The network for 't cell homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

t cell homeostasis

The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

Mus musculus
Name Description Probability Func Analog Organism
Foxp3 forkhead box P3 0.990
Stat3 signal transducer and activator of transcription 3 0.985
Trp53 transformation related protein 53 0.980
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.933
Bax BCL2-associated X protein 0.879
Casp8 caspase 8 0.792
Cd19 CD19 antigen 0.723
Fas Fas (TNF receptor superfamily member 6) 0.641
Mcl1 myeloid cell leukemia sequence 1 0.581
Irf9 interferon regulatory factor 9 0.565
Stat5a signal transducer and activator of transcription 5A 0.488
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.444
Myd88 myeloid differentiation primary response gene 88 0.426
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.392
Cdk1 cyclin-dependent kinase 1 0.374
Il1r1 interleukin 1 receptor, type I 0.332
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.299
Stat5b signal transducer and activator of transcription 5B 0.295
Tlr4 toll-like receptor 4 0.286
Kit kit oncogene 0.277
Casp1 caspase 1 0.262
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.259
Rc3h1 RING CCCH (C3H) domains 1 0.222
Tgfb1 transforming growth factor, beta 1 0.201
Il2 interleukin 2 0.199
Lyz2 lysozyme 2 0.192
Igh immunoglobulin heavy chain complex 0.184
Fadd Fas (TNFRSF6)-associated via death domain 0.161
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.160
Bcl2 B-cell leukemia/lymphoma 2 0.153
9430031J16Rik RIKEN cDNA 9430031J16 gene 0.151
Socs1 suppressor of cytokine signaling 1 0.146
Il10 interleukin 10 0.139
Prf1 perforin 1 (pore forming protein) 0.135
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.128
Jak2 Janus kinase 2 0.125
Tnf tumor necrosis factor 0.121
Stat6 signal transducer and activator of transcription 6 0.111
Bak1 BCL2-antagonist/killer 1 0.109
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.105
Ttc7 tetratricopeptide repeat domain 7 0.099
Il6st interleukin 6 signal transducer 0.099
Prc1 protein regulator of cytokinesis 1 0.096
Rxra retinoid X receptor alpha 0.090
Tnip1 TNFAIP3 interacting protein 1 0.088
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.087
Gbp5 guanylate binding protein 5 0.087
Pycard PYD and CARD domain containing 0.085
Ticam1 toll-like receptor adaptor molecule 1 0.079
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.078
Batf basic leucine zipper transcription factor, ATF-like 0.074
Traf6 TNF receptor-associated factor 6 0.070
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.068
Il18 interleukin 18 0.068
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.067
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.066
Wdr1 WD repeat domain 1 0.063
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.063
Ripk3 receptor-interacting serine-threonine kinase 3 0.059
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.059
Casp7 caspase 7 0.058
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.058
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.058
Arpc4 actin related protein 2/3 complex, subunit 4 0.056
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.056
Ghr growth hormone receptor 0.056
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.055
Lyst lysosomal trafficking regulator 0.055
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.053
Rag2 recombination activating gene 2 0.052
Hif1a hypoxia inducible factor 1, alpha subunit 0.051
Traf1 TNF receptor-associated factor 1 0.050
Ifnar1 interferon (alpha and beta) receptor 1 0.050
Il6 interleukin 6 0.049
Akt2 thymoma viral proto-oncogene 2 0.049
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.049
Cyld cylindromatosis (turban tumor syndrome) 0.048
Prlr prolactin receptor 0.046
Dbnl drebrin-like 0.045
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.044
Ptgs2 prostaglandin-endoperoxide synthase 2 0.043
Il4ra interleukin 4 receptor, alpha 0.042
Pdcd1 programmed cell death 1 0.041
Apc adenomatosis polyposis coli 0.041
Ncoa3 nuclear receptor coactivator 3 0.041
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.039
Bid BH3 interacting domain death agonist 0.037
Zfp36 zinc finger protein 36 0.037
Rara retinoic acid receptor, alpha 0.036
Ikbkg inhibitor of kappaB kinase gamma 0.036
Ly96 lymphocyte antigen 96 0.036
Cdk4 cyclin-dependent kinase 4 0.036
Mapkap1 mitogen-activated protein kinase associated protein 1 0.035
Zeb1 zinc finger E-box binding homeobox 1 0.034
Pten phosphatase and tensin homolog 0.034
Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) 0.034
Aim2 absent in melanoma 2 0.033
Trim21 tripartite motif-containing 21 0.033
0610031J06Rik RIKEN cDNA 0610031J06 gene 0.033
Capzb capping protein (actin filament) muscle Z-line, beta 0.033
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BCL2L1 BCL2-like 1 0.999
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.921
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.916
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.885
BID BH3 interacting domain death agonist 0.704
BAK1 BCL2-antagonist/killer 1 0.565
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.559
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.557
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.437
FASLG Fas ligand (TNF superfamily, member 6) 0.430
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.409
CDK2 cyclin-dependent kinase 2 0.373
BAD BCL2-associated agonist of cell death 0.269
BAX BCL2-associated X protein 0.251
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.248
FAS Fas (TNF receptor superfamily, member 6) 0.243
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.206
NOXA1 NADPH oxidase activator 1 0.193
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.187
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.178
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.174
BCL2 B-cell CLL/lymphoma 2 0.156
INSR insulin receptor 0.134
CFLAR CASP8 and FADD-like apoptosis regulator 0.124
IL2RB interleukin 2 receptor, beta 0.116
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.106
PXMP2 peroxisomal membrane protein 2, 22kDa 0.101
STAT5A signal transducer and activator of transcription 5A 0.100
FADD Fas (TNFRSF6)-associated via death domain 0.097
RNF144B ring finger protein 144B 0.090
RB1 retinoblastoma 1 0.089
SH3RF1 SH3 domain containing ring finger 1 0.088
PRKCZ protein kinase C, zeta 0.086
ENG endoglin 0.081
ARNT aryl hydrocarbon receptor nuclear translocator 0.078
BCL2L2 BCL2-like 2 0.066
CAV1 caveolin 1, caveolae protein, 22kDa 0.066
HPCAL4 hippocalcin like 4 0.066
JAK2 Janus kinase 2 0.060
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.059
RNR2 l-rRNA 0.057
PICK1 protein interacting with PRKCA 1 0.055
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.054
SOCS3 suppressor of cytokine signaling 3 0.054
FSTL1 follistatin-like 1 0.053
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.053
BECN1 beclin 1, autophagy related 0.053
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.052
NAF1 nuclear assembly factor 1 homolog (S. cerevisiae) 0.051
TSC22D1 TSC22 domain family, member 1 0.051
IRF2 interferon regulatory factor 2 0.050
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.050
CD247 CD247 molecule 0.049
JAK1 Janus kinase 1 0.048
NUMB numb homolog (Drosophila) 0.045
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.045
APAF1 apoptotic peptidase activating factor 1 0.043
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.043
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.043
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.042
NCOA7 nuclear receptor coactivator 7 0.042
AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) 0.041
CDCP1 CUB domain containing protein 1 0.040
ZNF71 zinc finger protein 71 0.040
SMG1 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 0.037
BIK BCL2-interacting killer (apoptosis-inducing) 0.037
STAP2 signal transducing adaptor family member 2 0.037
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.037
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.035
MAPT microtubule-associated protein tau 0.035
BBC3 BCL2 binding component 3 0.035
NMT2 N-myristoyltransferase 2 0.034
PDPK1 3-phosphoinositide dependent protein kinase-1 0.032
PRKCB protein kinase C, beta 0.032
CCL14 chemokine (C-C motif) ligand 14 0.031
SH2D1A SH2 domain containing 1A 0.031
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.031
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.030
PTK2B PTK2B protein tyrosine kinase 2 beta 0.030
CARD11 caspase recruitment domain family, member 11 0.030
TGFBR1 transforming growth factor, beta receptor 1 0.029
TGFB3 transforming growth factor, beta 3 0.027
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.027
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.026
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.025
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.024
RPS8 ribosomal protein S8 0.024
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.024
DCTN1 dynactin 1 0.023
TP53BP2 tumor protein p53 binding protein, 2 0.022
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.022
CCDC115 coiled-coil domain containing 115 0.022
MAPK1 mitogen-activated protein kinase 1 0.021
FYN FYN oncogene related to SRC, FGR, YES 0.021
CCND3 cyclin D3 0.020
LCK lymphocyte-specific protein tyrosine kinase 0.020
STAT5B signal transducer and activator of transcription 5B 0.020
PRMT2 protein arginine methyltransferase 2 0.020
RARA retinoic acid receptor, alpha 0.020
IRS2 insulin receptor substrate 2 0.020
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Rattus norvegicus
Name Description Probability Func Analog Organism
Tp53 tumor protein p53 0.155
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.114
Flt1 FMS-related tyrosine kinase 1 0.062
Il1r1 interleukin 1 receptor, type I 0.054
Spn sialophorin 0.052
Stat6 signal transducer and activator of transcription 6 0.042
Sh3bgrl3 SH3 domain binding glutamic acid-rich protein-like 3 0.041
Creb1 cAMP responsive element binding protein 1 0.039
Usf2 upstream transcription factor 2, c-fos interacting 0.038
Zyx zyxin 0.038
Cd247 Cd247 molecule 0.038
Tubb5 tubulin, beta 5 0.036
Bcl2l2 Bcl2-like 2 0.036
Pcdhga11 protocadherin gamma subfamily A, 11 0.036
Arrb2 arrestin, beta 2 0.034
Prrx1 paired related homeobox 1 0.034
Tfeb transcription factor EB 0.033
Arnt aryl hydrocarbon receptor nuclear translocator 0.033
Thumpd3 THUMP domain containing 3 0.031
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.030
Il2rg interleukin 2 receptor, gamma 0.030
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.028
Csnk1g1 casein kinase 1, gamma 1 0.028
Limd2 LIM domain containing 2 0.027
Podxl podocalyxin-like 0.026
Pfn1 profilin 1 0.025
Nos3 nitric oxide synthase 3, endothelial cell 0.025
Sept9 septin 9 0.025
Bcl2l1 Bcl2-like 1 0.023
MGC112715 hypothetical protein LOC690899 0.023
Lepr leptin receptor 0.023
Bak1 BCL2-antagonist/killer 1 0.023
Gata6 GATA binding protein 6 0.023
Smad3 SMAD family member 3 0.023
Cd37 CD37 molecule 0.022
Cotl1 coactosin-like 1 (Dictyostelium) 0.022
Crygf crystallin, gamma F 0.021
siat7D alpha-2,6-sialyltransferase ST6GalNAc IV 0.020
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.019
Tgfbr3 transforming growth factor, beta receptor III 0.019
Klf15 Kruppel-like factor 15 0.019
Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 0.019
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.018
Efhd2 EF-hand domain family, member D2 0.018
Sell selectin L 0.018
Ccnd3 cyclin D3 0.018
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.018
Akap1 A kinase (PRKA) anchor protein 1 0.018
Epn2 epsin 2 0.017
Sec31a SEC31 homolog A (S. cerevisiae) 0.017
Sbk1 SH3-binding domain kinase 1 0.017
Cdh4 cadherin 4 0.017
Zbp1 Z-DNA binding protein 1 0.017
Trim47 tripartite motif-containing 47 0.017
Gabrr2 gamma-aminobutyric acid (GABA) receptor, rho 2 0.017
Ier5l immediate early response 5-like 0.017
Dbnl drebrin-like 0.016
Zfp68 zinc finger protein 68 0.016
Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) 0.016
Tmsb10 thymosin, beta 10 0.016
Utrn utrophin 0.016
Lnpep leucyl/cystinyl aminopeptidase 0.016
Sox18 SRY (sex determining region Y)-box 18 0.015
Sardh sarcosine dehydrogenase 0.015
Egfl7 EGF-like-domain, multiple 7 0.015
Ahr aryl hydrocarbon receptor 0.015
Mobkl2a MOB1, Mps One Binder kinase activator-like 2A (yeast) 0.015
Fyn FYN oncogene related to SRC, FGR, YES 0.015
LOC683626 similar to limb-bud and heart 0.015
Met met proto-oncogene 0.015
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.015
Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.015
Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.015
Arhgap9 Rho GTPase activating protein 9 0.014
Trabd TraB domain containing 0.014
Shprh SNF2 histone linker PHD RING helicase 0.014
Olr1346 olfactory receptor 1346 0.014
Irs3 insulin receptor substrate 3 0.014
Gper G protein-coupled estrogen receptor 1 0.014
Sbno2 strawberry notch homolog 2 (Drosophila) 0.014
Cdh17 cadherin 17 0.014
Mecp2 methyl CpG binding protein 2 0.014
Acvr1b activin A receptor, type IB 0.014
Garnl1 GTPase activating Rap/RanGAP domain-like 1 0.014
Dhx40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.014
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.014
Cdgap Cdc42 GTPase-activating protein 0.013
Tek TEK tyrosine kinase, endothelial 0.013
Plekho1 pleckstrin homology domain containing, family O member 1 0.013
Capns1 calpain, small subunit 1 0.013
Ptbp1 polypyrimidine tract binding protein 1 0.013
Agtr2 angiotensin II receptor, type 2 0.013
Cd3g CD3 molecule, gamma 0.013
Trhr2 thyrotropin releasing hormone receptor 2 0.013
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.013
Lat linker for activation of T cells 0.013
Pftk1 PFTAIRE protein kinase 1 0.013
Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 0.013
Clcn5 chloride channel 5 0.013
Hmha1 histocompatibility (minor) HA-1 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism