IMP

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of acute inflammatory response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of acute inflammatory response" (in gray)

Name	Description	Probability	Func Analog Organism
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.991
Tnf	tumor necrosis factor	0.977
Cd44	CD44 antigen	0.934
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.882
Ccl2	chemokine (C-C motif) ligand 2	0.859
Il4	interleukin 4	0.772
Ifng	interferon gamma	0.746
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.742
Ptgs2	prostaglandin-endoperoxide synthase 2	0.662
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.627	Mouse
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.626
Il1b	interleukin 1 beta	0.585
Ccr1	chemokine (C-C motif) receptor 1	0.508	Mouse
Apoe	apolipoprotein E	0.489
Ccr2	chemokine (C-C motif) receptor 2	0.487	Mouse
Cd40	CD40 antigen	0.426	Mouse
Cxcl13	chemokine (C-X-C motif) ligand 13	0.418
Il1r1	interleukin 1 receptor, type I	0.395
Cd19	CD19 antigen	0.382
Tlr4	toll-like receptor 4	0.382
Icos	inducible T-cell co-stimulator	0.366
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.363
Ptprc	protein tyrosine phosphatase, receptor type, C	0.361
Xcr1	chemokine (C motif) receptor 1	0.343	Mouse
Nos2	nitric oxide synthase 2, inducible	0.339
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.333
Lta	lymphotoxin A	0.298	Mouse
Selp	selectin, platelet	0.289
Mmp9	matrix metallopeptidase 9	0.286
Adam12	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	0.284	Mouse
Ccr6	chemokine (C-C motif) receptor 6	0.282	Mouse
Il10	interleukin 10	0.254
Gpr132	G protein-coupled receptor 132	0.246
Igh	immunoglobulin heavy chain complex	0.245
Lyz2	lysozyme 2	0.216
Myd88	myeloid differentiation primary response gene 88	0.216
Spp1	secreted phosphoprotein 1	0.175
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.174	Mouse
Ifngr1	interferon gamma receptor 1	0.149
Il6	interleukin 6	0.145	Human
Tlr2	toll-like receptor 2	0.142
Il2rg	interleukin 2 receptor, gamma chain	0.140
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.136
C3ar1	complement component 3a receptor 1	0.128
Il1a	interleukin 1 alpha	0.126	Mouse
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.126
Cxcr5	chemokine (C-X-C motif) receptor 5	0.125	Mouse
Ccl3	chemokine (C-C motif) ligand 3	0.125
Ccl4	chemokine (C-C motif) ligand 4	0.123
C5ar1	complement component 5a receptor 1	0.121
Pdcd1	programmed cell death 1	0.118
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.116
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.115
Ccr5	chemokine (C-C motif) receptor 5	0.115	Mouse
Slpi	secretory leukocyte peptidase inhibitor	0.109
Stat3	signal transducer and activator of transcription 3	0.101
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.100
Ltb	lymphotoxin B	0.090
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.089	Mouse
Il7	interleukin 7	0.089
Ccr3	chemokine (C-C motif) receptor 3	0.089	Mouse
Plau	plasminogen activator, urokinase	0.087
Ch25h	cholesterol 25-hydroxylase	0.083
Irg1	immunoresponsive gene 1	0.081
Cxcr2	chemokine (C-X-C motif) receptor 2	0.081	Mouse
Ubd	ubiquitin D	0.075
Art2a-ps	ADP-ribosyltransferase 2a, pseudogene	0.074
Tgm2	transglutaminase 2, C polypeptide	0.074
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.074
Cd28	CD28 antigen	0.073
C3	complement component 3	0.072
Il1rn	interleukin 1 receptor antagonist	0.072	Mouse
Casp1	caspase 1	0.069
Icam1	intercellular adhesion molecule 1	0.069
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.065
Fasl	Fas ligand (TNF superfamily, member 6)	0.063	Mouse
Il27ra	interleukin 27 receptor, alpha	0.062
Mefv	Mediterranean fever	0.061
Efna1	ephrin A1	0.061
Blk	B lymphoid kinase	0.061
Cst7	cystatin F (leukocystatin)	0.060
Fas	Fas (TNF receptor superfamily member 6)	0.057
Gzmk	granzyme K	0.056
Lck	lymphocyte protein tyrosine kinase	0.056
Ccl8	chemokine (C-C motif) ligand 8	0.056
Cxcl10	chemokine (C-X-C motif) ligand 10	0.055
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.055
Osmr	oncostatin M receptor	0.055
Mcpt8	mast cell protease 8	0.054
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.053
Cxcl2	chemokine (C-X-C motif) ligand 2	0.052
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.052
Cr2	complement receptor 2	0.051
Ccl12	chemokine (C-C motif) ligand 12	0.050
Folr2	folate receptor 2 (fetal)	0.050
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.050
Mpl	myeloproliferative leukemia virus oncogene	0.049
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.049	Mouse
Bcl3	B-cell leukemia/lymphoma 3	0.048
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.048
Wisp2	WNT1 inducible signaling pathway protein 2	0.048
Rel	reticuloendotheliosis oncogene	0.048
Gcet2	germinal center expressed transcript 2	0.047
S1pr2	sphingosine-1-phosphate receptor 2	0.047
Pla2g2d	phospholipase A2, group IID	0.047
Cd4	CD4 antigen	0.046
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.044
Ncr1	natural cytotoxicity triggering receptor 1	0.043
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.043
Fpr3	formyl peptide receptor 3	0.043
Ikzf1	IKAROS family zinc finger 1	0.043
Hck	hemopoietic cell kinase	0.043
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.041
Ccr7	chemokine (C-C motif) receptor 7	0.040
Sdc3	syndecan 3	0.040
Prss29	protease, serine, 29	0.040
Csf1	colony stimulating factor 1 (macrophage)	0.039
Ciita	class II transactivator	0.039
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.039
Ccl7	chemokine (C-C motif) ligand 7	0.039
Socs3	suppressor of cytokine signaling 3	0.039
Cd86	CD86 antigen	0.039
Il1rl1	interleukin 1 receptor-like 1	0.038
Ccl17	chemokine (C-C motif) ligand 17	0.037
Cd80	CD80 antigen	0.036
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.035
Cd14	CD14 antigen	0.035
Ccl22	chemokine (C-C motif) ligand 22	0.035
Wnt10b	wingless related MMTV integration site 10b	0.035
Sh2d2a	SH2 domain protein 2A	0.035
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.034
Pax5	paired box gene 5	0.034
Cd180	CD180 antigen	0.034
Inpp5d	inositol polyphosphate-5-phosphatase D	0.033
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.032
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.031
Il15ra	interleukin 15 receptor, alpha chain	0.031
Cxcl1	chemokine (C-X-C motif) ligand 1	0.031
Rgs9	regulator of G-protein signaling 9	0.031
Plat	plasminogen activator, tissue	0.031
Adam2	a disintegrin and metallopeptidase domain 2	0.031	Mouse
Prnp	prion protein	0.031
Htr2b	5-hydroxytryptamine (serotonin) receptor 2B	0.030
Cd96	CD96 antigen	0.030
Ccr9	chemokine (C-C motif) receptor 9	0.030	Mouse
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.030
Acvrl1	activin A receptor, type II-like 1	0.029
Csn1s2a	casein alpha s2-like A	0.029
Adam15	a disintegrin and metallopeptidase domain 15 (metargidin)	0.029	Mouse
Fut4	fucosyltransferase 4	0.028
Itgax	integrin alpha X	0.028
Jak3	Janus kinase 3	0.028
Gzmb	granzyme B	0.028
Pdcd1lg2	programmed cell death 1 ligand 2	0.028
Vpreb3	pre-B lymphocyte gene 3	0.028
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.027
Itgal	integrin alpha L	0.027
Fndc7	fibronectin type III domain containing 7	0.027
Adora2a	adenosine A2a receptor	0.027
Slamf8	SLAM family member 8	0.026
Cybb	cytochrome b-245, beta polypeptide	0.026
Egr2	early growth response 2	0.026
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.026
Birc3	baculoviral IAP repeat-containing 3	0.026
Il6st	interleukin 6 signal transducer	0.026
Fcrla	Fc receptor-like A	0.026	Mouse
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.026
Gp9	glycoprotein 9 (platelet)	0.025
Itk	IL2-inducible T-cell kinase	0.025
Clec4n	C-type lectin domain family 4, member n	0.025
Pou2af1	POU domain, class 2, associating factor 1	0.025
Lcn4	lipocalin 4	0.024
Flt3	FMS-like tyrosine kinase 3	0.024
Nod2	nucleotide-binding oligomerization domain containing 2	0.024
Il2rb	interleukin 2 receptor, beta chain	0.024
Glipr2	GLI pathogenesis-related 2	0.024
Plaur	plasminogen activator, urokinase receptor	0.024
Il18r1	interleukin 18 receptor 1	0.024
Il15	interleukin 15	0.024
Prdm1	PR domain containing 1, with ZNF domain	0.024
Socs1	suppressor of cytokine signaling 1	0.023
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.023
Hrh1	histamine receptor H1	0.023
Aff2	AF4/FMR2 family, member 2	0.023
Mmp12	matrix metallopeptidase 12	0.023
Fut7	fucosyltransferase 7	0.023
Ifna2	interferon alpha 2	0.023
Sftpc	surfactant associated protein C	0.023
Ntf3	neurotrophin 3	0.022
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.022
Il22	interleukin 22	0.022
Ear5	eosinophil-associated, ribonuclease A family, member 5	0.022
LOC100502924	hypothetical protein LOC100502924	0.022
Cxcl9	chemokine (C-X-C motif) ligand 9	0.022
Sry	sex determining region of Chr Y	0.022
Nlrp3	NLR family, pyrin domain containing 3	0.022
Sele	selectin, endothelial cell	0.022
Lif	leukemia inhibitory factor	0.021
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.021
Zap70	zeta-chain (TCR) associated protein kinase	0.021
Itga2	integrin alpha 2	0.021
Hr	hairless	0.021
Il18rap	interleukin 18 receptor accessory protein	0.021
Nhedc2	Na+/H+ exchanger domain containing 2	0.021
Cxcr7	chemokine (C-X-C motif) receptor 7	0.020
Il2ra	interleukin 2 receptor, alpha chain	0.020
Il4ra	interleukin 4 receptor, alpha	0.020
Clec4d	C-type lectin domain family 4, member d	0.020
Npy1r	neuropeptide Y receptor Y1	0.020
AF251705	cDNA sequence AF251705	0.020
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.019
Retn	resistin	0.019
Gcm2	glial cells missing homolog 2 (Drosophila)	0.019
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.019
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.019	Mouse
Fbn1	fibrillin 1	0.019
Fcgr3	Fc receptor, IgG, low affinity III	0.019
Gbp1	guanylate binding protein 1	0.019
Gpr182	G protein-coupled receptor 182	0.019
Itgb3	integrin beta 3	0.018
Bex6	brain expressed gene 6	0.018
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.018
Ighg	Immunoglobulin heavy chain (gamma polypeptide)	0.018
Star	steroidogenic acute regulatory protein	0.018
Cd160	CD160 antigen	0.018
Pla2g4a	phospholipase A2, group IVA (cytosolic, calcium-dependent)	0.018	Rat
Avpr1a	arginine vasopressin receptor 1A	0.018
Ccl20	chemokine (C-C motif) ligand 20	0.018
Fgf7	fibroblast growth factor 7	0.017
LOC100504404	h-2 class II histocompatibility antigen, E-K alpha chain-like	0.017
Bmx	BMX non-receptor tyrosine kinase	0.017
Tnfaip2	tumor necrosis factor, alpha-induced protein 2	0.017
Mmp3	matrix metallopeptidase 3	0.017
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.017
Litaf	LPS-induced TN factor	0.017
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.017
Sh2d1b1	SH2 domain protein 1B1	0.016
Gja10	gap junction protein, alpha 10	0.016
Il12rb2	interleukin 12 receptor, beta 2	0.016
Cxcl5	chemokine (C-X-C motif) ligand 5	0.016
Ltbp2	latent transforming growth factor beta binding protein 2	0.016
Tnfrsf17	tumor necrosis factor receptor superfamily, member 17	0.016
Il9r	interleukin 9 receptor	0.016
Inhba	inhibin beta-A	0.016
Cd68	CD68 antigen	0.015
H2-M9	histocompatibility 2, M region locus 9	0.015
Clec7a	C-type lectin domain family 7, member a	0.015
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.015
Vcam1	vascular cell adhesion molecule 1	0.015
Inhbe	inhibin beta E	0.015
Gja1	gap junction protein, alpha 1	0.015
Havcr2	hepatitis A virus cellular receptor 2	0.015
Klrb1c	killer cell lectin-like receptor subfamily B member 1C	0.015
C2	complement component 2 (within H-2S)	0.015
Cacna1e	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.015
Traf1	TNF receptor-associated factor 1	0.015
Il7r	interleukin 7 receptor	0.015
Olfr140	olfactory receptor 140	0.015
Cd5l	CD5 antigen-like	0.015
Ptgir	prostaglandin I receptor (IP)	0.015	Mouse
Serpina3g	serine (or cysteine) peptidase inhibitor, clade A, member 3G	0.015
C1ra	complement component 1, r subcomponent A	0.015
Nos1	nitric oxide synthase 1, neuronal	0.015
Mdfic	MyoD family inhibitor domain containing	0.014
Fcgr1	Fc receptor, IgG, high affinity I	0.014
Gp5	glycoprotein 5 (platelet)	0.014
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.014
Fpr1	formyl peptide receptor 1	0.014
Prg2	proteoglycan 2, bone marrow	0.014
Clnk	cytokine-dependent hematopoietic cell linker	0.014
Tg	thyroglobulin	0.014
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.014
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.014
Has2	hyaluronan synthase 2	0.013
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.013
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.013
Il13ra1	interleukin 13 receptor, alpha 1	0.013
Mcpt2	mast cell protease 2	0.013
Slfn1	schlafen 1	0.013
Hic1	hypermethylated in cancer 1	0.013
Kcnmb1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	0.013
Tm4sf1	transmembrane 4 superfamily member 1	0.013
Htra3	HtrA serine peptidase 3	0.013
Cd22	CD22 antigen	0.013
Lcp2	lymphocyte cytosolic protein 2	0.013
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.013
H2-Ob	histocompatibility 2, O region beta locus	0.013
Sell	selectin, lymphocyte	0.013
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.013
Efnb2	ephrin B2	0.013
Btg4	B-cell translocation gene 4	0.013
Zpbp	zona pellucida binding protein	0.013
Itgb2	integrin beta 2	0.013
Itgae	integrin alpha E, epithelial-associated	0.013
Saa4	serum amyloid A 4	0.013
Cx3cr1	chemokine (C-X3-C) receptor 1	0.012	Mouse
Lbp	lipopolysaccharide binding protein	0.012
Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase	0.012
Grin2c	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	0.012
Vim	vimentin	0.012
Alox15	arachidonate 15-lipoxygenase	0.012
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.012
Calcrl	calcitonin receptor-like	0.012
Prf1	perforin 1 (pore forming protein)	0.012
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.012
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.012	Mouse
Pabpc2	poly(A) binding protein, cytoplasmic 2	0.012
Adipoq	adiponectin, C1Q and collagen domain containing	0.012
Ptprv	protein tyrosine phosphatase, receptor type, V	0.012
Ctsw	cathepsin W	0.012
Ahr	aryl-hydrocarbon receptor	0.012
BC100451	cDNA sequence BC100451	0.012
Treml1	triggering receptor expressed on myeloid cells-like 1	0.012
Batf	basic leucine zipper transcription factor, ATF-like	0.012
Sfpi1	SFFV proviral integration 1	0.012
Procr	protein C receptor, endothelial	0.012
Il10ra	interleukin 10 receptor, alpha	0.012
Dnase1l3	deoxyribonuclease 1-like 3	0.012
Niacr1	niacin receptor 1	0.012	Mouse
Irf5	interferon regulatory factor 5	0.012
Meox1	mesenchyme homeobox 1	0.012
Cfh	complement component factor h	0.012
Tll1	tolloid-like	0.012
Msmb	beta-microseminoprotein	0.011
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.011
Cd6	CD6 antigen	0.011
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.011
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.011
Igk	immunoglobulin kappa chain complex	0.011
Soat1	sterol O-acyltransferase 1	0.011
Fpr-rs3	formyl peptide receptor, related sequence 3	0.011
Fgl2	fibrinogen-like protein 2	0.011
Cd8a	CD8 antigen, alpha chain	0.011
S1pr4	sphingosine-1-phosphate receptor 4	0.011
Aoah	acyloxyacyl hydrolase	0.011
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.011
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.011
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.011	Mouse
Krt85	keratin 85	0.011
Cmklr1	chemokine-like receptor 1	0.011
Plscr1	phospholipid scramblase 1	0.011
Cd209g	CD209g antigen	0.011
Il17a	interleukin 17A	0.011
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.011
Gimap7	GTPase, IMAP family member 7	0.011
Asprv1	aspartic peptidase, retroviral-like 1	0.011
Irf4	interferon regulatory factor 4	0.011
Itgav	integrin alpha V	0.011
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.011
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.011
Edaradd	EDAR (ectodysplasin-A receptor)-associated death domain	0.011
Hc	hemolytic complement	0.011	Mouse
Fcer1a	Fc receptor, IgE, high affinity I, alpha polypeptide	0.011
Lcn2	lipocalin 2	0.011
Lce1b	late cornified envelope 1B	0.011
Tlr6	toll-like receptor 6	0.011
Cel	carboxyl ester lipase	0.011
Lrg1	leucine-rich alpha-2-glycoprotein 1	0.011
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.011
Il1f9	interleukin 1 family, member 9	0.011
Zan	zonadhesin	0.010
Hivep3	human immunodeficiency virus type I enhancer binding protein 3	0.010
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.010
Il1r2	interleukin 1 receptor, type II	0.010
Xcl1	chemokine (C motif) ligand 1	0.010
Marco	macrophage receptor with collagenous structure	0.010
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.010
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.010
Ggt5	gamma-glutamyltransferase 5	0.010
Oxt	oxytocin	0.010
Cyld	cylindromatosis (turban tumor syndrome)	0.010
Cma1	chymase 1, mast cell	0.010
Bdkrb1	bradykinin receptor, beta 1	0.010
Slc25a45	solute carrier family 25, member 45	0.010
Ptgs1	prostaglandin-endoperoxide synthase 1	0.010	Mouse
Col10a1	collagen, type X, alpha 1	0.010
Obox2	oocyte specific homeobox 2	0.010