IMP

Process View

Homo sapiens

29 genes annotated in human

regulation of ligase activity

Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of ligase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of ligase activity" (in gray)

Name	Description	Probability	Func Analog Organism
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.996	Yeast
RNF2	ring finger protein 2	0.990
RING1	ring finger protein 1	0.985
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.946	Yeast
SMAD7	SMAD family member 7	0.911
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.900	Yeast
SMAD1	SMAD family member 1	0.856	Human
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.843
CBX7	chromobox homolog 7	0.729
USP11	ubiquitin specific peptidase 11	0.679
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.656
RNF11	ring finger protein 11	0.644
SIRT2	sirtuin 2	0.624
MAGEA3	melanoma antigen family A, 3	0.603
SPRY4	sprouty homolog 4 (Drosophila)	0.601
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.542
ARIH2	ariadne homolog 2 (Drosophila)	0.505
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.468
CBX8	chromobox homolog 8	0.425
RBX1	ring-box 1, E3 ubiquitin protein ligase	0.423
MAGEA12	melanoma antigen family A, 12	0.414	Human
PSEN1	presenilin 1	0.413	Mouse
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.388
NAP1L5	nucleosome assembly protein 1-like 5	0.385
CTAG1B	cancer/testis antigen 1B	0.375
TEKT4	tektin 4	0.366
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.362
CUL2	cullin 2	0.354
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.338
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.326
SMAD2	SMAD family member 2	0.323	Human
MAGEA6	melanoma antigen family A, 6	0.308	Human
SMAD5	SMAD family member 5	0.293	Human
YY1	YY1 transcription factor	0.250
RYBP	RING1 and YY1 binding protein	0.249
FLNB	filamin B, beta	0.238
EID2	EP300 interacting inhibitor of differentiation 2	0.220
FHL1	four and a half LIM domains 1	0.216
CBX6	chromobox homolog 6	0.204
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.169
VHL	von Hippel-Lindau tumor suppressor	0.155
GCLC	glutamate-cysteine ligase, catalytic subunit	0.149
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.149
CDK2	cyclin-dependent kinase 2	0.145
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.140
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0.133
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.127
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.124
PML	promyelocytic leukemia	0.121
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.120
ANAPC11	anaphase promoting complex subunit 11	0.119
EID2B	EP300 interacting inhibitor of differentiation 2B	0.115
MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	0.110	Human
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.106
SUFU	suppressor of fused homolog (Drosophila)	0.105
FHL2	four and a half LIM domains 2	0.102
CCNB1	cyclin B1	0.100
CFL1	cofilin 1 (non-muscle)	0.098
KAT5	K(lysine) acetyltransferase 5	0.097
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.091
PPM1F	protein phosphatase, Mg2+/Mn2+ dependent, 1F	0.091
PIAS4	protein inhibitor of activated STAT, 4	0.090
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.088
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.087
BCOR	BCL6 corepressor	0.087
CBX4	chromobox homolog 4	0.085
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.082	Yeast
PJA1	praja ring finger 1	0.082
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.082
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.081
HSF1	heat shock transcription factor 1	0.078
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.075
AR	androgen receptor	0.075
GSK3B	glycogen synthase kinase 3 beta	0.074
APLF	aprataxin and PNKP like factor	0.074
SFN	stratifin	0.073	Yeast
SOD1	superoxide dismutase 1, soluble	0.072
CLSPN	claspin	0.071
TUBB2C	tubulin, beta 2C	0.070
EID3	EP300 interacting inhibitor of differentiation 3	0.069
EID1	EP300 interacting inhibitor of differentiation 1	0.067
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.067
PRNP	prion protein	0.066
ANKRD52	ankyrin repeat domain 52	0.065
MAGEA5	melanoma antigen family A, 5	0.062
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.062
CCDC6	coiled-coil domain containing 6	0.061
ARIH1	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)	0.060
PSEN2	presenilin 2 (Alzheimer disease 4)	0.059	Mouse
FBXO5	F-box protein 5	0.057
TP53	tumor protein p53	0.056
FBXL15	F-box and leucine-rich repeat protein 15	0.056
BST2	bone marrow stromal cell antigen 2	0.054
SNIP1	Smad nuclear interacting protein 1	0.053
MAGEA4	melanoma antigen family A, 4	0.052	Human
YAF2	YY1 associated factor 2	0.052
CCNA2	cyclin A2	0.052
TRIM69	tripartite motif containing 69	0.051
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.051
HERC2	hect domain and RLD 2	0.046
POLR2K	polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa	0.046
CUL5	cullin 5	0.043
BAG1	BCL2-associated athanogene	0.042
ERH	enhancer of rudimentary homolog (Drosophila)	0.041
ATF5	activating transcription factor 5	0.041
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.039
COMMD1	copper metabolism (Murr1) domain containing 1	0.038
NCSTN	nicastrin	0.038
RNF31	ring finger protein 31	0.038
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.037
MAGEC1	melanoma antigen family C, 1	0.037	Human
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.037
SLC39A7	solute carrier family 39 (zinc transporter), member 7	0.036
MOAP1	modulator of apoptosis 1	0.036
USP49	ubiquitin specific peptidase 49	0.035	Human
AXIN1	axin 1	0.035
TRIM32	tripartite motif containing 32	0.035
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.035
FGFR1	fibroblast growth factor receptor 1	0.035
SKP2	S-phase kinase-associated protein 2 (p45)	0.035
SKP1	S-phase kinase-associated protein 1	0.034
MAGEB2	melanoma antigen family B, 2	0.034	Human
SMAD6	SMAD family member 6	0.033	Human
PTTG1	pituitary tumor-transforming 1	0.033
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.033
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.033
LIG4	ligase IV, DNA, ATP-dependent	0.032
PRAME	preferentially expressed antigen in melanoma	0.031
TUBG1	tubulin, gamma 1	0.030
MAGEA11	melanoma antigen family A, 11	0.030
RIN1	Ras and Rab interactor 1	0.030
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.029
DDIT4	DNA-damage-inducible transcript 4	0.029
HIPK3	homeodomain interacting protein kinase 3	0.029
USP44	ubiquitin specific peptidase 44	0.028
ZNF654	zinc finger protein 654	0.028
CXXC5	CXXC finger protein 5	0.028
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.028
FOXM1	forkhead box M1	0.027
DAXX	death-domain associated protein	0.026
TNIP1	TNFAIP3 interacting protein 1	0.026
ADARB1	adenosine deaminase, RNA-specific, B1	0.026
APTX	aprataxin	0.026
RNF144B	ring finger protein 144B	0.025
SSX3	synovial sarcoma, X breakpoint 3	0.025
TRAF4	TNF receptor-associated factor 4	0.024
C13orf27	chromosome 13 open reading frame 27	0.024
ADRB2	adrenergic, beta-2-, receptor, surface	0.024
NRIP1	nuclear receptor interacting protein 1	0.024
BTBD2	BTB (POZ) domain containing 2	0.024
SIRT1	sirtuin 1	0.023
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.023
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.023
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.023
RFWD2	ring finger and WD repeat domain 2	0.023
SMAD3	SMAD family member 3	0.023	Human
SIAH1	seven in absentia homolog 1 (Drosophila)	0.023
ARPP19	cAMP-regulated phosphoprotein, 19kDa	0.023
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.022
TADA3	transcriptional adaptor 3	0.022
SRI	sorcin	0.021
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.021
TUBA1C	tubulin, alpha 1c	0.021
TUBA1B	tubulin, alpha 1b	0.020
MAK	male germ cell-associated kinase	0.020
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.020
PHC2	polyhomeotic homolog 2 (Drosophila)	0.020
PRPS1	phosphoribosyl pyrophosphate synthetase 1	0.020
MYST1	MYST histone acetyltransferase 1	0.020
LNX1	ligand of numb-protein X 1	0.020
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.020
MAGEA2	melanoma antigen family A, 2	0.019
ING4	inhibitor of growth family, member 4	0.019
NHEJ1	nonhomologous end-joining factor 1	0.019
SOX7	SRY (sex determining region Y)-box 7	0.019
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.019
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.019
ACTB	actin, beta	0.019
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.019
BAG2	BCL2-associated athanogene 2	0.018
KRT15	keratin 15	0.018
GSK3A	glycogen synthase kinase 3 alpha	0.018
MKRN1	makorin ring finger protein 1	0.018
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.018
HUWE1	HECT, UBA and WWE domain containing 1	0.017
BIRC2	baculoviral IAP repeat containing 2	0.017
UBE2V2	ubiquitin-conjugating enzyme E2 variant 2	0.017
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.017
ARHGAP5	Rho GTPase activating protein 5	0.017
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.017
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.017
NUMB	numb homolog (Drosophila)	0.017
AXIN2	axin 2	0.017	Human
TPTE	transmembrane phosphatase with tensin homology	0.017
RAP1B	RAP1B, member of RAS oncogene family	0.017
PLK1	polo-like kinase 1	0.017
HLA-C	major histocompatibility complex, class I, C	0.017
COPS2	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	0.016
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.016
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.016
ENSA	endosulfine alpha	0.016
TRIM28	tripartite motif containing 28	0.016
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.016
MAGEA8	melanoma antigen family A, 8	0.016	Human
RHEB	Ras homolog enriched in brain	0.016
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.016
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.016
HIPK1	homeodomain interacting protein kinase 1	0.016
BAD	BCL2-associated agonist of cell death	0.016
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.016
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.016
KRR1	KRR1, small subunit (SSU) processome component, homolog (yeast)	0.016
PRMT6	protein arginine methyltransferase 6	0.016
MAGEA10	melanoma antigen family A, 10	0.015	Human
PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	0.015
SSX1	synovial sarcoma, X breakpoint 1	0.015
GAGE3	G antigen 3	0.015
UBE2S	ubiquitin-conjugating enzyme E2S	0.015
MAGEC2	melanoma antigen family C, 2	0.015
CTAG1A	cancer/testis antigen 1A	0.015
TUBB3	tubulin, beta 3	0.015
MAGEA9B	melanoma antigen family A, 9B	0.015	Human
HSPB1	heat shock 27kDa protein 1	0.015
CTDSPL2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	0.015
PTP4A1	protein tyrosine phosphatase type IVA, member 1	0.015
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.015
PRDX2	peroxiredoxin 2	0.015
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.015
KIAA1377	KIAA1377	0.014
SP110	SP110 nuclear body protein	0.014
CDK6	cyclin-dependent kinase 6	0.014
CDC37L1	cell division cycle 37 homolog (S. cerevisiae)-like 1	0.014
SSX4B	synovial sarcoma, X breakpoint 4B	0.014
GABPB1	GA binding protein transcription factor, beta subunit 1	0.014
GLI1	GLI family zinc finger 1	0.014
CDT1	chromatin licensing and DNA replication factor 1	0.014
GSTM4	glutathione S-transferase mu 4	0.014
PPP6R2	protein phosphatase 6, regulatory subunit 2	0.014
ERBB2IP	erbb2 interacting protein	0.014
DCK	deoxycytidine kinase	0.014
MT1A	metallothionein 1A	0.014
EVI5	ecotropic viral integration site 5	0.014
SSX2B	synovial sarcoma, X breakpoint 2B	0.013
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.013
POU5F1	POU class 5 homeobox 1	0.013
UBA1	ubiquitin-like modifier activating enzyme 1	0.013
MKL2	MKL/myocardin-like 2	0.013
NFYA	nuclear transcription factor Y, alpha	0.013
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.013
CENPQ	centromere protein Q	0.013
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.013
ZFYVE1	zinc finger, FYVE domain containing 1	0.013
GAGE12D	G antigen 12D	0.013
THOC4	THO complex 4	0.013
SH3KBP1	SH3-domain kinase binding protein 1	0.013
FBXW7	F-box and WD repeat domain containing 7	0.013
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.013
CDKN2AIP	CDKN2A interacting protein	0.013
HBP1	HMG-box transcription factor 1	0.013
PRDX1	peroxiredoxin 1	0.013
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.013
TGFBR1	transforming growth factor, beta receptor 1	0.013
RAB21	RAB21, member RAS oncogene family	0.012
PPIL4	peptidylprolyl isomerase (cyclophilin)-like 4	0.012
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.012
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.012
STX5	syntaxin 5	0.012
E2F1	E2F transcription factor 1	0.012
BCL2L1	BCL2-like 1	0.012
CUL7	cullin 7	0.012
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.012
BTRC	beta-transducin repeat containing	0.012
PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	0.012
CUL9	cullin 9	0.012
SMAD9	SMAD family member 9	0.012
WASF1	WAS protein family, member 1	0.012
KCTD9	potassium channel tetramerisation domain containing 9	0.012
CCNE1	cyclin E1	0.012	Fly
FAM123C	family with sequence similarity 123C	0.012
MARCH5	membrane-associated ring finger (C3HC4) 5	0.012
CAV2	caveolin 2	0.012
ADAM9	ADAM metallopeptidase domain 9	0.011
ZYG11B	zyg-11 homolog B (C. elegans)	0.011
CTAG2	cancer/testis antigen 2	0.011
FADD	Fas (TNFRSF6)-associated via death domain	0.011
EIF4E	eukaryotic translation initiation factor 4E	0.011
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.011
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.011
PEX26	peroxisomal biogenesis factor 26	0.011
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.011
PLAA	phospholipase A2-activating protein	0.011
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.011
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.011
YEATS4	YEATS domain containing 4	0.011
PSAT1	phosphoserine aminotransferase 1	0.011
FAM175B	family with sequence similarity 175, member B	0.011
MAGEB1	melanoma antigen family B, 1	0.011	Human
PCGF2	polycomb group ring finger 2	0.011	Human
CCND2	cyclin D2	0.011
ARRDC4	arrestin domain containing 4	0.011
WDTC1	WD and tetratricopeptide repeats 1	0.011
PTPRF	protein tyrosine phosphatase, receptor type, F	0.011
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.011
AKAP12	A kinase (PRKA) anchor protein 12	0.010
MAD2L1BP	MAD2L1 binding protein	0.010
EMD	emerin	0.010
RNF19B	ring finger protein 19B	0.010
RCHY1	ring finger and CHY zinc finger domain containing 1	0.010
RARRES3	retinoic acid receptor responder (tazarotene induced) 3	0.010
ANAPC4	anaphase promoting complex subunit 4	0.010
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.010
TFDP1	transcription factor Dp-1	0.010
C4orf43	chromosome 4 open reading frame 43	0.010
TXNIP	thioredoxin interacting protein	0.010	Human
CARS	cysteinyl-tRNA synthetase	0.010
MAGED1	melanoma antigen family D, 1	0.010