IMP

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Homo sapiens

25 genes annotated in human

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regulation of leukocyte apoptotic process

GO:2000106

Any process that modulates the frequency, rate or extent of leukocyte apoptotic process.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of leukocyte apoptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of leukocyte apoptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
SYK	spleen tyrosine kinase	0.930
LCK	lymphocyte-specific protein tyrosine kinase	0.922
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.857
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.854	Mouse
BIRC3	baculoviral IAP repeat containing 3	0.846	Human
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.830
CCR5	chemokine (C-C motif) receptor 5	0.787	Mouse
TRAF1	TNF receptor-associated factor 1	0.706
CAV1	caveolin 1, caveolae protein, 22kDa	0.588
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.529
CCL4	chemokine (C-C motif) ligand 4	0.486	Human
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.442
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.441
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.426
SH2D4A	SH2 domain containing 4A	0.426
CCL5	chemokine (C-C motif) ligand 5	0.417
BCL2	B-cell CLL/lymphoma 2	0.373
IL10RA	interleukin 10 receptor, alpha	0.357
CCR1	chemokine (C-C motif) receptor 1	0.351
CCR7	chemokine (C-C motif) receptor 7	0.343
BID	BH3 interacting domain death agonist	0.300
BMPR1A	bone morphogenetic protein receptor, type IA	0.298
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.263	Mouse
CARD11	caspase recruitment domain family, member 11	0.258
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.240
TGIF1	TGFB-induced factor homeobox 1	0.226
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.204
PILRA	paired immunoglobin-like type 2 receptor alpha	0.185
CD2	CD2 molecule	0.182
FASLG	Fas ligand (TNF superfamily, member 6)	0.176
FAS	Fas (TNF receptor superfamily, member 6)	0.175
CXCR4	chemokine (C-X-C motif) receptor 4	0.172
CD8A	CD8a molecule	0.170
DLG1	discs, large homolog 1 (Drosophila)	0.165
CCL13	chemokine (C-C motif) ligand 13	0.162	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.157
BIRC2	baculoviral IAP repeat containing 2	0.146	Human
BAK1	BCL2-antagonist/killer 1	0.145
CFLAR	CASP8 and FADD-like apoptosis regulator	0.134
MSN	moesin	0.128
IL1B	interleukin 1, beta	0.128
IL7R	interleukin 7 receptor	0.127
PRKCZ	protein kinase C, zeta	0.126	Human
EP300	E1A binding protein p300	0.122
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.120
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.114	Human
IL2RB	interleukin 2 receptor, beta	0.110
IL2RG	interleukin 2 receptor, gamma	0.110
CCL19	chemokine (C-C motif) ligand 19	0.110
BCL2L1	BCL2-like 1	0.109
IL8	interleukin 8	0.103
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.102
ICAM1	intercellular adhesion molecule 1	0.099
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.096
CD48	CD48 molecule	0.093
PTPRC	protein tyrosine phosphatase, receptor type, C	0.086
NOXA1	NADPH oxidase activator 1	0.086
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.083	Human
TRAF3	TNF receptor-associated factor 3	0.082
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.082
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.082
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.081
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.081
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.080
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.080
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.077
SH3BP2	SH3-domain binding protein 2	0.077
VCAM1	vascular cell adhesion molecule 1	0.076
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.074
TRADD	TNFRSF1A-associated via death domain	0.072
TNF	tumor necrosis factor	0.068
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.068
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.067	Rat
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.066
RIPK2	receptor-interacting serine-threonine kinase 2	0.065
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.064	Mouse
INSR	insulin receptor	0.063
HK3	hexokinase 3 (white cell)	0.062
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.062
CCL8	chemokine (C-C motif) ligand 8	0.062	Human
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.061
C9orf89	chromosome 9 open reading frame 89	0.061
IL4R	interleukin 4 receptor	0.059
CD83	CD83 molecule	0.059
IDE	insulin-degrading enzyme	0.055
XIAP	X-linked inhibitor of apoptosis	0.054	Human
DERL1	Der1-like domain family, member 1	0.054
PLEK	pleckstrin	0.053
EPOR	erythropoietin receptor	0.051
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.051
LAT	linker for activation of T cells	0.050
BCL2A1	BCL2-related protein A1	0.050	Mouse
HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.050
IL22RA1	interleukin 22 receptor, alpha 1	0.049
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.048
MAGEA11	melanoma antigen family A, 11	0.048
IL10	interleukin 10	0.047
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.046	Mouse
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.045
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.045
SQSTM1	sequestosome 1	0.043
IL22RA2	interleukin 22 receptor, alpha 2	0.042
CD80	CD80 molecule	0.041
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.040
C1QA	complement component 1, q subcomponent, A chain	0.040
IL6	interleukin 6 (interferon, beta 2)	0.039
CD86	CD86 molecule	0.039
PPP4C	protein phosphatase 4, catalytic subunit	0.038
PRF1	perforin 1 (pore forming protein)	0.037
CD40	CD40 molecule, TNF receptor superfamily member 5	0.037
CCL2	chemokine (C-C motif) ligand 2	0.036	Human
TRAF2	TNF receptor-associated factor 2	0.035
CSK	c-src tyrosine kinase	0.034
CD52	CD52 molecule	0.034
APAF1	apoptotic peptidase activating factor 1	0.034
USP15	ubiquitin specific peptidase 15	0.034
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.033
MARCO	macrophage receptor with collagenous structure	0.032
SIGLEC7	sialic acid binding Ig-like lectin 7	0.032
CCL22	chemokine (C-C motif) ligand 22	0.032	Human
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.032	Human
INCENP	inner centromere protein antigens 135/155kDa	0.031
FPR3	formyl peptide receptor 3	0.031
CCL20	chemokine (C-C motif) ligand 20	0.030	Human
MICA	MHC class I polypeptide-related sequence A	0.030
CCR4	chemokine (C-C motif) receptor 4	0.030
CCL3	chemokine (C-C motif) ligand 3	0.030	Human
CDCP1	CUB domain containing protein 1	0.029
IL2RA	interleukin 2 receptor, alpha	0.029
DPP4	dipeptidyl-peptidase 4	0.028
CD5	CD5 molecule	0.028
GNLY	granulysin	0.028
NKG7	natural killer cell group 7 sequence	0.028
CYBA	cytochrome b-245, alpha polypeptide	0.028
SH3RF1	SH3 domain containing ring finger 1	0.028
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.028
BAX	BCL2-associated X protein	0.027	Mouse
C1QB	complement component 1, q subcomponent, B chain	0.026
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.026
CD6	CD6 molecule	0.026
SPRR2A	small proline-rich protein 2A	0.025
UBD	ubiquitin D	0.025
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.025	Human
CXCR6	chemokine (C-X-C motif) receptor 6	0.025
CXCL10	chemokine (C-X-C motif) ligand 10	0.024
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.024
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.024
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.024
WRN	Werner syndrome, RecQ helicase-like	0.024
VCP	valosin containing protein	0.023
NOD2	nucleotide-binding oligomerization domain containing 2	0.023
IL18RAP	interleukin 18 receptor accessory protein	0.023
FSTL1	follistatin-like 1	0.023
VCAN	versican	0.023
ESR1	estrogen receptor 1	0.023
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.023
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.023
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.023
HDAC4	histone deacetylase 4	0.022
IL32	interleukin 32	0.022
SLAMF7	SLAM family member 7	0.022
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.022
DBNDD2	dysbindin (dystrobrevin binding protein 1) domain containing 2	0.022
IFNG	interferon, gamma	0.022
CST7	cystatin F (leukocystatin)	0.022
PTAFR	platelet-activating factor receptor	0.021
KPNA1	karyopherin alpha 1 (importin alpha 5)	0.021
RGS1	regulator of G-protein signaling 1	0.021
CCL7	chemokine (C-C motif) ligand 7	0.021	Human
RUNX1	runt-related transcription factor 1	0.021
CD33	CD33 molecule	0.021
ANXA5	annexin A5	0.021
WIPF1	WAS/WASL interacting protein family, member 1	0.021
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.021
PLAUR	plasminogen activator, urokinase receptor	0.020
IL1R2	interleukin 1 receptor, type II	0.020
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.019
PRKCB	protein kinase C, beta	0.019
SLAMF8	SLAM family member 8	0.019
TREM1	triggering receptor expressed on myeloid cells 1	0.019
CD40LG	CD40 ligand	0.019
IL1RN	interleukin 1 receptor antagonist	0.019
RIPK3	receptor-interacting serine-threonine kinase 3	0.019	Mouse
CCL14	chemokine (C-C motif) ligand 14	0.019	Human
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.019
CLEC10A	C-type lectin domain family 10, member A	0.019
CA12	carbonic anhydrase XII	0.019
S100A11	S100 calcium binding protein A11	0.019
CH25H	cholesterol 25-hydroxylase	0.018
CDK6	cyclin-dependent kinase 6	0.018
ROS1	c-ros oncogene 1 , receptor tyrosine kinase	0.018
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.018	Human
CXCL13	chemokine (C-X-C motif) ligand 13	0.018
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.018
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.018
AQP9	aquaporin 9	0.018
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.018
GZMK	granzyme K (granzyme 3; tryptase II)	0.018
DARC	Duffy blood group, chemokine receptor	0.018
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.018
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.018	Human
CCR2	chemokine (C-C motif) receptor 2	0.018	Mouse
RUNX3	runt-related transcription factor 3	0.017
CMKLR1	chemokine-like receptor 1	0.017
CXCL5	chemokine (C-X-C motif) ligand 5	0.017
CTSW	cathepsin W	0.017
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.017
PICK1	protein interacting with PRKCA 1	0.017
C3AR1	complement component 3a receptor 1	0.017
MANF	mesencephalic astrocyte-derived neurotrophic factor	0.017
C2	complement component 2	0.017
HIPK2	homeodomain interacting protein kinase 2	0.017
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.016
CD28	CD28 molecule	0.016
CCND1	cyclin D1	0.016
IGL@	immunoglobulin lambda locus	0.016
ADAMDEC1	ADAM-like, decysin 1	0.016
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.016
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.016
CSF1	colony stimulating factor 1 (macrophage)	0.016
LAMP3	lysosomal-associated membrane protein 3	0.016
VSIG4	V-set and immunoglobulin domain containing 4	0.016
AOAH	acyloxyacyl hydrolase (neutrophil)	0.016
NLRP3	NLR family, pyrin domain containing 3	0.016
CRLF3	cytokine receptor-like factor 3	0.016
CD22	CD22 molecule	0.016
TARP	TCR gamma alternate reading frame protein	0.016
ITGB7	integrin, beta 7	0.016
SH2D2A	SH2 domain containing 2A	0.016
GPR171	G protein-coupled receptor 171	0.015
GABARAPL1	GABA(A) receptor-associated protein like 1	0.015
VIM	vimentin	0.015
S100A8	S100 calcium binding protein A8	0.015
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.015
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.015
VAV1	vav 1 guanine nucleotide exchange factor	0.015
EZR	ezrin	0.015
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.015	Human
FHL1	four and a half LIM domains 1	0.015
ICOS	inducible T-cell co-stimulator	0.015
CSF1R	colony stimulating factor 1 receptor	0.015
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.015
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.015
HPCAL4	hippocalcin like 4	0.015
IL1A	interleukin 1, alpha	0.015
UBASH3B	ubiquitin associated and SH3 domain containing B	0.015
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.015
CXCR3	chemokine (C-X-C motif) receptor 3	0.015
SLAMF1	signaling lymphocytic activation molecule family member 1	0.014
RAP1A	RAP1A, member of RAS oncogene family	0.014
CCR3	chemokine (C-C motif) receptor 3	0.014
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.014
CD2BP2	CD2 (cytoplasmic tail) binding protein 2	0.014
IRS1	insulin receptor substrate 1	0.014
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.014
TRIM9	tripartite motif containing 9	0.014
TYROBP	TYRO protein tyrosine kinase binding protein	0.014
SPTBN1	spectrin, beta, non-erythrocytic 1	0.014
RND1	Rho family GTPase 1	0.014
NUMB	numb homolog (Drosophila)	0.014
CALCOCO2	calcium binding and coiled-coil domain 2	0.014
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	0.014
EBI3	Epstein-Barr virus induced 3	0.014
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.014
HCK	hemopoietic cell kinase	0.014
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.013
MSR1	macrophage scavenger receptor 1	0.013
EGLN1	egl nine homolog 1 (C. elegans)	0.013
CD163	CD163 molecule	0.013
FADD	Fas (TNFRSF6)-associated via death domain	0.013	Mouse
SETDB1	SET domain, bifurcated 1	0.013
IRF8	interferon regulatory factor 8	0.013
CD69	CD69 molecule	0.013
BAD	BCL2-associated agonist of cell death	0.013
TCL1A	T-cell leukemia/lymphoma 1A	0.013
CD72	CD72 molecule	0.013
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.013
S100A6	S100 calcium binding protein A6	0.013
SELE	selectin E	0.013
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.013
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.013
GPR109B	G protein-coupled receptor 109B	0.013
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.013	Human
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.013
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.012
SOCS3	suppressor of cytokine signaling 3	0.012
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.012
PECAM1	platelet/endothelial cell adhesion molecule	0.012
FAIM3	Fas apoptotic inhibitory molecule 3	0.012
TRAT1	T cell receptor associated transmembrane adaptor 1	0.012
CD14	CD14 molecule	0.012
EPAS1	endothelial PAS domain protein 1	0.012
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.012	Human
CCL17	chemokine (C-C motif) ligand 17	0.012	Human
KAT2B	K(lysine) acetyltransferase 2B	0.012
SRGN	serglycin	0.012
STAT5B	signal transducer and activator of transcription 5B	0.012
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.012
AIF1	allograft inflammatory factor 1	0.012
IL13	interleukin 13	0.012
CD27	CD27 molecule	0.012	Mouse
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.012
RNR2	l-rRNA	0.012
RCC1	regulator of chromosome condensation 1	0.012
VHL	von Hippel-Lindau tumor suppressor	0.012	Mouse
IRF4	interferon regulatory factor 4	0.012
STAT4	signal transducer and activator of transcription 4	0.012
JAK3	Janus kinase 3	0.012	Mouse
LY86	lymphocyte antigen 86	0.012
CCND3	cyclin D3	0.011
CD63	CD63 molecule	0.011
CHIT1	chitinase 1 (chitotriosidase)	0.011
CREBBP	CREB binding protein	0.011
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.011
IDO1	indoleamine 2,3-dioxygenase 1	0.011
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.011
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.011
SIRPB1	signal-regulatory protein beta 1	0.011
IL21R	interleukin 21 receptor	0.011
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.011
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.011
EMP3	epithelial membrane protein 3	0.011
TYMP	thymidine phosphorylase	0.011
CXCL3	chemokine (C-X-C motif) ligand 3	0.011
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.011
IL1F5	interleukin 1 family, member 5 (delta)	0.011
FCAR	Fc fragment of IgA, receptor for	0.011	Human
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.011
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.011
GIMAP5	GTPase, IMAP family member 5	0.011
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.010
EGLN3	egl nine homolog 3 (C. elegans)	0.010
TLR2	toll-like receptor 2	0.010
CD209	CD209 molecule	0.010
ZBP1	Z-DNA binding protein 1	0.010
DBNL	drebrin-like	0.010	Human
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.010
RNF144B	ring finger protein 144B	0.010
PDPK1	3-phosphoinositide dependent protein kinase-1	0.010
ZHX1	zinc fingers and homeoboxes 1	0.010
ITK	IL2-inducible T-cell kinase	0.010
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.010
TRIP10	thyroid hormone receptor interactor 10	0.010
CD274	CD274 molecule	0.010
SH3KBP1	SH3-domain kinase binding protein 1	0.010
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.010	Human