IMP

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Homo sapiens

27 genes annotated in human

regulation of mitotic sister chromatid separation

Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of mitotic sister chromatid separation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of mitotic sister chromatid separation" (in gray)

Name	Description	Probability	Func Analog Organism
CDC27	cell division cycle 27 homolog (S. cerevisiae)	1.000
CDC20	cell division cycle 20 homolog (S. cerevisiae)	1.000	Yeast Worm Fly
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	1.000	Mouse Fly
CDK2	cyclin-dependent kinase 2	1.000
ANAPC4	anaphase promoting complex subunit 4	1.000
CCNA2	cyclin A2	0.997
ANAPC7	anaphase promoting complex subunit 7	0.985
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.985	Fly
ANAPC1	anaphase promoting complex subunit 1	0.982	Worm
CCNB1	cyclin B1	0.980
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.977
ANAPC5	anaphase promoting complex subunit 5	0.948
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.945
TCP1	t-complex 1	0.941
SKP2	S-phase kinase-associated protein 2 (p45)	0.932
RB1	retinoblastoma 1	0.890
CDT1	chromatin licensing and DNA replication factor 1	0.762
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.690
RBL1	retinoblastoma-like 1 (p107)	0.677	Human
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.655
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.569
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.569	Fly
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.540
ANAPC11	anaphase promoting complex subunit 11	0.498
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.460
SMC3	structural maintenance of chromosomes 3	0.448
ORC1	origin recognition complex, subunit 1	0.401
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.393	Worm Fly
STAG1	stromal antigen 1	0.361
CCNE1	cyclin E1	0.355	Fly
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.318
ORC2	origin recognition complex, subunit 2	0.292
CCT6A	chaperonin containing TCP1, subunit 6A (zeta 1)	0.267
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.266
E2F1	E2F transcription factor 1	0.257
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.254
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.252
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.231
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.219
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.203
PTTG1	pituitary tumor-transforming 1	0.198
CBX5	chromobox homolog 5	0.197
SMAD2	SMAD family member 2	0.175
CDKN3	cyclin-dependent kinase inhibitor 3	0.169
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.168
CUL1	cullin 1	0.163
SKA1	spindle and kinetochore associated complex subunit 1	0.161
AURKB	aurora kinase B	0.145
BRCA1	breast cancer 1, early onset	0.135
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.131
PLK1	polo-like kinase 1	0.129
SMC6	structural maintenance of chromosomes 6	0.128
SKA2	spindle and kinetochore associated complex subunit 2	0.126
RAD21	RAD21 homolog (S. pombe)	0.126
FBXO5	F-box protein 5	0.118
BRCA2	breast cancer 2, early onset	0.114
VHL	von Hippel-Lindau tumor suppressor	0.112
CCNB2	cyclin B2	0.103
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.101
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0.099
CD44	CD44 molecule (Indian blood group)	0.095
TFDP1	transcription factor Dp-1	0.092
PTEN	phosphatase and tensin homolog	0.091
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.088
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.085
RBBP8	retinoblastoma binding protein 8	0.080
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.080
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.080
SKA3	spindle and kinetochore associated complex subunit 3	0.075
CUL2	cullin 2	0.075	Worm
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.072
ZWINT	ZW10 interactor	0.069
MDC1	mediator of DNA-damage checkpoint 1	0.067
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.063
SMC1A	structural maintenance of chromosomes 1A	0.060
STAG2	stromal antigen 2	0.057
TTK	TTK protein kinase	0.056	Yeast
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.056
RBL2	retinoblastoma-like 2 (p130)	0.054	Human
C19orf39	chromosome 19 open reading frame 39	0.054
EZR	ezrin	0.053	Fly
KIF18A	kinesin family member 18A	0.051
NEK9	NIMA (never in mitosis gene a)- related kinase 9	0.048
TBC1D10A	TBC1 domain family, member 10A	0.048
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.048
CUL4A	cullin 4A	0.047
LRR1	leucine rich repeat protein 1	0.047
CASC5	cancer susceptibility candidate 5	0.046
CCNE2	cyclin E2	0.046	Fly
PRC1	protein regulator of cytokinesis 1	0.042
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.041
SGOL2	shugoshin-like 2 (S. pombe)	0.040
CKS2	CDC28 protein kinase regulatory subunit 2	0.040
RIF1	RAP1 interacting factor homolog (yeast)	0.039
CCND1	cyclin D1	0.038
CLSPN	claspin	0.038
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.038
ANKRD52	ankyrin repeat domain 52	0.037
PXN	paxillin	0.036
SGOL1	shugoshin-like 1 (S. pombe)	0.035
CREBBP	CREB binding protein	0.034
KAT2B	K(lysine) acetyltransferase 2B	0.033
WBP4	WW domain binding protein 4 (formin binding protein 21)	0.033
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.033
SIRT2	sirtuin 2	0.032
PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	0.032
AXIN1	axin 1	0.031
FYN	FYN oncogene related to SRC, FGR, YES	0.031
SKP1	S-phase kinase-associated protein 1	0.031
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.031
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.030
HERC2	hect domain and RLD 2	0.030
VCP	valosin containing protein	0.029
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.029
ANAPC16	anaphase promoting complex subunit 16	0.029
TRIP13	thyroid hormone receptor interactor 13	0.028
TP53BP1	tumor protein p53 binding protein 1	0.028
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.028
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.028
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.028
FEN1	flap structure-specific endonuclease 1	0.026
FXR2	fragile X mental retardation, autosomal homolog 2	0.026
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.025
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.025
MYST1	MYST histone acetyltransferase 1	0.025
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.025
CENPE	centromere protein E, 312kDa	0.025
EP300	E1A binding protein p300	0.025
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.024
CUL5	cullin 5	0.024
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.024
HIST1H4A	histone cluster 1, H4a	0.024
MAK	male germ cell-associated kinase	0.024
AXIN2	axin 2	0.024
ANAPC13	anaphase promoting complex subunit 13	0.024
PARP3	poly (ADP-ribose) polymerase family, member 3	0.023
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.023
PPP4C	protein phosphatase 4, catalytic subunit	0.022
RAD51C	RAD51 homolog C (S. cerevisiae)	0.022
INCENP	inner centromere protein antigens 135/155kDa	0.021
WAPAL	wings apart-like homolog (Drosophila)	0.021
PLK4	polo-like kinase 4	0.021
E2F4	E2F transcription factor 4, p107/p130-binding	0.021
ATMIN	ATM interactor	0.021
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.021
HIST1H3F	histone cluster 1, H3f	0.021
HIST1H2AB	histone cluster 1, H2ab	0.021
MYH9	myosin, heavy chain 9, non-muscle	0.021
RFWD2	ring finger and WD repeat domain 2	0.021
RANBP9	RAN binding protein 9	0.021
HIST1H4D	histone cluster 1, H4d	0.021
ORC3	origin recognition complex, subunit 3	0.020
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.020
CDCA8	cell division cycle associated 8	0.020
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.020
KIF5B	kinesin family member 5B	0.019
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.019
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.019
TOP3A	topoisomerase (DNA) III alpha	0.019
E2F5	E2F transcription factor 5, p130-binding	0.019
UBASH3B	ubiquitin associated and SH3 domain containing B	0.019
SMC4	structural maintenance of chromosomes 4	0.019
LMNA	lamin A/C	0.019
LIN54	lin-54 homolog (C. elegans)	0.018
NBN	nibrin	0.018
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.018
C13orf34	chromosome 13 open reading frame 34	0.018
HIST1H1E	histone cluster 1, H1e	0.018
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.017
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.017
EIF3A	eukaryotic translation initiation factor 3, subunit A	0.017
FOXM1	forkhead box M1	0.017
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.017
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.017
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.017
CCDC99	coiled-coil domain containing 99	0.017
SERTAD4	SERTA domain containing 4	0.017
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.017
TERF2	telomeric repeat binding factor 2	0.017	Human
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.017
KDM4A	lysine (K)-specific demethylase 4A	0.017
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.016
PRNP	prion protein	0.016
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.016
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.016
BIRC5	baculoviral IAP repeat containing 5	0.016
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.015
HUWE1	HECT, UBA and WWE domain containing 1	0.015
CLIP1	CAP-GLY domain containing linker protein 1	0.015
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.015
C13orf27	chromosome 13 open reading frame 27	0.015
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.015
MIS18BP1	MIS18 binding protein 1	0.015
FANCI	Fanconi anemia, complementation group I	0.015
RBX1	ring-box 1, E3 ubiquitin protein ligase	0.015	Worm
ERBB2IP	erbb2 interacting protein	0.015
HIST1H1B	histone cluster 1, H1b	0.015
COMMD4	COMM domain containing 4	0.015
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.015
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.015
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.015
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.015
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.015
TAGLN2	transgelin 2	0.015
CCND3	cyclin D3	0.014
CEP55	centrosomal protein 55kDa	0.014
MSN	moesin	0.014	Fly
DEPDC1	DEP domain containing 1	0.014
HIST1H4F	histone cluster 1, H4f	0.014
DEK	DEK oncogene	0.014
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.014
UBE2C	ubiquitin-conjugating enzyme E2C	0.014	Fly
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.014
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.014
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.014
STRN3	striatin, calmodulin binding protein 3	0.014
C12orf48	chromosome 12 open reading frame 48	0.014
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.014
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.013	Yeast Fly
DCLRE1C	DNA cross-link repair 1C	0.013
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.013
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.013
BAG2	BCL2-associated athanogene 2	0.013
MCM10	minichromosome maintenance complex component 10	0.013
EHD1	EH-domain containing 1	0.013
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.013
CENPN	centromere protein N	0.013
CDK1	cyclin-dependent kinase 1	0.013
UBE2S	ubiquitin-conjugating enzyme E2S	0.013
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.013
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.013
STK24	serine/threonine kinase 24	0.013
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.012	Worm
HIST1H3B	histone cluster 1, H3b	0.012	Yeast
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.012
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.012
CENPF	centromere protein F, 350/400kDa (mitosin)	0.012
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.012
EML2	echinoderm microtubule associated protein like 2	0.012
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.012
UBXN7	UBX domain protein 7	0.012
MASTL	microtubule associated serine/threonine kinase-like	0.012
KIF11	kinesin family member 11	0.012
HIST1H2BB	histone cluster 1, H2bb	0.012
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.012
PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.012
LIN9	lin-9 homolog (C. elegans)	0.012
HIST1H3G	histone cluster 1, H3g	0.012
L3MBTL1	l(3)mbt-like 1 (Drosophila)	0.012
POLR2K	polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa	0.011
MTMR2	myotubularin related protein 2	0.011
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.011
FANCD2	Fanconi anemia, complementation group D2	0.011
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.011
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.011
DYNLT3	dynein, light chain, Tctex-type 3	0.011
CARD11	caspase recruitment domain family, member 11	0.011
MYO1C	myosin IC	0.011
DHX33	DEAH (Asp-Glu-Ala-His) box polypeptide 33	0.011
MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.011
CDCA3	cell division cycle associated 3	0.011
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.011
HIST1H3A	histone cluster 1, H3a	0.011	Yeast
KIAA1949	KIAA1949	0.011
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.011
BRD7	bromodomain containing 7	0.011
USP9X	ubiquitin specific peptidase 9, X-linked	0.011
ATM	ataxia telangiectasia mutated	0.010
COTL1	coactosin-like 1 (Dictyostelium)	0.010
IQGAP1	IQ motif containing GTPase activating protein 1	0.010
HIST1H1D	histone cluster 1, H1d	0.010
FBXO4	F-box protein 4	0.010
DCUN1D5	DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)	0.010
BTBD10	BTB (POZ) domain containing 10	0.010
KDM5C	lysine (K)-specific demethylase 5C	0.010
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.010
RHOG	ras homolog gene family, member G (rho G)	0.010
MKI67	antigen identified by monoclonal antibody Ki-67	0.010