IMP

Process View

Homo sapiens

32 genes annotated in human

cellular response to ionizing radiation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
BRCA1	breast cancer 1, early onset	0.980
CRYAB	crystallin, alpha B	0.947
HSPB8	heat shock 22kDa protein 8	0.940	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.906
RAD1	RAD1 homolog (S. pombe)	0.906
TAL1	T-cell acute lymphocytic leukemia 1	0.678
HIPK2	homeodomain interacting protein kinase 2	0.667
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.651
HSPB1	heat shock 27kDa protein 1	0.624
NBN	nibrin	0.558
EP300	E1A binding protein p300	0.540
GADD45GIP1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	0.518
HSPB2	heat shock 27kDa protein 2	0.424	Human
RAD50	RAD50 homolog (S. cerevisiae)	0.417
MAP2K4	mitogen-activated protein kinase kinase 4	0.373
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.372
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.364
TP53BP2	tumor protein p53 binding protein, 2	0.341
RAD52	RAD52 homolog (S. cerevisiae)	0.335
SMAD4	SMAD family member 4	0.287
HUS1	HUS1 checkpoint homolog (S. pombe)	0.268
ARHGAP1	Rho GTPase activating protein 1	0.244
WRN	Werner syndrome, RecQ helicase-like	0.208
WWOX	WW domain containing oxidoreductase	0.208
YY1	YY1 transcription factor	0.197
NRP1	neuropilin 1	0.196
IL4R	interleukin 4 receptor	0.195
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.189
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.173
RPA2	replication protein A2, 32kDa	0.166
CLSPN	claspin	0.154
INSR	insulin receptor	0.144
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.140
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.139
RAD17	RAD17 homolog (S. pombe)	0.134
VAV1	vav 1 guanine nucleotide exchange factor	0.132
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.128
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.126
JUN	jun proto-oncogene	0.125
ARRB1	arrestin, beta 1	0.122
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.122
RAD18	RAD18 homolog (S. cerevisiae)	0.118
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.103
BAG3	BCL2-associated athanogene 3	0.102
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.098
APTX	aprataxin	0.097
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.095
CCND1	cyclin D1	0.094
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.085
SP3	Sp3 transcription factor	0.085
MRPL38	mitochondrial ribosomal protein L38	0.082
ACTL6A	actin-like 6A	0.081
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.081
RBBP8	retinoblastoma binding protein 8	0.080
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.079
TNFAIP1	tumor necrosis factor, alpha-induced protein 1 (endothelial)	0.078
SMC2	structural maintenance of chromosomes 2	0.078
PCNA	proliferating cell nuclear antigen	0.078
CUL7	cullin 7	0.078
BHLHE40	basic helix-loop-helix family, member e40	0.077
PLCG1	phospholipase C, gamma 1	0.074
BRCA2	breast cancer 2, early onset	0.074
TP53	tumor protein p53	0.072
SNAI1	snail homolog 1 (Drosophila)	0.072
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.072	Human
KRT5	keratin 5	0.071
ARIH2	ariadne homolog 2 (Drosophila)	0.070
KAT2B	K(lysine) acetyltransferase 2B	0.067
DTL	denticleless homolog (Drosophila)	0.066
PARP1	poly (ADP-ribose) polymerase 1	0.065
MED1	mediator complex subunit 1	0.063
BCL2	B-cell CLL/lymphoma 2	0.063
BLM	Bloom syndrome, RecQ helicase-like	0.062
MAGEA2	melanoma antigen family A, 2	0.059
SP1	Sp1 transcription factor	0.058
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.057
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.056
ASF1A	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	0.055
SATB2	SATB homeobox 2	0.054
CREBBP	CREB binding protein	0.052
PIAS2	protein inhibitor of activated STAT, 2	0.052
RACGAP1	Rac GTPase activating protein 1	0.052
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.050
AMOTL1	angiomotin like 1	0.047
CABLES1	Cdk5 and Abl enzyme substrate 1	0.043
SLBP	stem-loop binding protein	0.042
MIDN	midnolin	0.042
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.041
TP53BP1	tumor protein p53 binding protein 1	0.041
DUSP1	dual specificity phosphatase 1	0.040
RPA1	replication protein A1, 70kDa	0.040
IL2RB	interleukin 2 receptor, beta	0.040
GSK3B	glycogen synthase kinase 3 beta	0.039
CDK6	cyclin-dependent kinase 6	0.039
CD28	CD28 molecule	0.039
USP42	ubiquitin specific peptidase 42	0.039
TBX5	T-box 5	0.038
FANCD2	Fanconi anemia, complementation group D2	0.038
INO80D	INO80 complex subunit D	0.037
FYB	FYN binding protein	0.037
BCL2L1	BCL2-like 1	0.036	Mouse
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.036
CENPK	centromere protein K	0.036
PGF	placental growth factor	0.035
TRPS1	trichorhinophalangeal syndrome I	0.035
CCND3	cyclin D3	0.035
H2AFX	H2A histone family, member X	0.034
TJP1	tight junction protein 1 (zona occludens 1)	0.034
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.032
MAPK14	mitogen-activated protein kinase 14	0.032
TMEM173	transmembrane protein 173	0.032
PHF3	PHD finger protein 3	0.032
SCAF8	SR-related CTD-associated factor 8	0.032
CCNE2	cyclin E2	0.031
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.031
TOPBP1	topoisomerase (DNA) II binding protein 1	0.030
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.030
CPNE6	copine VI (neuronal)	0.030
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.029
KIAA1524	KIAA1524	0.029
CRYBB2	crystallin, beta B2	0.029
PRMT6	protein arginine methyltransferase 6	0.029
AMOTL2	angiomotin like 2	0.029
NFYA	nuclear transcription factor Y, alpha	0.028
RPL39	ribosomal protein L39	0.028
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.028
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.028
FBXO5	F-box protein 5	0.028
IER2	immediate early response 2	0.027
CHRAC1	chromatin accessibility complex 1	0.027
EGR3	early growth response 3	0.027
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.027
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.027
CDK2	cyclin-dependent kinase 2	0.026
RUNX1	runt-related transcription factor 1	0.026
SETD7	SET domain containing (lysine methyltransferase) 7	0.026
JMJD1C	jumonji domain containing 1C	0.026
STAP2	signal transducing adaptor family member 2	0.026
ACTR8	ARP8 actin-related protein 8 homolog (yeast)	0.026
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.026
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.026
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.025
POU2F1	POU class 2 homeobox 1	0.025
MAPK15	mitogen-activated protein kinase 15	0.025
PDGFA	platelet-derived growth factor alpha polypeptide	0.024
CENPQ	centromere protein Q	0.024
DNA2	DNA replication helicase 2 homolog (yeast)	0.023
SKP2	S-phase kinase-associated protein 2 (p45)	0.023
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.023
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	0.023
PALB2	partner and localizer of BRCA2	0.023
MAPK8	mitogen-activated protein kinase 8	0.022	Human
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.022
SIRT1	sirtuin 1	0.022	Mouse
ZNF420	zinc finger protein 420	0.022
DCK	deoxycytidine kinase	0.022
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.021
CTGF	connective tissue growth factor	0.021
COL5A1	collagen, type V, alpha 1	0.021
ATF3	activating transcription factor 3	0.021
CCND2	cyclin D2	0.020
MKRN1	makorin ring finger protein 1	0.020
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.020
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.020
RMI1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)	0.020
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.020
GADD45B	growth arrest and DNA-damage-inducible, beta	0.020	Human
PXN	paxillin	0.020
STAG2	stromal antigen 2	0.020
PML	promyelocytic leukemia	0.019
DAXX	death-domain associated protein	0.019
COL4A1	collagen, type IV, alpha 1	0.019
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.019
ING4	inhibitor of growth family, member 4	0.019
CCDC99	coiled-coil domain containing 99	0.018
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.018
KLF13	Kruppel-like factor 13	0.018
CYR61	cysteine-rich, angiogenic inducer, 61	0.018
CPSF2	cleavage and polyadenylation specific factor 2, 100kDa	0.018
MYST1	MYST histone acetyltransferase 1	0.018	Fly
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.018
RBBP5	retinoblastoma binding protein 5	0.018
MT1A	metallothionein 1A	0.017
PRIM2	primase, DNA, polypeptide 2 (58kDa)	0.017
EGR2	early growth response 2	0.017
TLK2	tousled-like kinase 2	0.017
XPO7	exportin 7	0.017
CUL9	cullin 9	0.017
OBSL1	obscurin-like 1	0.017
HDAC4	histone deacetylase 4	0.017
CHMP4B	chromatin modifying protein 4B	0.017
ATM	ataxia telangiectasia mutated	0.016
SSX2IP	synovial sarcoma, X breakpoint 2 interacting protein	0.016
HAUS6	HAUS augmin-like complex, subunit 6	0.016
SGOL2	shugoshin-like 2 (S. pombe)	0.016
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.016
GSTM4	glutathione S-transferase mu 4	0.016
POLE4	polymerase (DNA-directed), epsilon 4 (p12 subunit)	0.016
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.016
C12orf4	chromosome 12 open reading frame 4	0.016
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.016
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.016
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.016
SASS6	spindle assembly 6 homolog (C. elegans)	0.015
RFC1	replication factor C (activator 1) 1, 145kDa	0.015
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.015
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.015
PIAS4	protein inhibitor of activated STAT, 4	0.015
UBE3A	ubiquitin protein ligase E3A	0.015
ERI1	exoribonuclease 1	0.015
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.015
RPLP1	ribosomal protein, large, P1	0.015
TERF2	telomeric repeat binding factor 2	0.015
ZNF24	zinc finger protein 24	0.015
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.014
ACACA	acetyl-CoA carboxylase alpha	0.014
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.014
MSH3	mutS homolog 3 (E. coli)	0.014
RSBN1	round spermatid basic protein 1	0.014
COL2A1	collagen, type II, alpha 1	0.014
STAG1	stromal antigen 1	0.014
TJP2	tight junction protein 2 (zona occludens 2)	0.014
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.014
TMEM194A	transmembrane protein 194A	0.014
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.014
IL4	interleukin 4	0.014
RFWD2	ring finger and WD repeat domain 2	0.014
TTF2	transcription termination factor, RNA polymerase II	0.014
CHAC2	ChaC, cation transport regulator homolog 2 (E. coli)	0.013
YEATS4	YEATS domain containing 4	0.013
KLF2	Kruppel-like factor 2 (lung)	0.013
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.013
IRS1	insulin receptor substrate 1	0.013
KRT6C	keratin 6C	0.013
PPP1R13B	protein phosphatase 1, regulatory (inhibitor) subunit 13B	0.013
SSU72	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0.013
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.013
TLK1	tousled-like kinase 1	0.013	Human
ECT2	epithelial cell transforming sequence 2 oncogene	0.013
LMNA	lamin A/C	0.013
GINS1	GINS complex subunit 1 (Psf1 homolog)	0.013
MASTL	microtubule associated serine/threonine kinase-like	0.013
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.013
PCDHA4	protocadherin alpha 4	0.012
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.012
CENPH	centromere protein H	0.012
LAMA4	laminin, alpha 4	0.012
TSEN15	tRNA splicing endonuclease 15 homolog (S. cerevisiae)	0.012
YAF2	YY1 associated factor 2	0.012
S1PR5	sphingosine-1-phosphate receptor 5	0.012
ITGA6	integrin, alpha 6	0.012
ARHGAP25	Rho GTPase activating protein 25	0.012
PTPRC	protein tyrosine phosphatase, receptor type, C	0.012
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.012
DIAPH3	diaphanous homolog 3 (Drosophila)	0.012
RAD51AP1	RAD51 associated protein 1	0.012
RAD54B	RAD54 homolog B (S. cerevisiae)	0.012
BTN3A1	butyrophilin, subfamily 3, member A1	0.012
CRYGC	crystallin, gamma C	0.012
MAVS	mitochondrial antiviral signaling protein	0.012
CCNE1	cyclin E1	0.012
APLF	aprataxin and PNKP like factor	0.012
SPIN4	spindlin family, member 4	0.012
KAT5	K(lysine) acetyltransferase 5	0.012	Rat
CLEC2B	C-type lectin domain family 2, member B	0.012
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.012
HCFC1	host cell factor C1 (VP16-accessory protein)	0.012
CSRNP1	cysteine-serine-rich nuclear protein 1	0.012
FLNB	filamin B, beta	0.011
MAPK1	mitogen-activated protein kinase 1	0.011
CNOT4	CCR4-NOT transcription complex, subunit 4	0.011
NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.011
COL1A1	collagen, type I, alpha 1	0.011
C5orf34	chromosome 5 open reading frame 34	0.011
MOAP1	modulator of apoptosis 1	0.011
COL6A1	collagen, type VI, alpha 1	0.011
HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	0.011
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.011
WBP1	WW domain binding protein 1	0.011
RBL1	retinoblastoma-like 1 (p107)	0.011
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.011
YAP1	Yes-associated protein 1	0.011
BBOX1	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	0.011
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.011	Fly
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.011
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.011
RNF38	ring finger protein 38	0.011
GATA2	GATA binding protein 2	0.011	Human
CCDC106	coiled-coil domain containing 106	0.011
SLC25A40	solute carrier family 25, member 40	0.011
KIAA1377	KIAA1377	0.011
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.011
HES1	hairy and enhancer of split 1, (Drosophila)	0.011
HSPB6	heat shock protein, alpha-crystallin-related, B6	0.011	Human
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.011
VEZF1	vascular endothelial zinc finger 1	0.011
FANCM	Fanconi anemia, complementation group M	0.011
RAD9A	RAD9 homolog A (S. pombe)	0.011
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.011
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.011
DCLRE1B	DNA cross-link repair 1B	0.011
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.011
MSH6	mutS homolog 6 (E. coli)	0.011
GRB7	growth factor receptor-bound protein 7	0.011
NCOA2	nuclear receptor coactivator 2	0.011
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.010
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.010
RARA	retinoic acid receptor, alpha	0.010
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.010
CCDC138	coiled-coil domain containing 138	0.010
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.010
HNRNPCL1	heterogeneous nuclear ribonucleoprotein C-like 1	0.010
TIMP1	TIMP metallopeptidase inhibitor 1	0.010
BAK1	BCL2-antagonist/killer 1	0.010
TOP3A	topoisomerase (DNA) III alpha	0.010
PKN1	protein kinase N1	0.010
ZFPM1	zinc finger protein, multitype 1	0.010
TEAD3	TEA domain family member 3	0.010
USP24	ubiquitin specific peptidase 24	0.010
CRYBA1	crystallin, beta A1	0.010
TEAD4	TEA domain family member 4	0.010
FBXW11	F-box and WD repeat domain containing 11	0.010
HAND2	heart and neural crest derivatives expressed 2	0.010