IMP

Process View

Mus musculus

22 genes annotated in mouse

regulation of extrinsic apoptotic signaling pathway via death domain receptors

GO:1902041

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of extrinsic apoptotic signaling pathway via death domain receptors"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of extrinsic apoptotic signaling pathway via death domain receptors" (in gray)

Name	Description	Probability	Func Analog Organism
Apc	adenomatosis polyposis coli	0.983
Tgfbr2	transforming growth factor, beta receptor II	0.794	Mouse
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.654
Ptgs2	prostaglandin-endoperoxide synthase 2	0.619
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.567
Braf	Braf transforming gene	0.558	Mouse
Pten	phosphatase and tensin homolog	0.552
Notch1	Notch gene homolog 1 (Drosophila)	0.540
Mdm2	transformed mouse 3T3 cell double minute 2	0.530
Fas	Fas (TNF receptor superfamily member 6)	0.505
Cd44	CD44 antigen	0.485
Notch2	Notch gene homolog 2 (Drosophila)	0.470
Tgfbr1	transforming growth factor, beta receptor I	0.403	Mouse
Trp53	transformation related protein 53	0.381
Psen1	presenilin 1	0.289	Mouse
Fgfr2	fibroblast growth factor receptor 2	0.258
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.239
Mmp9	matrix metallopeptidase 9	0.231
Vegfa	vascular endothelial growth factor A	0.200
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.152
Egfr	epidermal growth factor receptor	0.151
Ccl2	chemokine (C-C motif) ligand 2	0.134
Esr1	estrogen receptor 1 (alpha)	0.126
Nos1	nitric oxide synthase 1, neuronal	0.119
Casp8	caspase 8	0.115
Acvr1	activin A receptor, type 1	0.110	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.103
Tlr4	toll-like receptor 4	0.099
Lyz2	lysozyme 2	0.090
Fgg	fibrinogen gamma chain	0.083
Nos2	nitric oxide synthase 2, inducible	0.079
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.078
Eng	endoglin	0.068
Stat3	signal transducer and activator of transcription 3	0.064
Smad4	MAD homolog 4 (Drosophila)	0.062
Nos3	nitric oxide synthase 3, endothelial cell	0.061
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.060	Mouse
Rxra	retinoid X receptor alpha	0.060
Foxc1	forkhead box C1	0.060
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.058
Il6st	interleukin 6 signal transducer	0.056
Ncstn	nicastrin	0.054
Pvr	poliovirus receptor	0.052
Vhl	von Hippel-Lindau tumor suppressor	0.052
Apoa1	apolipoprotein A-I	0.051
Cav1	caveolin 1, caveolae protein	0.051
Adam17	a disintegrin and metallopeptidase domain 17	0.051
Sufu	suppressor of fused homolog (Drosophila)	0.050
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.050
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.049
Hif1a	hypoxia inducible factor 1, alpha subunit	0.047
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.047
Fst	follistatin	0.047
Rb1	retinoblastoma 1	0.044
Csf1	colony stimulating factor 1 (macrophage)	0.044
Mcl1	myeloid cell leukemia sequence 1	0.043
Runx1	runt related transcription factor 1	0.042
Thbs1	thrombospondin 1	0.042	Human
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.042
Ambp	alpha 1 microglobulin/bikunin	0.041
Tmpo	thymopoietin	0.039
Ptch1	patched homolog 1	0.038
Trp73	transformation related protein 73	0.038
Inhba	inhibin beta-A	0.038
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.037
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.036
Bcl2	B-cell leukemia/lymphoma 2	0.034
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.034
Plaur	plasminogen activator, urokinase receptor	0.033
Rras	Harvey rat sarcoma oncogene, subgroup R	0.033
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.033
Plau	plasminogen activator, urokinase	0.032	Mouse
Kit	kit oncogene	0.031
Psen2	presenilin 2	0.031
Plg	plasminogen	0.031	Mouse
Itgb3	integrin beta 3	0.030
Il4ra	interleukin 4 receptor, alpha	0.030
F2	coagulation factor II	0.029
Cyld	cylindromatosis (turban tumor syndrome)	0.029
Aph1a	anterior pharynx defective 1a homolog (C. elegans)	0.029
Fgfr1	fibroblast growth factor receptor 1	0.029
Fzd1	frizzled homolog 1 (Drosophila)	0.028
Myc	myelocytomatosis oncogene	0.028
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.028
Rbl1	retinoblastoma-like 1 (p107)	0.027
Pml	promyelocytic leukemia	0.027
Sav1	salvador homolog 1 (Drosophila)	0.027
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.026
Lif	leukemia inhibitory factor	0.026
Coq7	demethyl-Q 7	0.026
Ldlr	low density lipoprotein receptor	0.025
Stk4	serine/threonine kinase 4	0.025
Klf3	Kruppel-like factor 3 (basic)	0.025
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.025
Skil	SKI-like	0.024
Fadd	Fas (TNFRSF6)-associated via death domain	0.023
Stxbp5	syntaxin binding protein 5 (tomosyn)	0.023
Ednra	endothelin receptor type A	0.023
Kitl	kit ligand	0.023
S100a6	S100 calcium binding protein A6 (calcyclin)	0.022
Xiap	X-linked inhibitor of apoptosis	0.022
Ctnnb1	catenin (cadherin associated protein), beta 1	0.022
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.022
Ikbkb	inhibitor of kappaB kinase beta	0.022
Apoa4	apolipoprotein A-IV	0.021
Pnpla6	patatin-like phospholipase domain containing 6	0.021
Nod2	nucleotide-binding oligomerization domain containing 2	0.021
Lmna	lamin A	0.021
Ednrb	endothelin receptor type B	0.021
Ier3	immediate early response 3	0.021
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.021
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.021
Tgfbr3	transforming growth factor, beta receptor III	0.020
Zfp36	zinc finger protein 36	0.020
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.020
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.020
Atf3	activating transcription factor 3	0.020
Smad7	MAD homolog 7 (Drosophila)	0.020
Hnf4a	hepatic nuclear factor 4, alpha	0.020
Pgr	progesterone receptor	0.020
Ahsg	alpha-2-HS-glycoprotein	0.019
Kng1	kininogen 1	0.019
Sertad1	SERTA domain containing 1	0.019
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.019
Stk11	serine/threonine kinase 11	0.019
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.019
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.019
Lyst	lysosomal trafficking regulator	0.018
Shc1	src homology 2 domain-containing transforming protein C1	0.018
Ret	ret proto-oncogene	0.018
Itch	itchy, E3 ubiquitin protein ligase	0.018
Wrn	Werner syndrome homolog (human)	0.018
Ptma	prothymosin alpha	0.018
Cd9	CD9 antigen	0.018
Anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.018
Qsox1	quiescin Q6 sulfhydryl oxidase 1	0.017
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.017
Gnrh1	gonadotropin releasing hormone 1	0.017
Emp1	epithelial membrane protein 1	0.017
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.017
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.017
Raf1	v-raf-leukemia viral oncogene 1	0.017
Inhbb	inhibin beta-B	0.017
Osmr	oncostatin M receptor	0.017
Anxa1	annexin A1	0.017
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.017
Spp1	secreted phosphoprotein 1	0.017
Ext1	exostoses (multiple) 1	0.016
Litaf	LPS-induced TN factor	0.016
Ece1	endothelin converting enzyme 1	0.016
Selp	selectin, platelet	0.016
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.016
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.016
Cpd	carboxypeptidase D	0.016
Ncoa3	nuclear receptor coactivator 3	0.016
Mvp	major vault protein	0.016
Socs3	suppressor of cytokine signaling 3	0.016
Daxx	Fas death domain-associated protein	0.016
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.015
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.015
Cxcl2	chemokine (C-X-C motif) ligand 2	0.015
Hip1	huntingtin interacting protein 1	0.015
Il6	interleukin 6	0.015
Itih1	inter-alpha trypsin inhibitor, heavy chain 1	0.015
Hipk3	homeodomain interacting protein kinase 3	0.015
Mapk14	mitogen-activated protein kinase 14	0.015
Epas1	endothelial PAS domain protein 1	0.014
Ifngr1	interferon gamma receptor 1	0.014
Sox9	SRY-box containing gene 9	0.014
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.014
Igh	immunoglobulin heavy chain complex	0.014
Cxcr4	chemokine (C-X-C motif) receptor 4	0.014
Ikbkg	inhibitor of kappaB kinase gamma	0.014
Meox2	mesenchyme homeobox 2	0.014
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.014
Apof	apolipoprotein F	0.014
Tgm2	transglutaminase 2, C polypeptide	0.014
Anxa2	annexin A2	0.014
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.014
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.014
Stat6	signal transducer and activator of transcription 6	0.014
Cfi	complement component factor i	0.014
Aff1	AF4/FMR2 family, member 1	0.014
Pkd1	polycystic kidney disease 1 homolog	0.013
Pofut1	protein O-fucosyltransferase 1	0.013
Apaf1	apoptotic peptidase activating factor 1	0.013
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.013	Mouse
Il1r1	interleukin 1 receptor, type I	0.013
Casp3	caspase 3	0.013
Vav2	vav 2 oncogene	0.013
Gc	group specific component	0.013
Met	met proto-oncogene	0.013
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.013
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.013
Hnrnpa1	heterogeneous nuclear ribonucleoprotein A1	0.013
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.013
Gata4	GATA binding protein 4	0.013
Efnb2	ephrin B2	0.013
Apom	apolipoprotein M	0.013
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.013
Zc3h12a	zinc finger CCCH type containing 12A	0.013
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.013
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.013
Apoe	apolipoprotein E	0.013
Iqgap1	IQ motif containing GTPase activating protein 1	0.013
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.013
Vcl	vinculin	0.013
Ccr1	chemokine (C-C motif) receptor 1	0.013
Traf6	TNF receptor-associated factor 6	0.013
Dll1	delta-like 1 (Drosophila)	0.013
Cldn2	claudin 2	0.013
Hs2st1	heparan sulfate 2-O-sulfotransferase 1	0.013
Smad5	MAD homolog 5 (Drosophila)	0.012
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.012
Erlin2	ER lipid raft associated 2	0.012
Egr1	early growth response 1	0.012
Ptrf	polymerase I and transcript release factor	0.012
Fxyd5	FXYD domain-containing ion transport regulator 5	0.012
Ch25h	cholesterol 25-hydroxylase	0.012
Sntb2	syntrophin, basic 2	0.012
Tgfb1	transforming growth factor, beta 1	0.012
Prr13	proline rich 13	0.012
Kif3a	kinesin family member 3A	0.012
Irf1	interferon regulatory factor 1	0.012
Msh2	mutS homolog 2 (E. coli)	0.012
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.012
Cyp2d10	cytochrome P450, family 2, subfamily d, polypeptide 10	0.012
Nt5e	5' nucleotidase, ecto	0.012
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.012
Adm	adrenomedullin	0.012
Atr	ataxia telangiectasia and Rad3 related	0.012
Dck	deoxycytidine kinase	0.011
Cbl	Casitas B-lineage lymphoma	0.011
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.011
Gsn	gelsolin	0.011
Nfib	nuclear factor I/B	0.011
Lrdd	leucine-rich and death domain containing	0.011
Prkg1	protein kinase, cGMP-dependent, type I	0.011
Hdac2	histone deacetylase 2	0.011
Itgav	integrin alpha V	0.011
Spnb2	spectrin beta 2	0.011
St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.011
Cpn1	carboxypeptidase N, polypeptide 1	0.011
Rbbp4	retinoblastoma binding protein 4	0.011
App	amyloid beta (A4) precursor protein	0.011
Ccr2	chemokine (C-C motif) receptor 2	0.011
Fbn1	fibrillin 1	0.011
Prss23	protease, serine, 23	0.011
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.011
Mapk3	mitogen-activated protein kinase 3	0.011
Fosl2	fos-like antigen 2	0.011
Mat1a	methionine adenosyltransferase I, alpha	0.011
Anxa5	annexin A5	0.011
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.011
Plxna1	plexin A1	0.011
Xpa	xeroderma pigmentosum, complementation group A	0.011
C3	complement component 3	0.011
Car5a	carbonic anhydrase 5a, mitochondrial	0.011
Agxt	alanine-glyoxylate aminotransferase	0.011
Itgb5	integrin beta 5	0.010
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.010
Junb	Jun-B oncogene	0.010
Stmn1	stathmin 1	0.010
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.010
Mxd4	Max dimerization protein 4	0.010
Brca2	breast cancer 2	0.010
Ces1c	carboxylesterase 1C	0.010
Cflar	CASP8 and FADD-like apoptosis regulator	0.010	Human
Myd88	myeloid differentiation primary response gene 88	0.010
Akt3	thymoma viral proto-oncogene 3	0.010
Anxa8	annexin A8	0.010
Rarg	retinoic acid receptor, gamma	0.010
Rara	retinoic acid receptor, alpha	0.010
Pltp	phospholipid transfer protein	0.010
Actn1	actinin, alpha 1	0.010
Diablo	diablo homolog (Drosophila)	0.010
Nupr1	nuclear protein 1	0.010
Plat	plasminogen activator, tissue	0.010	Mouse
Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3	0.010
Lect2	leukocyte cell-derived chemotaxin 2	0.010