IMP
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negative regulation of toll like receptor signaling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of toll like receptor signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Axl | AXL receptor tyrosine kinase | 0.988 | Mouse | |
| Igh | immunoglobulin heavy chain complex | 0.988 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.944 | ||
| Traf6 | TNF receptor-associated factor 6 | 0.926 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.828 | ||
| Trim30d | tripartite motif-containing 30D | 0.827 | Mouse | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.824 | ||
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.754 | ||
| Lyz2 | lysozyme 2 | 0.729 | ||
| Plcg2 | phospholipase C, gamma 2 | 0.689 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.680 | ||
| Stat2 | signal transducer and activator of transcription 2 | 0.639 | ||
| Arrb1 | arrestin, beta 1 | 0.583 | Mouse | |
| Cd44 | CD44 antigen | 0.565 | ||
| Blnk | B-cell linker | 0.553 | ||
| Gnrh1 | gonadotropin releasing hormone 1 | 0.549 | ||
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.541 | ||
| Kiss1 | KiSS-1 metastasis-suppressor | 0.537 | ||
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.500 | ||
| Trim30a | tripartite motif-containing 30A | 0.497 | ||
| Arrb2 | arrestin, beta 2 | 0.478 | ||
| Gab1 | growth factor receptor bound protein 2-associated protein 1 | 0.462 | ||
| Tyro3 | TYRO3 protein tyrosine kinase 3 | 0.453 | ||
| Pten | phosphatase and tensin homolog | 0.409 | ||
| Irf9 | interferon regulatory factor 9 | 0.390 | Mouse | |
| Grb2 | growth factor receptor bound protein 2 | 0.357 | ||
| Il2rg | interleukin 2 receptor, gamma chain | 0.347 | ||
| Irak4 | interleukin-1 receptor-associated kinase 4 | 0.321 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.316 | ||
| Fshr | follicle stimulating hormone receptor | 0.288 | Mouse | |
| Fcgr2b | Fc receptor, IgG, low affinity IIb | 0.279 | ||
| Tnf | tumor necrosis factor | 0.275 | ||
| Sfpi1 | SFFV proviral integration 1 | 0.272 | ||
| Cbl | Casitas B-lineage lymphoma | 0.249 | ||
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.246 | ||
| Stat1 | signal transducer and activator of transcription 1 | 0.237 | ||
| Gbp7 | guanylate binding protein 7 | 0.224 | ||
| Trim21 | tripartite motif-containing 21 | 0.220 | Mouse | |
| Cyp19a1 | cytochrome P450, family 19, subfamily a, polypeptide 1 | 0.216 | ||
| Unc93b1 | unc-93 homolog B1 (C. elegans) | 0.211 | ||
| Irf8 | interferon regulatory factor 8 | 0.209 | Mouse | |
| Uba7 | ubiquitin-like modifier activating enzyme 7 | 0.198 | ||
| Pax8 | paired box gene 8 | 0.192 | ||
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.192 | ||
| Cd19 | CD19 antigen | 0.191 | ||
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.189 | ||
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.187 | ||
| Was | Wiskott-Aldrich syndrome homolog (human) | 0.184 | ||
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.182 | ||
| Sp100 | nuclear antigen Sp100 | 0.180 | ||
| Pycard | PYD and CARD domain containing | 0.179 | ||
| Bglap | bone gamma carboxyglutamate protein | 0.175 | ||
| Ifnar1 | interferon (alpha and beta) receptor 1 | 0.166 | ||
| Il27ra | interleukin 27 receptor, alpha | 0.165 | ||
| BC013712 | cDNA sequence BC013712 | 0.158 | ||
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.153 | ||
| Psmb9 | proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) | 0.152 | ||
| Tifa | TRAF-interacting protein with forkhead-associated domain | 0.149 | ||
| Parp14 | poly (ADP-ribose) polymerase family, member 14 | 0.146 | ||
| Spib | Spi-B transcription factor (Spi-1/PU.1 related) | 0.145 | ||
| Dok1 | docking protein 1 | 0.144 | ||
| Cd40 | CD40 antigen | 0.141 | ||
| Casp1 | caspase 1 | 0.141 | ||
| Hcls1 | hematopoietic cell specific Lyn substrate 1 | 0.137 | ||
| Trim12a | tripartite motif-containing 12A | 0.134 | Mouse | |
| Timp1 | tissue inhibitor of metalloproteinase 1 | 0.132 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.122 | ||
| Pyhin1 | pyrin and HIN domain family, member 1 | 0.121 | ||
| Tlr4 | toll-like receptor 4 | 0.113 | ||
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.110 | ||
| Duox2 | dual oxidase 2 | 0.109 | ||
| Ptpre | protein tyrosine phosphatase, receptor type, E | 0.106 | ||
| Tcirg1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 | 0.101 | ||
| Cd86 | CD86 antigen | 0.100 | ||
| Mx2 | myxovirus (influenza virus) resistance 2 | 0.093 | ||
| Dock2 | dedicator of cyto-kinesis 2 | 0.085 | ||
| Igf1 | insulin-like growth factor 1 | 0.084 | ||
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.084 | ||
| Itgal | integrin alpha L | 0.081 | ||
| Sykb | spleen tyrosine kinase | 0.078 | ||
| Ptk2b | PTK2 protein tyrosine kinase 2 beta | 0.078 | ||
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.076 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.072 | ||
| Prlr | prolactin receptor | 0.072 | ||
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.071 | ||
| Tor3a | torsin family 3, member A | 0.071 | ||
| Itgb2 | integrin beta 2 | 0.071 | ||
| Laptm5 | lysosomal-associated protein transmembrane 5 | 0.068 | ||
| Birc3 | baculoviral IAP repeat-containing 3 | 0.065 | ||
| Lhcgr | luteinizing hormone/choriogonadotropin receptor | 0.065 | Mouse | |
| Irak3 | interleukin-1 receptor-associated kinase 3 | 0.064 | ||
| Tnip1 | TNFAIP3 interacting protein 1 | 0.064 | ||
| Irf1 | interferon regulatory factor 1 | 0.064 | Mouse | |
| Oas3 | 2'-5' oligoadenylate synthetase 3 | 0.064 | ||
| Il6 | interleukin 6 | 0.063 | ||
| Il1r1 | interleukin 1 receptor, type I | 0.063 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.063 | ||
| Cd180 | CD180 antigen | 0.062 | ||
| Stat6 | signal transducer and activator of transcription 6 | 0.061 | ||
| Rsad2 | radical S-adenosyl methionine domain containing 2 | 0.061 | ||
| Prkcd | protein kinase C, delta | 0.060 | ||
| Fyb | FYN binding protein | 0.060 | ||
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.060 | ||
| Cga | glycoprotein hormones, alpha subunit | 0.059 | ||
| Socs1 | suppressor of cytokine signaling 1 | 0.059 | ||
| Eif2ak2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.058 | ||
| Bcl3 | B-cell leukemia/lymphoma 3 | 0.054 | ||
| Prf1 | perforin 1 (pore forming protein) | 0.053 | ||
| Irgm2 | immunity-related GTPase family M member 2 | 0.052 | ||
| Lyl1 | lymphoblastomic leukemia 1 | 0.051 | ||
| Icos | inducible T-cell co-stimulator | 0.050 | ||
| Ciita | class II transactivator | 0.050 | ||
| Ghr | growth hormone receptor | 0.048 | ||
| Cd72 | CD72 antigen | 0.047 | ||
| Ar | androgen receptor | 0.047 | ||
| Ddx60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.047 | ||
| Hck | hemopoietic cell kinase | 0.046 | Mouse | |
| BC006779 | cDNA sequence BC006779 | 0.045 | ||
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.045 | ||
| Ms4a4c | membrane-spanning 4-domains, subfamily A, member 4C | 0.045 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.045 | ||
| Irgm1 | immunity-related GTPase family M member 1 | 0.044 | ||
| Lck | lymphocyte protein tyrosine kinase | 0.044 | Mouse | |
| Ddx58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.043 | ||
| Il2rb | interleukin 2 receptor, beta chain | 0.043 | ||
| Il10 | interleukin 10 | 0.042 | ||
| Irf4 | interferon regulatory factor 4 | 0.042 | ||
| Trp53 | transformation related protein 53 | 0.041 | ||
| Epsti1 | epithelial stromal interaction 1 (breast) | 0.040 | ||
| Ifi203 | interferon activated gene 203 | 0.039 | ||
| Dok2 | docking protein 2 | 0.038 | ||
| Samhd1 | SAM domain and HD domain, 1 | 0.038 | ||
| Il10ra | interleukin 10 receptor, alpha | 0.038 | ||
| Cd300ld | CD300 molecule-like family member d | 0.038 | ||
| Prkce | protein kinase C, epsilon | 0.038 | ||
| Dhx58 | DEXH (Asp-Glu-X-His) box polypeptide 58 | 0.037 | ||
| Slamf8 | SLAM family member 8 | 0.036 | ||
| Cd22 | CD22 antigen | 0.035 | ||
| Foxp3 | forkhead box P3 | 0.035 | ||
| Ifi44 | interferon-induced protein 44 | 0.035 | ||
| Csf1r | colony stimulating factor 1 receptor | 0.034 | ||
| Traf2 | TNF receptor-associated factor 2 | 0.033 | ||
| Mx1 | myxovirus (influenza virus) resistance 1 | 0.033 | ||
| Map3k3 | mitogen-activated protein kinase kinase kinase 3 | 0.033 | ||
| Inhba | inhibin beta-A | 0.033 | ||
| H2-DMb2 | histocompatibility 2, class II, locus Mb2 | 0.031 | ||
| Src | Rous sarcoma oncogene | 0.031 | Mouse | |
| Card11 | caspase recruitment domain family, member 11 | 0.031 | ||
| Batf | basic leucine zipper transcription factor, ATF-like | 0.031 | ||
| Lcp1 | lymphocyte cytosolic protein 1 | 0.031 | ||
| Cd247 | CD247 antigen | 0.031 | ||
| Nlrp3 | NLR family, pyrin domain containing 3 | 0.030 | Mouse | |
| Emr1 | EGF-like module containing, mucin-like, hormone receptor-like sequence 1 | 0.030 | ||
| Il17ra | interleukin 17 receptor A | 0.030 | ||
| Zbp1 | Z-DNA binding protein 1 | 0.030 | ||
| Pml | promyelocytic leukemia | 0.030 | ||
| Parp10 | poly (ADP-ribose) polymerase family, member 10 | 0.029 | ||
| P2rx7 | purinergic receptor P2X, ligand-gated ion channel, 7 | 0.028 | ||
| Apobec1 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 | 0.028 | ||
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.028 | ||
| Tnfrsf13b | tumor necrosis factor receptor superfamily, member 13b | 0.028 | ||
| Cdcp1 | CUB domain containing protein 1 | 0.027 | ||
| Mertk | c-mer proto-oncogene tyrosine kinase | 0.027 | Mouse | |
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.026 | ||
| Ifi47 | interferon gamma inducible protein 47 | 0.026 | ||
| Irf5 | interferon regulatory factor 5 | 0.026 | Mouse | |
| Irf7 | interferon regulatory factor 7 | 0.026 | Mouse | |
| Runx1 | runt related transcription factor 1 | 0.025 | ||
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.025 | ||
| Cftr | cystic fibrosis transmembrane conductance regulator homolog | 0.025 | ||
| Tcrd | T-cell receptor delta chain | 0.025 | ||
| Pilrb1 | paired immunoglobin-like type 2 receptor beta 1 | 0.025 | ||
| Icam1 | intercellular adhesion molecule 1 | 0.024 | ||
| Ncoa3 | nuclear receptor coactivator 3 | 0.024 | ||
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.024 | ||
| Tnfrsf13c | tumor necrosis factor receptor superfamily, member 13c | 0.024 | ||
| Prdm1 | PR domain containing 1, with ZNF domain | 0.024 | ||
| Tnfsf10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.023 | ||
| Spnb2 | spectrin beta 2 | 0.023 | ||
| Nhlh2 | nescient helix loop helix 2 | 0.023 | ||
| Slfn4 | schlafen 4 | 0.023 | ||
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.023 | ||
| Lcp2 | lymphocyte cytosolic protein 2 | 0.022 | ||
| Pik3ap1 | phosphoinositide-3-kinase adaptor protein 1 | 0.022 | ||
| Tnfrsf11a | tumor necrosis factor receptor superfamily, member 11a | 0.021 | ||
| Tirap | toll-interleukin 1 receptor (TIR) domain-containing adaptor protein | 0.021 | ||
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.021 | ||
| Ifnar2 | interferon (alpha and beta) receptor 2 | 0.021 | ||
| Dynlt1b | dynein light chain Tctex-type 1D | 0.021 | ||
| Myf5 | myogenic factor 5 | 0.020 | ||
| Adar | adenosine deaminase, RNA-specific | 0.020 | ||
| Cybb | cytochrome b-245, beta polypeptide | 0.020 | ||
| Cd38 | CD38 antigen | 0.020 | ||
| Rel | reticuloendotheliosis oncogene | 0.020 | ||
| Gzmb | granzyme B | 0.020 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.019 | ||
| Foxn1 | forkhead box N1 | 0.019 | ||
| Igtp | interferon gamma induced GTPase | 0.019 | ||
| Cd4 | CD4 antigen | 0.019 | ||
| H2-Q7 | histocompatibility 2, Q region locus 7 | 0.019 | ||
| Clnk | cytokine-dependent hematopoietic cell linker | 0.019 | ||
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.019 | ||
| Itsn1 | intersectin 1 (SH3 domain protein 1A) | 0.019 | ||
| Aim2 | absent in melanoma 2 | 0.018 | ||
| Ikbkb | inhibitor of kappaB kinase beta | 0.018 | ||
| Ikbkg | inhibitor of kappaB kinase gamma | 0.018 | ||
| Oas2 | 2'-5' oligoadenylate synthetase 2 | 0.018 | ||
| Il1rn | interleukin 1 receptor antagonist | 0.018 | ||
| Jak3 | Janus kinase 3 | 0.018 | ||
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.018 | ||
| Herc6 | hect domain and RLD 6 | 0.017 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.017 | ||
| Slfn2 | schlafen 2 | 0.017 | ||
| Dtx3l | deltex 3-like (Drosophila) | 0.017 | ||
| Pik3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | 0.017 | ||
| 2410004A20Rik | RIKEN cDNA 2410004A20 gene | 0.017 | ||
| Trim34a | tripartite motif-containing 34A | 0.017 | Mouse | |
| Traf3ip2 | TRAF3 interacting protein 2 | 0.017 | ||
| Itgax | integrin alpha X | 0.017 | ||
| Tap2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 0.017 | ||
| Sirt7 | sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae) | 0.016 | ||
| Ifng | interferon gamma | 0.016 | ||
| Il22 | interleukin 22 | 0.016 | ||
| H2-M3 | histocompatibility 2, M region locus 3 | 0.016 | ||
| Myo1g | myosin IG | 0.016 | ||
| Wbp7 | WW domain binding protein 7 | 0.015 | ||
| Foxf2 | forkhead box F2 | 0.015 | ||
| Naip6 | NLR family, apoptosis inhibitory protein 6 | 0.015 | ||
| Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.015 | ||
| Oas1b | 2'-5' oligoadenylate synthetase 1B | 0.014 | ||
| Gbp3 | guanylate binding protein 3 | 0.014 | ||
| Cd37 | CD37 antigen | 0.014 | ||
| Ubd | ubiquitin D | 0.014 | ||
| Pxn | paxillin | 0.014 | ||
| Arhgap30 | Rho GTPase activating protein 30 | 0.014 | ||
| Plekho2 | pleckstrin homology domain containing, family O member 2 | 0.014 | ||
| Fyn | Fyn proto-oncogene | 0.014 | Mouse | |
| Rasal3 | RAS protein activator like 3 | 0.014 | ||
| Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | 0.014 | ||
| Zc3hav1 | zinc finger CCCH type, antiviral 1 | 0.014 | ||
| Mcoln2 | mucolipin 2 | 0.014 | ||
| Oasl1 | 2'-5' oligoadenylate synthetase-like 1 | 0.013 | ||
| Cd96 | CD96 antigen | 0.013 | ||
| Il1b | interleukin 1 beta | 0.013 | ||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.013 | ||
| Bcar1 | breast cancer anti-estrogen resistance 1 | 0.013 | ||
| Sla2 | Src-like-adaptor 2 | 0.013 | ||
| Tapbp | TAP binding protein | 0.012 | ||
| Mnda | myeloid cell nuclear differentiation antigen | 0.012 | ||
| Sp110 | Sp110 nuclear body protein | 0.012 | ||
| Trim5 | tripartite motif-containing 5 | 0.012 | Mouse | |
| Ly86 | lymphocyte antigen 86 | 0.012 | ||
| Gbp5 | guanylate binding protein 5 | 0.012 | ||
| Dab1 | disabled homolog 1 (Drosophila) | 0.012 | ||
| Fcgr1 | Fc receptor, IgG, high affinity I | 0.012 | ||
| Tmem106a | transmembrane protein 106A | 0.012 | ||
| Traf1 | TNF receptor-associated factor 1 | 0.012 | ||
| Aicda | activation-induced cytidine deaminase | 0.012 | ||
| Parp9 | poly (ADP-ribose) polymerase family, member 9 | 0.012 | ||
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.011 | ||
| Taok3 | TAO kinase 3 | 0.011 | ||
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.011 | ||
| Batf3 | basic leucine zipper transcription factor, ATF-like 3 | 0.011 | ||
| Trp53bp2 | transformation related protein 53 binding protein 2 | 0.011 | ||
| BC017643 | cDNA sequence BC017643 | 0.011 | ||
| Cxcr6 | chemokine (C-X-C motif) receptor 6 | 0.011 | ||
| Skap2 | src family associated phosphoprotein 2 | 0.011 | ||
| Ikzf3 | IKAROS family zinc finger 3 | 0.011 | ||
| Apobec3 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 | 0.011 | ||
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | 0.011 | ||
| Inha | inhibin alpha | 0.011 | ||
| Ido1 | indoleamine 2,3-dioxygenase 1 | 0.010 | ||
| Nr1h3 | nuclear receptor subfamily 1, group H, member 3 | 0.010 | ||
| Trim11 | tripartite motif-containing 11 | 0.010 | Mouse | |
| H2-Eb1 | histocompatibility 2, class II antigen E beta | 0.010 | ||
| Slamf1 | signaling lymphocytic activation molecule family member 1 | 0.010 | ||
| Cd274 | CD274 antigen | 0.010 | ||
| Gbp1 | guanylate binding protein 1 | 0.010 |