The network for 'cell activation involved in immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell activation involved in immune response

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.

Mus musculus
Name Description Probability Func Analog Organism
Ikzf1 IKAROS family zinc finger 1 0.999
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.984
Ptprc protein tyrosine phosphatase, receptor type, C 0.984
Cd28 CD28 antigen 0.970
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.941
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.940
Lyz2 lysozyme 2 0.926
Il10ra interleukin 10 receptor, alpha 0.907
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.899
Prf1 perforin 1 (pore forming protein) 0.895
Cd40 CD40 antigen 0.890
Lepr leptin receptor 0.889
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.885
Il2rg interleukin 2 receptor, gamma chain 0.882
Il4 interleukin 4 0.855
Stat3 signal transducer and activator of transcription 3 0.848
Cd247 CD247 antigen 0.832
Ccr2 chemokine (C-C motif) receptor 2 0.817
Myd88 myeloid differentiation primary response gene 88 0.811
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.793
Fyn Fyn proto-oncogene 0.782
Cd19 CD19 antigen 0.768
Il2rb interleukin 2 receptor, beta chain 0.758
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.755
Jak2 Janus kinase 2 0.753
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.738
Tbx3 T-box 3 0.730
Bcl3 B-cell leukemia/lymphoma 3 0.723
Tnf tumor necrosis factor 0.715
Irf5 interferon regulatory factor 5 0.697
Rag1 recombination activating gene 1 0.695
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.667
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.661
Fas Fas (TNF receptor superfamily member 6) 0.661
Ldb3 LIM domain binding 3 0.647
Prdm1 PR domain containing 1, with ZNF domain 0.647
Stat6 signal transducer and activator of transcription 6 0.645
Ccl2 chemokine (C-C motif) ligand 2 0.637
Il10 interleukin 10 0.635
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.634
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.626
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.623
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.621
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.615
Pten phosphatase and tensin homolog 0.610
Cd180 CD180 antigen 0.587
Inpp5d inositol polyphosphate-5-phosphatase D 0.580
Mefv Mediterranean fever 0.577
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.572
Slamf1 signaling lymphocytic activation molecule family member 1 0.571
Gzmk granzyme K 0.561
Il18rap interleukin 18 receptor accessory protein 0.560
Ccl4 chemokine (C-C motif) ligand 4 0.555
Pitx1 paired-like homeodomain transcription factor 1 0.554
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.547
Zeb1 zinc finger E-box binding homeobox 1 0.547
Emx1 empty spiracles homolog 1 (Drosophila) 0.540
Socs1 suppressor of cytokine signaling 1 0.537
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.537
Itgax integrin alpha X 0.529
Runx1 runt related transcription factor 1 0.522
Selp selectin, platelet 0.506
Itgal integrin alpha L 0.503
Stat5b signal transducer and activator of transcription 5B 0.498
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.494
Ncr1 natural cytotoxicity triggering receptor 1 0.490
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.487
Stat1 signal transducer and activator of transcription 1 0.479
Itk IL2-inducible T-cell kinase 0.478
Cd86 CD86 antigen 0.468
Nlrp3 NLR family, pyrin domain containing 3 0.457
Irf4 interferon regulatory factor 4 0.452
Il6 interleukin 6 0.441
Il1r1 interleukin 1 receptor, type I 0.440
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.437
Batf basic leucine zipper transcription factor, ATF-like 0.436
AF251705 cDNA sequence AF251705 0.433
Fgf10 fibroblast growth factor 10 0.431
Dok1 docking protein 1 0.428
Lcp2 lymphocyte cytosolic protein 2 0.428
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.425
Tbx21 T-box 21 0.423
Traf6 TNF receptor-associated factor 6 0.421
Cd7 CD7 antigen 0.418
Il4ra interleukin 4 receptor, alpha 0.414
Sell selectin, lymphocyte 0.412
Clec7a C-type lectin domain family 7, member a 0.409
Gpr132 G protein-coupled receptor 132 0.409
Cish cytokine inducible SH2-containing protein 0.398
Kit kit oncogene 0.389
Icos inducible T-cell co-stimulator 0.387
Sfpi1 SFFV proviral integration 1 0.375
Ifng interferon gamma 0.375
Cd96 CD96 antigen 0.373
Il1b interleukin 1 beta 0.370
Il1rn interleukin 1 receptor antagonist 0.370
Ccr6 chemokine (C-C motif) receptor 6 0.369
Hcst hematopoietic cell signal transducer 0.361
Socs3 suppressor of cytokine signaling 3 0.360
Stat5a signal transducer and activator of transcription 5A 0.343
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.992
BRCA1 breast cancer 1, early onset 0.965
FHL2 four and a half LIM domains 2 0.927
SYK spleen tyrosine kinase 0.744
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.672
GRAP2 GRB2-related adaptor protein 2 0.610
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.594
CCR5 chemokine (C-C motif) receptor 5 0.513
LAT linker for activation of T cells 0.511
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.510
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.457
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.427
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.421
CCL4 chemokine (C-C motif) ligand 4 0.385
ICAM1 intercellular adhesion molecule 1 0.358
APLF aprataxin and PNKP like factor 0.351
CD80 CD80 molecule 0.346
CCR1 chemokine (C-C motif) receptor 1 0.345
BLNK B-cell linker 0.334
ENG endoglin 0.332
TICAM2 toll-like receptor adaptor molecule 2 0.331
H2AFX H2A histone family, member X 0.324
MDC1 mediator of DNA-damage checkpoint 1 0.322
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.305
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.304
CCR2 chemokine (C-C motif) receptor 2 0.295
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.268
CAV1 caveolin 1, caveolae protein, 22kDa 0.265
SNAP23 synaptosomal-associated protein, 23kDa 0.261
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.258
VCAM1 vascular cell adhesion molecule 1 0.244
FN1 fibronectin 1 0.226
CCL5 chemokine (C-C motif) ligand 5 0.223
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.207
IL2RG interleukin 2 receptor, gamma 0.202
TRAF1 TNF receptor-associated factor 1 0.196
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.194
PILRA paired immunoglobin-like type 2 receptor alpha 0.189
CXCL9 chemokine (C-X-C motif) ligand 9 0.185
CREBBP CREB binding protein 0.184
FLNA filamin A, alpha 0.183
PSEN2 presenilin 2 (Alzheimer disease 4) 0.178
MSH6 mutS homolog 6 (E. coli) 0.175
TGFB1 transforming growth factor, beta 1 0.174
TGIF1 TGFB-induced factor homeobox 1 0.169
BIRC3 baculoviral IAP repeat containing 3 0.162
PTPRC protein tyrosine phosphatase, receptor type, C 0.157
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.155
HCK hemopoietic cell kinase 0.153
CCR7 chemokine (C-C motif) receptor 7 0.150
IL4R interleukin 4 receptor 0.144
CD63 CD63 molecule 0.129
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.129
LIN9 lin-9 homolog (C. elegans) 0.127
CCL22 chemokine (C-C motif) ligand 22 0.127
RAD50 RAD50 homolog (S. cerevisiae) 0.126
SOCS3 suppressor of cytokine signaling 3 0.121
HK3 hexokinase 3 (white cell) 0.120
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.117
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.117
C19orf50 chromosome 19 open reading frame 50 0.115
CCL8 chemokine (C-C motif) ligand 8 0.115
NLRC4 NLR family, CARD domain containing 4 0.114
AR androgen receptor 0.113
IL23A interleukin 23, alpha subunit p19 0.112
TRAF3 TNF receptor-associated factor 3 0.110
LST1 leukocyte specific transcript 1 0.109
IL4 interleukin 4 0.106
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.104
TLR2 toll-like receptor 2 0.104
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.103
PLEK pleckstrin 0.103
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.099
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.098
IGSF6 immunoglobulin superfamily, member 6 0.098
CFP complement factor properdin 0.095
CD48 CD48 molecule 0.095
NRP1 neuropilin 1 0.095
TP53BP1 tumor protein p53 binding protein 1 0.094
NCOR2 nuclear receptor corepressor 2 0.093
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.093
IL10RA interleukin 10 receptor, alpha 0.091
IL2RB interleukin 2 receptor, beta 0.091
SIGLEC7 sialic acid binding Ig-like lectin 7 0.090
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.090
LAPTM5 lysosomal protein transmembrane 5 0.089
PSEN1 presenilin 1 0.089
CXCL10 chemokine (C-X-C motif) ligand 10 0.088
GBA glucosidase, beta, acid 0.085
SIRPB1 signal-regulatory protein beta 1 0.084
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.082
PECAM1 platelet/endothelial cell adhesion molecule 0.082
IRF4 interferon regulatory factor 4 0.082
IL7R interleukin 7 receptor 0.080
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.079
IL10 interleukin 10 0.078
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.076
IFNG interferon, gamma 0.075
PPL periplakin 0.075
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.075
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hck hemopoietic cell kinase 0.344
Cd53 Cd53 molecule 0.279
Il2rb interleukin 2 receptor, beta 0.212
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.209
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.209
Cd4 Cd4 molecule 0.180
Cd38 CD38 molecule 0.168
Sirpa signal-regulatory protein alpha 0.163
Ptprc protein tyrosine phosphatase, receptor type, C 0.147
Cybb cytochrome b-245, beta polypeptide 0.145
Ptafr platelet-activating factor receptor 0.133
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.110
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.109
Csf1 colony stimulating factor 1 (macrophage) 0.108
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.096
Ripk3 receptor-interacting serine-threonine kinase 3 0.091
Tgfbr2 transforming growth factor, beta receptor II 0.083
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.082
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.079
Dock8 dedicator of cytokinesis 8 0.078
Il2rg interleukin 2 receptor, gamma 0.077
Vav1 vav 1 guanine nucleotide exchange factor 0.076
Plau plasminogen activator, urokinase 0.076
Bin2 bridging integrator 2 0.075
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.073
Casp1 caspase 1 0.069
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.069
Inpp5d inositol polyphosphate-5-phosphatase D 0.064
Arl11 ADP-ribosylation factor-like 11 0.064
Ctse cathepsin E 0.062
Cd247 Cd247 molecule 0.062
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.054
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.053
Prf1 perforin 1 (pore forming protein) 0.053
Ccr5 chemokine (C-C motif) receptor 5 0.049
Morf4l2 mortality factor 4 like 2 0.049
Ciita class II, major histocompatibility complex, transactivator 0.048
Myo1f myosin IF 0.047
Arhgap4 Rho GTPase activating protein 4 0.047
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.046
Clec4a3 C-type lectin domain family 4, member a3 0.046
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.045
Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.045
Wdr1 WD repeat domain 1 0.045
Cmklr1 chemokine-like receptor 1 0.042
Lcp2 lymphocyte cytosolic protein 2 0.041
Plcg2 phospholipase C, gamma 2 0.041
Psd4 pleckstrin and Sec7 domain containing 4 0.037
Soat1 sterol O-acyltransferase 1 0.036
Igsf6 immunoglobulin superfamily, member 6 0.036
Icam1 intercellular adhesion molecule 1 0.035
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.035
Itgb2 integrin, beta 2 0.035
Cd86 CD86 molecule 0.035
Icos inducible T-cell co-stimulator 0.034
Sell selectin L 0.033
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.032
Pitpna phosphatidylinositol transfer protein, alpha 0.032
Rhoh ras homolog gene family, member H 0.031
Arrdc1 arrestin domain containing 1 0.031
Calm1 calmodulin 1 0.031
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.031
Irf5 interferon regulatory factor 5 0.030
Gzmk granzyme K 0.030
Cd8b CD8b molecule 0.030
Il17ra interleukin 17 receptor A 0.029
Arhgap9 Rho GTPase activating protein 9 0.029
Faslg Fas ligand (TNF superfamily, member 6) 0.028
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.027
Tlr4 toll-like receptor 4 0.027
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.026
Arhgap25 Rho GTPase activating protein 25 0.026
Cd3g CD3 molecule, gamma 0.026
Klhl6 kelch-like 6 (Drosophila) 0.026
Tbxas1 thromboxane A synthase 1, platelet 0.025
Mov10 Moloney leukemia virus 10 0.025
Lypd3 Ly6/Plaur domain containing 3 0.025
Laptm5 lysosomal protein transmembrane 5 0.025
Epor erythropoietin receptor 0.024
Cd37 CD37 molecule 0.024
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.024
Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 0.023
Cxcr3 chemokine (C-X-C motif) receptor 3 0.023
Acrv1 acrosomal vesicle protein 1 0.023
Ctsc cathepsin C 0.023
Mpeg1 macrophage expressed 1 0.023
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.023
Havcr1 hepatitis A virus cellular receptor 1 0.023
Mutyh mutY homolog (E. coli) 0.023
Hrh2 histamine receptor H 2 0.022
Dok2 docking protein 2 0.022
Tgfbr3 transforming growth factor, beta receptor III 0.022
Phox2a paired-like homeobox 2a 0.021
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.021
Dchs1 dachsous 1 (Drosophila) 0.021
C5ar1 complement component 5a receptor 1 0.021
Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.021
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.021
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.020
Bdkrb2 bradykinin receptor B2 0.020
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism