IMP

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Homo sapiens

27 genes annotated in human

cytokine production involved in immune response

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.979
TRAF1	TNF receptor-associated factor 1	0.960	Human
TRAF6	TNF receptor-associated factor 6	0.943
CCR5	chemokine (C-C motif) receptor 5	0.813
CD40	CD40 molecule, TNF receptor superfamily member 5	0.803
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.799
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.763
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.744
TRAF2	TNF receptor-associated factor 2	0.578
NRP1	neuropilin 1	0.545
IL10RA	interleukin 10 receptor, alpha	0.540
CCR1	chemokine (C-C motif) receptor 1	0.533
CCL4	chemokine (C-C motif) ligand 4	0.526	Human
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.481
SIGLEC7	sialic acid binding Ig-like lectin 7	0.479
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.446
BIRC3	baculoviral IAP repeat containing 3	0.438
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.372	Human
RIPK2	receptor-interacting serine-threonine kinase 2	0.370
ANGPT2	angiopoietin 2	0.367
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.362
CD14	CD14 molecule	0.359
TGIF1	TGFB-induced factor homeobox 1	0.353
TRAF5	TNF receptor-associated factor 5	0.352	Human
AXL	AXL receptor tyrosine kinase	0.350
CCL8	chemokine (C-C motif) ligand 8	0.331	Human
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.320	Human
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.304
TGFB1	transforming growth factor, beta 1	0.270
CXCL9	chemokine (C-X-C motif) ligand 9	0.262
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.260	Human
VEGFA	vascular endothelial growth factor A	0.220
IL4R	interleukin 4 receptor	0.218
TICAM2	toll-like receptor adaptor molecule 2	0.207
PILRA	paired immunoglobin-like type 2 receptor alpha	0.206
IL22RA1	interleukin 22 receptor, alpha 1	0.190
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.176
IRAK2	interleukin-1 receptor-associated kinase 2	0.170
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.164	Human
A2M	alpha-2-macroglobulin	0.157
IL2RG	interleukin 2 receptor, gamma	0.155
CD86	CD86 molecule	0.155
ENG	endoglin	0.152
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.151
APOC1	apolipoprotein C-I	0.148
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.143	Human
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.139	Human
HP	haptoglobin	0.136
CCR7	chemokine (C-C motif) receptor 7	0.134
TRAF3	TNF receptor-associated factor 3	0.133	Human
CALCOCO2	calcium binding and coiled-coil domain 2	0.130
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.128
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.126
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.119
HK3	hexokinase 3 (white cell)	0.109
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.109
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.106	Mouse
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.102
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.094
NCOR2	nuclear receptor corepressor 2	0.093
BIRC2	baculoviral IAP repeat containing 2	0.090
LAT	linker for activation of T cells	0.088
ANGPT1	angiopoietin 1	0.085	Mouse
CCL13	chemokine (C-C motif) ligand 13	0.085	Human
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.085
CCL7	chemokine (C-C motif) ligand 7	0.084	Human
PTPRB	protein tyrosine phosphatase, receptor type, B	0.084
TNF	tumor necrosis factor	0.081
IFNG	interferon, gamma	0.079
TRADD	TNFRSF1A-associated via death domain	0.079
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.076	Human
NLRP3	NLR family, pyrin domain containing 3	0.069	Human
TYMP	thymidine phosphorylase	0.069
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.067
SYK	spleen tyrosine kinase	0.067
IDE	insulin-degrading enzyme	0.064
ADAM17	ADAM metallopeptidase domain 17	0.064
CCL22	chemokine (C-C motif) ligand 22	0.062	Human
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.062
CCR4	chemokine (C-C motif) receptor 4	0.061
CXCL10	chemokine (C-X-C motif) ligand 10	0.057
ZMYND11	zinc finger, MYND-type containing 11	0.056
HLA-F	major histocompatibility complex, class I, F	0.056
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.055
LGALS9	lectin, galactoside-binding, soluble, 9	0.054	Human
IL22RA2	interleukin 22 receptor, alpha 2	0.054
FSTL1	follistatin-like 1	0.053
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.050
CXCR4	chemokine (C-X-C motif) receptor 4	0.050
CDH5	cadherin 5, type 2 (vascular endothelium)	0.050
SLA	Src-like-adaptor	0.048
CXCL13	chemokine (C-X-C motif) ligand 13	0.048
CCL11	chemokine (C-C motif) ligand 11	0.048	Human
DPP4	dipeptidyl-peptidase 4	0.048
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.045	Human
LCAT	lecithin-cholesterol acyltransferase	0.045
CD80	CD80 molecule	0.044
HLA-C	major histocompatibility complex, class I, C	0.043
IL1R1	interleukin 1 receptor, type I	0.043
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.042
PTAFR	platelet-activating factor receptor	0.042
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.041
IRF4	interferon regulatory factor 4	0.041
FZD1	frizzled homolog 1 (Drosophila)	0.039
CD48	CD48 molecule	0.038
HLA-A	major histocompatibility complex, class I, A	0.038
CCL5	chemokine (C-C motif) ligand 5	0.038	Human
TEK	TEK tyrosine kinase, endothelial	0.038	Mouse
IL1B	interleukin 1, beta	0.037
TREM1	triggering receptor expressed on myeloid cells 1	0.037
AOAH	acyloxyacyl hydrolase (neutrophil)	0.037
AQP9	aquaporin 9	0.037
CCR3	chemokine (C-C motif) receptor 3	0.036
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.036
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.036
HLA-G	major histocompatibility complex, class I, G	0.036
TGFB3	transforming growth factor, beta 3	0.035
HDAC9	histone deacetylase 9	0.034
CCL2	chemokine (C-C motif) ligand 2	0.034	Human
KITLG	KIT ligand	0.034
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.034
IL4	interleukin 4	0.034
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.034
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.033
SOCS3	suppressor of cytokine signaling 3	0.033
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.032
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.031
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.031
CXCL11	chemokine (C-X-C motif) ligand 11	0.031
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.030
IFITM1	interferon induced transmembrane protein 1 (9-27)	0.030
CCL1	chemokine (C-C motif) ligand 1	0.030	Human
CA12	carbonic anhydrase XII	0.030
PLEK	pleckstrin	0.030
FGFR1	fibroblast growth factor receptor 1	0.029
APOC3	apolipoprotein C-III	0.029
SOS1	son of sevenless homolog 1 (Drosophila)	0.029
PGF	placental growth factor	0.029
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.029
NOD2	nucleotide-binding oligomerization domain containing 2	0.028
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.027
CD40LG	CD40 ligand	0.027
CCR2	chemokine (C-C motif) receptor 2	0.027
PCDH9	protocadherin 9	0.027
PBK	PDZ binding kinase	0.027
SIGLEC5	sialic acid binding Ig-like lectin 5	0.026
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.026
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.026
STAB1	stabilin 1	0.026
MARCO	macrophage receptor with collagenous structure	0.026
APOC2	apolipoprotein C-II	0.026
ADAMDEC1	ADAM-like, decysin 1	0.024
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.024
FCAR	Fc fragment of IgA, receptor for	0.024	Human
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.023
SLC15A3	solute carrier family 15, member 3	0.023
CMIP	c-Maf-inducing protein	0.022
RUNX3	runt-related transcription factor 3	0.022
ALB	albumin	0.022
NKG7	natural killer cell group 7 sequence	0.022
OASL	2'-5'-oligoadenylate synthetase-like	0.022
IDO1	indoleamine 2,3-dioxygenase 1	0.022
SLAMF7	SLAM family member 7	0.022
FPR2	formyl peptide receptor 2	0.022
C3AR1	complement component 3a receptor 1	0.021
BECN1	beclin 1, autophagy related	0.021
C2	complement component 2	0.021
MAPK8	mitogen-activated protein kinase 8	0.021
CD300A	CD300a molecule	0.021
PYDC2	pyrin domain containing 2	0.021
BCL10	B-cell CLL/lymphoma 10	0.021
CD209	CD209 molecule	0.021
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.021
LBP	lipopolysaccharide binding protein	0.021
CCL19	chemokine (C-C motif) ligand 19	0.021	Human
SMAD3	SMAD family member 3	0.021
VCAM1	vascular cell adhesion molecule 1	0.020
CSF1	colony stimulating factor 1 (macrophage)	0.020
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.020
SIRPA	signal-regulatory protein alpha	0.020
XCL1	chemokine (C motif) ligand 1	0.020
CD33	CD33 molecule	0.020
RETN	resistin	0.020
AIF1	allograft inflammatory factor 1	0.020
IL2RB	interleukin 2 receptor, beta	0.020
IL13	interleukin 13	0.020	Human
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.020
NUMBL	numb homolog (Drosophila)-like	0.019
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.019
ASGR2	asialoglycoprotein receptor 2	0.019
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.019
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.019
TNFRSF8	tumor necrosis factor receptor superfamily, member 8	0.019
BATF	basic leucine zipper transcription factor, ATF-like	0.019
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.019
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.019	Human
SIRPB1	signal-regulatory protein beta 1	0.019
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.019
CD68	CD68 molecule	0.018
GHR	growth hormone receptor	0.018
IFNB1	interferon, beta 1, fibroblast	0.018
CD300C	CD300c molecule	0.018
CCL3	chemokine (C-C motif) ligand 3	0.018	Human
EBI3	Epstein-Barr virus induced 3	0.018
PYCARD	PYD and CARD domain containing	0.018
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.018
CMKLR1	chemokine-like receptor 1	0.018
CYBB	cytochrome b-245, beta polypeptide	0.018
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.017
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.017
SIGLEC9	sialic acid binding Ig-like lectin 9	0.017
CD28	CD28 molecule	0.017
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.017
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.017
UBD	ubiquitin D	0.017
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.017
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.017	Human
HLA-B	major histocompatibility complex, class I, B	0.016
NOD1	nucleotide-binding oligomerization domain containing 1	0.016
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.016
FGA	fibrinogen alpha chain	0.016
CCL23	chemokine (C-C motif) ligand 23	0.016	Human
PPAP2B	phosphatidic acid phosphatase type 2B	0.016
IL2RA	interleukin 2 receptor, alpha	0.015
FPR3	formyl peptide receptor 3	0.015
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.015
CD163	CD163 molecule	0.015
IGSF6	immunoglobulin superfamily, member 6	0.015
SLAMF8	SLAM family member 8	0.015
IL21R	interleukin 21 receptor	0.015
MSC	musculin	0.015
RNASE3	ribonuclease, RNase A family, 3	0.015
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.015
VEGFC	vascular endothelial growth factor C	0.015
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.014
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.014
IFNA10	interferon, alpha 10	0.014	Human
IFITM3	interferon induced transmembrane protein 3 (1-8U)	0.014
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.014
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.014
WDFY3	WD repeat and FYVE domain containing 3	0.014
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.014	Human
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.014
RARRES3	retinoic acid receptor responder (tazarotene induced) 3	0.014
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
IL1RN	interleukin 1 receptor antagonist	0.014
GPR132	G protein-coupled receptor 132	0.013
IL32	interleukin 32	0.013
IRF5	interferon regulatory factor 5	0.013
SQSTM1	sequestosome 1	0.013
PDIA3	protein disulfide isomerase family A, member 3	0.013
IL9	interleukin 9	0.013
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.013
IL18BP	interleukin 18 binding protein	0.013
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.013
TANK	TRAF family member-associated NFKB activator	0.013
CD1B	CD1b molecule	0.013
CD164	CD164 molecule, sialomucin	0.013
TGFBR3	transforming growth factor, beta receptor III	0.013
CIITA	class II, major histocompatibility complex, transactivator	0.013
IL3RA	interleukin 3 receptor, alpha (low affinity)	0.013
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.013
CPD	carboxypeptidase D	0.013
CYLC1	cylicin, basic protein of sperm head cytoskeleton 1	0.013
INSR	insulin receptor	0.013
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.013
APOA2	apolipoprotein A-II	0.013
PRKCQ	protein kinase C, theta	0.013
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.012
SOS2	son of sevenless homolog 2 (Drosophila)	0.012
CCRL2	chemokine (C-C motif) receptor-like 2	0.012
CARD11	caspase recruitment domain family, member 11	0.012
NOS2	nitric oxide synthase 2, inducible	0.012
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.012
S100A12	S100 calcium binding protein A12	0.012
CHIT1	chitinase 1 (chitotriosidase)	0.012
COL6A1	collagen, type VI, alpha 1	0.012
TGFBR1	transforming growth factor, beta receptor 1	0.012
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.012
BCAR1	breast cancer anti-estrogen resistance 1	0.012
BIN2	bridging integrator 2	0.012
PDGFC	platelet derived growth factor C	0.012
IL6	interleukin 6 (interferon, beta 2)	0.012
RUNX2	runt-related transcription factor 2	0.012
WIPI1	WD repeat domain, phosphoinositide interacting 1	0.012
LDLR	low density lipoprotein receptor	0.012
IL19	interleukin 19	0.012	Human
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.012
GAB1	GRB2-associated binding protein 1	0.011
CD83	CD83 molecule	0.011
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.011
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.011
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.011
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.011	Human
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.011
APOBR	apolipoprotein B receptor	0.011
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.011
NRP2	neuropilin 2	0.011
IL18RAP	interleukin 18 receptor accessory protein	0.011
MEFV	Mediterranean fever	0.011
AKAP2	A kinase (PRKA) anchor protein 2	0.011
PLTP	phospholipid transfer protein	0.011
CH25H	cholesterol 25-hydroxylase	0.011
IL1F5	interleukin 1 family, member 5 (delta)	0.011
JAK3	Janus kinase 3	0.011	Mouse
ZNF71	zinc finger protein 71	0.011
GPR35	G protein-coupled receptor 35	0.011
ICOSLG	inducible T-cell co-stimulator ligand	0.010
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.010
HCP5	HLA complex P5	0.010
IRF8	interferon regulatory factor 8	0.010
CD27	CD27 molecule	0.010
LY96	lymphocyte antigen 96	0.010
IL21	interleukin 21	0.010
CRLF2	cytokine receptor-like factor 2	0.010
SELE	selectin E	0.010
SASH3	SAM and SH3 domain containing 3	0.010	Mouse
HAMP	hepcidin antimicrobial peptide	0.010
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.010
ETV7	ets variant 7	0.010
NCKAP1L	NCK-associated protein 1-like	0.010