 forkhead box P3 0.983
Fyn Fyn proto-oncogene 0.980
Prf1 perforin 1 (pore forming protein) 0.955
Rag1 recombination activating gene 1 0.950
Cd19 CD19 antigen 0.942
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.901
Il6 interleukin 6 0.897
Stat5b signal transducer and activator of transcription 5B 0.885
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.879
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.862
Tcra T-cell receptor alpha chain 0.843
Lef1 lymphoid enhancer binding factor 1 0.833
Tbx3 T-box 3 0.812
Cd40 CD40 antigen 0.803
Stat3 signal transducer and activator of transcription 3 0.800
Socs1 suppressor of cytokine signaling 1 0.784
Cd28 CD28 antigen 0.691
Pou5f1 POU domain, class 5, transcription factor 1 0.685
Card11 caspase recruitment domain family, member 11 0.655
Stat5a signal transducer and activator of transcription 5A 0.640
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.631
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.589
Cd247 CD247 antigen 0.572
Il2 interleukin 2 0.550
Lat linker for activation of T cells 0.523
Nos2 nitric oxide synthase 2, inducible 0.498
Zeb1 zinc finger E-box binding homeobox 1 0.483
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.480
Tlr4 toll-like receptor 4 0.475
Tcf3 transcription factor 3 0.453
Lta lymphotoxin A 0.446
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.442
Btk Bruton agammaglobulinemia tyrosine kinase 0.429
Brca1 breast cancer 1 0.426
Lck lymphocyte protein tyrosine kinase 0.405
Brca2 breast cancer 2 0.386
Il2rg interleukin 2 receptor, gamma chain 0.379
Irf9 interferon regulatory factor 9 0.358
Tcf7 transcription factor 7, T-cell specific 0.341
Chd7 chromodomain helicase DNA binding protein 7 0.334
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.333
Il21r interleukin 21 receptor 0.319
Ltb lymphotoxin B 0.317
Trp53 transformation related protein 53 0.314
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.314
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.314
Pitx1 paired-like homeodomain transcription factor 1 0.297
Inpp5d inositol polyphosphate-5-phosphatase D 0.290
Tbx21 T-box 21 0.275
Il1r1 interleukin 1 receptor, type I 0.274
Wt1 Wilms tumor 1 homolog 0.273
Mmp9 matrix metallopeptidase 9 0.261
Pten phosphatase and tensin homolog 0.238
Nlrp3 NLR family, pyrin domain containing 3 0.211
Tal1 T-cell acute lymphocytic leukemia 1 0.209
Fas Fas (TNF receptor superfamily member 6) 0.197
Nbn nibrin 0.194
Gli2 GLI-Kruppel family member GLI2 0.193
Il4ra interleukin 4 receptor, alpha 0.193
Il22 interleukin 22 0.185
Cd40lg CD40 ligand 0.181
Gdf3 growth differentiation factor 3 0.179
Itk IL2-inducible T-cell kinase 0.175
Sh2d1a SH2 domain protein 1A 0.175
Ccl2 chemokine (C-C motif) ligand 2 0.172
Rc3h1 RING CCCH (C3H) domains 1 0.167
Ccr7 chemokine (C-C motif) receptor 7 0.167
Myd88 myeloid differentiation primary response gene 88 0.166
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.145
Lag3 lymphocyte-activation gene 3 0.144
Lif leukemia inhibitory factor 0.143
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.138
Pdcd1 programmed cell death 1 0.135
Ptgs2 prostaglandin-endoperoxide synthase 2 0.135
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.133
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.132
Bcl6 B-cell leukemia/lymphoma 6 0.132
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.132
Fasl Fas ligand (TNF superfamily, member 6) 0.132
Timeless timeless homolog (Drosophila) 0.125
Stat2 signal transducer and activator of transcription 2 0.123
Trp63 transformation related protein 63 0.122
Lyz2 lysozyme 2 0.120
Pgrmc1 progesterone receptor membrane component 1 0.118
Orc1 origin recognition complex, subunit 1 0.117
Smad3 MAD homolog 3 (Drosophila) 0.114
Runx2 runt related transcription factor 2 0.113
Htt huntingtin 0.111
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.110
Tcrb T-cell receptor beta chain 0.109
Ppap2b phosphatidic acid phosphatase type 2B 0.108
Cd44 CD44 antigen 0.108
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
IL4R interleukin 4 receptor 0.581
RAD50 RAD50 homolog (S. cerevisiae) 0.560
MSH6 mutS homolog 6 (E. coli) 0.389
MDC1 mediator of DNA-damage checkpoint 1 0.315
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.245
APLF aprataxin and PNKP like factor 0.215
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.208
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.100
H2AFX H2A histone family, member X 0.098
TAL1 T-cell acute lymphocytic leukemia 1 0.088
TP53BP1 tumor protein p53 binding protein 1 0.083
BRCA1 breast cancer 1, early onset 0.073
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.068
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.065
GRAP2 GRB2-related adaptor protein 2 0.056
LIG4 ligase IV, DNA, ATP-dependent 0.053
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.053
MSH3 mutS homolog 3 (E. coli) 0.043
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.042
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.037
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.034
RUNX1 runt-related transcription factor 1 0.034
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.032
SMC1A structural maintenance of chromosomes 1A 0.031
PCNA proliferating cell nuclear antigen 0.031
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.027
HMGB2 high mobility group box 2 0.026
THOC5 THO complex 5 0.025
ZNF830 zinc finger protein 830 0.024
FANCD2 Fanconi anemia, complementation group D2 0.023
PARP1 poly (ADP-ribose) polymerase 1 0.021
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.021
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.021
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.021
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.020
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.020
HMGB1 high mobility group box 1 0.019
CSNK1A1 casein kinase 1, alpha 1 0.018
PTMA prothymosin, alpha 0.018
CD22 CD22 molecule 0.016
FERMT2 fermitin family member 2 0.014
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.014
RAD21 RAD21 homolog (S. pombe) 0.014
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.013
IK IK cytokine, down-regulator of HLA II 0.013
TCF12 transcription factor 12 0.012
PCDH9 protocadherin 9 0.012
RPA1 replication protein A1, 70kDa 0.012
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.011
TCF4 transcription factor 4 0.011
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hspa8 heat shock protein 8 0.066
Cycs cytochrome c, somatic 0.049
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.041
Ppid peptidylprolyl isomerase D (cyclophilin D) 0.034
Cd37 CD37 molecule 0.034
Hspa5 heat shock protein 5 0.033
Hsph1 heat shock 105/110 protein 1 0.030
Casp1 caspase 1 0.027
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.021
Bin2 bridging integrator 2 0.021
Cxcr4 chemokine (C-X-C motif) receptor 4 0.021
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.020
Arl5c ADP-ribosylation factor-like 5C 0.019
Ndufab1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 0.016
Hck hemopoietic cell kinase 0.016
Ptafr platelet-activating factor receptor 0.015
Plcg2 phospholipase C, gamma 2 0.014
LOC681996 similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 1 0.014
Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 0.014
Lcp2 lymphocyte cytosolic protein 2 0.014
Hspe1 heat shock protein 1 (chaperonin 10) 0.014
Myh9 myosin, heavy chain 9, non-muscle 0.014
Smad7 SMAD family member 7 0.014
Chordc1 cysteine and histidine-rich domain (CHORD)-containing 1 0.013
Fmnl1 formin-like 1 0.013
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.013
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.013
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.012
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.012
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.012
RT1-Ba RT1 class II, locus Ba 0.012
Il2rg interleukin 2 receptor, gamma 0.012
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.012
Cd2 Cd2 molecule 0.012
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.012
RGD1305222 similar to RIKEN cDNA 1810029B16 0.012
Myo1e myosin IE 0.011
Syk spleen tyrosine kinase 0.011
Ndufa5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5 0.011
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.011
Il1b interleukin 1 beta 0.011
Clec9a C-type lectin domain family 9, member a 0.011
Psd4 pleckstrin and Sec7 domain containing 4 0.011
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.011
Dnm2 dynamin 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism