IMP

Process View

Homo sapiens

35 genes annotated in human

release of cytochrome c from mitochondria

The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "release of cytochrome c from mitochondria"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "release of cytochrome c from mitochondria" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	1.000	Human Mouse
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	1.000	Human
BAD	BCL2-associated agonist of cell death	1.000
CASP8	caspase 8, apoptosis-related cysteine peptidase	1.000
BCL2L11	BCL2-like 11 (apoptosis facilitator)	1.000
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	1.000	Human
BCL2L1	BCL2-like 1	1.000
BAX	BCL2-associated X protein	0.999
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.998	Human
BID	BH3 interacting domain death agonist	0.995
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.987
CFLAR	CASP8 and FADD-like apoptosis regulator	0.951
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.918	Human
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.908
BECN1	beclin 1, autophagy related	0.876
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.783
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.765
BAK1	BCL2-antagonist/killer 1	0.760
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.741
TP53BP2	tumor protein p53 binding protein, 2	0.686
MAPK8	mitogen-activated protein kinase 8	0.661
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.658	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.650
SMCR7L	Smith-Magenis syndrome chromosome region, candidate 7-like	0.623
XIAP	X-linked inhibitor of apoptosis	0.621
FADD	Fas (TNFRSF6)-associated via death domain	0.555
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.540
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.509
ZNF746	zinc finger protein 746	0.475
MAP2K4	mitogen-activated protein kinase kinase 4	0.473
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.458
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.449
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.447	Human
BCAP31	B-cell receptor-associated protein 31	0.418
BBC3	BCL2 binding component 3	0.346
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.325	Mouse
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.308	Human
PDZD11	PDZ domain containing 11	0.308
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.255	Human
FKBP8	FK506 binding protein 8, 38kDa	0.246
VDAC2	voltage-dependent anion channel 2	0.243
MAPK1	mitogen-activated protein kinase 1	0.200
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.194
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.192
BIK	BCL2-interacting killer (apoptosis-inducing)	0.176
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.172
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.162
NLRC4	NLR family, CARD domain containing 4	0.147
APAF1	apoptotic peptidase activating factor 1	0.133
RIPK2	receptor-interacting serine-threonine kinase 2	0.119
WWOX	WW domain containing oxidoreductase	0.114
FBXO7	F-box protein 7	0.113
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.110
BIRC2	baculoviral IAP repeat containing 2	0.108
KRT5	keratin 5	0.102
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.095
MAPK14	mitogen-activated protein kinase 14	0.094
AP2S1	adaptor-related protein complex 2, sigma 1 subunit	0.091
HDAC4	histone deacetylase 4	0.091
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.086
AMBRA1	autophagy/beclin-1 regulator 1	0.083
SMCR7	Smith-Magenis syndrome chromosome region, candidate 7	0.081
ZFYVE1	zinc finger, FYVE domain containing 1	0.078
MEFV	Mediterranean fever	0.076
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.074
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.074
ENO1	enolase 1, (alpha)	0.066
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.066
GPX4	glutathione peroxidase 4 (phospholipid hydroperoxidase)	0.065
MAGEH1	melanoma antigen family H, 1	0.064
IFI44L	interferon-induced protein 44-like	0.063
TSPO	translocator protein (18kDa)	0.061
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.058
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.058	Mouse
PLAT	plasminogen activator, tissue	0.055	Human
LRRK2	leucine-rich repeat kinase 2	0.054
ACTB	actin, beta	0.054
S100A6	S100 calcium binding protein A6	0.053
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.051
CABLES1	Cdk5 and Abl enzyme substrate 1	0.050
HIST2H3C	histone cluster 2, H3c	0.050
VDAC1	voltage-dependent anion channel 1	0.049
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.049
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.049
SFN	stratifin	0.045
HUWE1	HECT, UBA and WWE domain containing 1	0.044
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.043
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.042
MRPS12	mitochondrial ribosomal protein S12	0.042
PAFAH1B2	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	0.041
FOSL1	FOS-like antigen 1	0.039
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.039
FLNA	filamin A, alpha	0.038
TAGLN2	transgelin 2	0.037
ISG15	ISG15 ubiquitin-like modifier	0.037
SATB2	SATB homeobox 2	0.036
TMEM11	transmembrane protein 11	0.036
SPNS1	spinster homolog 1 (Drosophila)	0.036
FASLG	Fas ligand (TNF superfamily, member 6)	0.036	Human
RNF144B	ring finger protein 144B	0.035
PLAUR	plasminogen activator, urokinase receptor	0.034
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.034
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.034
PLAU	plasminogen activator, urokinase	0.033	Human
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.032
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.031
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.030
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.030
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.030
ARRB1	arrestin, beta 1	0.029
RGS2	regulator of G-protein signaling 2, 24kDa	0.028
MARK2	MAP/microtubule affinity-regulating kinase 2	0.028
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.028
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.027
CLU	clusterin	0.027
SS18L2	synovial sarcoma translocation gene on chromosome 18-like 2	0.027
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.026
MAP2K1	mitogen-activated protein kinase kinase 1	0.026
GRPEL1	GrpE-like 1, mitochondrial (E. coli)	0.026
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.025
RHEB	Ras homolog enriched in brain	0.025
CFL1	cofilin 1 (non-muscle)	0.025
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.025
LY6E	lymphocyte antigen 6 complex, locus E	0.024
GBP2	guanylate binding protein 2, interferon-inducible	0.024
BIRC3	baculoviral IAP repeat containing 3	0.024
PDHX	pyruvate dehydrogenase complex, component X	0.024
BCL2L2	BCL2-like 2	0.023	Human
PDCD2	programmed cell death 2	0.023
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.023
DIABLO	diablo, IAP-binding mitochondrial protein	0.023
MAPK9	mitogen-activated protein kinase 9	0.023	Rat
ORM1	orosomucoid 1	0.023
IL8	interleukin 8	0.022
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.022
UBASH3B	ubiquitin associated and SH3 domain containing B	0.022
TKT	transketolase	0.021
MAP2K7	mitogen-activated protein kinase kinase 7	0.021
YAP1	Yes-associated protein 1	0.020
RSAD2	radical S-adenosyl methionine domain containing 2	0.020
TRIM37	tripartite motif containing 37	0.020
RAB5C	RAB5C, member RAS oncogene family	0.020
S100A2	S100 calcium binding protein A2	0.020
C4orf14	chromosome 4 open reading frame 14	0.019
NARS	asparaginyl-tRNA synthetase	0.019
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.019
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.019
VTN	vitronectin	0.019
BST2	bone marrow stromal cell antigen 2	0.019
NAF1	nuclear assembly factor 1 homolog (S. cerevisiae)	0.019
IFIT3	interferon-induced protein with tetratricopeptide repeats 3	0.018
KRT6C	keratin 6C	0.018
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.018
PLSCR1	phospholipid scramblase 1	0.018
TSC2	tuberous sclerosis 2	0.018
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.018
HLTF	helicase-like transcription factor	0.018
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.018
XPO7	exportin 7	0.018
CYCS	cytochrome c, somatic	0.018
KLHDC2	kelch domain containing 2	0.018
POLE4	polymerase (DNA-directed), epsilon 4 (p12 subunit)	0.018
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.018
GCGR	glucagon receptor	0.017
ARF5	ADP-ribosylation factor 5	0.017
CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.016
TCEAL4	transcription elongation factor A (SII)-like 4	0.016
IFI44	interferon-induced protein 44	0.016
SEPW1	selenoprotein W, 1	0.016
NOTCH1	notch 1	0.016
GNB5	guanine nucleotide binding protein (G protein), beta 5	0.016
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.016
BBS10	Bardet-Biedl syndrome 10	0.016
GBP1	guanylate binding protein 1, interferon-inducible	0.016
TRMT61B	tRNA methyltransferase 61 homolog B (S. cerevisiae)	0.016
KNG1	kininogen 1	0.016
ING1	inhibitor of growth family, member 1	0.015
BAG1	BCL2-associated athanogene	0.015
TRAF1	TNF receptor-associated factor 1	0.015
CHPF	chondroitin polymerizing factor	0.015
TUBB6	tubulin, beta 6	0.015
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.015
ATOX1	ATX1 antioxidant protein 1 homolog (yeast)	0.015
UBASH3A	ubiquitin associated and SH3 domain containing A	0.015
MRPS24	mitochondrial ribosomal protein S24	0.015
COMMD1	copper metabolism (Murr1) domain containing 1	0.015
MRPL14	mitochondrial ribosomal protein L14	0.015
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.015
DUSP1	dual specificity phosphatase 1	0.014
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.014
MRPS35	mitochondrial ribosomal protein S35	0.014
HSPB1	heat shock 27kDa protein 1	0.014
MAPK3	mitogen-activated protein kinase 3	0.014
BOLA3	bolA homolog 3 (E. coli)	0.014
HPX	hemopexin	0.014
CXCL11	chemokine (C-X-C motif) ligand 11	0.014
BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1	0.014
IFIH1	interferon induced with helicase C domain 1	0.014
C16orf61	chromosome 16 open reading frame 61	0.014
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.014
S1PR5	sphingosine-1-phosphate receptor 5	0.013
EFHD2	EF-hand domain family, member D2	0.013
USP18	ubiquitin specific peptidase 18	0.013
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.013
HSPH1	heat shock 105kDa/110kDa protein 1	0.013
ATP6V1F	ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F	0.013
PACRG	PARK2 co-regulated	0.013
GCH1	GTP cyclohydrolase 1	0.013
PAAF1	proteasomal ATPase-associated factor 1	0.013
MTFP1	mitochondrial fission process 1	0.013
IFI27	interferon, alpha-inducible protein 27	0.013	Human
RIPK4	receptor-interacting serine-threonine kinase 4	0.013
ACTG1	actin, gamma 1	0.013
POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	0.013
FAM136A	family with sequence similarity 136, member A	0.012
IFIT2	interferon-induced protein with tetratricopeptide repeats 2	0.012
PSEN2	presenilin 2 (Alzheimer disease 4)	0.012
PTPLB	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b	0.012
BZW2	basic leucine zipper and W2 domains 2	0.012
SIVA1	SIVA1, apoptosis-inducing factor	0.012
DTX1	deltex homolog 1 (Drosophila)	0.012
IER3	immediate early response 3	0.012
MRPL11	mitochondrial ribosomal protein L11	0.012
C20orf24	chromosome 20 open reading frame 24	0.012
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.012
PDPK1	3-phosphoinositide dependent protein kinase-1	0.012
ZNF219	zinc finger protein 219	0.012
MAPT	microtubule-associated protein tau	0.012
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.012
NPM3	nucleophosmin/nucleoplasmin 3	0.012
CCNE1	cyclin E1	0.012
C7orf36	chromosome 7 open reading frame 36	0.012
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.012
TUBA3E	tubulin, alpha 3e	0.012
MAP2K3	mitogen-activated protein kinase kinase 3	0.011
PNP	purine nucleoside phosphorylase	0.011
NAMPT	nicotinamide phosphoribosyltransferase	0.011
CD151	CD151 molecule (Raph blood group)	0.011
CHCHD3	coiled-coil-helix-coiled-coil-helix domain containing 3	0.011
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.011
EMD	emerin	0.011
HAGH	hydroxyacylglutathione hydrolase	0.011
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.011
PEBP4	phosphatidylethanolamine-binding protein 4	0.011
LPA	lipoprotein, Lp(a)	0.011	Human
ACTN1	actinin, alpha 1	0.011
TSPYL4	TSPY-like 4	0.011
IGFBP3	insulin-like growth factor binding protein 3	0.011
CCKBR	cholecystokinin B receptor	0.011
PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.011
FBP1	fructose-1,6-bisphosphatase 1	0.011
NFIL3	nuclear factor, interleukin 3 regulated	0.011
FNBP1	formin binding protein 1	0.011
GLRX	glutaredoxin (thioltransferase)	0.011
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.011
FYCO1	FYVE and coiled-coil domain containing 1	0.011
MKKS	McKusick-Kaufman syndrome	0.011
AKT1S1	AKT1 substrate 1 (proline-rich)	0.011
TOMM5	translocase of outer mitochondrial membrane 5 homolog (yeast)	0.011
C12orf45	chromosome 12 open reading frame 45	0.011
ARRB2	arrestin, beta 2	0.011	Rat
S100A4	S100 calcium binding protein A4	0.011
PPP1R13B	protein phosphatase 1, regulatory (inhibitor) subunit 13B	0.011
FUS	fused in sarcoma	0.011
DLD	dihydrolipoamide dehydrogenase	0.011
SNX9	sorting nexin 9	0.011
ZNHIT1	zinc finger, HIT-type containing 1	0.011
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.011
HDAC6	histone deacetylase 6	0.011
TIMM44	translocase of inner mitochondrial membrane 44 homolog (yeast)	0.011
HNRNPCL1	heterogeneous nuclear ribonucleoprotein C-like 1	0.011
C7orf59	chromosome 7 open reading frame 59	0.010
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.010
CAPG	capping protein (actin filament), gelsolin-like	0.010
HPD	4-hydroxyphenylpyruvate dioxygenase	0.010
MAP1B	microtubule-associated protein 1B	0.010
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.010
MRPS22	mitochondrial ribosomal protein S22	0.010
POLR2J	polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa	0.010
CCNG2	cyclin G2	0.010
GCKR	glucokinase (hexokinase 4) regulator	0.010
TRAF3	TNF receptor-associated factor 3	0.010
ZNF511	zinc finger protein 511	0.010
MYH9	myosin, heavy chain 9, non-muscle	0.010
LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	0.010
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.010
DCTN6	dynactin 6	0.010
ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	0.010
RIPK3	receptor-interacting serine-threonine kinase 3	0.010
DDIT3	DNA-damage-inducible transcript 3	0.010
HIPK2	homeodomain interacting protein kinase 2	0.010