IMP

Process View

Homo sapiens

39 genes annotated in human

cellular response to mechanical stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	0.999
CFLAR	CASP8 and FADD-like apoptosis regulator	0.998
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.997
BCL2L1	BCL2-like 1	0.996	Human
TRAF1	TNF receptor-associated factor 1	0.990
MAPK14	mitogen-activated protein kinase 14	0.988	Human
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.986	Human
FADD	Fas (TNFRSF6)-associated via death domain	0.983
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.975	Human
MYD88	myeloid differentiation primary response gene (88)	0.971
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.915	Human
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.913	Human
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.893
XIAP	X-linked inhibitor of apoptosis	0.860
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.859
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.822	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.759
IL1R1	interleukin 1 receptor, type I	0.758
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.713	Human
BCL3	B-cell CLL/lymphoma 3	0.687
APAF1	apoptotic peptidase activating factor 1	0.664
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.653
ATF2	activating transcription factor 2	0.643
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.643
MAPK8	mitogen-activated protein kinase 8	0.636
CASP2	caspase 2, apoptosis-related cysteine peptidase	0.588
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.508
BID	BH3 interacting domain death agonist	0.502
BMPR1A	bone morphogenetic protein receptor, type IA	0.458
PLAUR	plasminogen activator, urokinase receptor	0.429
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.428
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.402
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.379
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.376
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.362	Human
TP53	tumor protein p53	0.350
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.345	Human
GBP2	guanylate binding protein 2, interferon-inducible	0.340
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.337
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.328
TRAF5	TNF receptor-associated factor 5	0.324
CD40	CD40 molecule, TNF receptor superfamily member 5	0.321
BAK1	BCL2-antagonist/killer 1	0.316
GADD45GIP1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	0.303
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.302
NLRC4	NLR family, CARD domain containing 4	0.297
IRF1	interferon regulatory factor 1	0.295
STAT2	signal transducer and activator of transcription 2, 113kDa	0.294
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.288	Human
PLAU	plasminogen activator, urokinase	0.283
TRADD	TNFRSF1A-associated via death domain	0.270
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.269
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.267
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.256
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.250
NOSTRIN	nitric oxide synthase trafficker	0.245
PRKD2	protein kinase D2	0.244
HSPB8	heat shock 22kDa protein 8	0.242
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.241
LRDD	leucine-rich repeats and death domain containing	0.236
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.214	Human
ARRB2	arrestin, beta 2	0.212
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.204
TLR2	toll-like receptor 2	0.201
LRRK2	leucine-rich repeat kinase 2	0.199
SOCS3	suppressor of cytokine signaling 3	0.199
KCNIP2	Kv channel interacting protein 2	0.194
BAX	BCL2-associated X protein	0.184	Human
IL8	interleukin 8	0.179
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.178
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.170
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.159	Rat
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.159	Human
MAP2K4	mitogen-activated protein kinase kinase 4	0.156
MAPK9	mitogen-activated protein kinase 9	0.155	Human
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.154
DUSP1	dual specificity phosphatase 1	0.151
C9orf89	chromosome 9 open reading frame 89	0.151
LY96	lymphocyte antigen 96	0.148
JUN	jun proto-oncogene	0.147
CHUK	conserved helix-loop-helix ubiquitous kinase	0.138
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.136
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.132
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.125
BAD	BCL2-associated agonist of cell death	0.121
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.119
TLR4	toll-like receptor 4	0.118
FAM101B	family with sequence similarity 101, member B	0.118
TRAF2	TNF receptor-associated factor 2	0.115
VAC14	Vac14 homolog (S. cerevisiae)	0.108
FLNA	filamin A, alpha	0.106
HSPB1	heat shock 27kDa protein 1	0.105
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.100
ICAM1	intercellular adhesion molecule 1	0.099
HSPA1B	heat shock 70kDa protein 1B	0.093
CRYAB	crystallin, alpha B	0.092
AR	androgen receptor	0.091
KAT2B	K(lysine) acetyltransferase 2B	0.090
PIAS4	protein inhibitor of activated STAT, 4	0.084
TRIM21	tripartite motif containing 21	0.083
TNF	tumor necrosis factor	0.083
PLAT	plasminogen activator, tissue	0.082
RIPK2	receptor-interacting serine-threonine kinase 2	0.082
CSTA	cystatin A (stefin A)	0.079
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.076
MAP2K5	mitogen-activated protein kinase kinase 5	0.076
MAPK1	mitogen-activated protein kinase 1	0.075	Human
TLR1	toll-like receptor 1	0.074	Human
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.073
CTSS	cathepsin S	0.073
TRAF3	TNF receptor-associated factor 3	0.071
IRF7	interferon regulatory factor 7	0.069	Human
ARRB1	arrestin, beta 1	0.069
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.068
BCL2A1	BCL2-related protein A1	0.067
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.066
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.063
IRAK1	interleukin-1 receptor-associated kinase 1	0.063
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.062	Human
IFI16	interferon, gamma-inducible protein 16	0.061
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.061
COL1A2	collagen, type I, alpha 2	0.060
ADAMTSL4	ADAMTS-like 4	0.060
IER2	immediate early response 2	0.060
MYH9	myosin, heavy chain 9, non-muscle	0.057
HDAC4	histone deacetylase 4	0.055	Rat
RGS2	regulator of G-protein signaling 2, 24kDa	0.054
CARD11	caspase recruitment domain family, member 11	0.053
IFI35	interferon-induced protein 35	0.052
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.052
BBC3	BCL2 binding component 3	0.049
BIRC3	baculoviral IAP repeat containing 3	0.049
BBS10	Bardet-Biedl syndrome 10	0.048
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.047
ELF4	E74-like factor 4 (ets domain transcription factor)	0.047
LMNA	lamin A/C	0.042
SQSTM1	sequestosome 1	0.041
SPHK1	sphingosine kinase 1	0.041
ZYX	zyxin	0.041
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.040	Human
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.040
IGFBP3	insulin-like growth factor binding protein 3	0.040
COL4A1	collagen, type IV, alpha 1	0.040
RNF144B	ring finger protein 144B	0.039
SNAI1	snail homolog 1 (Drosophila)	0.039
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.038
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.037
VIM	vimentin	0.037
THBS1	thrombospondin 1	0.037
LMO4	LIM domain only 4	0.036
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.036
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.036
ITGB1BP1	integrin beta 1 binding protein 1	0.034
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	0.034
HSPA1A	heat shock 70kDa protein 1A	0.034
FAM107A	family with sequence similarity 107, member A	0.034
PLSCR1	phospholipid scramblase 1	0.032
BTRC	beta-transducin repeat containing	0.032
FASLG	Fas ligand (TNF superfamily, member 6)	0.031	Human
C1orf93	chromosome 1 open reading frame 93	0.030
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.030
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.030
FSTL1	follistatin-like 1	0.030
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.029
CD63	CD63 molecule	0.029
MPRIP	myosin phosphatase Rho interacting protein	0.029
NOTCH1	notch 1	0.029
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.029
GNB5	guanine nucleotide binding protein (G protein), beta 5	0.028
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.028
SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.028
ITGA6	integrin, alpha 6	0.028
IRF3	interferon regulatory factor 3	0.028	Human
FLNB	filamin B, beta	0.027
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.027
IL1R2	interleukin 1 receptor, type II	0.027
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.027	Human
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.026
TP53BP2	tumor protein p53 binding protein, 2	0.026
DUSP9	dual specificity phosphatase 9	0.026
TPM1	tropomyosin 1 (alpha)	0.026
MIDN	midnolin	0.026
NUCB2	nucleobindin 2	0.025
PIAS1	protein inhibitor of activated STAT, 1	0.025
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.025
CARD16	caspase recruitment domain family, member 16	0.025
IRAK2	interleukin-1 receptor-associated kinase 2	0.024
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.024
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.024
IL15RA	interleukin 15 receptor, alpha	0.023
APP	amyloid beta (A4) precursor protein	0.023
EDN1	endothelin 1	0.023
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.023
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.023
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.023
MAP2K7	mitogen-activated protein kinase kinase 7	0.023	Human
TICAM2	toll-like receptor adaptor molecule 2	0.023
DBN1	drebrin 1	0.022
MYL9	myosin, light chain 9, regulatory	0.022
EGR3	early growth response 3	0.022
TRAF6	TNF receptor-associated factor 6	0.022
ENG	endoglin	0.021
IGF2R	insulin-like growth factor 2 receptor	0.021
ISG20	interferon stimulated exonuclease gene 20kDa	0.020
CCR1	chemokine (C-C motif) receptor 1	0.020
CPNE6	copine VI (neuronal)	0.020
RNR2	l-rRNA	0.020
BCL2L2	BCL2-like 2	0.020	Human
IL15	interleukin 15	0.020
PKN1	protein kinase N1	0.020
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.020
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.020
HTT	huntingtin	0.020
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.019
CREBBP	CREB binding protein	0.019
MAP2K6	mitogen-activated protein kinase kinase 6	0.019	Human
SP1	Sp1 transcription factor	0.019
TPM4	tropomyosin 4	0.019
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.019
LOX	lysyl oxidase	0.019
EHD1	EH-domain containing 1	0.018
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	0.018
TRIM22	tripartite motif containing 22	0.018
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.018	Rat
EGLN1	egl nine homolog 1 (C. elegans)	0.018
HSPB2	heat shock 27kDa protein 2	0.018
TMEM11	transmembrane protein 11	0.018
KIAA1377	KIAA1377	0.018
CLSPN	claspin	0.018
IRF2BP2	interferon regulatory factor 2 binding protein 2	0.018
KIF1C	kinesin family member 1C	0.018
TTN	titin	0.018
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.018	Rat
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.018
GADD45B	growth arrest and DNA-damage-inducible, beta	0.017	Human
STX11	syntaxin 11	0.017
AMBP	alpha-1-microglobulin/bikunin precursor	0.017
ORM1	orosomucoid 1	0.017
CYR61	cysteine-rich, angiogenic inducer, 61	0.017
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.017
OPTN	optineurin	0.017
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.017
KYNU	kynureninase	0.017
LY86	lymphocyte antigen 86	0.017
PRDM1	PR domain containing 1, with ZNF domain	0.017
IL1A	interleukin 1, alpha	0.016	Human
MAPK3	mitogen-activated protein kinase 3	0.016
CD9	CD9 molecule	0.016
IGFBP5	insulin-like growth factor binding protein 5	0.016
CXCL10	chemokine (C-X-C motif) ligand 10	0.016
PML	promyelocytic leukemia	0.016
INHBA	inhibin, beta A	0.016
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.016	Rat
EFHD2	EF-hand domain family, member D2	0.016
NMI	N-myc (and STAT) interactor	0.016
TGOLN2	trans-golgi network protein 2	0.016
VNN2	vanin 2	0.016
MAPK15	mitogen-activated protein kinase 15	0.016
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.016
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.015
IL10	interleukin 10	0.015
VDAC1	voltage-dependent anion channel 1	0.015
ELK1	ELK1, member of ETS oncogene family	0.015
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.015
RXRA	retinoid X receptor, alpha	0.015
FGA	fibrinogen alpha chain	0.015
MT2A	metallothionein 2A	0.015
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.015
TIMP1	TIMP metallopeptidase inhibitor 1	0.015
VTN	vitronectin	0.015
XPO7	exportin 7	0.015
TIFA	TRAF-interacting protein with forkhead-associated domain	0.015
DUSP16	dual specificity phosphatase 16	0.015
ADM	adrenomedullin	0.014
KCNIP1	Kv channel interacting protein 1	0.014
IRF8	interferon regulatory factor 8	0.014	Human
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.014
BTK	Bruton agammaglobulinemia tyrosine kinase	0.014
RAI1	retinoic acid induced 1	0.014
SFN	stratifin	0.014
EZR	ezrin	0.014
GLIS2	GLIS family zinc finger 2	0.014
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.014
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.014
KCTD17	potassium channel tetramerisation domain containing 17	0.014
FHL2	four and a half LIM domains 2	0.014
CD14	CD14 molecule	0.013
S100A9	S100 calcium binding protein A9	0.013
RB1	retinoblastoma 1	0.013
POU2F2	POU class 2 homeobox 2	0.013
PSEN1	presenilin 1	0.013
IL18	interleukin 18 (interferon-gamma-inducing factor)	0.013
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.013
OBSL1	obscurin-like 1	0.013
IRAK3	interleukin-1 receptor-associated kinase 3	0.013
DUSP4	dual specificity phosphatase 4	0.013
HDAC5	histone deacetylase 5	0.013
TLR6	toll-like receptor 6	0.013	Human
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.013
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.013
IL4R	interleukin 4 receptor	0.013
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.012
MARK2	MAP/microtubule affinity-regulating kinase 2	0.012
PDLIM7	PDZ and LIM domain 7 (enigma)	0.012
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.012
FGFR1	fibroblast growth factor receptor 1	0.012
HCK	hemopoietic cell kinase	0.012
MSR1	macrophage scavenger receptor 1	0.012
ALPL	alkaline phosphatase, liver/bone/kidney	0.012
CTGF	connective tissue growth factor	0.012
SOCS1	suppressor of cytokine signaling 1	0.012
TUBB2B	tubulin, beta 2B	0.012
STAT1	signal transducer and activator of transcription 1, 91kDa	0.012
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.012
C4orf14	chromosome 4 open reading frame 14	0.012
IRF2	interferon regulatory factor 2	0.012	Human
PARD3B	par-3 partitioning defective 3 homolog B (C. elegans)	0.012
CYBB	cytochrome b-245, beta polypeptide	0.012
ZBTB48	zinc finger and BTB domain containing 48	0.012
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.012
MR1	major histocompatibility complex, class I-related	0.012
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.012
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.012
TAOK2	TAO kinase 2	0.011
PIK3CD	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.011
STAP2	signal transducing adaptor family member 2	0.011
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.011
SMAD1	SMAD family member 1	0.011
NPC2	Niemann-Pick disease, type C2	0.011
IL10RB	interleukin 10 receptor, beta	0.011
IGF1R	insulin-like growth factor 1 receptor	0.011
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.011
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.011
PDPK1	3-phosphoinositide dependent protein kinase-1	0.011
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.011
BATF	basic leucine zipper transcription factor, ATF-like	0.011
VWF	von Willebrand factor	0.011
JAK3	Janus kinase 3	0.011
C1orf38	chromosome 1 open reading frame 38	0.011
MDFI	MyoD family inhibitor	0.011
SQRDL	sulfide quinone reductase-like (yeast)	0.011
TNFRSF10D	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	0.011	Human
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.011
MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	0.010
TFEC	transcription factor EC	0.010
CATSPER1	cation channel, sperm associated 1	0.010
MEF2C	myocyte enhancer factor 2C	0.010
BBS1	Bardet-Biedl syndrome 1	0.010
MXD1	MAX dimerization protein 1	0.010
KIAA1274	KIAA1274	0.010
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.010
SAT1	spermidine/spermine N1-acetyltransferase 1	0.010
CD47	CD47 molecule	0.010
IGFBP4	insulin-like growth factor binding protein 4	0.010
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.010
ALDOB	aldolase B, fructose-bisphosphate	0.010
TGFB2	transforming growth factor, beta 2	0.010
WWTR1	WW domain containing transcription regulator 1	0.010