IMP

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Mus musculus

16 genes annotated in mouse

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

GO:2001240

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" (in gray)

Name	Description	Probability	Func Analog Organism
Ikzf1	IKAROS family zinc finger 1	0.626
Trp53	transformation related protein 53	0.537
Tnf	tumor necrosis factor	0.512
Col3a1	collagen, type III, alpha 1	0.483	Mouse
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.474
Fbn1	fibrillin 1	0.395
Col5a2	collagen, type V, alpha 2	0.365	Mouse
Col1a1	collagen, type I, alpha 1	0.340	Mouse
Ifng	interferon gamma	0.306
Col1a2	collagen, type I, alpha 2	0.291	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.283
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.264
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.232
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.224
Pten	phosphatase and tensin homolog	0.201
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.176
Pax2	paired box gene 2	0.161
Vhl	von Hippel-Lindau tumor suppressor	0.156
Lyz2	lysozyme 2	0.154
Fas	Fas (TNF receptor superfamily member 6)	0.134
Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	0.124
Sox10	SRY-box containing gene 10	0.124
Prrx2	paired related homeobox 2	0.120
Ret	ret proto-oncogene	0.119
Ccr1	chemokine (C-C motif) receptor 1	0.116	Mouse
Pbx1	pre B-cell leukemia transcription factor 1	0.109
Lta	lymphotoxin A	0.107
Thbs1	thrombospondin 1	0.104
Cd44	CD44 antigen	0.104
Il18rap	interleukin 18 receptor accessory protein	0.098
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.097
Snai1	snail homolog 1 (Drosophila)	0.096	Mouse
Hr	hairless	0.092
Bcl2	B-cell leukemia/lymphoma 2	0.089	Human
Col11a1	collagen, type XI, alpha 1	0.086	Mouse
Fstl1	follistatin-like 1	0.083
Cd19	CD19 antigen	0.082
Meox2	mesenchyme homeobox 2	0.078
Pthlh	parathyroid hormone-like peptide	0.077
Cxcl13	chemokine (C-X-C motif) ligand 13	0.077
Col6a1	collagen, type VI, alpha 1	0.075
Gli3	GLI-Kruppel family member GLI3	0.074
Lox	lysyl oxidase	0.073
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.073
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.072
Foxp3	forkhead box P3	0.070
Col6a3	collagen, type VI, alpha 3	0.068
Postn	periostin, osteoblast specific factor	0.064
Slamf1	signaling lymphocytic activation molecule family member 1	0.063
Smad3	MAD homolog 3 (Drosophila)	0.060
Gli2	GLI-Kruppel family member GLI2	0.060
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.059
Col6a2	collagen, type VI, alpha 2	0.059
Ptprc	protein tyrosine phosphatase, receptor type, C	0.054
Bdnf	brain derived neurotrophic factor	0.054
Sharpin	SHANK-associated RH domain interacting protein	0.054
Kit	kit oncogene	0.053
Acan	aggrecan	0.053
Socs1	suppressor of cytokine signaling 1	0.052
Inpp5d	inositol polyphosphate-5-phosphatase D	0.052
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.050
Il4	interleukin 4	0.049
Efnb2	ephrin B2	0.049
Ltb	lymphotoxin B	0.049
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.048
Cd28	CD28 antigen	0.048
Casp8	caspase 8	0.048
Tnc	tenascin C	0.046
Tlr2	toll-like receptor 2	0.046
Cxcl12	chemokine (C-X-C motif) ligand 12	0.044
Twist2	twist homolog 2 (Drosophila)	0.044
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.044
Lepr	leptin receptor	0.044
Igh	immunoglobulin heavy chain complex	0.042
Col5a1	collagen, type V, alpha 1	0.041	Mouse
Hoxa1	homeobox A1	0.041
Icos	inducible T-cell co-stimulator	0.041
Rxra	retinoid X receptor alpha	0.041
Nog	noggin	0.040
Sparc	secreted acidic cysteine rich glycoprotein	0.039
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.039
Ceacam16	carcinoembryonic antigen-related cell adhesion molecule 16	0.039
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.039
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.038
Gata3	GATA binding protein 3	0.038
Shh	sonic hedgehog	0.038
Grb10	growth factor receptor bound protein 10	0.037
Runx1	runt related transcription factor 1	0.037
Cd7	CD7 antigen	0.037
Fam96a	family with sequence similarity 96, member A	0.036
Tox	thymocyte selection-associated high mobility group box	0.036
Bgn	biglycan	0.036
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.036
Lef1	lymphoid enhancer binding factor 1	0.035
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.034
Ptx3	pentraxin related gene	0.033
Cd40	CD40 antigen	0.033
Twist1	twist homolog 1 (Drosophila)	0.032
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.032
Lmna	lamin A	0.031
Nrk	Nik related kinase	0.031
Traf6	TNF receptor-associated factor 6	0.031
Mmp16	matrix metallopeptidase 16	0.031
Selp	selectin, platelet	0.031
Kitl	kit ligand	0.031
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.031
Cdh11	cadherin 11	0.031
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.031
Gbx2	gastrulation brain homeobox 2	0.030
Notch2	Notch gene homolog 2 (Drosophila)	0.030
Wisp1	WNT1 inducible signaling pathway protein 1	0.030
Ntf3	neurotrophin 3	0.030
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.030
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.030
Il2rg	interleukin 2 receptor, gamma chain	0.029
Mmp2	matrix metallopeptidase 2	0.029
Creb3l1	cAMP responsive element binding protein 3-like 1	0.028
Sell	selectin, lymphocyte	0.028
Prrx1	paired related homeobox 1	0.028
Fkbp10	FK506 binding protein 10	0.028
Hoxd11	homeobox D11	0.027
Hoxa11	homeobox A11	0.027
Wt1	Wilms tumor 1 homolog	0.027
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.026
Ctnna1	catenin (cadherin associated protein), alpha 1	0.026
Zeb1	zinc finger E-box binding homeobox 1	0.026
Foxc1	forkhead box C1	0.026
Capn6	calpain 6	0.026
Mmp9	matrix metallopeptidase 9	0.026
Cd160	CD160 antigen	0.025
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.025
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.025
Runx2	runt related transcription factor 2	0.025
Phox2a	paired-like homeobox 2a	0.025
Il6st	interleukin 6 signal transducer	0.025
Elf4	E74-like factor 4 (ets domain transcription factor)	0.025
Isl1	ISL1 transcription factor, LIM/homeodomain	0.025
Fcrla	Fc receptor-like A	0.025
Gpr132	G protein-coupled receptor 132	0.024
Fasl	Fas ligand (TNF superfamily, member 6)	0.024
Lum	lumican	0.024
Ccl3	chemokine (C-C motif) ligand 3	0.024
Fgfr2	fibroblast growth factor receptor 2	0.024
Il1a	interleukin 1 alpha	0.024
Fgf5	fibroblast growth factor 5	0.024	Mouse
Col4a1	collagen, type IV, alpha 1	0.024
Pdcd1	programmed cell death 1	0.023
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.023
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.023
Rapsn	receptor-associated protein of the synapse	0.023
Itgal	integrin alpha L	0.023
Tbx15	T-box 15	0.022
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.022
Sox2	SRY-box containing gene 2	0.022
Ccr2	chemokine (C-C motif) receptor 2	0.022	Mouse
Blk	B lymphoid kinase	0.022
Nptx2	neuronal pentraxin 2	0.022
Ciita	class II transactivator	0.022
Cxcr2	chemokine (C-X-C motif) receptor 2	0.022	Mouse
Gcet2	germinal center expressed transcript 2	0.022
Efs	embryonal Fyn-associated substrate	0.022
Il2ra	interleukin 2 receptor, alpha chain	0.021
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.021
Map3k3	mitogen-activated protein kinase kinase kinase 3	0.021
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.021
Phox2b	paired-like homeobox 2b	0.021
Tbx1	T-box 1	0.021
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.021
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.021
Egfr	epidermal growth factor receptor	0.021
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.021
Ebf3	early B-cell factor 3	0.021
Numb	numb gene homolog (Drosophila)	0.021
Uts2r	urotensin 2 receptor	0.021
Has2	hyaluronan synthase 2	0.020
Fbln2	fibulin 2	0.020
Bdkrb1	bradykinin receptor, beta 1	0.020
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.020
F2r	coagulation factor II (thrombin) receptor	0.020
Lyst	lysosomal trafficking regulator	0.020
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.020
Fgfr3	fibroblast growth factor receptor 3	0.020
Ifngr1	interferon gamma receptor 1	0.020
Cntn4	contactin 4	0.020
Thbs2	thrombospondin 2	0.020
Cd6	CD6 antigen	0.020
Vim	vimentin	0.019
Gab1	growth factor receptor bound protein 2-associated protein 1	0.019
Pcolce	procollagen C-endopeptidase enhancer protein	0.019
Ppic	peptidylprolyl isomerase C	0.019
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.019
Tbx10	T-box 10	0.019
Angpt4	angiopoietin 4	0.019
Itga4	integrin alpha 4	0.019
Rasgrp1	RAS guanyl releasing protein 1	0.018
Hoxd13	homeobox D13	0.018
Prdm1	PR domain containing 1, with ZNF domain	0.018
Barx1	BarH-like homeobox 1	0.018
Pax8	paired box gene 8	0.018
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.018
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.018
Nlrp3	NLR family, pyrin domain containing 3	0.018
Ptk2	PTK2 protein tyrosine kinase 2	0.018
Il18r1	interleukin 18 receptor 1	0.018
Col8a1	collagen, type VIII, alpha 1	0.018
Col4a5	collagen, type IV, alpha 5	0.018
Col14a1	collagen, type XIV, alpha 1	0.018
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.018
Gad2	glutamic acid decarboxylase 2	0.017
Fgf7	fibroblast growth factor 7	0.017	Mouse
Pkdcc	protein kinase domain containing, cytoplasmic	0.017
Cd248	CD248 antigen, endosialin	0.017
Eln	elastin	0.017
Bax	BCL2-associated X protein	0.017
Gsc	goosecoid homeobox	0.017
Kdelr3	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3	0.017
Esr1	estrogen receptor 1 (alpha)	0.017
Cxcr3	chemokine (C-X-C motif) receptor 3	0.017	Mouse
Hrh1	histamine receptor H1	0.017
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.017
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.017
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.017
Col16a1	collagen, type XVI, alpha 1	0.017
Kcnd1	potassium voltage-gated channel, Shal-related family, member 1	0.016
Sh2d2a	SH2 domain protein 2A	0.016
Ncr1	natural cytotoxicity triggering receptor 1	0.016
Il10	interleukin 10	0.016
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.016
Cbl	Casitas B-lineage lymphoma	0.016
Il27ra	interleukin 27 receptor, alpha	0.016
Cd4	CD4 antigen	0.016
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.016
Lmx1a	LIM homeobox transcription factor 1 alpha	0.016
Lhx3	LIM homeobox protein 3	0.016
Thrb	thyroid hormone receptor beta	0.016
Il7	interleukin 7	0.016
Capn3	calpain 3	0.016
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.016
Rad21l	RAD21-like (S. pombe)	0.016
Tgfb2	transforming growth factor, beta 2	0.015
Ikbkg	inhibitor of kappaB kinase gamma	0.015
Prlr	prolactin receptor	0.015
Ltbp2	latent transforming growth factor beta binding protein 2	0.015
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.015
Wisp2	WNT1 inducible signaling pathway protein 2	0.015
Cd96	CD96 antigen	0.015
Art5	ADP-ribosyltransferase 5	0.015
Tbx21	T-box 21	0.015
Wnt10a	wingless related MMTV integration site 10a	0.015
Csf1	colony stimulating factor 1 (macrophage)	0.015
Phldb2	pleckstrin homology-like domain, family B, member 2	0.015
Oxt	oxytocin	0.015
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.014
Shc3	src homology 2 domain-containing transforming protein C3	0.014
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.014
Foxf1a	forkhead box F1a	0.014
Loxl2	lysyl oxidase-like 2	0.014
Gfap	glial fibrillary acidic protein	0.014
Tlx2	T-cell leukemia, homeobox 2	0.014
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.014
Il12a	interleukin 12a	0.014
Fst	follistatin	0.014
Prf1	perforin 1 (pore forming protein)	0.014
Tmem45a	transmembrane protein 45a	0.014
Cd86	CD86 antigen	0.014
Cyld	cylindromatosis (turban tumor syndrome)	0.014
Bmp5	bone morphogenetic protein 5	0.014
Slc26a4	solute carrier family 26, member 4	0.014
Ccr5	chemokine (C-C motif) receptor 5	0.014	Mouse
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.014
Snai2	snail homolog 2 (Drosophila)	0.014
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.014
Pyhin1	pyrin and HIN domain family, member 1	0.014
Gsg1	germ cell-specific gene 1	0.013
Spn	sialophorin	0.013
Fbn2	fibrillin 2	0.013
Nfe2	nuclear factor, erythroid derived 2	0.013
Col15a1	collagen, type XV, alpha 1	0.013
H2-Eb2	histocompatibility 2, class II antigen E beta2	0.013
Il7r	interleukin 7 receptor	0.013
Gpr83	G protein-coupled receptor 83	0.013
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.013
Tll1	tolloid-like	0.013
Olfr140	olfactory receptor 140	0.013
Prkci	protein kinase C, iota	0.013
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.013	Human
Ntf5	neurotrophin 5	0.013
Pou3f3	POU domain, class 3, transcription factor 3	0.013
Ilk	integrin linked kinase	0.013
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.013
Zic4	zinc finger protein of the cerebellum 4	0.013
Ccdc80	coiled-coil domain containing 80	0.013
Zfpm2	zinc finger protein, multitype 2	0.013
Npy1r	neuropeptide Y receptor Y1	0.013
Fiz1	Flt3 interacting zinc finger protein 1	0.013
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.013
Apc	adenomatosis polyposis coli	0.013
H2-Ob	histocompatibility 2, O region beta locus	0.013
Itch	itchy, E3 ubiquitin protein ligase	0.013
Xcr1	chemokine (C motif) receptor 1	0.013	Mouse
Fbln1	fibulin 1	0.013
Mag	myelin-associated glycoprotein	0.012
Tmed10	transmembrane emp24-like trafficking protein 10 (yeast)	0.012
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.012
Tcf21	transcription factor 21	0.012
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.012
Mmp8	matrix metallopeptidase 8	0.012
Rbl1	retinoblastoma-like 1 (p107)	0.012
Cd8b1	CD8 antigen, beta chain 1	0.012
Ar	androgen receptor	0.012
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.012
Pcsk1	proprotein convertase subtilisin/kexin type 1	0.012
Nsd1	nuclear receptor-binding SET-domain protein 1	0.012
Ccr1l1	chemokine (C-C motif) receptor 1-like 1	0.012	Mouse
Adam12	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	0.012
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.012
Slamf6	SLAM family member 6	0.012
Abcb9	ATP-binding cassette, sub-family B (MDR/TAP), member 9	0.012
Gsx1	GS homeobox 1	0.012
Sult4a1	sulfotransferase family 4A, member 1	0.012
Pnoc	prepronociceptin	0.012
Hbb-b1	hemoglobin, beta adult major chain	0.011
Mrc2	mannose receptor, C type 2	0.011
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.011
Crlf1	cytokine receptor-like factor 1	0.011
Grid1	glutamate receptor, ionotropic, delta 1	0.011
Crhr1	corticotropin releasing hormone receptor 1	0.011
Tal1	T-cell acute lymphocytic leukemia 1	0.011
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.011
S1pr4	sphingosine-1-phosphate receptor 4	0.011
Gnb3	guanine nucleotide binding protein (G protein), beta 3	0.011
Grem1	gremlin 1	0.011
Pdlim5	PDZ and LIM domain 5	0.011
Gsdma3	gasdermin A3	0.011
Cybb	cytochrome b-245, beta polypeptide	0.011
Batf	basic leucine zipper transcription factor, ATF-like	0.011
Sh2d1a	SH2 domain protein 1A	0.011
Il17a	interleukin 17A	0.011
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.011
Foxb1	forkhead box B1	0.011
Slc8a2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.011
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.011
Itgam	integrin alpha M	0.011
Ptgir	prostaglandin I receptor (IP)	0.011
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.011
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.011
Cd22	CD22 antigen	0.011
Th	tyrosine hydroxylase	0.011
Khdrbs2	KH domain containing, RNA binding, signal transduction associated 2	0.011
Rel	reticuloendotheliosis oncogene	0.011
Vipr1	vasoactive intestinal peptide receptor 1	0.011
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.011
Trp63	transformation related protein 63	0.011
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.011
Pdcd1lg2	programmed cell death 1 ligand 2	0.011
Kif5c	kinesin family member 5C	0.011
Adamts2	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2	0.011
Ifnar1	interferon (alpha and beta) receptor 1	0.011
Nefm	neurofilament, medium polypeptide	0.011
Adra2a	adrenergic receptor, alpha 2a	0.011
Cacng3	calcium channel, voltage-dependent, gamma subunit 3	0.011
Il15	interleukin 15	0.011
Smn1	survival motor neuron 1	0.011
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.011
Pax5	paired box gene 5	0.011
Rara	retinoic acid receptor, alpha	0.011
Nrtn	neurturin	0.011
Saa4	serum amyloid A 4	0.010
Il12rb2	interleukin 12 receptor, beta 2	0.010
Oprk1	opioid receptor, kappa 1	0.010
Cd5	CD5 antigen	0.010
Gzmb	granzyme B	0.010
Ikzf2	IKAROS family zinc finger 2	0.010
Ptk7	PTK7 protein tyrosine kinase 7	0.010
Vcl	vinculin	0.010	Mouse
Sox9	SRY-box containing gene 9	0.010
Ctsl	cathepsin L	0.010
Fn1	fibronectin 1	0.010
Fgfrl1	fibroblast growth factor receptor-like 1	0.010
Slfn4	schlafen 4	0.010
Il1rl1	interleukin 1 receptor-like 1	0.010
Cd180	CD180 antigen	0.010
Itgax	integrin alpha X	0.010
Hic1	hypermethylated in cancer 1	0.010
Itga2	integrin alpha 2	0.010
Npy5r	neuropeptide Y receptor Y5	0.010
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.010
Il2	interleukin 2	0.010
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.010
Gja1	gap junction protein, alpha 1	0.010
Fkbp9	FK506 binding protein 9	0.010