The network for 'b cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

b cell proliferation

The expansion of a B cell population by cell division. Follows B cell activation.

Mus musculus
Name Description Probability Func Analog Organism
Igh immunoglobulin heavy chain complex 1.000
Rnf2 ring finger protein 2 0.998
Cd40 CD40 antigen 0.995
Cd19 CD19 antigen 0.995
Tlr4 toll-like receptor 4 0.993
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.992
Btk Bruton agammaglobulinemia tyrosine kinase 0.988
Ikzf1 IKAROS family zinc finger 1 0.984
Tnf tumor necrosis factor 0.969
Bcl2 B-cell leukemia/lymphoma 2 0.961
Cd22 CD22 antigen 0.955
Ikzf3 IKAROS family zinc finger 3 0.941
Rybp RING1 and YY1 binding protein 0.939
Fyn Fyn proto-oncogene 0.939
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.923
Cd28 CD28 antigen 0.909
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.907
Ifng interferon gamma 0.896
Pou2af1 POU domain, class 2, associating factor 1 0.891
Inpp5d inositol polyphosphate-5-phosphatase D 0.888
Il4 interleukin 4 0.821
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.814
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.813
Casp1 caspase 1 0.726
Lyz2 lysozyme 2 0.717
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.716
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.692
Hdac7 histone deacetylase 7 0.672
Dok1 docking protein 1 0.620
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.615
Ptk2 PTK2 protein tyrosine kinase 2 0.612
Cd4 CD4 antigen 0.598
Myd88 myeloid differentiation primary response gene 88 0.595
Prkcd protein kinase C, delta 0.551
Plcg2 phospholipase C, gamma 2 0.536
Esr1 estrogen receptor 1 (alpha) 0.531
Ccr2 chemokine (C-C motif) receptor 2 0.527
Cd72 CD72 antigen 0.526
Icos inducible T-cell co-stimulator 0.524
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.524
Il2 interleukin 2 0.504
Blnk B-cell linker 0.503
Cd79b CD79B antigen 0.477
Tgfb1 transforming growth factor, beta 1 0.467
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.461
Ptprc protein tyrosine phosphatase, receptor type, C 0.459
Card11 caspase recruitment domain family, member 11 0.456
Prf1 perforin 1 (pore forming protein) 0.446
Bcl6 B-cell leukemia/lymphoma 6 0.443
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.441
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.416
Lama5 laminin, alpha 5 0.416
Tnfrsf13c tumor necrosis factor receptor superfamily, member 13c 0.413
Sykb spleen tyrosine kinase 0.410
Cr2 complement receptor 2 0.409
Cd40lg CD40 ligand 0.407
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.394
Fas Fas (TNF receptor superfamily member 6) 0.390
Cd247 CD247 antigen 0.388
Socs1 suppressor of cytokine signaling 1 0.386
Fasl Fas ligand (TNF superfamily, member 6) 0.384
Cbl Casitas B-lineage lymphoma 0.374
Trp63 transformation related protein 63 0.373
Hif1a hypoxia inducible factor 1, alpha subunit 0.365
Rc3h1 RING CCCH (C3H) domains 1 0.328
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.320
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.320
Lta lymphotoxin A 0.310
Il10 interleukin 10 0.309
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.308
Trp53 transformation related protein 53 0.306
Grb2 growth factor receptor bound protein 2 0.290
Ccr3 chemokine (C-C motif) receptor 3 0.283
Clec4n C-type lectin domain family 4, member n 0.283
Igk immunoglobulin kappa chain complex 0.283
Il2rb interleukin 2 receptor, beta chain 0.283
Nos2 nitric oxide synthase 2, inducible 0.282
Insr insulin receptor 0.280
Tbxa2r thromboxane A2 receptor 0.270
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.269
Cd14 CD14 antigen 0.265
Abcg3 ATP-binding cassette, sub-family G (WHITE), member 3 0.261
Il6 interleukin 6 0.252
Blk B lymphoid kinase 0.251
Bak1 BCL2-antagonist/killer 1 0.246
Pten phosphatase and tensin homolog 0.245
Ptgs2 prostaglandin-endoperoxide synthase 2 0.243
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.240
Mdm2 transformed mouse 3T3 cell double minute 2 0.238
Hdac4 histone deacetylase 4 0.229
Foxn1 forkhead box N1 0.227
Lck lymphocyte protein tyrosine kinase 0.223
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.218
Tlr2 toll-like receptor 2 0.213
Rag1 recombination activating gene 1 0.210
Brca1 breast cancer 1 0.208
Spp1 secreted phosphoprotein 1 0.199
Dok2 docking protein 2 0.196
Ccr6 chemokine (C-C motif) receptor 6 0.196
H2-Aa histocompatibility 2, class II antigen A, alpha 0.195
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tlr21 toll-like receptor 21 0.019
si:dkey-91i17.1 si:dkey-91i17.1 0.018
coro1a coronin, actin binding protein, 1A 0.018
sox3 SRY-box containing gene 3 0.018
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.017
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.017
bmi1b B lymphoma Mo-MLV insertion region 1b 0.014
ezr ezrin 0.014
lars leucyl-tRNA synthetase 0.014
arntl1b aryl hydrocarbon receptor nuclear translocator-like 1b 0.014
wnt3 wingless-type MMTV integration site family, member 3 0.013
csrnp1b cysteine-serine-rich nuclear protein 1b 0.013
insrb insulin receptor b 0.013
ckbb creatine kinase, brain b 0.012
asb8 ankyrin repeat and SOCS box-containing 8 0.012
sb:cb472 sb:cb472 0.012
zgc:66317 zgc:66317 0.012
ptp4a3 protein tyrosine phosphatase type IVA, member 3 0.012
rag1 recombination activating gene 1 0.012
bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.011
hspa9 heat shock protein 9 0.011
traf4a tnf receptor-associated factor 4a 0.011
disc1 disrupted in schizophrenia 1 0.011
zgc:101606 zgc:101606 0.011
zgc:56039 zgc:56039 0.010
mep1a.1 meprin A, alpha.1 0.010
tp53 tumor protein p53 0.010
eif2ak3 eukaryotic translation initiation factor 2-alpha kinase 3 0.010
fras1 Fraser syndrome 1 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.862
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.834
IL4R interleukin 4 receptor 0.666
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.423
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.404
SYK spleen tyrosine kinase 0.361
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.356
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.332
IL10RA interleukin 10 receptor, alpha 0.234
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.222
CD80 CD80 molecule 0.221
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.179
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.154
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.131
TAL1 T-cell acute lymphocytic leukemia 1 0.123
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.106
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.098
CD22 CD22 molecule 0.096
CD79B CD79b molecule, immunoglobulin-associated beta 0.095
BCL2 B-cell CLL/lymphoma 2 0.094
TICAM2 toll-like receptor adaptor molecule 2 0.092
LAT linker for activation of T cells 0.089
BCL2L1 BCL2-like 1 0.082
IL2RG interleukin 2 receptor, gamma 0.080
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.080
MYD88 myeloid differentiation primary response gene (88) 0.080
SLAMF1 signaling lymphocytic activation molecule family member 1 0.077
APAF1 apoptotic peptidase activating factor 1 0.069
BLNK B-cell linker 0.069
SH3BP2 SH3-domain binding protein 2 0.066
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.063
IL22RA2 interleukin 22 receptor, alpha 2 0.062
EP300 E1A binding protein p300 0.054
XIAP X-linked inhibitor of apoptosis 0.054
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.051
CCR7 chemokine (C-C motif) receptor 7 0.049
CD86 CD86 molecule 0.047
GRAP2 GRB2-related adaptor protein 2 0.046
CDK6 cyclin-dependent kinase 6 0.045
CDK2 cyclin-dependent kinase 2 0.044
BIRC3 baculoviral IAP repeat containing 3 0.043
TFF1 trefoil factor 1 0.043
PECAM1 platelet/endothelial cell adhesion molecule 0.042
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.041
CCND1 cyclin D1 0.040
VAV1 vav 1 guanine nucleotide exchange factor 0.039
PTK2B PTK2B protein tyrosine kinase 2 beta 0.038
INSR insulin receptor 0.038
LCK lymphocyte-specific protein tyrosine kinase 0.037
CXCR4 chemokine (C-X-C motif) receptor 4 0.037
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.034
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.034
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.033
GRB7 growth factor receptor-bound protein 7 0.033
CD19 CD19 molecule 0.031
MUC1 mucin 1, cell surface associated 0.031
TCF4 transcription factor 4 0.030
HDAC9 histone deacetylase 9 0.030
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.029
GAS7 growth arrest-specific 7 0.028
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.027
CDCP1 CUB domain containing protein 1 0.027
TP53 tumor protein p53 0.027
SH2D1A SH2 domain containing 1A 0.027
ARNT aryl hydrocarbon receptor nuclear translocator 0.026
PRKCB protein kinase C, beta 0.025
RB1 retinoblastoma 1 0.025
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.025
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.024
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.024
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.024
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.024
PIAS4 protein inhibitor of activated STAT, 4 0.023
ABI2 abl-interactor 2 0.023
MSH5 mutS homolog 5 (E. coli) 0.022
CCND3 cyclin D3 0.022
CYSLTR1 cysteinyl leukotriene receptor 1 0.022
LY96 lymphocyte antigen 96 0.022
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.021
IRF4 interferon regulatory factor 4 0.021
IL22RA1 interleukin 22 receptor, alpha 1 0.020
BAK1 BCL2-antagonist/killer 1 0.020
WASF1 WAS protein family, member 1 0.019
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.019
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.019
GRB10 growth factor receptor-bound protein 10 0.018
PILRA paired immunoglobin-like type 2 receptor alpha 0.018
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.018
NCOA7 nuclear receptor coactivator 7 0.018
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.018
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.018
HDAC4 histone deacetylase 4 0.018
RNF144B ring finger protein 144B 0.017
GAB2 GRB2-associated binding protein 2 0.017
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.017
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.017
IRS1 insulin receptor substrate 1 0.017
MAPK12 mitogen-activated protein kinase 12 0.017
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.016
FERMT2 fermitin family member 2 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Db1 RT1 class II, locus Db1 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism