IMP

Process View

Mus musculus

29 genes annotated in mouse

type i interferon production

The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "type i interferon production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "type i interferon production" (in gray)

Name	Description	Probability	Func Analog Organism
Myd88	myeloid differentiation primary response gene 88	0.998
Tlr4	toll-like receptor 4	0.977
Gbp7	guanylate binding protein 7	0.950	Mouse
Stat1	signal transducer and activator of transcription 1	0.917
Irf9	interferon regulatory factor 9	0.913
Irgm2	immunity-related GTPase family M member 2	0.902
Mavs	mitochondrial antiviral signaling protein	0.881
Trim30a	tripartite motif-containing 30A	0.881	Mouse
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.880
Irgm1	immunity-related GTPase family M member 1	0.876
Gbp2	guanylate binding protein 2	0.869	Mouse
Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.844
Ikbkg	inhibitor of kappaB kinase gamma	0.808
Trim21	tripartite motif-containing 21	0.757
Parp14	poly (ADP-ribose) polymerase family, member 14	0.666
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.657
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.646
Aim2	absent in melanoma 2	0.611
Casp1	caspase 1	0.595
Birc3	baculoviral IAP repeat-containing 3	0.591
Rtp4	receptor transporter protein 4	0.576
Ticam1	toll-like receptor adaptor molecule 1	0.560
Ifih1	interferon induced with helicase C domain 1	0.546	Human Mouse
Unc93b1	unc-93 homolog B1 (C. elegans)	0.438
Igtp	interferon gamma induced GTPase	0.421
Cd40	CD40 antigen	0.396
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.377
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.374
Nmi	N-myc (and STAT) interactor	0.374
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.343
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.325
Iigp1	interferon inducible GTPase 1	0.316
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.301
Chuk	conserved helix-loop-helix ubiquitous kinase	0.293	Mouse
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.287
Parp9	poly (ADP-ribose) polymerase family, member 9	0.266
Samd9l	sterile alpha motif domain containing 9-like	0.246
Irak1	interleukin-1 receptor-associated kinase 1	0.240
Ikbkb	inhibitor of kappaB kinase beta	0.236	Mouse
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.231
Usp18	ubiquitin specific peptidase 18	0.224
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.223
Gbp3	guanylate binding protein 3	0.213	Mouse
Uba7	ubiquitin-like modifier activating enzyme 7	0.207
Traf3	TNF receptor-associated factor 3	0.206
Ifi44	interferon-induced protein 44	0.205
Traf6	TNF receptor-associated factor 6	0.199	Mouse
Gbp6	guanylate binding protein 6	0.184	Mouse
Ifnar2	interferon (alpha and beta) receptor 2	0.177
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.176
Pyhin1	pyrin and HIN domain family, member 1	0.173
Erap1	endoplasmic reticulum aminopeptidase 1	0.148
Ccl4	chemokine (C-C motif) ligand 4	0.128
Ifi35	interferon-induced protein 35	0.120
Ifit2	interferon-induced protein with tetratricopeptide repeats 2	0.120
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.119
Isg15	ISG15 ubiquitin-like modifier	0.111
Trim25	tripartite motif-containing 25	0.106
Irak4	interleukin-1 receptor-associated kinase 4	0.105
Cblb	Casitas B-lineage lymphoma b	0.104
Hspa9	heat shock protein 9	0.104
Traf3ip2	TRAF3 interacting protein 2	0.103
BC006779	cDNA sequence BC006779	0.099
Tor3a	torsin family 3, member A	0.097
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.097
Cxcl10	chemokine (C-X-C motif) ligand 10	0.091
Dtx3l	deltex 3-like (Drosophila)	0.090
Stat2	signal transducer and activator of transcription 2	0.089
Trim12a	tripartite motif-containing 12A	0.088	Mouse
Sfpi1	SFFV proviral integration 1	0.088
Gbp10	guanylate-binding protein 10	0.087	Mouse
Traf2	TNF receptor-associated factor 2	0.086	Mouse
Irf5	interferon regulatory factor 5	0.084	Mouse
Sykb	spleen tyrosine kinase	0.082
Ifi47	interferon gamma inducible protein 47	0.075
Parp12	poly (ADP-ribose) polymerase family, member 12	0.072	Mouse
Cd274	CD274 antigen	0.071
Irf1	interferon regulatory factor 1	0.069
Igh	immunoglobulin heavy chain complex	0.068
Casp8	caspase 8	0.068
Mnda	myeloid cell nuclear differentiation antigen	0.067
Herc6	hect domain and RLD 6	0.065
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.063
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.062
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.061
Card11	caspase recruitment domain family, member 11	0.060
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.058
Zbp1	Z-DNA binding protein 1	0.057
Ifi203	interferon activated gene 203	0.056
Gbp4	guanylate binding protein 4	0.056
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.055
Trim30d	tripartite motif-containing 30D	0.053	Mouse
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.052
Ikzf3	IKAROS family zinc finger 3	0.051
Tlr2	toll-like receptor 2	0.050
Parp10	poly (ADP-ribose) polymerase family, member 10	0.048
Cd19	CD19 antigen	0.048
Tgtp2	T-cell specific GTPase 2	0.048
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.045
Rnf31	ring finger protein 31	0.044
Lair1	leukocyte-associated Ig-like receptor 1	0.043
Il1rn	interleukin 1 receptor antagonist	0.040
Rel	reticuloendotheliosis oncogene	0.040
Rsad2	radical S-adenosyl methionine domain containing 2	0.040
Nlrc5	NLR family, CARD domain containing 5	0.040
Irf7	interferon regulatory factor 7	0.039
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.038
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.038
Cd79b	CD79B antigen	0.037
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.037
Ikbke	inhibitor of kappaB kinase epsilon	0.036	Mouse
Apobec3	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3	0.036
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.035
Mcl1	myeloid cell leukemia sequence 1	0.034
Tnf	tumor necrosis factor	0.034
Btk	Bruton agammaglobulinemia tyrosine kinase	0.033
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.033
Trim34a	tripartite motif-containing 34A	0.033	Mouse
Tapbpl	TAP binding protein-like	0.032
Oas3	2'-5' oligoadenylate synthetase 3	0.031
Csf1	colony stimulating factor 1 (macrophage)	0.031
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.031
Tifa	TRAF-interacting protein with forkhead-associated domain	0.031
Ifnar1	interferon (alpha and beta) receptor 1	0.030
Stat6	signal transducer and activator of transcription 6	0.030
Samhd1	SAM domain and HD domain, 1	0.029
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.029
Prkcd	protein kinase C, delta	0.029
Irak3	interleukin-1 receptor-associated kinase 3	0.029
Icam1	intercellular adhesion molecule 1	0.029
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.029
Psme2	proteasome (prosome, macropain) 28 subunit, beta	0.028
H2-Q7	histocompatibility 2, Q region locus 7	0.028
Slc15a3	solute carrier family 15, member 3	0.027
Epsti1	epithelial stromal interaction 1 (breast)	0.027
Bcl3	B-cell leukemia/lymphoma 3	0.027
Stat3	signal transducer and activator of transcription 3	0.027
D14Ertd668e	DNA segment, Chr 14, ERATO Doi 668, expressed	0.027
Ccr2	chemokine (C-C motif) receptor 2	0.027
Trafd1	TRAF type zinc finger domain containing 1	0.026
Tmem106a	transmembrane protein 106A	0.026
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.026
Oas1b	2'-5' oligoadenylate synthetase 1B	0.025
Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.025
Lrpprc	leucine-rich PPR-motif containing	0.025
Rnf135	ring finger protein 135	0.025	Human
Csprs	component of Sp100-rs	0.024
BC013712	cDNA sequence BC013712	0.024
Plagl2	pleiomorphic adenoma gene-like 2	0.023
Irf8	interferon regulatory factor 8	0.023	Mouse
Itch	itchy, E3 ubiquitin protein ligase	0.022
Trim14	tripartite motif-containing 14	0.022
Irf4	interferon regulatory factor 4	0.022	Mouse
Tank	TRAF family member-associated Nf-kappa B activator	0.022
Sp100	nuclear antigen Sp100	0.022
Gsdmd	gasdermin D	0.021
Mlkl	mixed lineage kinase domain-like	0.021
Sh3bp2	SH3-domain binding protein 2	0.021
Vwa5a	von Willebrand factor A domain containing 5A	0.021
Ifngr1	interferon gamma receptor 1	0.021
Rnf41	ring finger protein 41	0.020
Rbm43	RNA binding motif protein 43	0.020
Trim5	tripartite motif-containing 5	0.020	Mouse
Adar	adenosine deaminase, RNA-specific	0.020
Clec4e	C-type lectin domain family 4, member e	0.020
Oas1a	2'-5' oligoadenylate synthetase 1A	0.020
Becn1	beclin 1, autophagy related	0.019
Zcchc6	zinc finger, CCHC domain containing 6	0.019
Pdcd1lg2	programmed cell death 1 ligand 2	0.018
Znfx1	zinc finger, NFX1-type containing 1	0.018
Bst2	bone marrow stromal cell antigen 2	0.018
Fadd	Fas (TNFRSF6)-associated via death domain	0.018
Socs1	suppressor of cytokine signaling 1	0.017
Cd300ld	CD300 molecule-like family member d	0.017
Cd84	CD84 antigen	0.017
Adap2	ArfGAP with dual PH domains 2	0.017
Naip6	NLR family, apoptosis inhibitory protein 6	0.017
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.017
Oas2	2'-5' oligoadenylate synthetase 2	0.017
Psme1	proteasome (prosome, macropain) 28 subunit, alpha	0.016
Aicda	activation-induced cytidine deaminase	0.016
Zc3hav1	zinc finger CCCH type, antiviral 1	0.016
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.016
Tlr3	toll-like receptor 3	0.016
Smad1	MAD homolog 1 (Drosophila)	0.016
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.016
H2-M3	histocompatibility 2, M region locus 3	0.016
Prkd2	protein kinase D2	0.016
Tnip1	TNFAIP3 interacting protein 1	0.016
Dhx30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.016
Il10ra	interleukin 10 receptor, alpha	0.016
Slamf8	SLAM family member 8	0.016
2010106G01Rik	RIKEN cDNA 2010106G01 gene	0.016
Slfn2	schlafen 2	0.016
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.016
Hpgds	hematopoietic prostaglandin D synthase	0.015
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.015
Vav1	vav 1 oncogene	0.015
Gm12185	predicted gene 12185	0.015
Cd33	CD33 antigen	0.015
Ube2l6	ubiquitin-conjugating enzyme E2L 6	0.015
Tapbp	TAP binding protein	0.015
Mx1	myxovirus (influenza virus) resistance 1	0.014
Naip1	NLR family, apoptosis inhibitory protein 1	0.014
Ubp1	upstream binding protein 1	0.014
Parp4	poly (ADP-ribose) polymerase family, member 4	0.014
Ccl2	chemokine (C-C motif) ligand 2	0.014
Pion	pigeon homolog (Drosophila)	0.014
Prdm1	PR domain containing 1, with ZNF domain	0.014
Nlrp3	NLR family, pyrin domain containing 3	0.014
Drosha	drosha, ribonuclease type III	0.014
Atg16l1	autophagy-related 16-like 1 (yeast)	0.013
Trim12c	tripartite motif-containing 12C	0.013	Mouse
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.013
Ly96	lymphocyte antigen 96	0.013
Tlr7	toll-like receptor 7	0.013
Clk1	CDC-like kinase 1	0.013
Nod1	nucleotide-binding oligomerization domain containing 1	0.013
Cd86	CD86 antigen	0.013
Tmem173	transmembrane protein 173	0.013
Cd22	CD22 antigen	0.013
Trim56	tripartite motif-containing 56	0.013
Batf	basic leucine zipper transcription factor, ATF-like	0.013
Slc37a2	solute carrier family 37 (glycerol-3-phosphate transporter), member 2	0.013
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.013
Gbp9	guanylate-binding protein 9	0.013	Mouse
Tlr9	toll-like receptor 9	0.013
Aim1	absent in melanoma 1	0.013
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.013
N4bp1	NEDD4 binding protein 1	0.013
H2-T10	histocompatibility 2, T region locus 10	0.012
Cd180	CD180 antigen	0.012	Mouse
Gmip	Gem-interacting protein	0.012
Gvin1	GTPase, very large interferon inducible 1	0.012
Kif3b	kinesin family member 3B	0.012
Runx3	runt related transcription factor 3	0.012
Rab32	RAB32, member RAS oncogene family	0.012
Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0.012
Bcl6	B-cell leukemia/lymphoma 6	0.012
Otud7b	OTU domain containing 7B	0.012
Ankfy1	ankyrin repeat and FYVE domain containing 1	0.012
Ctage5	CTAGE family, member 5	0.012
Tlr1	toll-like receptor 1	0.012	Mouse
Atr	ataxia telangiectasia and Rad3 related	0.012
AB124611	cDNA sequence AB124611	0.012
Parp3	poly (ADP-ribose) polymerase family, member 3	0.012
Crtc2	CREB regulated transcription coactivator 2	0.012
Tlr11	toll-like receptor 11	0.012	Mouse
Mov10	Moloney leukemia virus 10	0.012
Ncoa3	nuclear receptor coactivator 3	0.011
Siae	sialic acid acetylesterase	0.011
E330016A19Rik	RIKEN cDNA E330016A19 gene	0.011
Sptlc2	serine palmitoyltransferase, long chain base subunit 2	0.011
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.011
Tdrd7	tudor domain containing 7	0.011
Polg	polymerase (DNA directed), gamma	0.011
Bmf	BCL2 modifying factor	0.011
Fas	Fas (TNF receptor superfamily member 6)	0.011
Itga4	integrin alpha 4	0.011
Birc2	baculoviral IAP repeat-containing 2	0.011
Cd44	CD44 antigen	0.011
Plekhn1	pleckstrin homology domain containing, family N member 1	0.011
Arid3a	AT rich interactive domain 3A (BRIGHT-like)	0.011
Pou2af1	POU domain, class 2, associating factor 1	0.011
Ripk3	receptor-interacting serine-threonine kinase 3	0.011
Taf1a	TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A	0.011
Gm885	predicted gene 885	0.011
Mcm3ap	minichromosome maintenance deficient 3 (S. cerevisiae) associated protein	0.010
Mx2	myxovirus (influenza virus) resistance 2	0.010
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.010
Trim26	tripartite motif-containing 26	0.010
Anks3	ankyrin repeat and sterile alpha motif domain containing 3	0.010
Rasa4	RAS p21 protein activator 4	0.010
Il2ra	interleukin 2 receptor, alpha chain	0.010
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.010
Myo1g	myosin IG	0.010
Pml	promyelocytic leukemia	0.010
Tor1aip1	torsin A interacting protein 1	0.010
Pkhd1l1	polycystic kidney and hepatic disease 1-like 1	0.010