IMP

Process View

Homo sapiens

30 genes annotated in human

positive regulation of proteasomal ubiquitin dependent protein catabolic process

Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of proteasomal ubiquitin dependent protein catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of proteasomal ubiquitin dependent protein catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.998	Yeast
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.987
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.984	Yeast Fly
TP53	tumor protein p53	0.983
SMAD2	SMAD family member 2	0.914	Human
UBC	ubiquitin C	0.898
ANAPC4	anaphase promoting complex subunit 4	0.838
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.833
SMAD4	SMAD family member 4	0.804	Human
SMAD5	SMAD family member 5	0.740	Human
GSK3B	glycogen synthase kinase 3 beta	0.736	Mouse Fly
TADA3	transcriptional adaptor 3	0.714
SMAD1	SMAD family member 1	0.709	Human
RNF11	ring finger protein 11	0.587
SMAD7	SMAD family member 7	0.550
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.539
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.538
UBQLN1	ubiquilin 1	0.529
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.525	Fly
ANAPC7	anaphase promoting complex subunit 7	0.492
RB1	retinoblastoma 1	0.481
CUL2	cullin 2	0.441
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.405
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.398	Human
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.390
BCL2L1	BCL2-like 1	0.366
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.358
BBS10	Bardet-Biedl syndrome 10	0.335
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.323
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.304	Yeast
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.271
ATXN3	ataxin 3	0.243
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.240	Human
PTTG1	pituitary tumor-transforming 1	0.232
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.230
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.225
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.223
PLK1	polo-like kinase 1	0.201
SMAD3	SMAD family member 3	0.201	Human
AXIN1	axin 1	0.191	Mouse
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.182
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.166
ANAPC1	anaphase promoting complex subunit 1	0.164
PIAS4	protein inhibitor of activated STAT, 4	0.142
ZNF746	zinc finger protein 746	0.142
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.141
PRNP	prion protein	0.132
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.132	Yeast
CSNK1D	casein kinase 1, delta	0.128	Mouse Fly
RBBP8	retinoblastoma binding protein 8	0.126
ANAPC5	anaphase promoting complex subunit 5	0.124
EPOR	erythropoietin receptor	0.121
ADRM1	adhesion regulating molecule 1	0.118
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.110
POMP	proteasome maturation protein	0.110
CSNK1E	casein kinase 1, epsilon	0.103	Mouse Fly
RAD23B	RAD23 homolog B (S. cerevisiae)	0.101
SOCS1	suppressor of cytokine signaling 1	0.099	Human
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.096
SMC1A	structural maintenance of chromosomes 1A	0.095
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.087
UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	0.085
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.085	Fly
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.082
CUL5	cullin 5	0.080
HSPA4	heat shock 70kDa protein 4	0.079
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.076
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.076
HSPB1	heat shock 27kDa protein 1	0.075
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.075
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.074
ANAPC11	anaphase promoting complex subunit 11	0.070
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.069
SORBS3	sorbin and SH3 domain containing 3	0.069
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.067
HSPA8	heat shock 70kDa protein 8	0.066
PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.066	Fly
AIPL1	aryl hydrocarbon receptor interacting protein-like 1	0.064
EPS15	epidermal growth factor receptor pathway substrate 15	0.064
LRRK2	leucine-rich repeat kinase 2	0.063	Mouse
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.055
BAD	BCL2-associated agonist of cell death	0.055
CDK9	cyclin-dependent kinase 9	0.054
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.054
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.053	Fly
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.052
TRIM32	tripartite motif containing 32	0.050
PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.050
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.050	Yeast
BAG1	BCL2-associated athanogene	0.048
TBP	TATA box binding protein	0.047
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.047
HSF1	heat shock transcription factor 1	0.047
CREBBP	CREB binding protein	0.047
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.046
DAXX	death-domain associated protein	0.046
GCLM	glutamate-cysteine ligase, modifier subunit	0.043
MYO6	myosin VI	0.042
PTEN	phosphatase and tensin homolog	0.041
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.041
XIAP	X-linked inhibitor of apoptosis	0.040
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.040
ARIH2	ariadne homolog 2 (Drosophila)	0.039
BAG2	BCL2-associated athanogene 2	0.038
HDAC6	histone deacetylase 6	0.038
STAMBP	STAM binding protein	0.036
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.035
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.035
BCL2	B-cell CLL/lymphoma 2	0.035
SIRT2	sirtuin 2	0.034
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.034
GORAB	golgin, RAB6-interacting	0.033
FBXL15	F-box and leucine-rich repeat protein 15	0.033
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.033	Fly
CCNB1	cyclin B1	0.032
FUNDC2	FUN14 domain containing 2	0.032
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.031
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.031
ANKRD13A	ankyrin repeat domain 13A	0.031
SMAD6	SMAD family member 6	0.031	Human
VHL	von Hippel-Lindau tumor suppressor	0.031
POLH	polymerase (DNA directed), eta	0.031
SKIL	SKI-like oncogene	0.030
TGFBR1	transforming growth factor, beta receptor 1	0.030
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.030
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.030
LRP6	low density lipoprotein receptor-related protein 6	0.029
SMC6	structural maintenance of chromosomes 6	0.029
ANAPC10	anaphase promoting complex subunit 10	0.028	Yeast
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.028
BMI1	BMI1 polycomb ring finger oncogene	0.028
PSMD10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.027
CSNK1A1	casein kinase 1, alpha 1	0.026	Fly
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.026
MARCH5	membrane-associated ring finger (C3HC4) 5	0.026
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.025
ZFYVE9	zinc finger, FYVE domain containing 9	0.025
SOCS2	suppressor of cytokine signaling 2	0.025	Human
ZNRF1	zinc and ring finger 1	0.024
CEBPE	CCAAT/enhancer binding protein (C/EBP), epsilon	0.024
UBE3A	ubiquitin protein ligase E3A	0.024
CXXC5	CXXC finger protein 5	0.024
RCHY1	ring finger and CHY zinc finger domain containing 1	0.024
MAPT	microtubule-associated protein tau	0.024
RNF111	ring finger protein 111	0.024
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.023
ING2	inhibitor of growth family, member 2	0.023
MAK	male germ cell-associated kinase	0.023
SQSTM1	sequestosome 1	0.023
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.023
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.023
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.023
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.022
CUL4A	cullin 4A	0.022
TAF2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	0.022
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.022
STRN3	striatin, calmodulin binding protein 3	0.022
E2F5	E2F transcription factor 5, p130-binding	0.022
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.022
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.022
UBQLN2	ubiquilin 2	0.022
PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2	0.021
RBL2	retinoblastoma-like 2 (p130)	0.021	Human
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.020	Yeast
PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	0.020
PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	0.020
CLSPN	claspin	0.020
FLNB	filamin B, beta	0.019
TRAF4	TNF receptor-associated factor 4	0.019
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.019
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.018
CENPF	centromere protein F, 350/400kDa (mitosin)	0.018
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	0.018
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.018	Human
USPL1	ubiquitin specific peptidase like 1	0.018
ARHGAP5	Rho GTPase activating protein 5	0.018
CUL1	cullin 1	0.017
TUBA1C	tubulin, alpha 1c	0.017
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.017
TUBA1A	tubulin, alpha 1a	0.017
ZFYVE1	zinc finger, FYVE domain containing 1	0.017
KAT2B	K(lysine) acetyltransferase 2B	0.017
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.017
TGFB3	transforming growth factor, beta 3	0.016
SOX7	SRY (sex determining region Y)-box 7	0.016
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.016
CDK2	cyclin-dependent kinase 2	0.016
SOCS3	suppressor of cytokine signaling 3	0.016	Human
EIF1B	eukaryotic translation initiation factor 1B	0.016
HDAC11	histone deacetylase 11	0.016
MKL2	MKL/myocardin-like 2	0.015
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.015
RNF168	ring finger protein 168	0.015
BAG3	BCL2-associated athanogene 3	0.015
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.015
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.015	Yeast
BAX	BCL2-associated X protein	0.015
PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5	0.015
SNIP1	Smad nuclear interacting protein 1	0.015
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.014
ZMYND11	zinc finger, MYND-type containing 11	0.014
ZFAND5	zinc finger, AN1-type domain 5	0.014
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.014
AIG1	androgen-induced 1	0.014
AURKB	aurora kinase B	0.014
RYBP	RING1 and YY1 binding protein	0.014
HK2	hexokinase 2	0.014
TRAF6	TNF receptor-associated factor 6	0.014
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.014
ERBB2IP	erbb2 interacting protein	0.014
AR	androgen receptor	0.014
RPL11	ribosomal protein L11	0.014
CEP164	centrosomal protein 164kDa	0.014
PML	promyelocytic leukemia	0.013
JAK2	Janus kinase 2	0.013
SNX9	sorting nexin 9	0.013
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.013
PDCD10	programmed cell death 10	0.013
KRT18	keratin 18	0.013
WWOX	WW domain containing oxidoreductase	0.013
TUBA1B	tubulin, alpha 1b	0.013
FAF2	Fas associated factor family member 2	0.013
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.013
RNF20	ring finger protein 20	0.013
CASP8AP2	caspase 8 associated protein 2	0.013
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.013
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0.013
BIK	BCL2-interacting killer (apoptosis-inducing)	0.013
CSTF2T	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	0.013
ARRDC3	arrestin domain containing 3	0.013
NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.013
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.012
WT1	Wilms tumor 1	0.012
HSPA1B	heat shock 70kDa protein 1B	0.012
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.012
TTC35	tetratricopeptide repeat domain 35	0.012
HMGB2	high mobility group box 2	0.012
MRPL20	mitochondrial ribosomal protein L20	0.012
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.012
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.012
MBD1	methyl-CpG binding domain protein 1	0.012
MT1A	metallothionein 1A	0.012
TXNL1	thioredoxin-like 1	0.012
TRIM63	tripartite motif containing 63	0.012
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.012
E2F1	E2F transcription factor 1	0.012
PRKCZ	protein kinase C, zeta	0.012
OCLN	occludin	0.012
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.011
CUL3	cullin 3	0.011
RAD23A	RAD23 homolog A (S. cerevisiae)	0.011
PINK1	PTEN induced putative kinase 1	0.011
IL12RB2	interleukin 12 receptor, beta 2	0.011
RAP1B	RAP1B, member of RAS oncogene family	0.011
MAPK11	mitogen-activated protein kinase 11	0.011
PRDM1	PR domain containing 1, with ZNF domain	0.011
AXIN2	axin 2	0.011
UBQLN4	ubiquilin 4	0.011
UBASH3B	ubiquitin associated and SH3 domain containing B	0.011
USP9X	ubiquitin specific peptidase 9, X-linked	0.011
PIAS2	protein inhibitor of activated STAT, 2	0.011
HLTF	helicase-like transcription factor	0.011
KLHL12	kelch-like 12 (Drosophila)	0.011
KLF5	Kruppel-like factor 5 (intestinal)	0.011
DDB1	damage-specific DNA binding protein 1, 127kDa	0.011
PDPK1	3-phosphoinositide dependent protein kinase-1	0.011
MAP1S	microtubule-associated protein 1S	0.011
ZHX1	zinc fingers and homeoboxes 1	0.011
WNK1	WNK lysine deficient protein kinase 1	0.011
STAG1	stromal antigen 1	0.011
HSPA13	heat shock protein 70kDa family, member 13	0.011
MAP2K6	mitogen-activated protein kinase kinase 6	0.011
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.011
ADRBK1	adrenergic, beta, receptor kinase 1	0.011
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.011
SRI	sorcin	0.011
SIAH1	seven in absentia homolog 1 (Drosophila)	0.011
KCTD3	potassium channel tetramerisation domain containing 3	0.011
BRCA1	breast cancer 1, early onset	0.011
DYNLL1	dynein, light chain, LC8-type 1	0.011
COPS8	COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)	0.011
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.011
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.011
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	0.010
PAIP1	poly(A) binding protein interacting protein 1	0.010
RHOA	ras homolog gene family, member A	0.010
ZRANB1	zinc finger, RAN-binding domain containing 1	0.010
APC	adenomatous polyposis coli	0.010
ARL15	ADP-ribosylation factor-like 15	0.010
ALDOB	aldolase B, fructose-bisphosphate	0.010
ETV5	ets variant 5	0.010
GSK3A	glycogen synthase kinase 3 alpha	0.010	Fly
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.010
USP2	ubiquitin specific peptidase 2	0.010
TROAP	trophinin associated protein (tastin)	0.010
MAPK14	mitogen-activated protein kinase 14	0.010
BBC3	BCL2 binding component 3	0.010
S100A4	S100 calcium binding protein A4	0.010