The network for 'regulation of t cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of t cell differentiation

Any process that modulates the frequency, rate or extent of T cell differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Jak2 Janus kinase 2 0.997
Stat3 signal transducer and activator of transcription 3 0.996
Foxp3 forkhead box P3 0.991
Apc adenomatosis polyposis coli 0.984
Tnf tumor necrosis factor 0.977
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.973
Egfr epidermal growth factor receptor 0.969
Ar androgen receptor 0.958
Fgfr2 fibroblast growth factor receptor 2 0.953
Socs3 suppressor of cytokine signaling 3 0.951
Fyn Fyn proto-oncogene 0.935
Pten phosphatase and tensin homolog 0.926
Il2rg interleukin 2 receptor, gamma chain 0.878
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.871
Rybp RING1 and YY1 binding protein 0.858
Stat6 signal transducer and activator of transcription 6 0.853
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.849
Kit kit oncogene 0.846
Ifng interferon gamma 0.846
Inpp5d inositol polyphosphate-5-phosphatase D 0.845
Icos inducible T-cell co-stimulator 0.832
Runx1 runt related transcription factor 1 0.831
Lck lymphocyte protein tyrosine kinase 0.829
Stat5a signal transducer and activator of transcription 5A 0.819
Nf1 neurofibromatosis 1 0.809
Stat5b signal transducer and activator of transcription 5B 0.780
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.774
Gli3 GLI-Kruppel family member GLI3 0.773
Cd80 CD80 antigen 0.768
Rnf2 ring finger protein 2 0.753
Trp53 transformation related protein 53 0.743
Smad4 MAD homolog 4 (Drosophila) 0.743
Ikzf1 IKAROS family zinc finger 1 0.728
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.723
Sox9 SRY-box containing gene 9 0.710
Foxn1 forkhead box N1 0.707
Il6st interleukin 6 signal transducer 0.707
Fas Fas (TNF receptor superfamily member 6) 0.703
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.702
Grb2 growth factor receptor bound protein 2 0.697
Tgfb2 transforming growth factor, beta 2 0.694
Bcl2 B-cell leukemia/lymphoma 2 0.686
Ptprc protein tyrosine phosphatase, receptor type, C 0.681
Lepr leptin receptor 0.678
Rxra retinoid X receptor alpha 0.661
Lyz2 lysozyme 2 0.655
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.648
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.642
Egr2 early growth response 2 0.629
Cd247 CD247 antigen 0.619
Zeb1 zinc finger E-box binding homeobox 1 0.572
Bmpr1a bone morphogenetic protein receptor, type 1A 0.567
Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha 0.556
Irf8 interferon regulatory factor 8 0.555
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.552
Cbl Casitas B-lineage lymphoma 0.542
Esr1 estrogen receptor 1 (alpha) 0.539
Hhex hematopoietically expressed homeobox 0.529
Il1r1 interleukin 1 receptor, type I 0.529
Il1b interleukin 1 beta 0.525
Pgr progesterone receptor 0.494
Bcl3 B-cell leukemia/lymphoma 3 0.483
Cd40 CD40 antigen 0.481
Fos FBJ osteosarcoma oncogene 0.447
Gata4 GATA binding protein 4 0.446
Pnp2 purine-nucleoside phosphorylase 2 0.445
Gli2 GLI-Kruppel family member GLI2 0.444
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.442
Batf basic leucine zipper transcription factor, ATF-like 0.439
Rarg retinoic acid receptor, gamma 0.433
Nlrp3 NLR family, pyrin domain containing 3 0.420
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.413
H2-Eb1 histocompatibility 2, class II antigen E beta 0.413
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.410
Il27ra interleukin 27 receptor, alpha 0.403
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.396
Cd28 CD28 antigen 0.391
Trp63 transformation related protein 63 0.383
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.377
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.365
Ctla2b cytotoxic T lymphocyte-associated protein 2 beta 0.363
Tgfb1 transforming growth factor, beta 1 0.361
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.360
Shh sonic hedgehog 0.358
Nodal nodal 0.345
Smad3 MAD homolog 3 (Drosophila) 0.343
Meox2 mesenchyme homeobox 2 0.342
Ccl2 chemokine (C-C motif) ligand 2 0.341
Rag2 recombination activating gene 2 0.337
Kiss1 KiSS-1 metastasis-suppressor 0.336
Il2rb interleukin 2 receptor, beta chain 0.335
Sfpi1 SFFV proviral integration 1 0.334
Atxn1 ataxin 1 0.333
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.326
Cish cytokine inducible SH2-containing protein 0.313
Was Wiskott-Aldrich syndrome homolog (human) 0.313
Tcra T-cell receptor alpha chain 0.310
Cd4 CD4 antigen 0.307
Hr hairless 0.307
Sfn stratifin 0.306
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
LCK lymphocyte-specific protein tyrosine kinase 0.780
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.779
IL4R interleukin 4 receptor 0.740
B2M beta-2-microglobulin 0.686
LAT linker for activation of T cells 0.673
HLA-A major histocompatibility complex, class I, A 0.552
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.525
HLA-G major histocompatibility complex, class I, G 0.512
EGFR epidermal growth factor receptor 0.452
PLCG1 phospholipase C, gamma 1 0.333
HLA-F major histocompatibility complex, class I, F 0.298
HLA-E major histocompatibility complex, class I, E 0.296
CD80 CD80 molecule 0.275
HLA-B major histocompatibility complex, class I, B 0.269
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.231
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.196
HLA-DMB major histocompatibility complex, class II, DM beta 0.195
HLA-C major histocompatibility complex, class I, C 0.184
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.179
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.172
CD247 CD247 molecule 0.159
PILRA paired immunoglobin-like type 2 receptor alpha 0.143
BMPR1A bone morphogenetic protein receptor, type IA 0.130
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.124
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.118
IL2RG interleukin 2 receptor, gamma 0.109
BIRC3 baculoviral IAP repeat containing 3 0.100
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.098
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.094
NCOR2 nuclear receptor corepressor 2 0.086
TAPBP TAP binding protein (tapasin) 0.080
GRAP2 GRB2-related adaptor protein 2 0.059
TGIF1 TGFB-induced factor homeobox 1 0.059
VAV1 vav 1 guanine nucleotide exchange factor 0.058
CD86 CD86 molecule 0.056
IL2RB interleukin 2 receptor, beta 0.055
CD22 CD22 molecule 0.055
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.054
TRAF1 TNF receptor-associated factor 1 0.051
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.051
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.049
IL15RA interleukin 15 receptor, alpha 0.047
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.046
NCOA1 nuclear receptor coactivator 1 0.046
LIN9 lin-9 homolog (C. elegans) 0.045
ICAM1 intercellular adhesion molecule 1 0.045
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.045
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.042
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.040
JAK3 Janus kinase 3 0.040
SKI v-ski sarcoma viral oncogene homolog (avian) 0.039
CTBP1 C-terminal binding protein 1 0.036
IL6R interleukin 6 receptor 0.034
CXCR4 chemokine (C-X-C motif) receptor 4 0.034
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.033
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.032
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.032
FSTL1 follistatin-like 1 0.032
JAK1 Janus kinase 1 0.031
PPARA peroxisome proliferator-activated receptor alpha 0.030
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.029
CCND3 cyclin D3 0.029
IL1R1 interleukin 1 receptor, type I 0.027
CCR7 chemokine (C-C motif) receptor 7 0.026
SMAD7 SMAD family member 7 0.026
EPOR erythropoietin receptor 0.025
TGFB1 transforming growth factor, beta 1 0.024
BTN3A1 butyrophilin, subfamily 3, member A1 0.024
HDAC9 histone deacetylase 9 0.024
HLA-DRA major histocompatibility complex, class II, DR alpha 0.023
CDK6 cyclin-dependent kinase 6 0.023
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.023
TANK TRAF family member-associated NFKB activator 0.023
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.022
IL4 interleukin 4 0.022
RXRA retinoid X receptor, alpha 0.022
BTN3A3 butyrophilin, subfamily 3, member A3 0.022
PDPK1 3-phosphoinositide dependent protein kinase-1 0.022
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.021
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.021
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.020
CSK c-src tyrosine kinase 0.020
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.020
SOCS3 suppressor of cytokine signaling 3 0.020
ESR1 estrogen receptor 1 0.020
NOD2 nucleotide-binding oligomerization domain containing 2 0.020
CCND1 cyclin D1 0.020
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.020
MED25 mediator complex subunit 25 0.019
EP300 E1A binding protein p300 0.019
PML promyelocytic leukemia 0.019
SNX9 sorting nexin 9 0.018
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.018
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) 0.018
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 0.018
HCK hemopoietic cell kinase 0.017
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.017
SH3BP2 SH3-domain binding protein 2 0.017
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.017
CD40 CD40 molecule, TNF receptor superfamily member 5 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Db1 RT1 class II, locus Db1 0.458
Cd3g CD3 molecule, gamma 0.148
RT1-Da RT1 class II, locus Da 0.144
Cd247 Cd247 molecule 0.121
Tcrb T-cell receptor beta chain 0.108
Spn sialophorin 0.105
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.087
Il2rb interleukin 2 receptor, beta 0.070
RT1-Bb RT1 class II, locus Bb 0.052
RT1-Ba RT1 class II, locus Ba 0.049
Il1b interleukin 1 beta 0.045
Anpep alanyl (membrane) aminopeptidase 0.043
Cd2 Cd2 molecule 0.043
Cd37 CD37 molecule 0.043
Itgb7 integrin, beta 7 0.036
Cxcr4 chemokine (C-X-C motif) receptor 4 0.034
Cd5 Cd5 molecule 0.030
Gzmk granzyme K 0.030
Lat linker for activation of T cells 0.026
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.022
Igh-6 immunoglobulin heavy chain 6 0.021
Il1r1 interleukin 1 receptor, type I 0.021
Plac8 placenta-specific 8 0.021
Il2rg interleukin 2 receptor, gamma 0.018
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.018
Mybpc2 myosin binding protein C, fast-type 0.017
Mef2d myocyte enhancer factor 2D 0.016
Gimap4 GTPase, IMAP family member 4 0.016
Syk spleen tyrosine kinase 0.013
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.013
Cxcl10 chemokine (C-X-C motif) ligand 10 0.012
Foxs1 forkhead box S1 0.012
Neurl3 neuralized homolog 3 (Drosophila) 0.011
Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C 0.011
Bin2 bridging integrator 2 0.011
Ccl5 chemokine (C-C motif) ligand 5 0.010
Igsf6 immunoglobulin superfamily, member 6 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism