IMP

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Homo sapiens

35 genes annotated in human

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positive regulation of dna replication

GO:0045740

Any process that activates or increases the frequency, rate or extent of DNA replication.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of dna replication"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of dna replication" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	1.000
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	1.000
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.993	Human
FGFR2	fibroblast growth factor receptor 2	0.976
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.965
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.883	Human
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.863
E2F7	E2F transcription factor 7	0.801	Mouse
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.672
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.641
VEGFA	vascular endothelial growth factor A	0.626	Human
E2F8	E2F transcription factor 8	0.622	Mouse
NRP1	neuropilin 1	0.561
HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	0.545
BMPR1A	bone morphogenetic protein receptor, type IA	0.526
IGF1R	insulin-like growth factor 1 receptor	0.520
CDK2	cyclin-dependent kinase 2	0.492	Yeast Mouse
SUFU	suppressor of fused homolog (Drosophila)	0.467
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.454
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.395
FGFR1	fibroblast growth factor receptor 1	0.388
RAD50	RAD50 homolog (S. cerevisiae)	0.375
PDIA3	protein disulfide isomerase family A, member 3	0.372
BCAR1	breast cancer anti-estrogen resistance 1	0.342
PLCG1	phospholipase C, gamma 1	0.318
CAV1	caveolin 1, caveolae protein, 22kDa	0.314
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.306	Human
INSR	insulin receptor	0.264
LAT	linker for activation of T cells	0.254
EPOR	erythropoietin receptor	0.240
MAPK8	mitogen-activated protein kinase 8	0.239	Rat
CCNE1	cyclin E1	0.237
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.197
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.197	Human
PDGFA	platelet-derived growth factor alpha polypeptide	0.195
RB1	retinoblastoma 1	0.193
BMPR1B	bone morphogenetic protein receptor, type IB	0.188
MAPK9	mitogen-activated protein kinase 9	0.170
CDH5	cadherin 5, type 2 (vascular endothelium)	0.158
STK36	serine/threonine kinase 36	0.148
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.139
S100A4	S100 calcium binding protein A4	0.138
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.131
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.126
DBF4	DBF4 homolog (S. cerevisiae)	0.117
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.117
ACTR5	ARP5 actin-related protein 5 homolog (yeast)	0.117
CKS2	CDC28 protein kinase regulatory subunit 2	0.111
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.110
INO80E	INO80 complex subunit E	0.104
YY1	YY1 transcription factor	0.100
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.097	Rat
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.096
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.094
NBN	nibrin	0.091
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.089
PTPRB	protein tyrosine phosphatase, receptor type, B	0.088
WRN	Werner syndrome, RecQ helicase-like	0.087
JAK2	Janus kinase 2	0.084
MDC1	mediator of DNA-damage checkpoint 1	0.081
ATF2	activating transcription factor 2	0.080
CP110	CP110 protein	0.080
TGFB1	transforming growth factor, beta 1	0.079
YAF2	YY1 associated factor 2	0.075
IRS1	insulin receptor substrate 1	0.075
RPAP3	RNA polymerase II associated protein 3	0.074
RIF1	RAP1 interacting factor homolog (yeast)	0.073
PGF	placental growth factor	0.071	Human
ACD	adrenocortical dysplasia homolog (mouse)	0.070
FKBP4	FK506 binding protein 4, 59kDa	0.066
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.064
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.064
TERF2	telomeric repeat binding factor 2	0.062
CCNA2	cyclin A2	0.059
GAB1	GRB2-associated binding protein 1	0.056
NOG	noggin	0.054
PDGFC	platelet derived growth factor C	0.053
DCN	decorin	0.053
KITLG	KIT ligand	0.053
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.050
FGF8	fibroblast growth factor 8 (androgen-induced)	0.049
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.048
ITGB1BP3	integrin beta 1 binding protein 3	0.048
MAPK1	mitogen-activated protein kinase 1	0.047
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.047
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.046
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.044
ORC2	origin recognition complex, subunit 2	0.044
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.043
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.041
CCNE2	cyclin E2	0.041
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.040
FSTL1	follistatin-like 1	0.039
GHR	growth hormone receptor	0.039
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.037	Human
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.037
MAPK14	mitogen-activated protein kinase 14	0.036
CCNB2	cyclin B2	0.036	Yeast
CDK1	cyclin-dependent kinase 1	0.036	Yeast Rat
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.036
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.035
PDE4DIP	phosphodiesterase 4D interacting protein	0.035
ATM	ataxia telangiectasia mutated	0.034
COL2A1	collagen, type II, alpha 1	0.034
SIAH1	seven in absentia homolog 1 (Drosophila)	0.034
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.034	Human
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.033
FGF4	fibroblast growth factor 4	0.033	Human
MCM2	minichromosome maintenance complex component 2	0.032
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.032
TGFB2	transforming growth factor, beta 2	0.032
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.032
DUSP1	dual specificity phosphatase 1	0.030
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.030
APP	amyloid beta (A4) precursor protein	0.030
IQGAP1	IQ motif containing GTPase activating protein 1	0.030
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.030
VAV3	vav 3 guanine nucleotide exchange factor	0.029
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.028	Human
VEGFC	vascular endothelial growth factor C	0.027	Human
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.027
IGF2R	insulin-like growth factor 2 receptor	0.026
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.026
PAWR	PRKC, apoptosis, WT1, regulator	0.025
COL6A1	collagen, type VI, alpha 1	0.025
MAP2K1	mitogen-activated protein kinase kinase 1	0.025
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.025
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.025
RALGDS	ral guanine nucleotide dissociation stimulator	0.024
LDLR	low density lipoprotein receptor	0.024
ACTR8	ARP8 actin-related protein 8 homolog (yeast)	0.024
BLM	Bloom syndrome, RecQ helicase-like	0.024
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.024
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.024
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	0.024
RBL1	retinoblastoma-like 1 (p107)	0.024
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.023
GRB10	growth factor receptor-bound protein 10	0.023
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.023	Human
ORC6	origin recognition complex, subunit 6	0.023
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.022
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.022
S100A2	S100 calcium binding protein A2	0.022
TGFB3	transforming growth factor, beta 3	0.022
IGFBP5	insulin-like growth factor binding protein 5	0.022
DDR2	discoidin domain receptor tyrosine kinase 2	0.022
SMAD2	SMAD family member 2	0.022
BMP2	bone morphogenetic protein 2	0.022	Human
BMP4	bone morphogenetic protein 4	0.022
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.021
FNBP1	formin binding protein 1	0.021
RIN1	Ras and Rab interactor 1	0.021
CD151	CD151 molecule (Raph blood group)	0.021
E2F1	E2F transcription factor 1	0.020
TRO	trophinin	0.020
PEX26	peroxisomal biogenesis factor 26	0.020
GAB2	GRB2-associated binding protein 2	0.020
FRS2	fibroblast growth factor receptor substrate 2	0.020
BCR	breakpoint cluster region	0.020
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.020
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.020
RET	ret proto-oncogene	0.020
RALBP1	ralA binding protein 1	0.020
SUGT1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	0.019
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.019
INO80D	INO80 complex subunit D	0.019
STAT5A	signal transducer and activator of transcription 5A	0.019
SMEK1	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	0.019
CLSPN	claspin	0.019
PDIA4	protein disulfide isomerase family A, member 4	0.019
GMFB	glia maturation factor, beta	0.018
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.018
BRCA2	breast cancer 2, early onset	0.018
FCGRT	Fc fragment of IgG, receptor, transporter, alpha	0.018
WNT1	wingless-type MMTV integration site family, member 1	0.018
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.018
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.017
POT1	protection of telomeres 1 homolog (S. pombe)	0.017
HSPH1	heat shock 105kDa/110kDa protein 1	0.017
ATF3	activating transcription factor 3	0.017
LNPEP	leucyl/cystinyl aminopeptidase	0.017
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.017
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.017
ARRB1	arrestin, beta 1	0.016
SYK	spleen tyrosine kinase	0.016
PSG9	pregnancy specific beta-1-glycoprotein 9	0.016
GSTM5	glutathione S-transferase mu 5	0.016
QPRT	quinolinate phosphoribosyltransferase	0.016
DLG3	discs, large homolog 3 (Drosophila)	0.016
BTRC	beta-transducin repeat containing	0.016
DLG2	discs, large homolog 2 (Drosophila)	0.016
MAP2K7	mitogen-activated protein kinase kinase 7	0.016
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.016
RAD51AP1	RAD51 associated protein 1	0.016
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.016
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.015
UBA6	ubiquitin-like modifier activating enzyme 6	0.015
SLIT2	slit homolog 2 (Drosophila)	0.015
CTNND1	catenin (cadherin-associated protein), delta 1	0.015
PEBP4	phosphatidylethanolamine-binding protein 4	0.015
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.015
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.015
CRYAB	crystallin, alpha B	0.015
RBBP8	retinoblastoma binding protein 8	0.015
SMC2	structural maintenance of chromosomes 2	0.015
BZW1	basic leucine zipper and W2 domains 1	0.015
FGF3	fibroblast growth factor 3	0.015	Human
TMEM214	transmembrane protein 214	0.014
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.014
GMNN	geminin, DNA replication inhibitor	0.014
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.014
STAT5B	signal transducer and activator of transcription 5B	0.014
KRTAP4-12	keratin associated protein 4-12	0.014
PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	0.014
SRI	sorcin	0.014
CAV2	caveolin 2	0.014
THBS1	thrombospondin 1	0.014
HYOU1	hypoxia up-regulated 1	0.014
BAG1	BCL2-associated athanogene	0.014
PECAM1	platelet/endothelial cell adhesion molecule	0.014
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.014	Rat
ZFYVE9	zinc finger, FYVE domain containing 9	0.014
FLT4	fms-related tyrosine kinase 4	0.014	Human
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.014
ZNF764	zinc finger protein 764	0.014
FZD7	frizzled homolog 7 (Drosophila)	0.014
IGF2	insulin-like growth factor 2 (somatomedin A)	0.013	Human
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.013
MYO10	myosin X	0.013
DAXX	death-domain associated protein	0.013
MAPK10	mitogen-activated protein kinase 10	0.013
NOV	nephroblastoma overexpressed gene	0.013
CRELD2	cysteine-rich with EGF-like domains 2	0.013
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.013
ECT2	epithelial cell transforming sequence 2 oncogene	0.013
CCND1	cyclin D1	0.013
SOS1	son of sevenless homolog 1 (Drosophila)	0.013
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.013
CFD	complement factor D (adipsin)	0.013
RBM15	RNA binding motif protein 15	0.012
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.012
GAS1	growth arrest-specific 1	0.012
ATRIP	ATR interacting protein	0.012
STIL	SCL/TAL1 interrupting locus	0.012
CSK	c-src tyrosine kinase	0.012
JUN	jun proto-oncogene	0.012	Rat
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.012
PBK	PDZ binding kinase	0.012
STC1	stanniocalcin 1	0.012
CD81	CD81 molecule	0.012
MASTL	microtubule associated serine/threonine kinase-like	0.012
FERMT2	fermitin family member 2	0.012
FGFR3	fibroblast growth factor receptor 3	0.012
RHOC	ras homolog gene family, member C	0.012
FKBP8	FK506 binding protein 8, 38kDa	0.011
FBXW11	F-box and WD repeat domain containing 11	0.011
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.011
NRP2	neuropilin 2	0.011
PLCE1	phospholipase C, epsilon 1	0.011
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.011
TIMP1	TIMP metallopeptidase inhibitor 1	0.011
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.011
FANCG	Fanconi anemia, complementation group G	0.011
RHEB	Ras homolog enriched in brain	0.011
EXOC2	exocyst complex component 2	0.011
IGFBP3	insulin-like growth factor binding protein 3	0.011
MTF2	metal response element binding transcription factor 2	0.011
FGF10	fibroblast growth factor 10	0.011
SH3RF3	SH3 domain containing ring finger 3	0.011
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.011
PIAS2	protein inhibitor of activated STAT, 2	0.011
WNK1	WNK lysine deficient protein kinase 1	0.011
FYN	FYN oncogene related to SRC, FGR, YES	0.010
CTSB	cathepsin B	0.010
TCF4	transcription factor 4	0.010
PTCH1	patched 1	0.010
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.010
CBX2	chromobox homolog 2	0.010
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.010
VPRBP	Vpr (HIV-1) binding protein	0.010
BMP8B	bone morphogenetic protein 8b	0.010	Human
LTK	leukocyte receptor tyrosine kinase	0.010	Human
CEP135	centrosomal protein 135kDa	0.010
FGFBP1	fibroblast growth factor binding protein 1	0.010
IRS2	insulin receptor substrate 2	0.010
ANGPT1	angiopoietin 1	0.010
ITGB5	integrin, beta 5	0.010
IGFBP1	insulin-like growth factor binding protein 1	0.010