IMP

Process View

Mus musculus

23 genes annotated in mouse

positive t cell selection

The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive t cell selection"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive t cell selection" (in gray)

Name	Description	Probability	Func Analog Organism
Foxp3	forkhead box P3	0.993
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.990
Ikzf1	IKAROS family zinc finger 1	0.989
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.988
Lck	lymphocyte protein tyrosine kinase	0.974
Trp53	transformation related protein 53	0.957
Fyn	Fyn proto-oncogene	0.929
Kit	kit oncogene	0.924
Cd28	CD28 antigen	0.908
Stat2	signal transducer and activator of transcription 2	0.900	Mouse
H2-Eb1	histocompatibility 2, class II antigen E beta	0.891
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.869	Mouse
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.857
Cd19	CD19 antigen	0.853
H2-DMa	histocompatibility 2, class II, locus DMa	0.853
Lat	linker for activation of T cells	0.853
Stat5a	signal transducer and activator of transcription 5A	0.843	Mouse
Fgfr2	fibroblast growth factor receptor 2	0.819
Igh	immunoglobulin heavy chain complex	0.812
Fas	Fas (TNF receptor superfamily member 6)	0.783
Pten	phosphatase and tensin homolog	0.739
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.716
Il6st	interleukin 6 signal transducer	0.705
Il2	interleukin 2	0.694
Irf9	interferon regulatory factor 9	0.692	Mouse
Stat6	signal transducer and activator of transcription 6	0.680
Cd247	CD247 antigen	0.664
Cd22	CD22 antigen	0.651
Stat5b	signal transducer and activator of transcription 5B	0.631	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.621
Ptgs2	prostaglandin-endoperoxide synthase 2	0.611
Rag1	recombination activating gene 1	0.611
Lyz2	lysozyme 2	0.527
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.468
Tcrb	T-cell receptor beta chain	0.458
Il1r1	interleukin 1 receptor, type I	0.438
Il27ra	interleukin 27 receptor, alpha	0.437
Cd3g	CD3 antigen, gamma polypeptide	0.417	Mouse
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.391
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.382
Il21r	interleukin 21 receptor	0.382
Ncoa3	nuclear receptor coactivator 3	0.358
Apc	adenomatosis polyposis coli	0.343
Il4ra	interleukin 4 receptor, alpha	0.335
Socs1	suppressor of cytokine signaling 1	0.331
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.328
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.327
Ar	androgen receptor	0.304
Itk	IL2-inducible T-cell kinase	0.303
Stat1	signal transducer and activator of transcription 1	0.302	Mouse
Stat3	signal transducer and activator of transcription 3	0.296	Mouse
Ifng	interferon gamma	0.294
Il2rb	interleukin 2 receptor, beta chain	0.291
Tcra	T-cell receptor alpha chain	0.286
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.275
Irf5	interferon regulatory factor 5	0.258	Mouse
Vhl	von Hippel-Lindau tumor suppressor	0.255
Ciita	class II transactivator	0.225
Traf1	TNF receptor-associated factor 1	0.212
Dock2	dedicator of cyto-kinesis 2	0.210
Vav1	vav 1 oncogene	0.206
Smad4	MAD homolog 4 (Drosophila)	0.200
Cd2	CD2 antigen	0.191
Cd4	CD4 antigen	0.187
Irf4	interferon regulatory factor 4	0.186
Prf1	perforin 1 (pore forming protein)	0.179
Tgfb1	transforming growth factor, beta 1	0.178
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.174
Itgal	integrin alpha L	0.173
Inpp5d	inositol polyphosphate-5-phosphatase D	0.171
Was	Wiskott-Aldrich syndrome homolog (human)	0.170
Lef1	lymphoid enhancer binding factor 1	0.162
Isg15	ISG15 ubiquitin-like modifier	0.160
Uba7	ubiquitin-like modifier activating enzyme 7	0.151
Esr1	estrogen receptor 1 (alpha)	0.148
Cd8a	CD8 antigen, alpha chain	0.138
Irf8	interferon regulatory factor 8	0.132	Mouse
Wt1	Wilms tumor 1 homolog	0.130
Ptprc	protein tyrosine phosphatase, receptor type, C	0.129
Cxcr3	chemokine (C-X-C motif) receptor 3	0.121
Sh2d2a	SH2 domain protein 2A	0.120
Notch2	Notch gene homolog 2 (Drosophila)	0.120
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.120
Lyst	lysosomal trafficking regulator	0.119
Ikzf3	IKAROS family zinc finger 3	0.119
Gli3	GLI-Kruppel family member GLI3	0.119
Cd3d	CD3 antigen, delta polypeptide	0.116
Cd3e	CD3 antigen, epsilon polypeptide	0.113	Mouse
Blnk	B-cell linker	0.110
Trim21	tripartite motif-containing 21	0.108
Zap70	zeta-chain (TCR) associated protein kinase	0.104
Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein	0.103
Nckap1l	NCK associated protein 1 like	0.103
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.099
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.097
Rhoh	ras homolog gene family, member H	0.096
Il10	interleukin 10	0.095
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.093
Ifnar1	interferon (alpha and beta) receptor 1	0.092
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.091
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.091
Cd5	CD5 antigen	0.090
Sox9	SRY-box containing gene 9	0.088
Tnf	tumor necrosis factor	0.087
Cd6	CD6 antigen	0.085
Cd7	CD7 antigen	0.085
Cd72	CD72 antigen	0.084
Grb2	growth factor receptor bound protein 2	0.083
Mmp9	matrix metallopeptidase 9	0.083
Srebf2	sterol regulatory element binding factor 2	0.079
Unc93b1	unc-93 homolog B1 (C. elegans)	0.077
Bcl2	B-cell leukemia/lymphoma 2	0.077
Prkcq	protein kinase C, theta	0.077
Itgb7	integrin beta 7	0.077
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.073
Ccl5	chemokine (C-C motif) ligand 5	0.072
Lepr	leptin receptor	0.070
Ltb	lymphotoxin B	0.068
Il4	interleukin 4	0.067
Batf	basic leucine zipper transcription factor, ATF-like	0.066
Fasl	Fas ligand (TNF superfamily, member 6)	0.066
Tapbp	TAP binding protein	0.065
Efnb2	ephrin B2	0.065
Cd40	CD40 antigen	0.063
Pdcd1	programmed cell death 1	0.062
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.061
Icos	inducible T-cell co-stimulator	0.060
Cbl	Casitas B-lineage lymphoma	0.059
Cd27	CD27 antigen	0.058
Ctsw	cathepsin W	0.057
H2-Oa	histocompatibility 2, O region alpha locus	0.056	Mouse
Hif1a	hypoxia inducible factor 1, alpha subunit	0.056
Jak1	Janus kinase 1	0.055
Ifnar2	interferon (alpha and beta) receptor 2	0.053
Prlr	prolactin receptor	0.053
Cst7	cystatin F (leukocystatin)	0.053
Pxn	paxillin	0.051
Vav2	vav 2 oncogene	0.050
Adar	adenosine deaminase, RNA-specific	0.050
Nsf	N-ethylmaleimide sensitive fusion protein	0.050
Cd79b	CD79B antigen	0.050
Laptm5	lysosomal-associated protein transmembrane 5	0.050
Card11	caspase recruitment domain family, member 11	0.050
Sh2d1a	SH2 domain protein 1A	0.049
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.049
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.048
Znfx1	zinc finger, NFX1-type containing 1	0.047
Irf1	interferon regulatory factor 1	0.046	Mouse
Rac2	RAS-related C3 botulinum substrate 2	0.045
Zbp1	Z-DNA binding protein 1	0.044
Cd96	CD96 antigen	0.044
Ptch1	patched homolog 1	0.043
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.042
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.042
Rxra	retinoid X receptor alpha	0.041
Itgax	integrin alpha X	0.041
Ctnnb1	catenin (cadherin associated protein), beta 1	0.039
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.038
Sp100	nuclear antigen Sp100	0.037
Cd8b1	CD8 antigen, beta chain 1	0.037
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.036
Gli2	GLI-Kruppel family member GLI2	0.036
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.036
Hhex	hematopoietically expressed homeobox	0.035
Map4k1	mitogen-activated protein kinase kinase kinase kinase 1	0.035
Sfpi1	SFFV proviral integration 1	0.035
Il17ra	interleukin 17 receptor A	0.032
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.032
Rasal3	RAS protein activator like 3	0.031
Fgf9	fibroblast growth factor 9	0.031
Parp14	poly (ADP-ribose) polymerase family, member 14	0.031
Stk11	serine/threonine kinase 11	0.030
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.030
Hmha1	histocompatibility (minor) HA-1	0.030
Tspan32	tetraspanin 32	0.029
Pthlh	parathyroid hormone-like peptide	0.029
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.028
Zfp36	zinc finger protein 36	0.028
Rag2	recombination activating gene 2	0.028
Myd88	myeloid differentiation primary response gene 88	0.027
Cd37	CD37 antigen	0.027
Msh2	mutS homolog 2 (E. coli)	0.027
Ikbkb	inhibitor of kappaB kinase beta	0.026
AW112010	expressed sequence AW112010	0.026
Fgfr3	fibroblast growth factor receptor 3	0.026
Arhgap9	Rho GTPase activating protein 9	0.026
Ccr7	chemokine (C-C motif) receptor 7	0.026
Traf3	TNF receptor-associated factor 3	0.025
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.025
Igtp	interferon gamma induced GTPase	0.025
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.025
Mx2	myxovirus (influenza virus) resistance 2	0.025
Ly9	lymphocyte antigen 9	0.024
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.024
Cxcr4	chemokine (C-X-C motif) receptor 4	0.024
Stk10	serine/threonine kinase 10	0.024
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.024
Gata3	GATA binding protein 3	0.024
Sept1	septin 1	0.024
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.024
Prkcd	protein kinase C, delta	0.024
Abcg1	ATP-binding cassette, sub-family G (WHITE), member 1	0.024
Dnase1l3	deoxyribonuclease 1-like 3	0.023
Cytip	cytohesin 1 interacting protein	0.023
Sla2	Src-like-adaptor 2	0.023
Sfn	stratifin	0.022
Gimap1	GTPase, IMAP family member 1	0.022
Gfi1	growth factor independent 1	0.022
Ptprn	protein tyrosine phosphatase, receptor type, N	0.022
Foxn1	forkhead box N1	0.022
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.022
Mdm2	transformed mouse 3T3 cell double minute 2	0.022
Adam17	a disintegrin and metallopeptidase domain 17	0.021
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.021
Hcls1	hematopoietic cell specific Lyn substrate 1	0.021
Xcl1	chemokine (C motif) ligand 1	0.021
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.021
Parp10	poly (ADP-ribose) polymerase family, member 10	0.020
Pgr	progesterone receptor	0.020
Jak3	Janus kinase 3	0.020
Map2k2	mitogen-activated protein kinase kinase 2	0.020
Dusp2	dual specificity phosphatase 2	0.020
Pparg	peroxisome proliferator activated receptor gamma	0.020
Map4k4	mitogen-activated protein kinase kinase kinase kinase 4	0.020
Pml	promyelocytic leukemia	0.020
Arid1b	AT rich interactive domain 1B (SWI-like)	0.019
Smad1	MAD homolog 1 (Drosophila)	0.019
Tlr4	toll-like receptor 4	0.019
Daxx	Fas death domain-associated protein	0.019
Itga6	integrin alpha 6	0.019
Junb	Jun-B oncogene	0.019
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.019
Npr2	natriuretic peptide receptor 2	0.019
Notch1	Notch gene homolog 1 (Drosophila)	0.019
Pyhin1	pyrin and HIN domain family, member 1	0.018
Rbl1	retinoblastoma-like 1 (p107)	0.018
Slc12a7	solute carrier family 12, member 7	0.018
Nfil3	nuclear factor, interleukin 3, regulated	0.018
Zeb1	zinc finger E-box binding homeobox 1	0.018
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.018
Lama5	laminin, alpha 5	0.018
Elf1	E74-like factor 1	0.018
Rc3h1	RING CCCH (C3H) domains 1	0.018
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.018
Nos1	nitric oxide synthase 1, neuronal	0.017
Irgm2	immunity-related GTPase family M member 2	0.017
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.017
Bcl2l1	BCL2-like 1	0.017	Mouse
Itgae	integrin alpha E, epithelial-associated	0.017
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.017
Il12b	interleukin 12b	0.017
H2-Ob	histocompatibility 2, O region beta locus	0.016
Adora2a	adenosine A2a receptor	0.016
Amhr2	anti-Mullerian hormone type 2 receptor	0.016
Flii	flightless I homolog (Drosophila)	0.016
Hras1	Harvey rat sarcoma virus oncogene 1	0.016
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.016
Cxcl9	chemokine (C-X-C motif) ligand 9	0.015
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.015	Mouse
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.015
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.015
Bach2	BTB and CNC homology 2	0.015
Cxcr6	chemokine (C-X-C motif) receptor 6	0.015
Trp73	transformation related protein 73	0.015
Rnpepl1	arginyl aminopeptidase (aminopeptidase B)-like 1	0.015
Dennd5a	DENN/MADD domain containing 5A	0.015
Ptprj	protein tyrosine phosphatase, receptor type, J	0.015
Plcg1	phospholipase C, gamma 1	0.015
Vdr	vitamin D receptor	0.015
Bcl6	B-cell leukemia/lymphoma 6	0.015
Csk	c-src tyrosine kinase	0.015
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.015
Stat4	signal transducer and activator of transcription 4	0.015	Mouse
Sema4d	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.015
Numb	numb gene homolog (Drosophila)	0.014
Sit1	suppression inducing transmembrane adaptor 1	0.014
Tnfsf9	tumor necrosis factor (ligand) superfamily, member 9	0.014
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.014
Ticam1	toll-like receptor adaptor molecule 1	0.014
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.014
Il2rg	interleukin 2 receptor, gamma chain	0.014
9130017N09Rik	RIKEN cDNA 9130017N09 gene	0.014
Tbk1	TANK-binding kinase 1	0.014
Il2ra	interleukin 2 receptor, alpha chain	0.014
Jph3	junctophilin 3	0.014
Traf2	TNF receptor-associated factor 2	0.014
Trp63	transformation related protein 63	0.014
Itga4	integrin alpha 4	0.014
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.014
Tnip1	TNFAIP3 interacting protein 1	0.014
Runx1	runt related transcription factor 1	0.014
Tapbpl	TAP binding protein-like	0.014
Flt3	FMS-like tyrosine kinase 3	0.013
Elmo1	engulfment and cell motility 1, ced-12 homolog (C. elegans)	0.013
Gna13	guanine nucleotide binding protein, alpha 13	0.013
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.013
Tcf7	transcription factor 7, T-cell specific	0.013
BC006779	cDNA sequence BC006779	0.013
Cd44	CD44 antigen	0.013
Trim25	tripartite motif-containing 25	0.013
Vav3	vav 3 oncogene	0.013
Mapk14	mitogen-activated protein kinase 14	0.013
Tbc1d10c	TBC1 domain family, member 10c	0.013
Tor3a	torsin family 3, member A	0.013
Mfn2	mitofusin 2	0.013
Vasp	vasodilator-stimulated phosphoprotein	0.013
Gimap7	GTPase, IMAP family member 7	0.013
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.013
Epas1	endothelial PAS domain protein 1	0.013
Ftsjd2	FtsJ methyltransferase domain containing 2	0.013
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.013
Itga3	integrin alpha 3	0.013
Pkd1	polycystic kidney disease 1 homolog	0.013
Prkd2	protein kinase D2	0.013
Cnr2	cannabinoid receptor 2 (macrophage)	0.012
Rasgrp1	RAS guanyl releasing protein 1	0.012
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.012
Lrmp	lymphoid-restricted membrane protein	0.012
Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)	0.012
Trim26	tripartite motif-containing 26	0.012
Bbc3	BCL2 binding component 3	0.012
Nup62-il4i1	Nup62-Il4i1 protein	0.012
Wnt9b	wingless-type MMTV integration site 9B	0.012
Itgb2	integrin beta 2	0.012
Kitl	kit ligand	0.012
Irgm1	immunity-related GTPase family M member 1	0.012
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.012
Ahr	aryl-hydrocarbon receptor	0.012
Gbp1	guanylate binding protein 1	0.012
Pag1	phosphoprotein associated with glycosphingolipid microdomains 1	0.012
Skil	SKI-like	0.012
Cd83	CD83 antigen	0.011
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.011
Mbp	myelin basic protein	0.011
Map2k1	mitogen-activated protein kinase kinase 1	0.011
Sh2b3	SH2B adaptor protein 3	0.011
Fgf10	fibroblast growth factor 10	0.011
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.011
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.011
Huwe1	HECT, UBA and WWE domain containing 1	0.011
Hrh2	histamine receptor H2	0.011
Lcp2	lymphocyte cytosolic protein 2	0.011
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.011
Col2a1	collagen, type II, alpha 1	0.011
Ly75	lymphocyte antigen 75	0.011
Diap1	diaphanous homolog 1 (Drosophila)	0.011
Il25	interleukin 25	0.011
Spry4	sprouty homolog 4 (Drosophila)	0.011
Wipf1	WAS/WASL interacting protein family, member 1	0.011
Foxa2	forkhead box A2	0.011
Il12rb1	interleukin 12 receptor, beta 1	0.011
Vegfa	vascular endothelial growth factor A	0.011
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.011
Parvg	parvin, gamma	0.011
Psen1	presenilin 1	0.010
Tcf21	transcription factor 21	0.010
Apoe	apolipoprotein E	0.010
Tgif2	TGFB-induced factor homeobox 2	0.010
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.010
Dgka	diacylglycerol kinase, alpha	0.010
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.010
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.010
Klk8	kallikrein related-peptidase 8	0.010
Napsa	napsin A aspartic peptidase	0.010
Traf6	TNF receptor-associated factor 6	0.010
Ebi3	Epstein-Barr virus induced gene 3	0.010
Arid3b	AT rich interactive domain 3B (BRIGHT-like)	0.010
Etv6	ets variant gene 6 (TEL oncogene)	0.010
Ncf1	neutrophil cytosolic factor 1	0.010
Blk	B lymphoid kinase	0.010
Nkx2-1	NK2 homeobox 1	0.010
Rasa3	RAS p21 protein activator 3	0.010
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.010
Plekho2	pleckstrin homology domain containing, family O member 2	0.010