The network for 'positive regulation of adaptive immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of adaptive immune response

Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Igh immunoglobulin heavy chain complex 0.999
Lyz2 lysozyme 2 0.999
Fas Fas (TNF receptor superfamily member 6) 0.997
Cd19 CD19 antigen 0.994
Cd28 CD28 antigen 0.994
Cd40 CD40 antigen 0.992
Il4 interleukin 4 0.992
Ifng interferon gamma 0.992
Lta lymphotoxin A 0.982
Il6st interleukin 6 signal transducer 0.970
Ccr1 chemokine (C-C motif) receptor 1 0.959
Ccr2 chemokine (C-C motif) receptor 2 0.948
B2m beta-2 microglobulin 0.944
Ikzf1 IKAROS family zinc finger 1 0.939
Cd44 CD44 antigen 0.937
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.929
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.929
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.923
Lepr leptin receptor 0.904
Ccr7 chemokine (C-C motif) receptor 7 0.903
Ccl2 chemokine (C-C motif) ligand 2 0.892
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.887
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.871
Ptprc protein tyrosine phosphatase, receptor type, C 0.866
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.847
Stat3 signal transducer and activator of transcription 3 0.832
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.824
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.824
Foxp3 forkhead box P3 0.793
Ltb lymphotoxin B 0.748
Cxcr5 chemokine (C-X-C motif) receptor 5 0.742
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.741
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.740
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.720
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.705
Pax5 paired box gene 5 0.677
Tcra T-cell receptor alpha chain 0.663
Fyn Fyn proto-oncogene 0.646
Il2rg interleukin 2 receptor, gamma chain 0.644
Btk Bruton agammaglobulinemia tyrosine kinase 0.640
Cd4 CD4 antigen 0.614
Il10 interleukin 10 0.611
Stat5a signal transducer and activator of transcription 5A 0.607
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.590
Il27ra interleukin 27 receptor, alpha 0.575
Rag2 recombination activating gene 2 0.559
Casp8 caspase 8 0.553
Il6 interleukin 6 0.536
H2-Eb1 histocompatibility 2, class II antigen E beta 0.519
H2-K1 histocompatibility 2, K1, K region 0.514
Irf1 interferon regulatory factor 1 0.512
C3ar1 complement component 3a receptor 1 0.506
Icos inducible T-cell co-stimulator 0.465
Cxcl13 chemokine (C-X-C motif) ligand 13 0.446
Ccr5 chemokine (C-C motif) receptor 5 0.436
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.432
Tapbp TAP binding protein 0.427
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.416
Lag3 lymphocyte-activation gene 3 0.405
Zeb1 zinc finger E-box binding homeobox 1 0.391
Ifngr1 interferon gamma receptor 1 0.365
Apoe apolipoprotein E 0.361
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.360
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.346
Stat5b signal transducer and activator of transcription 5B 0.335
Ciita class II transactivator 0.323
Irf8 interferon regulatory factor 8 0.310
H2-Aa histocompatibility 2, class II antigen A, alpha 0.301
Myd88 myeloid differentiation primary response gene 88 0.300
Ikbkg inhibitor of kappaB kinase gamma 0.296
Tbx3 T-box 3 0.287
Prdm1 PR domain containing 1, with ZNF domain 0.287
H2-D1 histocompatibility 2, D region locus 1 0.277
Irf9 interferon regulatory factor 9 0.270
Il7r interleukin 7 receptor 0.266
H2-Q7 histocompatibility 2, Q region locus 7 0.259
Pdcd1 programmed cell death 1 0.256
Ptgs2 prostaglandin-endoperoxide synthase 2 0.255
Kit kit oncogene 0.249
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.248
H2-DMb2 histocompatibility 2, class II, locus Mb2 0.242
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.242
Il1r1 interleukin 1 receptor, type I 0.240
Pnp2 purine-nucleoside phosphorylase 2 0.238
Il1b interleukin 1 beta 0.229
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.224
Cd22 CD22 antigen 0.222
Lat linker for activation of T cells 0.216
Socs1 suppressor of cytokine signaling 1 0.213
Rag1 recombination activating gene 1 0.209
Sfpi1 SFFV proviral integration 1 0.205
Creb1 cAMP responsive element binding protein 1 0.202
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.199
Mefv Mediterranean fever 0.199
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.199
Sh2d2a SH2 domain protein 2A 0.196
Pou5f1 POU domain, class 5, transcription factor 1 0.195
Tbx21 T-box 21 0.192
Itk IL2-inducible T-cell kinase 0.191
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
B2M beta-2-microglobulin 0.921
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.881
HLA-A major histocompatibility complex, class I, A 0.875
HLA-B major histocompatibility complex, class I, B 0.845
TRAF1 TNF receptor-associated factor 1 0.838
TRAF3 TNF receptor-associated factor 3 0.798
TRAF6 TNF receptor-associated factor 6 0.748
SYK spleen tyrosine kinase 0.745
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.740
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.697
HLA-G major histocompatibility complex, class I, G 0.689
BIRC3 baculoviral IAP repeat containing 3 0.663
HLA-F major histocompatibility complex, class I, F 0.607
HLA-C major histocompatibility complex, class I, C 0.595
HLA-E major histocompatibility complex, class I, E 0.568
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.549
CXCL9 chemokine (C-X-C motif) ligand 9 0.548
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.538
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.534
IL4R interleukin 4 receptor 0.531
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.519
TAPBP TAP binding protein (tapasin) 0.457
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.395
CD40 CD40 molecule, TNF receptor superfamily member 5 0.372
CCL4 chemokine (C-C motif) ligand 4 0.332
CCR5 chemokine (C-C motif) receptor 5 0.309
CCL5 chemokine (C-C motif) ligand 5 0.262
HLA-DRA major histocompatibility complex, class II, DR alpha 0.260
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.225
HLA-DMB major histocompatibility complex, class II, DM beta 0.163
TRAF2 TNF receptor-associated factor 2 0.149
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.146
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.127
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.125
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.120
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.106
GRAP2 GRB2-related adaptor protein 2 0.105
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.102
TNF tumor necrosis factor 0.099
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.093
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.093
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.091
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.090
FAS Fas (TNF receptor superfamily, member 6) 0.088
CXCL10 chemokine (C-X-C motif) ligand 10 0.086
CCR7 chemokine (C-C motif) receptor 7 0.084
IL23A interleukin 23, alpha subunit p19 0.083
LCK lymphocyte-specific protein tyrosine kinase 0.073
FASLG Fas ligand (TNF superfamily, member 6) 0.073
CREBBP CREB binding protein 0.069
RIPK2 receptor-interacting serine-threonine kinase 2 0.068
TRADD TNFRSF1A-associated via death domain 0.067
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.061
IDE insulin-degrading enzyme 0.055
CCL2 chemokine (C-C motif) ligand 2 0.054
CSF1R colony stimulating factor 1 receptor 0.054
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.053
NLRC4 NLR family, CARD domain containing 4 0.053
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.052
NCOA6 nuclear receptor coactivator 6 0.051
CD80 CD80 molecule 0.051
CFH complement factor H 0.049
IL10RA interleukin 10 receptor, alpha 0.048
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.046
CXCL11 chemokine (C-X-C motif) ligand 11 0.046
HSPH1 heat shock 105kDa/110kDa protein 1 0.044
BIRC2 baculoviral IAP repeat containing 2 0.044
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.044
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.044
CCL8 chemokine (C-C motif) ligand 8 0.041
CCL22 chemokine (C-C motif) ligand 22 0.041
CD86 CD86 molecule 0.040
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.040
IFNG interferon, gamma 0.040
ZMYND11 zinc finger, MYND-type containing 11 0.039
H2AFX H2A histone family, member X 0.037
TANK TRAF family member-associated NFKB activator 0.037
IL2RB interleukin 2 receptor, beta 0.036
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.036
AR androgen receptor 0.035
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.035
PVRL4 poliovirus receptor-related 4 0.032
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.032
ICAM1 intercellular adhesion molecule 1 0.031
CCR1 chemokine (C-C motif) receptor 1 0.031
CXCL13 chemokine (C-X-C motif) ligand 13 0.031
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.030
IL7R interleukin 7 receptor 0.028
IRF4 interferon regulatory factor 4 0.027
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.026
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.026
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.026
SQSTM1 sequestosome 1 0.026
IL10 interleukin 10 0.023
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.023
CCR4 chemokine (C-C motif) receptor 4 0.023
CCL13 chemokine (C-C motif) ligand 13 0.023
ENG endoglin 0.023
BCL10 B-cell CLL/lymphoma 10 0.023
IL4 interleukin 4 0.022
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.605
RT1-Ba RT1 class II, locus Ba 0.046
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.020
RT1-Da RT1 class II, locus Da 0.020
Cd37 CD37 molecule 0.019
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.014
Cxcr4 chemokine (C-X-C motif) receptor 4 0.013
Casp1 caspase 1 0.013
RT1-Db1 RT1 class II, locus Db1 0.012
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.012
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.011
Hspb1 heat shock protein 1 0.011
Gbp2 guanylate binding protein 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism