IMP

Process View

Mus musculus

13 genes annotated in mouse

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

GO:1902043

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of extrinsic apoptotic signaling pathway via death domain receptors"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of extrinsic apoptotic signaling pathway via death domain receptors" (in gray)

Name	Description	Probability	Func Analog Organism
Apc	adenomatosis polyposis coli	1.000
Trp53	transformation related protein 53	1.000
Acvr1	activin A receptor, type 1	0.999	Mouse
Pten	phosphatase and tensin homolog	0.999
Tgfbr2	transforming growth factor, beta receptor II	0.997	Mouse
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.994	Mouse
Smad4	MAD homolog 4 (Drosophila)	0.993
Vegfa	vascular endothelial growth factor A	0.986
Notch1	Notch gene homolog 1 (Drosophila)	0.981
Smad3	MAD homolog 3 (Drosophila)	0.980
Ctnnb1	catenin (cadherin associated protein), beta 1	0.980
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.971
Tgfbr1	transforming growth factor, beta receptor I	0.971	Mouse
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.964
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.944
Notch2	Notch gene homolog 2 (Drosophila)	0.938
Mdm2	transformed mouse 3T3 cell double minute 2	0.929
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.790
Psen1	presenilin 1	0.788	Mouse
Rxra	retinoid X receptor alpha	0.722
Braf	Braf transforming gene	0.720
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.701
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.652
Foxc1	forkhead box C1	0.628
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.581
Tgfb1	transforming growth factor, beta 1	0.580
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.559
Ptch1	patched homolog 1	0.522
Smad2	MAD homolog 2 (Drosophila)	0.515
Hif1a	hypoxia inducible factor 1, alpha subunit	0.511
Vhl	von Hippel-Lindau tumor suppressor	0.504
Shc1	src homology 2 domain-containing transforming protein C1	0.504
Sfrp2	secreted frizzled-related protein 2	0.485
Esr1	estrogen receptor 1 (alpha)	0.447
Eng	endoglin	0.447
Tgfbr3	transforming growth factor, beta receptor III	0.443
Ptgs2	prostaglandin-endoperoxide synthase 2	0.443
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.423	Mouse
Rara	retinoic acid receptor, alpha	0.403
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.400
Gsk3b	glycogen synthase kinase 3 beta	0.394
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.375
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.359
Rac1	RAS-related C3 botulinum substrate 1	0.349
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.346
Ece1	endothelin converting enzyme 1	0.346
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.311
Nf2	neurofibromatosis 2	0.308
Mcl1	myeloid cell leukemia sequence 1	0.307
Fas	Fas (TNF receptor superfamily member 6)	0.301
Casp8	caspase 8	0.290
Cd44	CD44 antigen	0.287
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.279
Xiap	X-linked inhibitor of apoptosis	0.271
Cav1	caveolin 1, caveolae protein	0.264
Sox9	SRY-box containing gene 9	0.237
Runx1	runt related transcription factor 1	0.231
Isl1	ISL1 transcription factor, LIM/homeodomain	0.211
Adam17	a disintegrin and metallopeptidase domain 17	0.208
Kif3a	kinesin family member 3A	0.207
Kitl	kit ligand	0.206
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.205
Stat3	signal transducer and activator of transcription 3	0.183
Vcl	vinculin	0.179
Il6st	interleukin 6 signal transducer	0.166
Csf1	colony stimulating factor 1 (macrophage)	0.163
Sav1	salvador homolog 1 (Drosophila)	0.162
Smad1	MAD homolog 1 (Drosophila)	0.161
Stk4	serine/threonine kinase 4	0.159
Fbn1	fibrillin 1	0.147
Hipk3	homeodomain interacting protein kinase 3	0.141
Nos3	nitric oxide synthase 3, endothelial cell	0.140
Yap1	yes-associated protein 1	0.140
Stk11	serine/threonine kinase 11	0.138
Gja1	gap junction protein, alpha 1	0.136
Ikbkb	inhibitor of kappaB kinase beta	0.135
Wls	wntless homolog (Drosophila)	0.134
Pml	promyelocytic leukemia	0.131
Trp73	transformation related protein 73	0.131
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.130
Rarg	retinoic acid receptor, gamma	0.129
Smad7	MAD homolog 7 (Drosophila)	0.117
Ccnd1	cyclin D1	0.111
Egr1	early growth response 1	0.101
Cpd	carboxypeptidase D	0.098
Hoxa3	homeobox A3	0.094
Myc	myelocytomatosis oncogene	0.092
Kiss1	KiSS-1 metastasis-suppressor	0.089
Ahr	aryl-hydrocarbon receptor	0.088
Gata4	GATA binding protein 4	0.087
Itgav	integrin alpha V	0.086
Psen2	presenilin 2	0.085
Pnpla6	patatin-like phospholipase domain containing 6	0.084
Daxx	Fas death domain-associated protein	0.081
Mapk3	mitogen-activated protein kinase 3	0.081
Efnb2	ephrin B2	0.075
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.075
Mdm4	transformed mouse 3T3 cell double minute 4	0.074
Egfr	epidermal growth factor receptor	0.072
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.072
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.071
Fst	follistatin	0.068
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.067
Spin1	spindlin 1	0.065
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.064
Inhba	inhibin beta-A	0.064
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.063
Jag1	jagged 1	0.062
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.062
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.060
Diablo	diablo homolog (Drosophila)	0.060
Tgfb2	transforming growth factor, beta 2	0.059
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.055
Nf1	neurofibromatosis 1	0.055
Cdh5	cadherin 5	0.054
Ncoa3	nuclear receptor coactivator 3	0.054
Axin1	axin 1	0.053
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.052
Foxo1	forkhead box O1	0.052
Wrn	Werner syndrome homolog (human)	0.051
Jun	Jun oncogene	0.050
Fzd4	frizzled homolog 4 (Drosophila)	0.050
Skil	SKI-like	0.049
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.048
Inhbb	inhibin beta-B	0.047
Smad5	MAD homolog 5 (Drosophila)	0.046
Mapk8	mitogen-activated protein kinase 8	0.045
Fzd1	frizzled homolog 1 (Drosophila)	0.045
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.045
Ext1	exostoses (multiple) 1	0.044
Smo	smoothened homolog (Drosophila)	0.044
Fmn1	formin 1	0.043
Fgfr1	fibroblast growth factor receptor 1	0.042
Met	met proto-oncogene	0.042
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.042
Cxcr4	chemokine (C-X-C motif) receptor 4	0.041
Bmp2	bone morphogenetic protein 2	0.040
Col1a1	collagen, type I, alpha 1	0.040
Akt3	thymoma viral proto-oncogene 3	0.040
Med14	mediator complex subunit 14	0.039
Apaf1	apoptotic peptidase activating factor 1	0.039
Kit	kit oncogene	0.037
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.036
Vav2	vav 2 oncogene	0.036
Numb	numb gene homolog (Drosophila)	0.035
Id1	inhibitor of DNA binding 1	0.035
Tlr4	toll-like receptor 4	0.035
Prkg1	protein kinase, cGMP-dependent, type I	0.034
Galnt2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2	0.034
Hip1	huntingtin interacting protein 1	0.034
Npc1	Niemann Pick type C1	0.033
Htt	huntingtin	0.033
Ednra	endothelin receptor type A	0.033
Creb1	cAMP responsive element binding protein 1	0.033
Sgpl1	sphingosine phosphate lyase 1	0.033
Timp2	tissue inhibitor of metalloproteinase 2	0.033
Meox2	mesenchyme homeobox 2	0.032
Ikbip	IKBKB interacting protein	0.031
Lyst	lysosomal trafficking regulator	0.031
Gpc3	glypican 3	0.031
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.031
Ids	iduronate 2-sulfatase	0.031
Usp12	ubiquitin specific peptidase 12	0.031
Wnt5a	wingless-related MMTV integration site 5A	0.030
Ncstn	nicastrin	0.030
Ctsk	cathepsin K	0.029
Cbl	Casitas B-lineage lymphoma	0.029
Lepr	leptin receptor	0.029
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.029
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.029
Mkl2	MKL/myocardin-like 2	0.029
Klf6	Kruppel-like factor 6	0.028
F2r	coagulation factor II (thrombin) receptor	0.027
Hs2st1	heparan sulfate 2-O-sulfotransferase 1	0.027
Bmp4	bone morphogenetic protein 4	0.027
Man1a2	mannosidase, alpha, class 1A, member 2	0.026
Ar	androgen receptor	0.026
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.025
Rfwd2	ring finger and WD repeat domain 2	0.025
Fshr	follicle stimulating hormone receptor	0.025
Cyld	cylindromatosis (turban tumor syndrome)	0.025
Adam10	a disintegrin and metallopeptidase domain 10	0.025
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.025
Nodal	nodal	0.025
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.024
Ep300	E1A binding protein p300	0.024
Pkn2	protein kinase N2	0.024
Mapk14	mitogen-activated protein kinase 14	0.023
Tsc1	tuberous sclerosis 1	0.023
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.023
Fos	FBJ osteosarcoma oncogene	0.023
Aff1	AF4/FMR2 family, member 1	0.023
Wwc2	WW, C2 and coiled-coil domain containing 2	0.023
Thbs1	thrombospondin 1	0.022	Human
Erlin2	ER lipid raft associated 2	0.022
Gna11	guanine nucleotide binding protein, alpha 11	0.022
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.022
Rdh10	retinol dehydrogenase 10 (all-trans)	0.021
Trp63	transformation related protein 63	0.021
Ldlr	low density lipoprotein receptor	0.021
Pgr	progesterone receptor	0.021
Lats2	large tumor suppressor 2	0.021
Klf4	Kruppel-like factor 4 (gut)	0.021
Pofut1	protein O-fucosyltransferase 1	0.021
Ptk2	PTK2 protein tyrosine kinase 2	0.021
Gnrh1	gonadotropin releasing hormone 1	0.021
Zfp362	zinc finger protein 362	0.021
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.020
Ctnna1	catenin (cadherin associated protein), alpha 1	0.020
Ikbkg	inhibitor of kappaB kinase gamma	0.020
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.020
Lpar1	lysophosphatidic acid receptor 1	0.020
Cdh1	cadherin 1	0.020
Cttnbp2nl	CTTNBP2 N-terminal like	0.020
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.020
Angptl2	angiopoietin-like 2	0.019
Dok1	docking protein 1	0.019
Ilk	integrin linked kinase	0.018
Map4k4	mitogen-activated protein kinase kinase kinase kinase 4	0.018
Fadd	Fas (TNFRSF6)-associated via death domain	0.018
Lif	leukemia inhibitory factor	0.018
Ctsl	cathepsin L	0.017
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.017
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.017
Psap	prosaposin	0.017
Ogg1	8-oxoguanine DNA-glycosylase 1	0.017
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.017
Galc	galactosylceramidase	0.017
Esr2	estrogen receptor 2 (beta)	0.016
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.016
Pask	PAS domain containing serine/threonine kinase	0.016
Zfp146	zinc finger protein 146	0.016
Gnptab	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	0.016
Smad6	MAD homolog 6 (Drosophila)	0.016
Rhob	ras homolog gene family, member B	0.016
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.016
Ptprg	protein tyrosine phosphatase, receptor type, G	0.016
Arf2	ADP-ribosylation factor 2	0.015
Ptrf	polymerase I and transcript release factor	0.015
Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3	0.015
Krt19	keratin 19	0.015
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.015
Homer1	homer homolog 1 (Drosophila)	0.015
Iqgap1	IQ motif containing GTPase activating protein 1	0.015
Rps6ka3	ribosomal protein S6 kinase polypeptide 3	0.014
Rab23	RAB23, member RAS oncogene family	0.014
Ap1s2	adaptor-related protein complex 1, sigma 2 subunit	0.014
Msh2	mutS homolog 2 (E. coli)	0.014
Nr1h3	nuclear receptor subfamily 1, group H, member 3	0.014
Enah	enabled homolog (Drosophila)	0.014
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.014
Psenen	presenilin enhancer 2 homolog (C. elegans)	0.014
Zswim6	zinc finger, SWIM domain containing 6	0.014
Arl4c	ADP-ribosylation factor-like 4C	0.014
Prlr	prolactin receptor	0.014
Camk2d	calcium/calmodulin-dependent protein kinase II, delta	0.014
Zbtb7a	zinc finger and BTB domain containing 7a	0.014
Kl	klotho	0.014
Actn1	actinin, alpha 1	0.014
Atr	ataxia telangiectasia and Rad3 related	0.013
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.013
E2f1	E2F transcription factor 1	0.013
Hes1	hairy and enhancer of split 1 (Drosophila)	0.013
Hist1h1c	histone cluster 1, H1c	0.013
Arhgap1	Rho GTPase activating protein 1	0.013
Btbd3	BTB (POZ) domain containing 3	0.013
Plat	plasminogen activator, tissue	0.013
Klf10	Kruppel-like factor 10	0.013
Errfi1	ERBB receptor feedback inhibitor 1	0.013
Fgf2	fibroblast growth factor 2	0.013
Spnb2	spectrin beta 2	0.013
Pdgfb	platelet derived growth factor, B polypeptide	0.013
Ifngr1	interferon gamma receptor 1	0.013
Klf7	Kruppel-like factor 7 (ubiquitous)	0.013
Ets2	E26 avian leukemia oncogene 2, 3' domain	0.013
Gsn	gelsolin	0.012
Thbd	thrombomodulin	0.012
Tax1bp3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.012
Csrp1	cysteine and glycine-rich protein 1	0.012
Sfn	stratifin	0.012
Abl2	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	0.012
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.012
Cyth3	cytohesin 3	0.012
Myadm	myeloid-associated differentiation marker	0.012
Rbl1	retinoblastoma-like 1 (p107)	0.012
Nkx2-1	NK2 homeobox 1	0.012
Dusp1	dual specificity phosphatase 1	0.012
Nfib	nuclear factor I/B	0.012
Sntb2	syntrophin, basic 2	0.012
Plxna1	plexin A1	0.012
Pld1	phospholipase D1	0.011
Pikfyve	phosphoinositide kinase, FYVE finger containing	0.011
Slc25a24	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24	0.011
Fgfr2	fibroblast growth factor receptor 2	0.011
Nrp1	neuropilin 1	0.011
Lmna	lamin A	0.011
Zfp236	zinc finger protein 236	0.011
Ppard	peroxisome proliferator activator receptor delta	0.011
Pdlim5	PDZ and LIM domain 5	0.011
Id2	inhibitor of DNA binding 2	0.011
Dclre1a	DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)	0.011
Pparg	peroxisome proliferator activated receptor gamma	0.011
Gpr137b	G protein-coupled receptor 137B	0.011
Prss23	protease, serine, 23	0.011
Tmem2	transmembrane protein 2	0.011
Arid4a	AT rich interactive domain 4A (RBP1-like)	0.011
Emp2	epithelial membrane protein 2	0.011
Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	0.011
Tmc6	transmembrane channel-like gene family 6	0.011
Man1c1	mannosidase, alpha, class 1C, member 1	0.011
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.011
Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	0.011
Mapk9	mitogen-activated protein kinase 9	0.011
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.010
Nuak1	NUAK family, SNF1-like kinase, 1	0.010
Acvr2a	activin receptor IIA	0.010
Fert2	fer (fms/fps related) protein kinase, testis specific 2	0.010
Egr2	early growth response 2	0.010
Krt7	keratin 7	0.010
Mybl2	myeloblastosis oncogene-like 2	0.010
Igf1	insulin-like growth factor 1	0.010