The network for 'b cell activation involved in immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

b cell activation involved in immune response

The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.998
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.996
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.990
Ifng interferon gamma 0.982
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.978
Il4 interleukin 4 0.971
Foxp3 forkhead box P3 0.966
Ikzf1 IKAROS family zinc finger 1 0.964
Il10 interleukin 10 0.955
Igh immunoglobulin heavy chain complex 0.938
Il2rg interleukin 2 receptor, gamma chain 0.936
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.932
Cd40 CD40 antigen 0.931
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.895
Socs1 suppressor of cytokine signaling 1 0.869
Fyn Fyn proto-oncogene 0.857
Ltb lymphotoxin B 0.781
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.735
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.686
Lyz2 lysozyme 2 0.680
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.679
Stat3 signal transducer and activator of transcription 3 0.677
Lta lymphotoxin A 0.650
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.645
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.598
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.596
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.592
Bcl6 B-cell leukemia/lymphoma 6 0.579
Irf9 interferon regulatory factor 9 0.575
Hspa5 heat shock protein 5 0.545
Pitx1 paired-like homeodomain transcription factor 1 0.540
Gdf3 growth differentiation factor 3 0.506
Batf basic leucine zipper transcription factor, ATF-like 0.497
Stat6 signal transducer and activator of transcription 6 0.478
Cd28 CD28 antigen 0.468
Irf4 interferon regulatory factor 4 0.448
Inpp5d inositol polyphosphate-5-phosphatase D 0.425
Il4ra interleukin 4 receptor, alpha 0.422
Fasl Fas ligand (TNF superfamily, member 6) 0.391
Bcl3 B-cell leukemia/lymphoma 3 0.347
Tcra T-cell receptor alpha chain 0.344
Ncoa3 nuclear receptor coactivator 3 0.328
Gpr132 G protein-coupled receptor 132 0.326
Prdm1 PR domain containing 1, with ZNF domain 0.325
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.321
Stat1 signal transducer and activator of transcription 1 0.320
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.316
Il6 interleukin 6 0.304
Foxp1 forkhead box P1 0.297
Trp53 transformation related protein 53 0.288
Tlr4 toll-like receptor 4 0.286
Atm ataxia telangiectasia mutated homolog (human) 0.284
Cxcr5 chemokine (C-X-C motif) receptor 5 0.276
Il2rb interleukin 2 receptor, beta chain 0.267
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.261
Cd19 CD19 antigen 0.261
Cd40lg CD40 ligand 0.257
Il10ra interleukin 10 receptor, alpha 0.254
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.248
Il21r interleukin 21 receptor 0.237
Cd22 CD22 antigen 0.236
Ccr7 chemokine (C-C motif) receptor 7 0.236
Tbx5 T-box 5 0.235
Prf1 perforin 1 (pore forming protein) 0.222
Icos inducible T-cell co-stimulator 0.221
Cyld cylindromatosis (turban tumor syndrome) 0.216
Vav1 vav 1 oncogene 0.216
Sfpi1 SFFV proviral integration 1 0.215
Nos2 nitric oxide synthase 2, inducible 0.205
Lat linker for activation of T cells 0.205
Irf1 interferon regulatory factor 1 0.202
Tcf3 transcription factor 3 0.200
Gja5 gap junction protein, alpha 5 0.199
Itgal integrin alpha L 0.195
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.190
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.190
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.186
Tlr2 toll-like receptor 2 0.184
Ccr1 chemokine (C-C motif) receptor 1 0.183
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.177
Sufu suppressor of fused homolog (Drosophila) 0.167
Casp1 caspase 1 0.162
Myd88 myeloid differentiation primary response gene 88 0.160
Birc3 baculoviral IAP repeat-containing 3 0.160
Ccl2 chemokine (C-C motif) ligand 2 0.158
Pdcd1 programmed cell death 1 0.155
Cd44 CD44 antigen 0.155
Trim21 tripartite motif-containing 21 0.153
Lcp1 lymphocyte cytosolic protein 1 0.151
Fgf10 fibroblast growth factor 10 0.146
Tbx3 T-box 3 0.144
Pou5f1 POU domain, class 5, transcription factor 1 0.139
Ccr2 chemokine (C-C motif) receptor 2 0.138
Gli2 GLI-Kruppel family member GLI2 0.137
Itk IL2-inducible T-cell kinase 0.136
Zeb1 zinc finger E-box binding homeobox 1 0.130
Il2 interleukin 2 0.129
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.128
Il7 interleukin 7 0.126
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.121
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.057
IL4R interleukin 4 receptor 0.038
APLF aprataxin and PNKP like factor 0.019
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.015
MSH6 mutS homolog 6 (E. coli) 0.013
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.011
GRAP2 GRB2-related adaptor protein 2 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.396
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.244
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.182
Ctse cathepsin E 0.166
Casp1 caspase 1 0.147
Il2rb interleukin 2 receptor, beta 0.129
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.107
Cycs cytochrome c, somatic 0.101
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.079
Ccr1 chemokine (C-C motif) receptor 1 0.079
Cd37 CD37 molecule 0.078
Hspa8 heat shock protein 8 0.078
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.073
Hck hemopoietic cell kinase 0.073
Hspa5 heat shock protein 5 0.065
Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 0.064
Hsph1 heat shock 105/110 protein 1 0.064
Ccl5 chemokine (C-C motif) ligand 5 0.063
Igsf6 immunoglobulin superfamily, member 6 0.061
Cd247 Cd247 molecule 0.059
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.052
Ptprc protein tyrosine phosphatase, receptor type, C 0.051
Tlr7 toll-like receptor 7 0.050
Bak1 BCL2-antagonist/killer 1 0.048
Srpr signal recognition particle receptor ('docking protein') 0.048
Arl5c ADP-ribosylation factor-like 5C 0.048
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.047
LOC681996 similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 1 0.046
Arhgap25 Rho GTPase activating protein 25 0.044
Syk spleen tyrosine kinase 0.044
Il2rg interleukin 2 receptor, gamma 0.044
Myh9 myosin, heavy chain 9, non-muscle 0.043
Slc25a5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.043
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.043
Sec31a SEC31 homolog A (S. cerevisiae) 0.042
Mpeg1 macrophage expressed 1 0.041
Cd2 Cd2 molecule 0.040
Il16 interleukin 16 0.039
Plcg2 phospholipase C, gamma 2 0.037
RT1-Db1 RT1 class II, locus Db1 0.036
Sell selectin L 0.036
Cd38 CD38 molecule 0.036
Il7r interleukin 7 receptor 0.036
Cybb cytochrome b-245, beta polypeptide 0.036
Psd4 pleckstrin and Sec7 domain containing 4 0.035
Arfgap1 ADP-ribosylation factor GTPase activating protein 1 0.035
Mmp12 matrix metallopeptidase 12 0.035
Ly6b lymphocyte antigen 6 complex, locus B 0.034
Hspe1 heat shock protein 1 (chaperonin 10) 0.034
Il1b interleukin 1 beta 0.034
Pglyrp1 peptidoglycan recognition protein 1 0.033
Zc3h7a zinc finger CCCH type containing 7 A 0.033
Aspg asparaginase homolog (S. cerevisiae) 0.033
Cd3g CD3 molecule, gamma 0.033
Prkcd protein kinase C, delta 0.033
Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 0.033
Anpep alanyl (membrane) aminopeptidase 0.033
Cd53 Cd53 molecule 0.033
Havcr1 hepatitis A virus cellular receptor 1 0.032
Zyx zyxin 0.032
Fmnl1 formin-like 1 0.032
Pim1 pim-1 oncogene 0.032
Cxcr4 chemokine (C-X-C motif) receptor 4 0.031
Ccl3 chemokine (C-C motif) ligand 3 0.030
Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 0.030
ND4 NADH dehydrogenase subunit 4 0.030
Cd8a CD8a molecule 0.030
Mcpt3 mast cell peptidase 3 0.029
Ccr5 chemokine (C-C motif) receptor 5 0.029
Cd44 Cd44 molecule 0.029
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.029
Cd79b Cd79b molecule, immunoglobulin-associated beta 0.028
Arhgap4 Rho GTPase activating protein 4 0.028
Rgs1 regulator of G-protein signaling 1 0.027
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.027
Ly6c Ly6-C antigen 0.027
Prph2 peripherin 2 0.027
Mca32 mast cell antigen 32 0.027
Clk4 CDC like kinase 4 0.027
Exosc9 exosome component 9 0.027
Glipr1 GLI pathogenesis-related 1 0.027
Expi extracellular proteinase inhibitor 0.027
Cct4 chaperonin containing Tcp1, subunit 4 (delta) 0.027
Set SET nuclear oncogene 0.027
Dok2 docking protein 2 0.026
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.026
Vcam1 vascular cell adhesion molecule 1 0.026
Clec9a C-type lectin domain family 9, member a 0.026
Prkcb protein kinase C, beta 0.026
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.026
Bche butyrylcholinesterase 0.025
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.025
Ppid peptidylprolyl isomerase D (cyclophilin D) 0.025
Ptafr platelet-activating factor receptor 0.025
Il15 interleukin 15 0.025
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.025
Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) 0.025
Chat choline acetyltransferase 0.025
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.025
Vav1 vav 1 guanine nucleotide exchange factor 0.025
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism