IMP

Process View

Homo sapiens

21 genes annotated in human

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metaphase anaphase transition of cell cycle

GO:0044784

The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "metaphase anaphase transition of cell cycle"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "metaphase anaphase transition of cell cycle" (in gray)

Name	Description	Probability	Func Analog Organism
CDC20	cell division cycle 20 homolog (S. cerevisiae)	1.000	Yeast Worm Fly
CDC27	cell division cycle 27 homolog (S. cerevisiae)	1.000
ANAPC4	anaphase promoting complex subunit 4	0.998
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.998	Mouse Fly
CDK2	cyclin-dependent kinase 2	0.997
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.989	Worm Fly
CCNA2	cyclin A2	0.978
ANAPC5	anaphase promoting complex subunit 5	0.978
CCNB1	cyclin B1	0.965
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.952
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.938
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.894	Fly
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.876
ANAPC7	anaphase promoting complex subunit 7	0.836
SMC6	structural maintenance of chromosomes 6	0.808
ANAPC11	anaphase promoting complex subunit 11	0.760
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.744
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.686
SKP2	S-phase kinase-associated protein 2 (p45)	0.671
ORC1	origin recognition complex, subunit 1	0.592
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.566
CBX5	chromobox homolog 5	0.563
SMC3	structural maintenance of chromosomes 3	0.487
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.487
AURKB	aurora kinase B	0.477
PLK1	polo-like kinase 1	0.438
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.431
RB1	retinoblastoma 1	0.424
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.377
CDKN3	cyclin-dependent kinase inhibitor 3	0.349
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.314
CUL1	cullin 1	0.305
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.305
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.300
TCP1	t-complex 1	0.293
STAG1	stromal antigen 1	0.288
SKP1	S-phase kinase-associated protein 1	0.269
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.229
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.220	Fly
IGF1R	insulin-like growth factor 1 receptor	0.212
CCNE1	cyclin E1	0.211	Fly
VHL	von Hippel-Lindau tumor suppressor	0.196
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.179
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.171
CDT1	chromatin licensing and DNA replication factor 1	0.171
CD44	CD44 molecule (Indian blood group)	0.169
WAPAL	wings apart-like homolog (Drosophila)	0.166
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.163
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.154
ANAPC1	anaphase promoting complex subunit 1	0.144	Worm
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.135
PTTG1	pituitary tumor-transforming 1	0.133
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.127
ANAPC10	anaphase promoting complex subunit 10	0.126	Yeast
CUL2	cullin 2	0.116	Worm
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.116
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.116
SKA1	spindle and kinetochore associated complex subunit 1	0.115
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.110
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.106
CUL5	cullin 5	0.105
INCENP	inner centromere protein antigens 135/155kDa	0.098
HERC2	hect domain and RLD 2	0.097
CCNB2	cyclin B2	0.093
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.092
RAD21	RAD21 homolog (S. pombe)	0.091
UBE2C	ubiquitin-conjugating enzyme E2C	0.089	Fly
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.088
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.087
EZR	ezrin	0.085	Fly
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0.082
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.080
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.080
TBC1D10A	TBC1 domain family, member 10A	0.077
SKA3	spindle and kinetochore associated complex subunit 3	0.075
SMAD2	SMAD family member 2	0.072
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.072
PRNP	prion protein	0.071
NEK9	NIMA (never in mitosis gene a)- related kinase 9	0.071
COMMD1	copper metabolism (Murr1) domain containing 1	0.070
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.069
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.069
FBXO5	F-box protein 5	0.068
CENPE	centromere protein E, 312kDa	0.064
PARP3	poly (ADP-ribose) polymerase family, member 3	0.063
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.062
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.059
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.059
CLSPN	claspin	0.058
SIRT2	sirtuin 2	0.057
BRCA2	breast cancer 2, early onset	0.057
CCND3	cyclin D3	0.056
BTRC	beta-transducin repeat containing	0.056
SGOL1	shugoshin-like 1 (S. pombe)	0.054
CASC5	cancer susceptibility candidate 5	0.053
AXIN2	axin 2	0.052
E2F1	E2F transcription factor 1	0.051
UBE2S	ubiquitin-conjugating enzyme E2S	0.050
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.049
CREBBP	CREB binding protein	0.047
ZWINT	ZW10 interactor	0.047
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.047
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.046
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.045
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	0.045
HIST1H4A	histone cluster 1, H4a	0.045
E2F5	E2F transcription factor 5, p130-binding	0.045
RBBP8	retinoblastoma binding protein 8	0.045
TP53BP1	tumor protein p53 binding protein 1	0.043
AXIN1	axin 1	0.043
TFDP1	transcription factor Dp-1	0.042
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.041
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.041
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.041
GSK3B	glycogen synthase kinase 3 beta	0.041	Fly
FYN	FYN oncogene related to SRC, FGR, YES	0.040
WBP4	WW domain binding protein 4 (formin binding protein 21)	0.040
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.039
ARIH2	ariadne homolog 2 (Drosophila)	0.038
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.037
POLR2K	polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa	0.036
SMC1A	structural maintenance of chromosomes 1A	0.036
PPP4C	protein phosphatase 4, catalytic subunit	0.036
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.035
CDCA8	cell division cycle associated 8	0.035
BIRC5	baculoviral IAP repeat containing 5	0.035
ANKRD52	ankyrin repeat domain 52	0.035
MYST1	MYST histone acetyltransferase 1	0.034
MKI67	antigen identified by monoclonal antibody Ki-67	0.034
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.034
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.033
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.032
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.030
SKA2	spindle and kinetochore associated complex subunit 2	0.030
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.030
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.030
ATMIN	ATM interactor	0.030
FXR2	fragile X mental retardation, autosomal homolog 2	0.029
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.029
MDC1	mediator of DNA-damage checkpoint 1	0.029
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.029
TOP3A	topoisomerase (DNA) III alpha	0.028
APC	adenomatous polyposis coli	0.028
RANBP9	RAN binding protein 9	0.028
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.028
MAK	male germ cell-associated kinase	0.028
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.028
MSN	moesin	0.028	Fly
SGOL2	shugoshin-like 2 (S. pombe)	0.028
PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	0.027
MYH9	myosin, heavy chain 9, non-muscle	0.027
CAPRIN1	cell cycle associated protein 1	0.027
BRCA1	breast cancer 1, early onset	0.026
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.026
BTBD10	BTB (POZ) domain containing 10	0.026
CCDC101	coiled-coil domain containing 101	0.026
EML2	echinoderm microtubule associated protein like 2	0.026
LIN54	lin-54 homolog (C. elegans)	0.026
ZNHIT3	zinc finger, HIT-type containing 3	0.026
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.025
PXN	paxillin	0.025
EIF3A	eukaryotic translation initiation factor 3, subunit A	0.025
DYNC1I2	dynein, cytoplasmic 1, intermediate chain 2	0.025
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.025
MCM10	minichromosome maintenance complex component 10	0.024
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.024
STAG2	stromal antigen 2	0.024
PTEN	phosphatase and tensin homolog	0.023
HIST2H2BE	histone cluster 2, H2be	0.023
TRIP13	thyroid hormone receptor interactor 13	0.023
BRD7	bromodomain containing 7	0.023
KIF18A	kinesin family member 18A	0.023
PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	0.023
USP44	ubiquitin specific peptidase 44	0.022
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.022
HIST1H3D	histone cluster 1, H3d	0.022
CCND1	cyclin D1	0.022
KIF5B	kinesin family member 5B	0.022
ORC2	origin recognition complex, subunit 2	0.021
UBASH3B	ubiquitin associated and SH3 domain containing B	0.021
USP9X	ubiquitin specific peptidase 9, X-linked	0.021
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.021
USP49	ubiquitin specific peptidase 49	0.021	Human
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.021	Yeast
EHD1	EH-domain containing 1	0.020
C13orf34	chromosome 13 open reading frame 34	0.020
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.019
FOXM1	forkhead box M1	0.019
ZNF207	zinc finger protein 207	0.019
TROAP	trophinin associated protein (tastin)	0.019
CCND2	cyclin D2	0.019
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.019
STRN3	striatin, calmodulin binding protein 3	0.018
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.018
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.018
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.018
FBXW7	F-box and WD repeat domain containing 7	0.018
HIST1H1B	histone cluster 1, H1b	0.018
MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.018
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.018
PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.018
RBL1	retinoblastoma-like 1 (p107)	0.018	Human
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.017
SLC39A7	solute carrier family 39 (zinc transporter), member 7	0.017
HIST1H1E	histone cluster 1, H1e	0.017
GNL2	guanine nucleotide binding protein-like 2 (nucleolar)	0.017
PPME1	protein phosphatase methylesterase 1	0.017
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.017
ZYG11B	zyg-11 homolog B (C. elegans)	0.017
FBXW11	F-box and WD repeat domain containing 11	0.017
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.016
EML4	echinoderm microtubule associated protein like 4	0.016
C19orf39	chromosome 19 open reading frame 39	0.016
SERTAD4	SERTA domain containing 4	0.016
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.016
EIF4E	eukaryotic translation initiation factor 4E	0.016
KDM4A	lysine (K)-specific demethylase 4A	0.016
MED21	mediator complex subunit 21	0.016
ADRB2	adrenergic, beta-2-, receptor, surface	0.015
PKN2	protein kinase N2	0.015
PTK2	PTK2 protein tyrosine kinase 2	0.015
GTSE1	G-2 and S-phase expressed 1	0.015
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.015
ATAD2	ATPase family, AAA domain containing 2	0.015
CUL4A	cullin 4A	0.014
PSMD10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.014
MKRN1	makorin ring finger protein 1	0.014
NDNL2	necdin-like 2	0.014
C13orf27	chromosome 13 open reading frame 27	0.014
PIM1	pim-1 oncogene	0.014
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.013
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.013
STK24	serine/threonine kinase 24	0.013
LRR1	leucine rich repeat protein 1	0.013
SOCS2	suppressor of cytokine signaling 2	0.013
NCAPH2	non-SMC condensin II complex, subunit H2	0.013
NRD1	nardilysin (N-arginine dibasic convertase)	0.013
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	0.013
SKIV2L2	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	0.013
RFWD2	ring finger and WD repeat domain 2	0.013
ARRB1	arrestin, beta 1	0.013
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.013
LMNA	lamin A/C	0.013
ENY2	enhancer of yellow 2 homolog (Drosophila)	0.013
ERBB2IP	erbb2 interacting protein	0.013
VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)	0.013
LBR	lamin B receptor	0.013
ZFR	zinc finger RNA binding protein	0.013
CD97	CD97 molecule	0.013
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.013
FBXO4	F-box protein 4	0.013
KIF2C	kinesin family member 2C	0.013
HIST1H3F	histone cluster 1, H3f	0.013
AIRE	autoimmune regulator	0.012
PPP2R3B	protein phosphatase 2, regulatory subunit B'', beta	0.012
ADAM17	ADAM metallopeptidase domain 17	0.012
TPP2	tripeptidyl peptidase II	0.012
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.012
KIF11	kinesin family member 11	0.012
CENPQ	centromere protein Q	0.012
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.012
PHLPP2	PH domain and leucine rich repeat protein phosphatase 2	0.012
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.012
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.012
MBD1	methyl-CpG binding domain protein 1	0.012
KDM5C	lysine (K)-specific demethylase 5C	0.012
NF2	neurofibromin 2 (merlin)	0.012
PRAME	preferentially expressed antigen in melanoma	0.012
SCAF11	SR-related CTD-associated factor 11	0.012
HMGB1	high mobility group box 1	0.012
PSMD5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.012
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.012
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.012
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.012
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.012
MAPK1	mitogen-activated protein kinase 1	0.011
FANCD2	Fanconi anemia, complementation group D2	0.011
MLL4	myeloid/lymphoid or mixed-lineage leukemia 4	0.011
UTP18	UTP18, small subunit (SSU) processome component, homolog (yeast)	0.011
HUWE1	HECT, UBA and WWE domain containing 1	0.011
MIS18BP1	MIS18 binding protein 1	0.011
HIST1H4F	histone cluster 1, H4f	0.011
MAGEA2	melanoma antigen family A, 2	0.011
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.011
HIST1H3C	histone cluster 1, H3c	0.011	Yeast
ZNF828	zinc finger protein 828	0.011
SH2B3	SH2B adaptor protein 3	0.011
CKS2	CDC28 protein kinase regulatory subunit 2	0.011
FBXO3	F-box protein 3	0.011
PCM1	pericentriolar material 1	0.011
CEP55	centrosomal protein 55kDa	0.011
HIST1H2AB	histone cluster 1, H2ab	0.011
TUBB3	tubulin, beta 3	0.011
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	0.011	Fly
LIN52	lin-52 homolog (C. elegans)	0.011
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.011
L3MBTL1	l(3)mbt-like 1 (Drosophila)	0.010
SMC4	structural maintenance of chromosomes 4	0.010
SETD1A	SET domain containing 1A	0.010
HDGFRP2	hepatoma-derived growth factor-related protein 2	0.010
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.010
TLK1	tousled-like kinase 1	0.010
MAD2L1BP	MAD2L1 binding protein	0.010
SNAI1	snail homolog 1 (Drosophila)	0.010
KIAA1279	KIAA1279	0.010
RECQL4	RecQ protein-like 4	0.010
YTHDC2	YTH domain containing 2	0.010
CDK1	cyclin-dependent kinase 1	0.010
HIST1H4B	histone cluster 1, H4b	0.010
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.010
CCNA1	cyclin A1	0.010
IQGAP1	IQ motif containing GTPase activating protein 1	0.010
PSRC1	proline/serine-rich coiled-coil 1	0.010
TEX10	testis expressed 10	0.010
TAGLN2	transgelin 2	0.010
TOR1AIP2	torsin A interacting protein 2	0.010