IMP

Process View

Homo sapiens

25 genes annotated in human

anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
CDC27	cell division cycle 27 homolog (S. cerevisiae)	1.000
CDC20	cell division cycle 20 homolog (S. cerevisiae)	1.000
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.999	Mouse Fly
CDK2	cyclin-dependent kinase 2	0.994
ANAPC4	anaphase promoting complex subunit 4	0.965
CCNA2	cyclin A2	0.961
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.941
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.939
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.908	Yeast Fly
CCNB1	cyclin B1	0.890
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.856
SMC6	structural maintenance of chromosomes 6	0.784
ANAPC11	anaphase promoting complex subunit 11	0.580	Yeast
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.538
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.503
FBXO5	F-box protein 5	0.468
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.448
PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	0.422
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.420
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.413
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.387
ANAPC7	anaphase promoting complex subunit 7	0.386
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.379
CDKN3	cyclin-dependent kinase inhibitor 3	0.367
PLK1	polo-like kinase 1	0.290
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.286
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	0.277
SKP2	S-phase kinase-associated protein 2 (p45)	0.271
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.262
CD44	CD44 molecule (Indian blood group)	0.261
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.260	Worm Fly
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.253
PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	0.227
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.208
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.205
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.193
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.178	Fly
PPP4C	protein phosphatase 4, catalytic subunit	0.173
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.173
PSMB2	proteasome (prosome, macropain) subunit, beta type, 2	0.162
CDT1	chromatin licensing and DNA replication factor 1	0.161
PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2	0.159
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.153
POMP	proteasome maturation protein	0.152
ANAPC5	anaphase promoting complex subunit 5	0.144
PSMB1	proteasome (prosome, macropain) subunit, beta type, 1	0.142
RBL1	retinoblastoma-like 1 (p107)	0.129	Human
PSMA4	proteasome (prosome, macropain) subunit, alpha type, 4	0.124
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.123
TBC1D10A	TBC1 domain family, member 10A	0.117
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.113
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.110
ORC2	origin recognition complex, subunit 2	0.108
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.104
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.099
PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5	0.080
CASC5	cancer susceptibility candidate 5	0.078
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.077
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.077
PTTG1	pituitary tumor-transforming 1	0.075
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.075
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.075
PSMD3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.071
STAG1	stromal antigen 1	0.070
SKA3	spindle and kinetochore associated complex subunit 3	0.068
ORC4	origin recognition complex, subunit 4	0.065
NEK9	NIMA (never in mitosis gene a)- related kinase 9	0.064
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.064
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.062
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.062
ORC1	origin recognition complex, subunit 1	0.062
HERC2	hect domain and RLD 2	0.062
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.058
CBX5	chromobox homolog 5	0.057
AXIN2	axin 2	0.057
CCNB2	cyclin B2	0.056
TP53BP1	tumor protein p53 binding protein 1	0.056
KIF18A	kinesin family member 18A	0.056
PXN	paxillin	0.053
FYN	FYN oncogene related to SRC, FGR, YES	0.050
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.049
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.047
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.047
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.046
SMAD2	SMAD family member 2	0.046
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.046
TFDP1	transcription factor Dp-1	0.046
PSMB6	proteasome (prosome, macropain) subunit, beta type, 6	0.045
TRIP13	thyroid hormone receptor interactor 13	0.044
PRRC2C	proline-rich coiled-coil 2C	0.043
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.043
PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7	0.042
MYST1	MYST histone acetyltransferase 1	0.042
CCNE1	cyclin E1	0.042	Fly
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.040
CLSPN	claspin	0.038
ANAPC16	anaphase promoting complex subunit 16	0.037
SIRT2	sirtuin 2	0.037
C19orf39	chromosome 19 open reading frame 39	0.036
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.036
PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	0.036
SMC4	structural maintenance of chromosomes 4	0.036
TOP3A	topoisomerase (DNA) III alpha	0.034
ANAPC10	anaphase promoting complex subunit 10	0.034	Yeast
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.033
SMC3	structural maintenance of chromosomes 3	0.032
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.032
TUBB2C	tubulin, beta 2C	0.032
C13orf34	chromosome 13 open reading frame 34	0.031
KPNB1	karyopherin (importin) beta 1	0.031
HIST1H4A	histone cluster 1, H4a	0.030
APC	adenomatous polyposis coli	0.029
PSMB3	proteasome (prosome, macropain) subunit, beta type, 3	0.029
CUL1	cullin 1	0.029
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.028
GSK3B	glycogen synthase kinase 3 beta	0.028	Fly
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.028
TUBB3	tubulin, beta 3	0.027
ORC3	origin recognition complex, subunit 3	0.027
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.027
PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.027
PSMD10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.026
RFWD2	ring finger and WD repeat domain 2	0.026
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.026
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.026
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.025
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.025
ANAPC1	anaphase promoting complex subunit 1	0.024	Worm Fly
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.024
CCND1	cyclin D1	0.024
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.023
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.023
USP49	ubiquitin specific peptidase 49	0.023	Human
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.022
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.022
ATMIN	ATM interactor	0.022
ANKRD52	ankyrin repeat domain 52	0.022
USP44	ubiquitin specific peptidase 44	0.022
PRNP	prion protein	0.022
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.022
HUWE1	HECT, UBA and WWE domain containing 1	0.021
CCND3	cyclin D3	0.021
MYH9	myosin, heavy chain 9, non-muscle	0.020
CUL2	cullin 2	0.020
PPME1	protein phosphatase methylesterase 1	0.020
KDM4A	lysine (K)-specific demethylase 4A	0.020
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.020
PSMD8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	0.020
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.020
CREBBP	CREB binding protein	0.020
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.019
EML2	echinoderm microtubule associated protein like 2	0.019
KIAA1279	KIAA1279	0.019
E2F1	E2F transcription factor 1	0.019
L3MBTL1	l(3)mbt-like 1 (Drosophila)	0.019
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.019
CKS2	CDC28 protein kinase regulatory subunit 2	0.019
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.018
UCHL5	ubiquitin carboxyl-terminal hydrolase L5	0.018
MCM10	minichromosome maintenance complex component 10	0.018
STRN3	striatin, calmodulin binding protein 3	0.018
AXIN1	axin 1	0.018
PSMB4	proteasome (prosome, macropain) subunit, beta type, 4	0.018
RBBP8	retinoblastoma binding protein 8	0.018
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.018
E2F5	E2F transcription factor 5, p130-binding	0.018
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.018
IGF1R	insulin-like growth factor 1 receptor	0.018
RBL2	retinoblastoma-like 2 (p130)	0.017	Human
CCDC85B	coiled-coil domain containing 85B	0.017
ERBB2IP	erbb2 interacting protein	0.017
TTK	TTK protein kinase	0.017	Yeast
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.017
CBX1	chromobox homolog 1	0.017
ARIH2	ariadne homolog 2 (Drosophila)	0.017
TAGLN2	transgelin 2	0.017
EML4	echinoderm microtubule associated protein like 4	0.017
ZNF828	zinc finger protein 828	0.017
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.017
CCT3	chaperonin containing TCP1, subunit 3 (gamma)	0.017
KIF5B	kinesin family member 5B	0.017
TCP1	t-complex 1	0.016
HIST1H1B	histone cluster 1, H1b	0.016
IQGAP1	IQ motif containing GTPase activating protein 1	0.016
ZNHIT3	zinc finger, HIT-type containing 3	0.016
BTRC	beta-transducin repeat containing	0.016
VHL	von Hippel-Lindau tumor suppressor	0.016
SGOL2	shugoshin-like 2 (S. pombe)	0.016
PTK2	PTK2 protein tyrosine kinase 2	0.016
HIST1H4F	histone cluster 1, H4f	0.016
TOR1AIP2	torsin A interacting protein 2	0.016
WBP4	WW domain binding protein 4 (formin binding protein 21)	0.016
MIS18BP1	MIS18 binding protein 1	0.016
FRG1	FSHD region gene 1	0.016
PSMB5	proteasome (prosome, macropain) subunit, beta type, 5	0.016
SKA1	spindle and kinetochore associated complex subunit 1	0.016
CSNK1E	casein kinase 1, epsilon	0.016
NSMCE2	non-SMC element 2, MMS21 homolog (S. cerevisiae)	0.016
TROAP	trophinin associated protein (tastin)	0.016
HIST1H2AB	histone cluster 1, H2ab	0.015
PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	0.015
SERTAD4	SERTA domain containing 4	0.015
BRCA1	breast cancer 1, early onset	0.015
ATAD2	ATPase family, AAA domain containing 2	0.015
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.015
CCNE2	cyclin E2	0.015	Fly
NDNL2	necdin-like 2	0.015
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.015
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.015
CCDC99	coiled-coil domain containing 99	0.015
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.015
MT1A	metallothionein 1A	0.015
AURKB	aurora kinase B	0.015
SMC5	structural maintenance of chromosomes 5	0.014
EIF3A	eukaryotic translation initiation factor 3, subunit A	0.014
CARD11	caspase recruitment domain family, member 11	0.014
HIST1H3A	histone cluster 1, H3a	0.014	Yeast
HIST1H3F	histone cluster 1, H3f	0.014
CCDC101	coiled-coil domain containing 101	0.014
RB1	retinoblastoma 1	0.014
HIST1H2BB	histone cluster 1, H2bb	0.014
ZFR	zinc finger RNA binding protein	0.014
BCL2	B-cell CLL/lymphoma 2	0.014
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.013
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.013
HIST1H3B	histone cluster 1, H3b	0.013	Yeast
VCP	valosin containing protein	0.013
SLC39A7	solute carrier family 39 (zinc transporter), member 7	0.013
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.013
DEPDC1	DEP domain containing 1	0.013
ARRB1	arrestin, beta 1	0.013
NRD1	nardilysin (N-arginine dibasic convertase)	0.013
TPR	translocated promoter region (to activated MET oncogene)	0.013
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.012
LIN54	lin-54 homolog (C. elegans)	0.012
LMNA	lamin A/C	0.012
HIST1H4B	histone cluster 1, H4b	0.012
MAD2L1BP	MAD2L1 binding protein	0.012
VCL	vinculin	0.012
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.012
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.012
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.012
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.012
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.012
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.012
DCLRE1C	DNA cross-link repair 1C	0.012
C13orf27	chromosome 13 open reading frame 27	0.012
GTF2F2	general transcription factor IIF, polypeptide 2, 30kDa	0.012
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.012
HIST1H2AL	histone cluster 1, H2al	0.012
KDM5C	lysine (K)-specific demethylase 5C	0.012
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.012
TPP2	tripeptidyl peptidase II	0.012
PAIP1	poly(A) binding protein interacting protein 1	0.012
TACC2	transforming, acidic coiled-coil containing protein 2	0.012
USP9X	ubiquitin specific peptidase 9, X-linked	0.012
PRC1	protein regulator of cytokinesis 1	0.012
HIST1H1E	histone cluster 1, H1e	0.011
MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.011
UBE2C	ubiquitin-conjugating enzyme E2C	0.011
MKRN1	makorin ring finger protein 1	0.011
UTP18	UTP18, small subunit (SSU) processome component, homolog (yeast)	0.011
FOXM1	forkhead box M1	0.011
MED1	mediator complex subunit 1	0.011
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.011
MTMR2	myotubularin related protein 2	0.011
COTL1	coactosin-like 1 (Dictyostelium)	0.011
PPP5C	protein phosphatase 5, catalytic subunit	0.011
CUL5	cullin 5	0.011
DCLRE1B	DNA cross-link repair 1B	0.011
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.011	Fly
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.011
AIRE	autoimmune regulator	0.011
HIST1H4D	histone cluster 1, H4d	0.011
MLL2	myeloid/lymphoid or mixed-lineage leukemia 2	0.011
PLRG1	pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)	0.011
MYO1C	myosin IC	0.011
TTC35	tetratricopeptide repeat domain 35	0.011
USP1	ubiquitin specific peptidase 1	0.011
SCAF11	SR-related CTD-associated factor 11	0.011
HIST1H3I	histone cluster 1, H3i	0.011	Yeast
ADRB2	adrenergic, beta-2-, receptor, surface	0.011
MLL3	myeloid/lymphoid or mixed-lineage leukemia 3	0.011
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.011
RBBP5	retinoblastoma binding protein 5	0.011
HIST1H2BM	histone cluster 1, H2bm	0.011
CAST	calpastatin	0.011
MRPS31	mitochondrial ribosomal protein S31	0.011
BAG2	BCL2-associated athanogene 2	0.011
CCND2	cyclin D2	0.011
HDGFRP2	hepatoma-derived growth factor-related protein 2	0.011
MDC1	mediator of DNA-damage checkpoint 1	0.011
SUGT1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	0.011
MCF2	MCF.2 cell line derived transforming sequence	0.011
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.011
HIST1H3G	histone cluster 1, H3g	0.010
PSMD5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.010
EML3	echinoderm microtubule associated protein like 3	0.010
HIST1H3C	histone cluster 1, H3c	0.010	Yeast
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.010
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.010
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.010
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.010
JUP	junction plakoglobin	0.010
KIF4A	kinesin family member 4A	0.010
KIF2C	kinesin family member 2C	0.010
DCAF15	DDB1 and CUL4 associated factor 15	0.010
DHX29	DEAH (Asp-Glu-Ala-His) box polypeptide 29	0.010
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.010
PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	0.010