IMP

Process View

Homo sapiens

40 genes annotated in human

dna biosynthetic process

The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.990
WRN	Werner syndrome, RecQ helicase-like	0.954
PCNA	proliferating cell nuclear antigen	0.932
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.921
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.908
CDT1	chromatin licensing and DNA replication factor 1	0.900
E2F1	E2F transcription factor 1	0.880
RAD18	RAD18 homolog (S. cerevisiae)	0.874
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.802
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.656
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.592	Yeast
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.583
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.549
FGF1	fibroblast growth factor 1 (acidic)	0.528
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.510
TERF2	telomeric repeat binding factor 2	0.497	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.489	Human
POLD3	polymerase (DNA-directed), delta 3, accessory subunit	0.469
INSR	insulin receptor	0.435
DTL	denticleless homolog (Drosophila)	0.353
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.334
NRP1	neuropilin 1	0.320
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.298
POT1	protection of telomeres 1 homolog (S. pombe)	0.290
H2AFX	H2A histone family, member X	0.283
CDK2	cyclin-dependent kinase 2	0.278
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.270	Fly
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.242
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.231
TK1	thymidine kinase 1, soluble	0.209
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.208
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	0.202	Yeast
MSH6	mutS homolog 6 (E. coli)	0.202
BRCA1	breast cancer 1, early onset	0.197
ENG	endoglin	0.185
POLI	polymerase (DNA directed) iota	0.172	Mouse Fly
ORC1	origin recognition complex, subunit 1	0.169	Fly
BMP2	bone morphogenetic protein 2	0.166
PLCG1	phospholipase C, gamma 1	0.160
EP300	E1A binding protein p300	0.150
REV1	REV1 homolog (S. cerevisiae)	0.148	Yeast Mouse
EXO1	exonuclease 1	0.147
POLE	polymerase (DNA directed), epsilon	0.145
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.142	Mouse
BMPR1B	bone morphogenetic protein receptor, type IB	0.140	Human
FANCD2	Fanconi anemia, complementation group D2	0.138
CCNE2	cyclin E2	0.136	Fly
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.131
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.129
PDGFC	platelet derived growth factor C	0.128
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.123
CCNE1	cyclin E1	0.123	Fly
GINS2	GINS complex subunit 2 (Psf2 homolog)	0.121
TGFB1	transforming growth factor, beta 1	0.120
FEN1	flap structure-specific endonuclease 1	0.119	Yeast
GDF5	growth differentiation factor 5	0.117	Human
RAD54L	RAD54-like (S. cerevisiae)	0.100	Fly
RPA2	replication protein A2, 32kDa	0.097
PRIM1	primase, DNA, polypeptide 1 (49kDa)	0.094
POLH	polymerase (DNA directed), eta	0.092
RPA1	replication protein A1, 70kDa	0.092
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.090	Fly
TIMELESS	timeless homolog (Drosophila)	0.089
PDGFA	platelet-derived growth factor alpha polypeptide	0.083	Human
RB1	retinoblastoma 1	0.081
ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.081
ACVR1	activin A receptor, type I	0.079	Human
MCM2	minichromosome maintenance complex component 2	0.078
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.073
FKBP1A	FK506 binding protein 1A, 12kDa	0.073
BRCA2	breast cancer 2, early onset	0.073
SUPT5H	suppressor of Ty 5 homolog (S. cerevisiae)	0.071
REV3L	REV3-like, catalytic subunit of DNA polymerase zeta (yeast)	0.070
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.068
GINS4	GINS complex subunit 4 (Sld5 homolog)	0.067
RECQL4	RecQ protein-like 4	0.065
MAPK14	mitogen-activated protein kinase 14	0.064
CCNA2	cyclin A2	0.064
MAX	MYC associated factor X	0.064
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.062
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.058
BLM	Bloom syndrome, RecQ helicase-like	0.058	Fly
JUN	jun proto-oncogene	0.058
COL6A1	collagen, type VI, alpha 1	0.057
PLAU	plasminogen activator, urokinase	0.057	Human
POLD2	polymerase (DNA directed), delta 2, regulatory subunit 50kDa	0.056
C1QB	complement component 1, q subcomponent, B chain	0.056	Human
LIG1	ligase I, DNA, ATP-dependent	0.056
TGFB3	transforming growth factor, beta 3	0.055
SMAD7	SMAD family member 7	0.054
CDK6	cyclin-dependent kinase 6	0.054
ING2	inhibitor of growth family, member 2	0.053
C1QA	complement component 1, q subcomponent, A chain	0.052	Human
PRKG1	protein kinase, cGMP-dependent, type I	0.051
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.050
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.050
BMPR1A	bone morphogenetic protein receptor, type IA	0.050	Human
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.050
H2AFV	H2A histone family, member V	0.047
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.046
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.042
RBL1	retinoblastoma-like 1 (p107)	0.042
SKP2	S-phase kinase-associated protein 2 (p45)	0.041
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.041
CXXC1	CXXC finger protein 1	0.041
NOG	noggin	0.041
ATM	ataxia telangiectasia mutated	0.041
ORC2	origin recognition complex, subunit 2	0.041	Fly
BMP4	bone morphogenetic protein 4	0.040
MAPK8	mitogen-activated protein kinase 8	0.040
NEIL3	nei endonuclease VIII-like 3 (E. coli)	0.040
CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	0.040
MAPK3	mitogen-activated protein kinase 3	0.040
DDX11	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	0.040
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.039
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.038
PARP1	poly (ADP-ribose) polymerase 1	0.038
FOXM1	forkhead box M1	0.038
CLSPN	claspin	0.037
RAD52	RAD52 homolog (S. cerevisiae)	0.035	Yeast
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.035
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.034
PLAT	plasminogen activator, tissue	0.033	Human
POLK	polymerase (DNA directed) kappa	0.033
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.033
GRB10	growth factor receptor-bound protein 10	0.033
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.032
TCOF1	Treacher Collins-Franceschetti syndrome 1	0.032
CHRAC1	chromatin accessibility complex 1	0.032
FGF10	fibroblast growth factor 10	0.030
IRS2	insulin receptor substrate 2	0.030
NAP1L1	nucleosome assembly protein 1-like 1	0.030
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.030
RFC1	replication factor C (activator 1) 1, 145kDa	0.030
JAK2	Janus kinase 2	0.030
POLG2	polymerase (DNA directed), gamma 2, accessory subunit	0.029
TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	0.028
RPA3	replication protein A3, 14kDa	0.027
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.027
COBRA1	cofactor of BRCA1	0.027
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.026
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.026
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.026
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.026
TBC1D17	TBC1 domain family, member 17	0.026
RRM2	ribonucleotide reductase M2	0.026
TNIP1	TNFAIP3 interacting protein 1	0.026
TCF19	transcription factor 19	0.025
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.024
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.024
ARRB1	arrestin, beta 1	0.024
POLE4	polymerase (DNA-directed), epsilon 4 (p12 subunit)	0.023	Yeast
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.023
FGFR3	fibroblast growth factor receptor 3	0.023	Human
EGR1	early growth response 1	0.023
MCM10	minichromosome maintenance complex component 10	0.023
NCAPH	non-SMC condensin I complex, subunit H	0.023
TOP3A	topoisomerase (DNA) III alpha	0.023
RRBP1	ribosome binding protein 1 homolog 180kDa (dog)	0.023
IRF3	interferon regulatory factor 3	0.023
RAD17	RAD17 homolog (S. pombe)	0.022
DCLRE1B	DNA cross-link repair 1B	0.022
HDAC7	histone deacetylase 7	0.021
CAV1	caveolin 1, caveolae protein, 22kDa	0.021
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.021
IRS1	insulin receptor substrate 1	0.021
MAP2K1	mitogen-activated protein kinase kinase 1	0.021
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.021
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.021
FGF7	fibroblast growth factor 7	0.021
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.020
TRAIP	TRAF interacting protein	0.020
COL2A1	collagen, type II, alpha 1	0.020
SIVA1	SIVA1, apoptosis-inducing factor	0.020
MED25	mediator complex subunit 25	0.020
TCEA1	transcription elongation factor A (SII), 1	0.020
TTN	titin	0.020
TYMS	thymidylate synthetase	0.020
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.020	Rat
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.020
BTRC	beta-transducin repeat containing	0.020
ANKRA2	ankyrin repeat, family A (RFXANK-like), 2	0.020
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.019
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.019	Yeast
RFC3	replication factor C (activator 1) 3, 38kDa	0.019
KLF5	Kruppel-like factor 5 (intestinal)	0.019
STAB1	stabilin 1	0.019
MCM7	minichromosome maintenance complex component 7	0.019
C1orf135	chromosome 1 open reading frame 135	0.018
CDCA7	cell division cycle associated 7	0.018
C5orf54	chromosome 5 open reading frame 54	0.018
DNAJC9	DnaJ (Hsp40) homolog, subfamily C, member 9	0.018
RAD9A	RAD9 homolog A (S. pombe)	0.018
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.018
MAPK1	mitogen-activated protein kinase 1	0.018
E2F2	E2F transcription factor 2	0.017
TERT	telomerase reverse transcriptase	0.017
SMAD6	SMAD family member 6	0.017
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.017
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.017
ANKMY2	ankyrin repeat and MYND domain containing 2	0.017
ATF2	activating transcription factor 2	0.017
FANCI	Fanconi anemia, complementation group I	0.017
DZIP3	DAZ interacting protein 3, zinc finger	0.016
CCNB2	cyclin B2	0.016
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.016
DCN	decorin	0.016
DAXX	death-domain associated protein	0.016
DPY19L4	dpy-19-like 4 (C. elegans)	0.016
RAB5C	RAB5C, member RAS oncogene family	0.016
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.016
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.016
PLAUR	plasminogen activator, urokinase receptor	0.016
CEP57	centrosomal protein 57kDa	0.016
PTPRB	protein tyrosine phosphatase, receptor type, B	0.016
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.016
PDLIM7	PDZ and LIM domain 7 (enigma)	0.016
ESRRG	estrogen-related receptor gamma	0.015
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.015
PRPF8	PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)	0.015
CCNF	cyclin F	0.015
SMAD2	SMAD family member 2	0.015
TGFB2	transforming growth factor, beta 2	0.015
MEN1	multiple endocrine neoplasia I	0.015
DAZAP2	DAZ associated protein 2	0.015
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.015
PSMC3IP	PSMC3 interacting protein	0.015
HIPK3	homeodomain interacting protein kinase 3	0.015
USP15	ubiquitin specific peptidase 15	0.015
ZMYND11	zinc finger, MYND-type containing 11	0.015
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.015
CENPM	centromere protein M	0.015
ACD	adrenocortical dysplasia homolog (mouse)	0.014
ZFYVE9	zinc finger, FYVE domain containing 9	0.014
DNAJB11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.014
C16orf59	chromosome 16 open reading frame 59	0.014
GINS3	GINS complex subunit 3 (Psf3 homolog)	0.014
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.014
EIF3E	eukaryotic translation initiation factor 3, subunit E	0.014
MCM5	minichromosome maintenance complex component 5	0.014
GINS1	GINS complex subunit 1 (Psf1 homolog)	0.014
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.014
CABIN1	calcineurin binding protein 1	0.014
VEGFA	vascular endothelial growth factor A	0.014	Human
RNASEH2A	ribonuclease H2, subunit A	0.013
SUPT6H	suppressor of Ty 6 homolog (S. cerevisiae)	0.013
ANGPTL2	angiopoietin-like 2	0.013
HNF4A	hepatocyte nuclear factor 4, alpha	0.013
CHTF18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.013
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.013
E2F4	E2F transcription factor 4, p107/p130-binding	0.013
HIST2H2AB	histone cluster 2, H2ab	0.013
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.013
EDC4	enhancer of mRNA decapping 4	0.013
TGIF1	TGFB-induced factor homeobox 1	0.013
GSK3B	glycogen synthase kinase 3 beta	0.013
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.013
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.013
CDCA4	cell division cycle associated 4	0.013
FGF8	fibroblast growth factor 8 (androgen-induced)	0.013
CSNK1E	casein kinase 1, epsilon	0.013
BANP	BTG3 associated nuclear protein	0.012
GSG2	germ cell associated 2 (haspin)	0.012
NRP2	neuropilin 2	0.012
ZWINT	ZW10 interactor	0.012
AXIN1	axin 1	0.012
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.012
RBL2	retinoblastoma-like 2 (p130)	0.012
RPRD1B	regulation of nuclear pre-mRNA domain containing 1B	0.012
MAPK7	mitogen-activated protein kinase 7	0.012
CRYZL1	crystallin, zeta (quinone reductase)-like 1	0.012
RAB28	RAB28, member RAS oncogene family	0.012
LRDD	leucine-rich repeats and death domain containing	0.012
PEA15	phosphoprotein enriched in astrocytes 15	0.012
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.012
SMC1A	structural maintenance of chromosomes 1A	0.012
TAF1D	TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa	0.012
CBR4	carbonyl reductase 4	0.012
MARCO	macrophage receptor with collagenous structure	0.012
C15orf42	chromosome 15 open reading frame 42	0.012
NCAPH2	non-SMC condensin II complex, subunit H2	0.012
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.012
BIRC5	baculoviral IAP repeat containing 5	0.012
RHOB	ras homolog gene family, member B	0.012
ACVR1B	activin A receptor, type IB	0.011	Human
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.011
FANCA	Fanconi anemia, complementation group A	0.011
CIZ1	CDKN1A interacting zinc finger protein 1	0.011
FGF2	fibroblast growth factor 2 (basic)	0.011
LDLR	low density lipoprotein receptor	0.011
HBP1	HMG-box transcription factor 1	0.011
WDR76	WD repeat domain 76	0.011
PNP	purine nucleoside phosphorylase	0.011
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.011
RAD51AP1	RAD51 associated protein 1	0.011
HSPG2	heparan sulfate proteoglycan 2	0.011
GTSE1	G-2 and S-phase expressed 1	0.011
PSIP1	PC4 and SFRS1 interacting protein 1	0.011
CPSF1	cleavage and polyadenylation specific factor 1, 160kDa	0.011
MAP2K4	mitogen-activated protein kinase kinase 4	0.011
FANCG	Fanconi anemia, complementation group G	0.011
C1QC	complement component 1, q subcomponent, C chain	0.011	Human
FOXF1	forkhead box F1	0.011
CHRNA5	cholinergic receptor, nicotinic, alpha 5	0.011
OSMR	oncostatin M receptor	0.011
KNG1	kininogen 1	0.011
OSBPL9	oxysterol binding protein-like 9	0.011
KIF2C	kinesin family member 2C	0.011
SENP3	SUMO1/sentrin/SMT3 specific peptidase 3	0.011
SETD7	SET domain containing (lysine methyltransferase) 7	0.011
PTPRR	protein tyrosine phosphatase, receptor type, R	0.011
WDR34	WD repeat domain 34	0.011
CCND3	cyclin D3	0.011
SKA1	spindle and kinetochore associated complex subunit 1	0.011
PRR14	proline rich 14	0.011
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.011	Mouse
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.011
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.011
DHFR	dihydrofolate reductase	0.011
ERN1	endoplasmic reticulum to nucleus signaling 1	0.011
NCOR2	nuclear receptor corepressor 2	0.011
STC1	stanniocalcin 1	0.011
ZNF367	zinc finger protein 367	0.011
NNT	nicotinamide nucleotide transhydrogenase	0.011
STMN1	stathmin 1	0.010
RPS27L	ribosomal protein S27-like	0.010
COL6A2	collagen, type VI, alpha 2	0.010
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.010
MMP19	matrix metallopeptidase 19	0.010
BTBD2	BTB (POZ) domain containing 2	0.010
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.010
ARL4D	ADP-ribosylation factor-like 4D	0.010
TSC22D1	TSC22 domain family, member 1	0.010
CD248	CD248 molecule, endosialin	0.010
DNA2	DNA replication helicase 2 homolog (yeast)	0.010
WWOX	WW domain containing oxidoreductase	0.010
RHOT1	ras homolog gene family, member T1	0.010
RHOT2	ras homolog gene family, member T2	0.010
GRB7	growth factor receptor-bound protein 7	0.010
ZFAND1	zinc finger, AN1-type domain 1	0.010
CDCA3	cell division cycle associated 3	0.010
NCOA6	nuclear receptor coactivator 6	0.010
FSTL1	follistatin-like 1	0.010
PPIA	peptidylprolyl isomerase A (cyclophilin A)	0.010