The network for 'regulation of mapk cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of mapk cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.

Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.000
SMAD2 SMAD family member 2 0.999
MAPK14 mitogen-activated protein kinase 14 0.999
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.998
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.998
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.997
MAPK1 mitogen-activated protein kinase 1 0.997
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.997
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.997
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.996
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.995
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.995
IRAK1 interleukin-1 receptor-associated kinase 1 0.992
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.991
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.988
SMAD3 SMAD family member 3 0.986
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.985
FGFR2 fibroblast growth factor receptor 2 0.984
MAP2K1 mitogen-activated protein kinase kinase 1 0.984
FAS Fas (TNF receptor superfamily, member 6) 0.982
FGFR1 fibroblast growth factor receptor 1 0.980
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.978
CCR5 chemokine (C-C motif) receptor 5 0.977
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.975
CSNK1E casein kinase 1, epsilon 0.974
ESR1 estrogen receptor 1 0.972
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.969
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.968
LRRK2 leucine-rich repeat kinase 2 0.968
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.967
PLCG1 phospholipase C, gamma 1 0.966
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.965
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.964
DUSP1 dual specificity phosphatase 1 0.963
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.963
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.961
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.958
FGF1 fibroblast growth factor 1 (acidic) 0.957
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.957
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.952
MAPK8 mitogen-activated protein kinase 8 0.952
BCAR1 breast cancer anti-estrogen resistance 1 0.952
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.946
SMAD7 SMAD family member 7 0.946
CAV1 caveolin 1, caveolae protein, 22kDa 0.945
MAPK3 mitogen-activated protein kinase 3 0.944
GHR growth hormone receptor 0.938
SFN stratifin 0.936
GAB1 GRB2-associated binding protein 1 0.934
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.933
PTEN phosphatase and tensin homolog 0.929
ERBB2IP erbb2 interacting protein 0.928
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.927
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.918
IRAK2 interleukin-1 receptor-associated kinase 2 0.916
CHUK conserved helix-loop-helix ubiquitous kinase 0.912
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.910
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.908
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.908
TRAF3 TNF receptor-associated factor 3 0.904
TEK TEK tyrosine kinase, endothelial 0.891
MYD88 myeloid differentiation primary response gene (88) 0.890
SQSTM1 sequestosome 1 0.890
PTK2 PTK2 protein tyrosine kinase 2 0.887
GSK3B glycogen synthase kinase 3 beta 0.877
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.874
ZNF43 zinc finger protein 43 0.874
ARRB1 arrestin, beta 1 0.867
TRAF5 TNF receptor-associated factor 5 0.867
TRAF6 TNF receptor-associated factor 6 0.864
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.862
BIRC3 baculoviral IAP repeat containing 3 0.860
BMPR1A bone morphogenetic protein receptor, type IA 0.857
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.853
FGB fibrinogen beta chain 0.849
MAP2K4 mitogen-activated protein kinase kinase 4 0.835
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.834
ILK integrin-linked kinase 0.832
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.830
SKIL SKI-like oncogene 0.829
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.825
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 0.819
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.814
CCNE1 cyclin E1 0.810
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.807
BRAF v-raf murine sarcoma viral oncogene homolog B1 0.789
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.783
BBS10 Bardet-Biedl syndrome 10 0.782
STAT5A signal transducer and activator of transcription 5A 0.776
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.775
ZNF746 zinc finger protein 746 0.771
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.771
MET met proto-oncogene (hepatocyte growth factor receptor) 0.771
PRKCA protein kinase C, alpha 0.769
GUCY2C guanylate cyclase 2C (heat stable enterotoxin receptor) 0.766
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.765
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
msp-78 Protein MSP-78 0.637
bar-1 Protein BAR-1 0.603
egl-18 Protein EGL-18 0.370
msp-49 Protein MSP-49 0.368
mpk-1 Protein MPK-1 0.345
dpy-22 Protein DPY-22 0.334
nhr-6 Protein NHR-6 0.325
mec-2 Protein MEC-2 0.319
msp-77 Protein MSP-77 0.255
abl-1 Protein ABL-1 0.243
msp-36 Protein MSP-36 0.221
tbb-4 Protein TBB-4 0.217
msp-59 Protein MSP-59 0.198
msp-3 Protein MSP-3 0.181
msp-50 Protein MSP-50 0.178
msp-31 Protein MSP-31 0.173
glp-1 Protein GLP-1 0.169
lin-45 Protein LIN-45 0.168
cutl-24 Protein CUTL-24 0.161
lin-25 Protein LIN-25 0.160
msp-65 Protein MSP-65 0.160
sem-5 Protein SEM-5 0.154
msp-74 Protein MSP-74 0.151
sma-6 Protein SMA-6 0.142
lat-1 Protein LAT-1 0.140
vab-3 Protein VAB-3 0.137
chd-7 Protein CHD-7 0.136
ncam-1 Protein NCAM-1 0.135
CELE_Y59E9AR.7 Protein Y59E9AR.7 0.133
pal-1 Protein PAL-1 0.128
K08E3.5 Protein K08E3.5 0.127
sma-1 Protein SMA-1 0.127
msp-38 Protein MSP-38 0.122
tps-1 Protein TPS-1 0.120
msp-76 Protein MSP-76 0.111
magi-1 Protein MAGI-1 0.104
msp-79 Protein MSP-79 0.102
inx-3 Protein INX-3 0.102
msp-33 Protein MSP-33 0.102
msp-55 Protein MSP-55 0.102
mek-2 Protein MEK-2 0.098
mig-15 Protein MIG-15 0.096
F55F8.9 Protein F55F8.9 0.095
ceh-20 Protein CEH-20 0.092
pry-1 Protein PRY-1 0.090
ZK1248.17 Protein ZK1248.17 0.090
btbd-10 Protein BTBD-10 0.089
nipi-3 Protein NIPI-3 0.088
frm-7 Protein FRM-7 0.084
pqn-44 Protein PQN-44 0.083
zak-1 Protein ZAK-1 0.081
let-60 Protein LET-60 0.079
tol-1 Protein TOL-1 0.079
par-3 Protein PAR-3 0.078
sax-7 Protein SAX-7 0.074
msp-45 Protein MSP-45 0.072
inx-4 Protein INX-4 0.072
msp-152 Protein MSP-152 0.072
rpm-1 Protein RPM-1 0.071
egl-15 Protein EGL-15 0.071
egl-27 Protein EGL-27 0.069
gap-2 Protein GAP-2 0.069
msp-10 Protein MSP-10 0.065
axl-1 Protein AXL-1 0.064
cap-2 Protein CAP-2 0.064
ldb-1 Protein LDB-1 0.064
eps-8 Protein EPS-8 0.062
Y43H11AL.1 Protein Y43H11AL.1 0.061
zyg-9 Protein ZYG-9 0.060
F39B2.1 Protein F39B2.1 0.058
C14B1.2 Protein C14B1.2 0.057
mes-3 Protein MES-3 0.056
ubc-3 Protein UBC-3 0.056
msp-32 Protein MSP-32 0.056
daf-19 Protein DAF-19 0.055
sek-1 Protein SEK-1 0.055
inx-5 Protein INX-5 0.055
frm-2 Protein FRM-2 0.053
unc-32 Protein UNC-32 0.053
unc-7 Protein UNC-7 0.053
hum-5 Protein HUM-5 0.053
R03H10.2 Protein R03H10.2 0.052
lin-11 Protein LIN-11 0.052
cam-1 Protein CAM-1 0.052
zhp-3 Protein ZHP-3 0.052
spc-1 Protein SPC-1 0.052
unc-9 Protein UNC-9 0.051
pqn-51 Protein PQN-51 0.050
ykt-6 Protein YKT-6 0.050
psf-1 Protein PSF-1 0.050
plc-1 Protein PLC-1 0.050
daf-4 Protein DAF-4 0.049
swsn-2.1 Protein SWSN-2.1 0.047
ksr-1 Protein KSR-1 0.047
tir-1 Protein TIR-1 0.045
rhi-1 Protein RHI-1 0.045
msp-142 Protein MSP-142 0.043
snx-17 Protein SNX-17 0.043
fln-2 Protein FLN-2 0.042
msp-63 Protein MSP-63 0.042
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.243
twist1a twist1a 0.173
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.148
efnb2a ephrin B2a 0.094
dkk1b dickkopf 1b 0.091
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.085
wu:fv91b12 wu:fv91b12 0.082
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.076
lamc1 laminin, gamma 1 0.068
olfm1a olfactomedin 1a 0.064
odc1 ornithine decarboxylase 1 0.063
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.062
zbtb4 zinc finger and BTB domain containing 4 0.061
fn1 fibronectin 1 0.058
nf1a neurofibromin 1a 0.054
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.053
hoxa2b homeo box A2b 0.051
tlr3 toll-like receptor 3 0.051
crip2 cysteine-rich protein 2 0.050
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.050
bdnf brain-derived neurotrophic factor 0.050
tmem2 transmembrane protein 2 0.048
rnd3a Rho family GTPase 3a 0.048
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.047
rhoab ras homolog gene family, member Ab 0.045
igfbp3 insulin-like growth factor binding protein 3 0.045
brd2a bromodomain-containing 2a 0.044
nod1 nucleotide-binding oligomerization domain containing 1 0.043
nrp1a neuropilin 1a 0.043
tie1 endothelium-specific receptor tyrosine kinase 1 0.043
plcg1 phospholipase C, gamma 1 0.041
gro2 groucho 2 0.041
furinb furin (paired basic amino acid cleaving enzyme) b 0.041
crestin crestin 0.040
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.040
gdf6a growth differentiation factor 6a 0.039
lef1 lymphocyte enhancer binding factor 1 0.038
pycard PYD and CARD domain containing 0.038
vipr2 vasoactive intestinal peptide receptor 2 0.038
cnn2 calponin 2 0.038
mbtps1 membrane-bound transcription factor protease, site 1 0.037
tob1a transducer of ERBB2, 1a 0.037
fgf3 fibroblast growth factor 3 0.037
jag2 jagged 2 0.037
pcp4a Purkinje cell protein 4a 0.035
adipor2 adiponectin receptor 2 0.035
acvr2a activin receptor IIa 0.035
gclm glutamate-cysteine ligase, modifier subunit 0.035
igf2b insulin-like growth factor 2b 0.035
baxa bcl2-associated X protein, a 0.032
tagln2 transgelin 2 0.032
mpped2 metallophosphoesterase domain containing 2 0.032
rarga retinoic acid receptor gamma a 0.032
kiss1rb KISS1 receptor b 0.031
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.031
lepr leptin receptor 0.030
frzb frizzled-related protein 0.029
igf1 insulin-like growth factor 1 0.029
dag1 dystroglycan 1 0.028
jag1b jagged 1b 0.028
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.028
lama5 laminin, alpha 5 0.027
traf4a tnf receptor-associated factor 4a 0.027
nrp2a neuropilin 2a 0.027
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.027
tbp TATA box binding protein 0.027
sfrp1b secreted frizzled-related protein 1b 0.027
kita kit receptor a 0.026
mapk1 mitogen-activated protein kinase 1 0.026
fes feline sarcoma oncogene 0.026
inhbaa inhibin, beta Aa 0.025
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.025
aox3 aldehyde oxidase 3 0.025
pax7b paired box gene 7b 0.025
spry2 sprouty homolog 2 0.025
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.025
sf3b1 splicing factor 3b, subunit 1 0.025
wnt4a wingless-type MMTV integration site family, member 4a 0.025
pob partial optokinetic response b 0.024
osr1 odd-skipped related 1 (Drosophila) 0.024
ghra growth hormone receptor a 0.024
mstnb myostatin b 0.024
ptena phosphatase and tensin homolog A 0.024
atp6v1h ATPase, H+ transporting, lysosomal, V1 subunit H 0.024
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.024
fas Fas (TNF receptor superfamily, member 6) 0.024
cd63 Cd63 antigen 0.023
dzip1 DAZ interacting protein 1 0.023
zgc:85866 zgc:85866 0.023
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.023
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.023
sall1a sal-like 1a (Drosophila) 0.023
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.023
scinlb scinderin like b 0.023
ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.023
cltca clathrin, heavy polypeptide a (Hc) 0.022
mitfa microphthalmia-associated transcription factor a 0.022
cdh2 cadherin 2, neuronal 0.022
her6 hairy-related 6 0.022
lmo4a LIM domain only 4a 0.022
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.843
Smox Smad on X 0.709
Ras85D Ras oncogene at 85D 0.669
Mad Mothers against dpp 0.640
stck steamer duck 0.610
sax saxophone 0.591
NetB Netrin-B 0.572
puc puckered 0.549
pnut peanut 0.525
hep hemipterous 0.501
chico CG5686 gene product from transcript CG5686-RB 0.484
shi shibire 0.480
Akt1 CG4006 gene product from transcript CG4006-RA 0.474
rl rolled 0.453
Nrx-IV Neurexin IV 0.446
Adf1 Adh transcription factor 1 0.423
ctp cut up 0.414
Rac2 CG8556 gene product from transcript CG8556-RA 0.399
G-oalpha47A G protein oalpha 47A 0.398
key kenny 0.393
shn schnurri 0.391
rhea CG6831 gene product from transcript CG6831-RA 0.377
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.365
bsk basket 0.364
p120ctn Adherens junction protein p120 0.347
phl pole hole 0.338
kay kayak 0.334
p38b CG7393 gene product from transcript CG7393-RA 0.333
Stat92E Signal-transducer and activator of transcription protein at 92E 0.327
ecd ecdysoneless 0.324
cbs centrosomin's beautiful sister 0.323
lqf liquid facets 0.322
htl heartless 0.309
ed echinoid 0.305
rho rhomboid 0.303
Mpk2 CG5475 gene product from transcript CG5475-RB 0.299
Rab5 Rab-protein 5 0.283
babo baboon 0.278
rok Rho-kinase 0.267
Jra Jun-related antigen 0.260
rut rutabaga 0.258
Med Medea 0.251
dap dacapo 0.245
skpA CG16983 gene product from transcript CG16983-RD 0.239
wdb widerborst 0.238
spen split ends 0.236
Src42A Src oncogene at 42A 0.233
Klp64D Kinesin-like protein at 64D 0.231
Rheb CG1081 gene product from transcript CG1081-RA 0.229
Sema-1a CG18405 gene product from transcript CG18405-RD 0.227
hipk homeodomain interacting protein kinase 0.224
Atg1 Autophagy-specific gene 1 0.223
tamo CG4057 gene product from transcript CG4057-RA 0.220
CG10267 CG10267 gene product from transcript CG10267-RB 0.216
mew multiple edematous wings 0.216
mbc myoblast city 0.214
Pvr PDGF- and VEGF-receptor related 0.204
mtt mangetout 0.198
Myo31DF Myosin 31DF 0.193
sgg shaggy 0.184
spi spitz 0.183
aop anterior open 0.183
WASp CG1520 gene product from transcript CG1520-RA 0.183
trio CG18214 gene product from transcript CG18214-RA 0.180
Ptp69D Protein tyrosine phosphatase 69D 0.180
mib1 mind bomb 1 0.178
Irk2 Inwardly rectifying potassium channel 2 0.166
PGRP-LF Peptidoglycan recognition protein LF 0.166
CdsA CDP diglyceride synthetase 0.166
Cdc42 CG12530 gene product from transcript CG12530-RA 0.166
plexB plexin B 0.162
PGRP-LC Peptidoglycan recognition protein LC 0.161
mys myospheroid 0.160
Shc SHC-adaptor protein 0.155
arm armadillo 0.154
Ras64B Ras oncogene at 64B 0.149
Rab7 Rab-protein 7 0.149
lin lines 0.148
Apc APC-like 0.142
egr eiger 0.142
CkIIalpha Casein kinase II alpha subunit 0.142
LIMK1 LIM-kinase1 0.141
tkv thickveins 0.141
Dad Daughters against dpp 0.140
CaMKII Calcium/calmodulin-dependent protein kinase II 0.137
sli slit 0.136
sbb scribbler 0.134
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.133
fl(2)d female lethal d 0.131
Sos Son of sevenless 0.124
drk downstream of receptor kinase 0.124
az2 CG1605 gene product from transcript CG1605-RA 0.123
CG4168 CG4168 gene product from transcript CG4168-RA 0.123
ATP7 CG1886 gene product from transcript CG1886-RB 0.122
Sra-1 specifically Rac1-associated protein 1 0.120
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.119
Pten CG5671 gene product from transcript CG5671-RB 0.117
raw CG12437 gene product from transcript CG12437-RB 0.117
CG1792 CG1792 gene product from transcript CG1792-RA 0.115
AttA Attacin-A 0.113
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Grb2 growth factor receptor bound protein 2 1.000
Pten phosphatase and tensin homolog 1.000
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.999
Cbl Casitas B-lineage lymphoma 0.998
Apc adenomatosis polyposis coli 0.998
Shc1 src homology 2 domain-containing transforming protein C1 0.995
Efnb2 ephrin B2 0.993
Traf6 TNF receptor-associated factor 6 0.991
Inpp5d inositol polyphosphate-5-phosphatase D 0.984
Axin1 axin 1 0.983
Cd44 CD44 antigen 0.978
Ghr growth hormone receptor 0.976
Csf1 colony stimulating factor 1 (macrophage) 0.975
Egfr epidermal growth factor receptor 0.967
Cav1 caveolin 1, caveolae protein 0.964
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.962
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.953
Ctnnb1 catenin (cadherin associated protein), beta 1 0.951
Mapk8 mitogen-activated protein kinase 8 0.951
Ccl2 chemokine (C-C motif) ligand 2 0.950
Prkce protein kinase C, epsilon 0.948
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.947
Lepr leptin receptor 0.945
Acvr1 activin A receptor, type 1 0.944
Tgfb2 transforming growth factor, beta 2 0.940
Axl AXL receptor tyrosine kinase 0.934
Smad6 MAD homolog 6 (Drosophila) 0.933
Cd40 CD40 antigen 0.927
Stat3 signal transducer and activator of transcription 3 0.916
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.911
Wnt5a wingless-related MMTV integration site 5A 0.909
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.906
Tnf tumor necrosis factor 0.905
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.904
Mapk14 mitogen-activated protein kinase 14 0.900
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.900
Tbx3 T-box 3 0.895
Src Rous sarcoma oncogene 0.892
Kiss1 KiSS-1 metastasis-suppressor 0.891
Il6st interleukin 6 signal transducer 0.888
Fyn Fyn proto-oncogene 0.885
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.882
Smad4 MAD homolog 4 (Drosophila) 0.879
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.875
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.859
Ptk2 PTK2 protein tyrosine kinase 2 0.857
Il1r1 interleukin 1 receptor, type I 0.854
Dok1 docking protein 1 0.852
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.832
Tgfbr2 transforming growth factor, beta receptor II 0.832
Gli3 GLI-Kruppel family member GLI3 0.831
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.826
Prrx1 paired related homeobox 1 0.825
Cd22 CD22 antigen 0.817
Ephb3 Eph receptor B3 0.810
Smad3 MAD homolog 3 (Drosophila) 0.805
Apoe apolipoprotein E 0.801
Ccr1 chemokine (C-C motif) receptor 1 0.799
Gpc3 glypican 3 0.795
Plcg1 phospholipase C, gamma 1 0.787
Pthlh parathyroid hormone-like peptide 0.785
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.777
Mapk1 mitogen-activated protein kinase 1 0.775
Adam17 a disintegrin and metallopeptidase domain 17 0.768
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.765
Hbegf heparin-binding EGF-like growth factor 0.764
Vasp vasodilator-stimulated phosphoprotein 0.763
Bmpr1a bone morphogenetic protein receptor, type 1A 0.760
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.755
Fras1 Fraser syndrome 1 homolog (human) 0.754
Fcgr2b Fc receptor, IgG, low affinity IIb 0.752
Trp63 transformation related protein 63 0.746
Ptgs2 prostaglandin-endoperoxide synthase 2 0.738
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.737
Fzd4 frizzled homolog 4 (Drosophila) 0.732
Fgfr3 fibroblast growth factor receptor 3 0.731
Wnt3a wingless-related MMTV integration site 3A 0.731
Cx3cr1 chemokine (C-X3-C) receptor 1 0.727
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.721
Gsk3b glycogen synthase kinase 3 beta 0.720
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.720
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.718
Insr insulin receptor 0.709
Irs1 insulin receptor substrate 1 0.707
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.706
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.704
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.704
Ifngr1 interferon gamma receptor 1 0.702
Ahr aryl-hydrocarbon receptor 0.699
C3ar1 complement component 3a receptor 1 0.696
Map3k3 mitogen-activated protein kinase kinase kinase 3 0.695
Esr1 estrogen receptor 1 (alpha) 0.692
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.685
Pax2 paired box gene 2 0.685
Klf7 Kruppel-like factor 7 (ubiquitous) 0.684
Spnb2 spectrin beta 2 0.677
Spry4 sprouty homolog 4 (Drosophila) 0.671
Bdnf brain derived neurotrophic factor 0.671
Cyld cylindromatosis (turban tumor syndrome) 0.666
Rac1 RAS-related C3 botulinum substrate 1 0.664
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Rattus norvegicus
Name Description Probability Func Analog Organism
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.758
Bcan brevican 0.585
Itgam integrin, alpha M 0.532
Jak1 Janus kinase 1 0.529
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.494
Utrn utrophin 0.469
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.417
Ncan neurocan 0.398
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.374
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.367
Syt10 synaptotagmin X 0.367
Ptafr platelet-activating factor receptor 0.363
Ptprc protein tyrosine phosphatase, receptor type, C 0.354
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.333
Sstr5 somatostatin receptor 5 0.332
Irs1 insulin receptor substrate 1 0.322
Ptbp1 polypyrimidine tract binding protein 1 0.308
Cdh6 cadherin 6 0.305
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.302
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.300
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.300
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.294
Mr1 major histocompatibility complex, class I-related 0.289
Prkch protein kinase C, eta 0.285
Adora2a adenosine A2a receptor 0.284
Fgfr2 fibroblast growth factor receptor 2 0.280
Gna15 guanine nucleotide binding protein, alpha 15 0.276
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.269
Tgfbr2 transforming growth factor, beta receptor II 0.263
Grm7 glutamate receptor, metabotropic 7 0.260
Prdm2 PR domain containing 2, with ZNF domain 0.253
Map2 microtubule-associated protein 2 0.253
Egfr epidermal growth factor receptor 0.252
Met met proto-oncogene 0.250
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.248
Ednrb endothelin receptor type B 0.246
Grip1 glutamate receptor interacting protein 1 0.240
Olr287 olfactory receptor 287 0.239
Sell selectin L 0.237
Creb1 cAMP responsive element binding protein 1 0.228
Hpcal4 hippocalcin-like 4 0.224
Lphn2 latrophilin 2 0.222
Dmd dystrophin 0.220
RGD1564664 similar to LOC387763 protein 0.217
Adam17 ADAM metallopeptidase domain 17 0.217
Mapk1 mitogen activated protein kinase 1 0.216
Syt8 synaptotagmin VIII 0.216
Lpl lipoprotein lipase 0.215
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.215
Iapp islet amyloid polypeptide 0.214
Sirpa signal-regulatory protein alpha 0.213
Il1a interleukin 1 alpha 0.206
Svs1 seminal vesicle secretory protein 1 0.205
Prkg2 protein kinase, cGMP-dependent, type II 0.201
Map3k3 mitogen activated protein kinase kinase kinase 3 0.199
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.198
Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 0.196
Grp gastrin releasing peptide 0.195
Jtb jumping translocation breakpoint 0.194
Vegfa vascular endothelial growth factor A 0.190
MGC112715 hypothetical protein LOC690899 0.188
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.185
Tcf4 transcription factor 4 0.184
Crip2 cysteine-rich protein 2 0.183
Rhag Rh-associated glycoprotein 0.181
Robo1 roundabout homolog 1 (Drosophila) 0.179
Oprm1 opioid receptor, mu 1 0.178
Klf6 Kruppel-like factor 6 0.177
Pxn paxillin 0.177
Acr acrosin 0.176
Gzmb granzyme B 0.176
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.175
Calcrl calcitonin receptor-like 0.173
Il8ra interleukin 8 receptor, alpha 0.173
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.169
Rgs9 regulator of G-protein signaling 9 0.168
Prlhr prolactin releasing hormone receptor 0.167
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.166
Map3k1 mitogen activated protein kinase kinase kinase 1 0.165
Rgs14 regulator of G-protein signaling 14 0.163
Olr837 olfactory receptor 837 0.161
Mpeg1 macrophage expressed 1 0.159
Homer3 homer homolog 3 (Drosophila) 0.159
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.159
Crhbp corticotropin releasing hormone binding protein 0.158
Nab1 Ngfi-A binding protein 1 0.157
Barhl2 BarH-like homeobox 2 0.154
Ctsj cathepsin J 0.154
Agtr2 angiotensin II receptor, type 2 0.153
Hpca hippocalcin 0.152
Stk10 serine/threonine kinase 10 0.152
Gjb4 gap junction protein, beta 4 0.150
Mapk9 mitogen-activated protein kinase 9 0.150
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.150
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.150
Syt2 synaptotagmin II 0.148
Adrb1 adrenergic, beta-1-, receptor 0.148
Gria2 glutamate receptor, ionotropic, AMPA 2 0.147
Fgf16 fibroblast growth factor 16 0.147
Il9r interleukin 9 receptor 0.146
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
PBS2 Pbs2p 0.989
NBP2 Nbp2p 0.977
SSK2 Ssk2p 0.971
STE7 Ste7p 0.905
SLT2 Slt2p 0.860
STE4 Ste4p 0.844
FUS3 Fus3p 0.836
MSG5 Msg5p 0.816
BCK1 Bck1p 0.790
KSS1 Kss1p 0.743
CPR1 Cpr1p 0.612
STE5 Ste5p 0.437
STE20 Ste20p 0.343
BMH1 Bmh1p 0.316
STE11 Ste11p 0.316
SLA2 Sla2p 0.238
AHP1 Ahp1p 0.234
CYR1 Cyr1p 0.217
FAR1 Far1p 0.164
KIC1 Kic1p 0.159
PTC1 Ptc1p 0.159
CDC55 Cdc55p 0.154
ZDS1 Zds1p 0.148
BEM1 Bem1p 0.147
IRA1 Ira1p 0.145
CAK1 Cak1p 0.141
ASK10 Ask10p 0.134
CDC34 Cdc34p 0.114
HOS4 Hos4p 0.109
SSK1 Ssk1p 0.103
TRX2 Trx2p 0.100
CDC24 Cdc24p 0.093
SNT1 Snt1p 0.093
ALD6 Ald6p 0.092
RLM1 Rlm1p 0.089
LHS1 Lhs1p 0.082
EBS1 Ebs1p 0.080
KDX1 Kdx1p 0.067
ARF2 Arf2p 0.067
SSK22 Ssk22p 0.066
SHO1 Sho1p 0.061
UFO1 Ufo1p 0.059
ROM2 Rom2p 0.056
DBF2 Dbf2p 0.051
YEL1 Yel1p 0.050
CSI1 Csi1p 0.050
BCK2 Bck2p 0.045
SSN8 Ssn8p 0.044
HOG1 Hog1p 0.043
DIA2 Dia2p 0.042
FUS2 Fus2p 0.041
CLA4 Cla4p 0.039
YHB1 Yhb1p 0.039
SIF2 Sif2p 0.035
SKP1 Skp1p 0.035
PPH21 Pph21p 0.035
BOI1 Boi1p 0.034
HOS2 Hos2p 0.034
RPN13 Rpn13p 0.034
OYE2 Oye2p 0.033
YJR084W hypothetical protein 0.033
CRG1 Crg1p 0.032
HOR7 Hor7p 0.032
TEC1 Tec1p 0.031
DIG1 Dig1p 0.031
HST1 Hst1p 0.030
ZWF1 Zwf1p 0.030
PCI8 Pci8p 0.030
EHT1 Eht1p 0.029
CHS1 Chs1p 0.029
CRZ1 Crz1p 0.028
RHO4 Rho4p 0.027
RGD2 Rgd2p 0.027
VPS5 Vps5p 0.026
CNS1 Cns1p 0.026
RHO1 Rho1p 0.025
EAF3 Eaf3p 0.024
YJR141W hypothetical protein 0.023
CCS1 Ccs1p 0.023
SKT5 Skt5p 0.023
NAP1 Nap1p 0.023
YPL088W hypothetical protein 0.023
VMA13 Vma13p 0.022
FAA4 Faa4p 0.022
SHP1 Shp1p 0.021
ATP3 Atp3p 0.021
BNI1 Bni1p 0.020
STE2 Ste2p 0.020
SKM1 Skm1p 0.020
CSN9 Csn9p 0.020
BIT61 Bit61p 0.019
PTC3 Ptc3p 0.019
ENT3 Ent3p 0.019
CCT2 Cct2p 0.019
RAS2 Ras2p 0.019
YDR514C hypothetical protein 0.019
CKB1 Ckb1p 0.018
SIL1 Sil1p 0.018
LTV1 Ltv1p 0.017
ALG13 Alg13p 0.017