IMP

Process View

Mus musculus

23 genes annotated in mouse

Multi-species View

negative regulation of t cell differentiation

GO:0045581

Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of t cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of t cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Gli3	GLI-Kruppel family member GLI3	0.999
Stat3	signal transducer and activator of transcription 3	0.968
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.961
Fgfr2	fibroblast growth factor receptor 2	0.948
Shh	sonic hedgehog	0.942
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.932
Bcl3	B-cell leukemia/lymphoma 3	0.870
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.861
Pten	phosphatase and tensin homolog	0.837
Gli2	GLI-Kruppel family member GLI2	0.832	Mouse
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.823	Mouse
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.784
Socs3	suppressor of cytokine signaling 3	0.695	Mouse
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.660
Rc3h1	RING CCCH (C3H) domains 1	0.573
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.572
Sox9	SRY-box containing gene 9	0.518
Trp53	transformation related protein 53	0.506
Ptch1	patched homolog 1	0.496
Zeb1	zinc finger E-box binding homeobox 1	0.496
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.486	Mouse
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.475
Fgf9	fibroblast growth factor 9	0.450
Il6st	interleukin 6 signal transducer	0.445
Tnf	tumor necrosis factor	0.429
Igh	immunoglobulin heavy chain complex	0.428
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.405	Mouse
Stat6	signal transducer and activator of transcription 6	0.400
Lepr	leptin receptor	0.398
Twist2	twist homolog 2 (Drosophila)	0.355
Stat2	signal transducer and activator of transcription 2	0.335
Jak2	Janus kinase 2	0.320	Mouse
Pthlh	parathyroid hormone-like peptide	0.294
Foxp3	forkhead box P3	0.260
Trp63	transformation related protein 63	0.252
Cd40	CD40 antigen	0.242
Fgfr3	fibroblast growth factor receptor 3	0.232
Batf	basic leucine zipper transcription factor, ATF-like	0.226
H2-DMa	histocompatibility 2, class II, locus DMa	0.220
Apc	adenomatosis polyposis coli	0.213
Uba7	ubiquitin-like modifier activating enzyme 7	0.187
Fgf10	fibroblast growth factor 10	0.187
Nf1	neurofibromatosis 1	0.186
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.183
Il4ra	interleukin 4 receptor, alpha	0.181
Fas	Fas (TNF receptor superfamily member 6)	0.174
Irf8	interferon regulatory factor 8	0.173	Mouse
Vangl2	vang-like 2 (van gogh, Drosophila)	0.170
Ephb2	Eph receptor B2	0.168
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.159	Mouse
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.157
Tgfb1	transforming growth factor, beta 1	0.157
Sfpi1	SFFV proviral integration 1	0.152
Smo	smoothened homolog (Drosophila)	0.150
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.144
Meox2	mesenchyme homeobox 2	0.138
Irf5	interferon regulatory factor 5	0.137	Mouse
Ifng	interferon gamma	0.136
Ikzf1	IKAROS family zinc finger 1	0.135
Col1a1	collagen, type I, alpha 1	0.135
Irgm2	immunity-related GTPase family M member 2	0.131
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.117
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.115
Irf4	interferon regulatory factor 4	0.111	Mouse
Msx2	homeobox, msh-like 2	0.109
Cd19	CD19 antigen	0.108
Ar	androgen receptor	0.108
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.106
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.105
Hhex	hematopoietically expressed homeobox	0.102
Cish	cytokine inducible SH2-containing protein	0.100	Mouse
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.099
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.096
Stat5a	signal transducer and activator of transcription 5A	0.091
Tapbp	TAP binding protein	0.088
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.088
Icam1	intercellular adhesion molecule 1	0.084
Hoxa5	homeobox A5	0.082
Col2a1	collagen, type II, alpha 1	0.081
Sprr2k	small proline-rich protein 2K	0.077
Jak1	Janus kinase 1	0.076	Mouse
Junb	Jun-B oncogene	0.076
Egr2	early growth response 2	0.073
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.071
Runx2	runt related transcription factor 2	0.068
Stat1	signal transducer and activator of transcription 1	0.067
Ren1	renin 1 structural	0.066
Sfn	stratifin	0.065
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.062
Socs1	suppressor of cytokine signaling 1	0.061	Mouse
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.061
Kit	kit oncogene	0.060
Socs2	suppressor of cytokine signaling 2	0.059	Mouse
H2-Eb1	histocompatibility 2, class II antigen E beta	0.059
Phox2b	paired-like homeobox 2b	0.058
Sox10	SRY-box containing gene 10	0.057
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.056
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.053
Bdkrb2	bradykinin receptor, beta 2	0.052
Ret	ret proto-oncogene	0.052
Rb1	retinoblastoma 1	0.050
Icos	inducible T-cell co-stimulator	0.050
Sox2	SRY-box containing gene 2	0.049
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.048
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.047
Foxc1	forkhead box C1	0.047
Prdm1	PR domain containing 1, with ZNF domain	0.046
Irf1	interferon regulatory factor 1	0.046
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.045
Prkcd	protein kinase C, delta	0.044
Pou2af1	POU domain, class 2, associating factor 1	0.044
Parp14	poly (ADP-ribose) polymerase family, member 14	0.043
Isg15	ISG15 ubiquitin-like modifier	0.042
Plekho2	pleckstrin homology domain containing, family O member 2	0.042
Cd40lg	CD40 ligand	0.042
Bmp7	bone morphogenetic protein 7	0.041
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.040
Foxf1a	forkhead box F1a	0.039
Socs5	suppressor of cytokine signaling 5	0.039
Noto	notochord homolog (Xenopus laevis)	0.038
Nrg1	neuregulin 1	0.037
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.037
Mdm2	transformed mouse 3T3 cell double minute 2	0.037
Usp18	ubiquitin specific peptidase 18	0.036
Foxn1	forkhead box N1	0.036
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.036
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.035
Pax3	paired box gene 3	0.035
Stat5b	signal transducer and activator of transcription 5B	0.035
Zbp1	Z-DNA binding protein 1	0.035
Rag1	recombination activating gene 1	0.034
Trim21	tripartite motif-containing 21	0.034
Wnt5a	wingless-related MMTV integration site 5A	0.033
Cdkn2b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.033	Mouse
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.033
Pax1	paired box gene 1	0.032
Ptpn2	protein tyrosine phosphatase, non-receptor type 2	0.031
Creb1	cAMP responsive element binding protein 1	0.031
Traf6	TNF receptor-associated factor 6	0.031
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.031	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.031
Ifnar2	interferon (alpha and beta) receptor 2	0.030
Hdac7	histone deacetylase 7	0.030
Gm12597	predicted gene 12597	0.030	Human
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.030
Sox11	SRY-box containing gene 11	0.029
Gtse1	G two S phase expressed protein 1	0.029
Msh2	mutS homolog 2 (E. coli)	0.029
Lag3	lymphocyte-activation gene 3	0.029
Mx2	myxovirus (influenza virus) resistance 2	0.029
Il2rg	interleukin 2 receptor, gamma chain	0.028
Arrb2	arrestin, beta 2	0.028
Mapk8	mitogen-activated protein kinase 8	0.028
B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.028
Hbb-b1	hemoglobin, beta adult major chain	0.027
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.027
Il2rb	interleukin 2 receptor, beta chain	0.027
Card11	caspase recruitment domain family, member 11	0.027
Mks1	Meckel syndrome, type 1	0.027
Tnip1	TNFAIP3 interacting protein 1	0.027
Irf7	interferon regulatory factor 7	0.027	Mouse
Il17ra	interleukin 17 receptor A	0.026
Gdnf	glial cell line derived neurotrophic factor	0.026
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.026
Foxa2	forkhead box A2	0.026
Zfp36	zinc finger protein 36	0.025
Birc3	baculoviral IAP repeat-containing 3	0.025
Igtp	interferon gamma induced GTPase	0.025
Foxf2	forkhead box F2	0.025
Adar	adenosine deaminase, RNA-specific	0.025
Pkdcc	protein kinase domain containing, cytoplasmic	0.025
Cul5	cullin 5	0.024
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.024
Xpa	xeroderma pigmentosum, complementation group A	0.024
Plac1	placental specific protein 1	0.024
Hoxb3	homeobox B3	0.024
Mdm4	transformed mouse 3T3 cell double minute 4	0.024
a	nonagouti	0.024
Plcg2	phospholipase C, gamma 2	0.023
Ceacam16	carcinoembryonic antigen-related cell adhesion molecule 16	0.023
Tsc1	tuberous sclerosis 1	0.023
Cyld	cylindromatosis (turban tumor syndrome)	0.023
Irgm1	immunity-related GTPase family M member 1	0.023
Irf9	interferon regulatory factor 9	0.023	Mouse
Mvp	major vault protein	0.022
Kitl	kit ligand	0.022
Aqp2	aquaporin 2	0.022
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.022
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.022
Bmper	BMP-binding endothelial regulator	0.022
Pim1	proviral integration site 1	0.021
Hoxa13	homeobox A13	0.021
Drd3	dopamine receptor D3	0.021
Parp10	poly (ADP-ribose) polymerase family, member 10	0.021
Insm1	insulinoma-associated 1	0.021
Bmp15	bone morphogenetic protein 15	0.021
Kif19a	kinesin family member 19A	0.020
Foxo4	forkhead box O4	0.020
2310014H01Rik	RIKEN cDNA 2310014H01 gene	0.020
Rsad2	radical S-adenosyl methionine domain containing 2	0.020
Neurog3	neurogenin 3	0.020
Bcl6	B-cell leukemia/lymphoma 6	0.020
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.020
Vav2	vav 2 oncogene	0.019
Phox2a	paired-like homeobox 2a	0.019
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.019
Oas1a	2'-5' oligoadenylate synthetase 1A	0.019
Kif3a	kinesin family member 3A	0.019
Pax6	paired box gene 6	0.019
Sox7	SRY-box containing gene 7	0.019
Pdcd1	programmed cell death 1	0.019
Tead3	TEA domain family member 3	0.019
Bmp4	bone morphogenetic protein 4	0.018	Human
Ltbp2	latent transforming growth factor beta binding protein 2	0.018
Rc3h2	ring finger and CCCH-type zinc finger domains 2	0.018	Mouse
Zan	zonadhesin	0.018
Itch	itchy, E3 ubiquitin protein ligase	0.018
Il3ra	interleukin 3 receptor, alpha chain	0.018
Egr1	early growth response 1	0.018
Il21r	interleukin 21 receptor	0.018
Ifi35	interferon-induced protein 35	0.018
Ifnar1	interferon (alpha and beta) receptor 1	0.018
Esr2	estrogen receptor 2 (beta)	0.017
Gdf5	growth differentiation factor 5	0.017
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.017
Inpp5d	inositol polyphosphate-5-phosphatase D	0.017
Hoxb6	homeobox B6	0.017
Pitx2	paired-like homeodomain transcription factor 2	0.017
Hoxb9	homeobox B9	0.017
Dyrk1b	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b	0.017
BC006779	cDNA sequence BC006779	0.017
Gli1	GLI-Kruppel family member GLI1	0.017	Mouse
Parp9	poly (ADP-ribose) polymerase family, member 9	0.017
Ntf3	neurotrophin 3	0.017
Rel	reticuloendotheliosis oncogene	0.016
Insrr	insulin receptor-related receptor	0.016
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.016
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.016
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.016
Cd274	CD274 antigen	0.016
Upk2	uroplakin 2	0.016
Il27ra	interleukin 27 receptor, alpha	0.016
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.015
Jak3	Janus kinase 3	0.015
H2-K1	histocompatibility 2, K1, K region	0.015
Itga3	integrin alpha 3	0.015
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.015
Oas2	2'-5' oligoadenylate synthetase 2	0.015
Fgf18	fibroblast growth factor 18	0.015
Trp73	transformation related protein 73	0.015
Rarg	retinoic acid receptor, gamma	0.015
Samhd1	SAM domain and HD domain, 1	0.015
Tmem106a	transmembrane protein 106A	0.015
Tmem173	transmembrane protein 173	0.015
Adam8	a disintegrin and metallopeptidase domain 8	0.015
Nfil3	nuclear factor, interleukin 3, regulated	0.015
Fgf5	fibroblast growth factor 5	0.014
Tbx2	T-box 2	0.014
Lta	lymphotoxin A	0.014
Fes	feline sarcoma oncogene	0.014
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.014
Hoxd13	homeobox D13	0.014
Hesx1	homeobox gene expressed in ES cells	0.014
Rim4	recombination induced mutation 4	0.014
Dnahc11	dynein, axonemal, heavy chain 11	0.014
Ifnab	interferon alpha B	0.014	Human
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.014
Braf	Braf transforming gene	0.014
Ifnb1	interferon beta 1, fibroblast	0.014
Xcl1	chemokine (C motif) ligand 1	0.014
Robo3	roundabout homolog 3 (Drosophila)	0.014
C78228	expressed sequence C78228	0.013
Bik	BCL2-interacting killer	0.013
Sema6c	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	0.013
Cdh5	cadherin 5	0.013
Sptlc2	serine palmitoyltransferase, long chain base subunit 2	0.013
Gnao1	guanine nucleotide binding protein, alpha O	0.013
Il2	interleukin 2	0.013
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.013
Cxcl9	chemokine (C-X-C motif) ligand 9	0.013
Laptm5	lysosomal-associated protein transmembrane 5	0.013
H2-Q8	histocompatibility 2, Q region locus 8	0.013
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.013
Aicda	activation-induced cytidine deaminase	0.013
Sh3bp2	SH3-domain binding protein 2	0.012
Dock2	dedicator of cyto-kinesis 2	0.012
Ccr7	chemokine (C-C motif) receptor 7	0.012
St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.012
Fosb	FBJ osteosarcoma oncogene B	0.012
Kdm6b	KDM1 lysine (K)-specific demethylase 6B	0.012
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.012
Tcra	T-cell receptor alpha chain	0.012
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.012
Efna4	ephrin A4	0.012
Ctgf	connective tissue growth factor	0.012
Cdx1	caudal type homeobox 1	0.012
Stra8	stimulated by retinoic acid gene 8	0.012
Traf3ip2	TRAF3 interacting protein 2	0.012
Pitx3	paired-like homeodomain transcription factor 3	0.012
Il9	interleukin 9	0.012
Dsg4	desmoglein 4	0.012
Aplnr	apelin receptor	0.012
Syngr4	synaptogyrin 4	0.012
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.012
Sbno2	strawberry notch homolog 2 (Drosophila)	0.012
Gm3150	predicted gene 3150	0.012
Pax5	paired box gene 5	0.012
H2-D1	histocompatibility 2, D region locus 1	0.012
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.012
Tor3a	torsin family 3, member A	0.012
B2m	beta-2 microglobulin	0.012
Tpx2	TPX2, microtubule-associated protein homolog (Xenopus laevis)	0.011
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.011
Irf6	interferon regulatory factor 6	0.011	Mouse
Nkx3-2	NK3 homeobox 2	0.011
Trim30a	tripartite motif-containing 30A	0.011
Unc93b1	unc-93 homolog B1 (C. elegans)	0.011
Rtp4	receptor transporter protein 4	0.011
Dok3	docking protein 3	0.011
Zmym1	zinc finger, MYM domain containing 1	0.011
Utf1	undifferentiated embryonic cell transcription factor 1	0.011
Creb3l1	cAMP responsive element binding protein 3-like 1	0.011
Ltb	lymphotoxin B	0.011
Foxh1	forkhead box H1	0.011
Tead2	TEA domain family member 2	0.011
Dok1	docking protein 1	0.011
Nodal	nodal	0.011
Parp12	poly (ADP-ribose) polymerase family, member 12	0.011
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.011
Csf1	colony stimulating factor 1 (macrophage)	0.011
Plcg1	phospholipase C, gamma 1	0.011
Pvrl2	poliovirus receptor-related 2	0.011
Evx1	even skipped homeotic gene 1 homolog	0.011
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.011
Zic2	zinc finger protein of the cerebellum 2	0.011
Lamc1	laminin, gamma 1	0.011
Cd72	CD72 antigen	0.011
Vav3	vav 3 oncogene	0.011
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.011
Hoxd3	homeobox D3	0.011
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.011
Pitx1	paired-like homeodomain transcription factor 1	0.011
Lig4	ligase IV, DNA, ATP-dependent	0.010
Atxn1	ataxin 1	0.010
Chd7	chromodomain helicase DNA binding protein 7	0.010
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.010
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.010
Svs5	seminal vesicle secretory protein 5	0.010
Fcgbp	Fc fragment of IgG binding protein	0.010
Phospho1	phosphatase, orphan 1	0.010
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.010
Sfrp2	secreted frizzled-related protein 2	0.010
Nkx2-1	NK2 homeobox 1	0.010
Aim1	absent in melanoma 1	0.010
Ptch2	patched homolog 2	0.010
Pdx1	pancreatic and duodenal homeobox 1	0.010
Gata3	GATA binding protein 3	0.010
Itgal	integrin alpha L	0.010
Isl1	ISL1 transcription factor, LIM/homeodomain	0.010
Col11a2	collagen, type XI, alpha 2	0.010
Mib1	mindbomb homolog 1 (Drosophila)	0.010