IMP

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Homo sapiens

26 genes annotated in human

Multi-species View

negative regulation of leukocyte activation

GO:0002695

Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of leukocyte activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of leukocyte activation" (in gray)

Name	Description	Probability	Func Analog Organism
B2M	beta-2-microglobulin	0.965
HLA-C	major histocompatibility complex, class I, C	0.964	Human
HLA-B	major histocompatibility complex, class I, B	0.949
CD80	CD80 molecule	0.929
HLA-A	major histocompatibility complex, class I, A	0.875	Human
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.825
HLA-G	major histocompatibility complex, class I, G	0.793
HLA-E	major histocompatibility complex, class I, E	0.785	Human
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.746	Mouse
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.698	Mouse
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.611
CCR5	chemokine (C-C motif) receptor 5	0.477
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.470
HLA-F	major histocompatibility complex, class I, F	0.419	Human
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.396
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.373
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.319
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.299	Mouse
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.259	Human
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.230
CD86	CD86 molecule	0.226
PILRA	paired immunoglobin-like type 2 receptor alpha	0.210
CXCL9	chemokine (C-X-C motif) ligand 9	0.199
FSTL1	follistatin-like 1	0.193
IL2RG	interleukin 2 receptor, gamma	0.188
IL4R	interleukin 4 receptor	0.174	Mouse
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.172
UBC	ubiquitin C	0.168
BTN3A3	butyrophilin, subfamily 3, member A3	0.167
IL10	interleukin 10	0.157
POU5F1	POU class 5 homeobox 1	0.148
BMPR1A	bone morphogenetic protein receptor, type IA	0.143
CFLAR	CASP8 and FADD-like apoptosis regulator	0.138
BLNK	B-cell linker	0.133
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.131
DRD2	dopamine receptor D2	0.125
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.123
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.122	Mouse
CCL4	chemokine (C-C motif) ligand 4	0.119	Human
CD33	CD33 molecule	0.117
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.116
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.106	Human
CCL13	chemokine (C-C motif) ligand 13	0.106	Human
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.106
CCL2	chemokine (C-C motif) ligand 2	0.105	Human
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.104
RNF11	ring finger protein 11	0.103
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.102
PAX3	paired box 3	0.094
SYK	spleen tyrosine kinase	0.091
POU3F2	POU class 3 homeobox 2	0.088
GAS6	growth arrest-specific 6	0.086
IL10RA	interleukin 10 receptor, alpha	0.083
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.081
SIGLEC7	sialic acid binding Ig-like lectin 7	0.081
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.080
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.080
SLAMF1	signaling lymphocytic activation molecule family member 1	0.079
EPOR	erythropoietin receptor	0.079
CXCL10	chemokine (C-X-C motif) ligand 10	0.078
TRAF6	TNF receptor-associated factor 6	0.075
BIRC3	baculoviral IAP repeat containing 3	0.072
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.071
TFF1	trefoil factor 1	0.065
CCR1	chemokine (C-C motif) receptor 1	0.063
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.063
IL2RA	interleukin 2 receptor, alpha	0.061	Mouse
ICAM1	intercellular adhesion molecule 1	0.060
CCL7	chemokine (C-C motif) ligand 7	0.058	Human
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.058
LAT	linker for activation of T cells	0.058
XIAP	X-linked inhibitor of apoptosis	0.058
APAF1	apoptotic peptidase activating factor 1	0.057
HK3	hexokinase 3 (white cell)	0.056
CCL8	chemokine (C-C motif) ligand 8	0.056	Human
GHR	growth hormone receptor	0.054
IL22RA1	interleukin 22 receptor, alpha 1	0.053
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.051	Human
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.051
CD163	CD163 molecule	0.048
TAPBP	TAP binding protein (tapasin)	0.048
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.047
PINK1	PTEN induced putative kinase 1	0.047
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.047
CSK	c-src tyrosine kinase	0.046
ADAM17	ADAM metallopeptidase domain 17	0.045
VAV1	vav 1 guanine nucleotide exchange factor	0.045
NLRP3	NLR family, pyrin domain containing 3	0.043
IL4	interleukin 4	0.042	Mouse
CCR4	chemokine (C-C motif) receptor 4	0.042
FPR3	formyl peptide receptor 3	0.042
MICA	MHC class I polypeptide-related sequence A	0.042
CCL11	chemokine (C-C motif) ligand 11	0.042	Human
CCL22	chemokine (C-C motif) ligand 22	0.041	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.041
TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.041
HCK	hemopoietic cell kinase	0.040
FASLG	Fas ligand (TNF superfamily, member 6)	0.040
TNF	tumor necrosis factor	0.039
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.038
IDE	insulin-degrading enzyme	0.038
CXCL11	chemokine (C-X-C motif) ligand 11	0.038
IL22RA2	interleukin 22 receptor, alpha 2	0.038
HLA-DMB	major histocompatibility complex, class II, DM beta	0.038
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.037
HDAC9	histone deacetylase 9	0.036
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.036
IFNG	interferon, gamma	0.035
TRAF1	TNF receptor-associated factor 1	0.035
IL6	interleukin 6 (interferon, beta 2)	0.035
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.032
PTK2	PTK2 protein tyrosine kinase 2	0.032
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.032
C19orf50	chromosome 19 open reading frame 50	0.032
LAPTM5	lysosomal protein transmembrane 5	0.031
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.031	Human
CCR7	chemokine (C-C motif) receptor 7	0.030
CD28	CD28 molecule	0.030	Human
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.030
LCK	lymphocyte-specific protein tyrosine kinase	0.030
DPP4	dipeptidyl-peptidase 4	0.027
UBD	ubiquitin D	0.027
IRF9	interferon regulatory factor 9	0.026
CD14	CD14 molecule	0.026
CD83	CD83 molecule	0.026
GRAP2	GRB2-related adaptor protein 2	0.026
SH3BP2	SH3-domain binding protein 2	0.026
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.025
SOCS3	suppressor of cytokine signaling 3	0.025
CMKLR1	chemokine-like receptor 1	0.025
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.024
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.024
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.024
CD300A	CD300a molecule	0.024
IL15RA	interleukin 15 receptor, alpha	0.024
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.023	Human
PLEK	pleckstrin	0.023
CXCL13	chemokine (C-X-C motif) ligand 13	0.023
CCL19	chemokine (C-C motif) ligand 19	0.023	Human
PSAP	prosaposin	0.022
PLK3	polo-like kinase 3	0.022
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.022
STAT2	signal transducer and activator of transcription 2, 113kDa	0.022
APP	amyloid beta (A4) precursor protein	0.022
MARCO	macrophage receptor with collagenous structure	0.022
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.021
SLAMF7	SLAM family member 7	0.020
SMAD7	SMAD family member 7	0.020
CH25H	cholesterol 25-hydroxylase	0.020
BTN3A1	butyrophilin, subfamily 3, member A1	0.020
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.020
MSR1	macrophage scavenger receptor 1	0.020
THOC5	THO complex 5	0.020
SIRPA	signal-regulatory protein alpha	0.020
NMI	N-myc (and STAT) interactor	0.020
ATMIN	ATM interactor	0.020
THAP2	THAP domain containing, apoptosis associated protein 2	0.020
MAN2B1	mannosidase, alpha, class 2B, member 1	0.020
SLA	Src-like-adaptor	0.020
MEOX2	mesenchyme homeobox 2	0.019
DOK3	docking protein 3	0.019
CD40	CD40 molecule, TNF receptor superfamily member 5	0.019
GAB2	GRB2-associated binding protein 2	0.019
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.019
SNX18	sorting nexin 18	0.019
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.019
GBP4	guanylate binding protein 4	0.019
EBI3	Epstein-Barr virus induced 3	0.018
CD274	CD274 molecule	0.018	Mouse
IRF4	interferon regulatory factor 4	0.018
PBK	PDZ binding kinase	0.018
CCL3	chemokine (C-C motif) ligand 3	0.018	Human
BCL2A1	BCL2-related protein A1	0.018
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.018
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.018
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.017
PECAM1	platelet/endothelial cell adhesion molecule	0.017
GAB1	GRB2-associated binding protein 1	0.017
TRAF5	TNF receptor-associated factor 5	0.017
FTL	ferritin, light polypeptide	0.017
IL18RAP	interleukin 18 receptor accessory protein	0.017
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.017
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.017	Human Rat
CD72	CD72 molecule	0.017
CCR3	chemokine (C-C motif) receptor 3	0.017
MSTO1	misato homolog 1 (Drosophila)	0.016
IL1B	interleukin 1, beta	0.016
MAPK1	mitogen-activated protein kinase 1	0.016
APBA3	amyloid beta (A4) precursor protein-binding, family A, member 3	0.016
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.016	Human
TYMP	thymidine phosphorylase	0.016
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.016
BMP2	bone morphogenetic protein 2	0.016	Human
ADAMDEC1	ADAM-like, decysin 1	0.016
SIRPB1	signal-regulatory protein beta 1	0.015
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.015
CDK6	cyclin-dependent kinase 6	0.015
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.015
ZBTB48	zinc finger and BTB domain containing 48	0.015
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.015
MARCKSL1	MARCKS-like 1	0.015
IRF8	interferon regulatory factor 8	0.015
JAK2	Janus kinase 2	0.015
APOE	apolipoprotein E	0.015
ICOS	inducible T-cell co-stimulator	0.014
SELE	selectin E	0.014
CHIT1	chitinase 1 (chitotriosidase)	0.014
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.014
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.014
SCNM1	sodium channel modifier 1	0.014
ZNF282	zinc finger protein 282	0.014
C1QA	complement component 1, q subcomponent, A chain	0.014
SNAP23	synaptosomal-associated protein, 23kDa	0.014
ROS1	c-ros oncogene 1 , receptor tyrosine kinase	0.014
SNX9	sorting nexin 9	0.014
AOAH	acyloxyacyl hydrolase (neutrophil)	0.013
PTAFR	platelet-activating factor receptor	0.013
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.013
SIGLEC9	sialic acid binding Ig-like lectin 9	0.013
BTN2A2	butyrophilin, subfamily 2, member A2	0.013	Mouse
CD69	CD69 molecule	0.013
TNIP1	TNFAIP3 interacting protein 1	0.013
SLAMF8	SLAM family member 8	0.013
IFNB1	interferon, beta 1, fibroblast	0.013
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.013
IL13	interleukin 13	0.013
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.013
PPAP2B	phosphatidic acid phosphatase type 2B	0.012
TFEC	transcription factor EC	0.012
PCDH9	protocadherin 9	0.012
MAPK3	mitogen-activated protein kinase 3	0.012
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.012	Human
TAPBPL	TAP binding protein-like	0.012
TP73	tumor protein p73	0.012
HDAC5	histone deacetylase 5	0.012
SOS1	son of sevenless homolog 1 (Drosophila)	0.012
IL12RB1	interleukin 12 receptor, beta 1	0.012
SRGN	serglycin	0.012
STAT4	signal transducer and activator of transcription 4	0.012
CLEC10A	C-type lectin domain family 10, member A	0.012
ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	0.012
OPTN	optineurin	0.012
APOC1	apolipoprotein C-I	0.012
CSF1	colony stimulating factor 1 (macrophage)	0.012
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.012
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.012
PRDM1	PR domain containing 1, with ZNF domain	0.012	Mouse
ZFYVE9	zinc finger, FYVE domain containing 9	0.012
MAP2K1	mitogen-activated protein kinase kinase 1	0.012
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.012
IGSF6	immunoglobulin superfamily, member 6	0.011
IRF5	interferon regulatory factor 5	0.011
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.011
PDCD1LG2	programmed cell death 1 ligand 2	0.011	Mouse
C2	complement component 2	0.011
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.011
CD320	CD320 molecule	0.011
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.011
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.011
CXCR6	chemokine (C-X-C motif) receptor 6	0.011
IL2RB	interleukin 2 receptor, beta	0.011
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.011
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.011
TFG	TRK-fused gene	0.011
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.011
TYROBP	TYRO protein tyrosine kinase binding protein	0.011
CD1B	CD1b molecule	0.011
SOD2	superoxide dismutase 2, mitochondrial	0.011
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.011
CCL21	chemokine (C-C motif) ligand 21	0.011
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.011
FPR2	formyl peptide receptor 2	0.011
TREM1	triggering receptor expressed on myeloid cells 1	0.011
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.011
SIGLEC10	sialic acid binding Ig-like lectin 10	0.011
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.011
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.011
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.010
C3AR1	complement component 3a receptor 1	0.010
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.010
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.010
RNF111	ring finger protein 111	0.010
CCNL1	cyclin L1	0.010
PLUNC	palate, lung and nasal epithelium associated	0.010
STK36	serine/threonine kinase 36	0.010
CD247	CD247 molecule	0.010
IL1RN	interleukin 1 receptor antagonist	0.010
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	0.010
S100A12	S100 calcium binding protein A12	0.010
WNT2	wingless-type MMTV integration site family member 2	0.010
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.010