IMP

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Mus musculus

13 genes annotated in mouse

Multi-species View

negative regulation of b cell proliferation

GO:0030889

Any process that stops, prevents or reduces the rate or extent of B cell proliferation.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of b cell proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of b cell proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
Igh	immunoglobulin heavy chain complex	1.000
Cd40	CD40 antigen	0.995	Mouse
Cd19	CD19 antigen	0.977
Ptprc	protein tyrosine phosphatase, receptor type, C	0.914
Tnf	tumor necrosis factor	0.893
Inpp5d	inositol polyphosphate-5-phosphatase D	0.840
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.726
Fas	Fas (TNF receptor superfamily member 6)	0.724
Rc3h1	RING CCCH (C3H) domains 1	0.719
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.637
Prkcd	protein kinase C, delta	0.586
Btk	Bruton agammaglobulinemia tyrosine kinase	0.491	Mouse
Blnk	B-cell linker	0.413
Rb1	retinoblastoma 1	0.397
Was	Wiskott-Aldrich syndrome homolog (human)	0.311
Il2rg	interleukin 2 receptor, gamma chain	0.299
Ccr6	chemokine (C-C motif) receptor 6	0.276
Plcg2	phospholipase C, gamma 2	0.276
Cd4	CD4 antigen	0.237
Ifng	interferon gamma	0.235
Cd28	CD28 antigen	0.229
Il1r1	interleukin 1 receptor, type I	0.226
Tnip1	TNFAIP3 interacting protein 1	0.224
S1pr2	sphingosine-1-phosphate receptor 2	0.217
Lta	lymphotoxin A	0.215
Ccr7	chemokine (C-C motif) receptor 7	0.211
Bcl6	B-cell leukemia/lymphoma 6	0.208
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.206	Mouse
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.201
Pou2af1	POU domain, class 2, associating factor 1	0.185
Il6	interleukin 6	0.175
Csf1	colony stimulating factor 1 (macrophage)	0.161
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.161
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.158
Birc3	baculoviral IAP repeat-containing 3	0.149
Tlr4	toll-like receptor 4	0.148
Prdm1	PR domain containing 1, with ZNF domain	0.133
Fyn	Fyn proto-oncogene	0.133	Mouse
Lyz2	lysozyme 2	0.132
Aim2	absent in melanoma 2	0.128
Hck	hemopoietic cell kinase	0.128	Mouse
Il1b	interleukin 1 beta	0.124
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.123
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.116
Mdm2	transformed mouse 3T3 cell double minute 2	0.112
Ikzf1	IKAROS family zinc finger 1	0.095
Pycard	PYD and CARD domain containing	0.095
Gbp5	guanylate binding protein 5	0.095
Cxcr4	chemokine (C-X-C motif) receptor 4	0.088
Fasl	Fas ligand (TNF superfamily, member 6)	0.087
Pten	phosphatase and tensin homolog	0.087
Cbl	Casitas B-lineage lymphoma	0.085
Icos	inducible T-cell co-stimulator	0.077
Cd22	CD22 antigen	0.075
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.074
Bcl3	B-cell leukemia/lymphoma 3	0.072
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.071
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.068
Il27ra	interleukin 27 receptor, alpha	0.067
Nos2	nitric oxide synthase 2, inducible	0.066
Mefv	Mediterranean fever	0.065
Lck	lymphocyte protein tyrosine kinase	0.063	Mouse
Socs1	suppressor of cytokine signaling 1	0.063
Il18	interleukin 18	0.061
Grb2	growth factor receptor bound protein 2	0.060
Fadd	Fas (TNFRSF6)-associated via death domain	0.059
Cd180	CD180 antigen	0.058
Cd72	CD72 antigen	0.056
Hif1a	hypoxia inducible factor 1, alpha subunit	0.053
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.052
Ptgs2	prostaglandin-endoperoxide synthase 2	0.052
Myd88	myeloid differentiation primary response gene 88	0.052
Ptk2	PTK2 protein tyrosine kinase 2	0.051
Ccr1	chemokine (C-C motif) receptor 1	0.048
Cd38	CD38 antigen	0.046
Cd14	CD14 antigen	0.045
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.044
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.043
Dok1	docking protein 1	0.043
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.042
Il2rb	interleukin 2 receptor, beta chain	0.042
Ccl2	chemokine (C-C motif) ligand 2	0.042
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.041
Cr2	complement receptor 2	0.040
Il10	interleukin 10	0.040
C3ar1	complement component 3a receptor 1	0.040
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.040
Fcgr1	Fc receptor, IgG, high affinity I	0.040	Mouse
Ch25h	cholesterol 25-hydroxylase	0.039
Trp53	transformation related protein 53	0.038
Cd68	CD68 antigen	0.038
Prf1	perforin 1 (pore forming protein)	0.037
Cd40lg	CD40 ligand	0.037
Il4	interleukin 4	0.036
Pla2g4a	phospholipase A2, group IVA (cytosolic, calcium-dependent)	0.035
Cxcl13	chemokine (C-X-C motif) ligand 13	0.035
Ptpre	protein tyrosine phosphatase, receptor type, E	0.035
Traf2	TNF receptor-associated factor 2	0.034
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.034
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.034
Ubd	ubiquitin D	0.034
Nlrp3	NLR family, pyrin domain containing 3	0.033
Irf8	interferon regulatory factor 8	0.032
Brca1	breast cancer 1	0.032
Sorbs3	sorbin and SH3 domain containing 3	0.031
Sykb	spleen tyrosine kinase	0.031
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.030
Sfpi1	SFFV proviral integration 1	0.030
Ltb	lymphotoxin B	0.030
Rel	reticuloendotheliosis oncogene	0.029
Runx1	runt related transcription factor 1	0.028
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.027
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.027
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.027
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.027
Cd2ap	CD2-associated protein	0.026
Ripk3	receptor-interacting serine-threonine kinase 3	0.026
Cd86	CD86 antigen	0.026
Il17a	interleukin 17A	0.025
Cybb	cytochrome b-245, beta polypeptide	0.025
Ccl8	chemokine (C-C motif) ligand 8	0.025
Sell	selectin, lymphocyte	0.024
Pdcd1	programmed cell death 1	0.024
Skap2	src family associated phosphoprotein 2	0.024
Msh2	mutS homolog 2 (E. coli)	0.024
Il1a	interleukin 1 alpha	0.024
Apaf1	apoptotic peptidase activating factor 1	0.023
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.023
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.023
Pvrl2	poliovirus receptor-related 2	0.023
Cxcr5	chemokine (C-X-C motif) receptor 5	0.023
Casp8	caspase 8	0.023	Mouse
Cd96	CD96 antigen	0.022
Il13ra1	interleukin 13 receptor, alpha 1	0.022
Ebi3	Epstein-Barr virus induced gene 3	0.022
Kit	kit oncogene	0.022
Ccl4	chemokine (C-C motif) ligand 4	0.022
Irf4	interferon regulatory factor 4	0.022
Rbl1	retinoblastoma-like 1 (p107)	0.022
Bcar1	breast cancer anti-estrogen resistance 1	0.022
Sh3bp2	SH3-domain binding protein 2	0.021
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.021
Spp1	secreted phosphoprotein 1	0.021
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.021
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.021
Ltbr	lymphotoxin B receptor	0.021	Mouse
Nmi	N-myc (and STAT) interactor	0.021
Gimap1	GTPase, IMAP family member 1	0.021
Xpa	xeroderma pigmentosum, complementation group A	0.020
Parvg	parvin, gamma	0.019
Il7	interleukin 7	0.019
Ahr	aryl-hydrocarbon receptor	0.019
Slamf1	signaling lymphocytic activation molecule family member 1	0.019
Pou2f2	POU domain, class 2, transcription factor 2	0.019
Fcrl1	Fc receptor-like 1	0.019
Mcoln2	mucolipin 2	0.019
Stat6	signal transducer and activator of transcription 6	0.018
Clnk	cytokine-dependent hematopoietic cell linker	0.018
Plscr1	phospholipid scramblase 1	0.018
Asprv1	aspartic peptidase, retroviral-like 1	0.018
Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein	0.018
Zap70	zeta-chain (TCR) associated protein kinase	0.018
Ly96	lymphocyte antigen 96	0.018
Tlr6	toll-like receptor 6	0.018
Stk11	serine/threonine kinase 11	0.018
Drd4	dopamine receptor D4	0.018
Aif1	allograft inflammatory factor 1	0.017
Wisp2	WNT1 inducible signaling pathway protein 2	0.017
Ifitm6	interferon induced transmembrane protein 6	0.017
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.017
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.017
Blk	B lymphoid kinase	0.017	Mouse
Adam17	a disintegrin and metallopeptidase domain 17	0.017
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.016
Cfh	complement component factor h	0.016
Cyld	cylindromatosis (turban tumor syndrome)	0.016
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.016
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.016
Lat	linker for activation of T cells	0.016
Foxp3	forkhead box P3	0.016
Car6	carbonic anhydrase 6	0.016
Lama5	laminin, alpha 5	0.016
Shc1	src homology 2 domain-containing transforming protein C1	0.016
Prkce	protein kinase C, epsilon	0.016
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.016
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.016
Brca2	breast cancer 2	0.016
Casp3	caspase 3	0.016
Slpi	secretory leukocyte peptidase inhibitor	0.016
Kitl	kit ligand	0.016
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.015
Atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.015
Tgfbr1	transforming growth factor, beta receptor I	0.015
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.015
Marco	macrophage receptor with collagenous structure	0.015
Cd44	CD44 antigen	0.015
Adam10	a disintegrin and metallopeptidase domain 10	0.015
Ctnnb1	catenin (cadherin associated protein), beta 1	0.015
Plac8	placenta-specific 8	0.015
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.015
Vav1	vav 1 oncogene	0.015
Akr1b8	aldo-keto reductase family 1, member B8	0.015
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.015
Litaf	LPS-induced TN factor	0.015
Il10ra	interleukin 10 receptor, alpha	0.015
Hhex	hematopoietically expressed homeobox	0.015
Pou3f4	POU domain, class 3, transcription factor 4	0.015
Hcls1	hematopoietic cell specific Lyn substrate 1	0.015
Gna15	guanine nucleotide binding protein, alpha 15	0.015
Pdcd1lg2	programmed cell death 1 ligand 2	0.014
Cd79b	CD79B antigen	0.014
Aicda	activation-induced cytidine deaminase	0.014
Mrc1	mannose receptor, C type 1	0.014
Ptgir	prostaglandin I receptor (IP)	0.014
Dlg1	discs, large homolog 1 (Drosophila)	0.014
Ikzf3	IKAROS family zinc finger 3	0.014
Il2	interleukin 2	0.014
Arid3a	AT rich interactive domain 3A (BRIGHT-like)	0.014
Ep300	E1A binding protein p300	0.014
Cdcp1	CUB domain containing protein 1	0.014
Ncf4	neutrophil cytosolic factor 4	0.014
Pxn	paxillin	0.014
Ciita	class II transactivator	0.014
Tifa	TRAF-interacting protein with forkhead-associated domain	0.014
Casp7	caspase 7	0.014	Mouse
Foxn1	forkhead box N1	0.014
Il4ra	interleukin 4 receptor, alpha	0.014
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.014
Cd8a	CD8 antigen, alpha chain	0.014
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.014
Mmp13	matrix metallopeptidase 13	0.013
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.013
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.013
Tgm2	transglutaminase 2, C polypeptide	0.013
Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.013
Fgl2	fibrinogen-like protein 2	0.013
Osmr	oncostatin M receptor	0.013
Hmox1	heme oxygenase (decycling) 1	0.013
Gzmb	granzyme B	0.013
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.012
Rac2	RAS-related C3 botulinum substrate 2	0.012
Tsc1	tuberous sclerosis 1	0.012
C5ar1	complement component 5a receptor 1	0.012
Msr1	macrophage scavenger receptor 1	0.012
Ggta1	glycoprotein galactosyltransferase alpha 1, 3	0.012
Lig4	ligase IV, DNA, ATP-dependent	0.012
Thbs1	thrombospondin 1	0.012
Mdm4	transformed mouse 3T3 cell double minute 4	0.012
Vpreb3	pre-B lymphocyte gene 3	0.012
Nfya	nuclear transcription factor-Y alpha	0.012
Traf6	TNF receptor-associated factor 6	0.012
Cxcl2	chemokine (C-X-C motif) ligand 2	0.012
Ncr1	natural cytotoxicity triggering receptor 1	0.012
Cd80	CD80 antigen	0.012
Fpr2	formyl peptide receptor 2	0.012
Ppard	peroxisome proliferator activator receptor delta	0.012
Mvp	major vault protein	0.012
Rhod	ras homolog gene family, member D	0.012
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.011
Hgf	hepatocyte growth factor	0.011
Myo6	myosin VI	0.011
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.011
Igk	immunoglobulin kappa chain complex	0.011
Ccl22	chemokine (C-C motif) ligand 22	0.011
Itgax	integrin alpha X	0.011
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.011
Smad5	MAD homolog 5 (Drosophila)	0.011
Zfp292	zinc finger protein 292	0.011
Naip1	NLR family, apoptosis inhibitory protein 1	0.011
Pgm1	phosphoglucomutase 1	0.011
Traf3ip2	TRAF3 interacting protein 2	0.011
Irg1	immunoresponsive gene 1	0.011
Armc10	armadillo repeat containing 10	0.011
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.011
Cd5	CD5 antigen	0.011
F2r	coagulation factor II (thrombin) receptor	0.011
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.011
Tlr2	toll-like receptor 2	0.011
Clec4d	C-type lectin domain family 4, member d	0.011
Tlr8	toll-like receptor 8	0.011
Nfatc3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	0.011
Cd244	CD244 natural killer cell receptor 2B4	0.011
Wrn	Werner syndrome homolog (human)	0.011
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.011
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	0.011	Mouse
Tmpo	thymopoietin	0.011
Sh3d19	SH3 domain protein D19	0.010
Nmur1	neuromedin U receptor 1	0.010
Il6st	interleukin 6 signal transducer	0.010
Dock7	dedicator of cytokinesis 7	0.010
Apc	adenomatosis polyposis coli	0.010
Sash3	SAM and SH3 domain containing 3	0.010
Cdkn2b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.010	Mouse
Jak3	Janus kinase 3	0.010
Id2	inhibitor of DNA binding 2	0.010
Nat2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.010
Mmp9	matrix metallopeptidase 9	0.010
Stk4	serine/threonine kinase 4	0.010
Sprr1a	small proline-rich protein 1A	0.010
E2f1	E2F transcription factor 1	0.010
Ccr2	chemokine (C-C motif) receptor 2	0.010
Krt27	keratin 27	0.010
Vav2	vav 2 oncogene	0.010
Cyp4f18	cytochrome P450, family 4, subfamily f, polypeptide 18	0.010
BC013712	cDNA sequence BC013712	0.010
Zc3h12d	zinc finger CCCH type containing 12D	0.010