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Homo sapiens

26 genes annotated in human

g2 dna damage checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "g2 dna damage checkpoint"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "g2 dna damage checkpoint" (in gray)

Name	Description	Probability	Func Analog Organism
BRCA1	breast cancer 1, early onset	1.000
CDK2	cyclin-dependent kinase 2	0.999
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.999
RB1	retinoblastoma 1	0.998
H2AFX	H2A histone family, member X	0.986
E2F1	E2F transcription factor 1	0.983
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.980
FANCD2	Fanconi anemia, complementation group D2	0.975
CCNA2	cyclin A2	0.971
RAD50	RAD50 homolog (S. cerevisiae)	0.960
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.951	Mouse Fly
TP53	tumor protein p53	0.937
PARP1	poly (ADP-ribose) polymerase 1	0.934
NBN	nibrin	0.928
MDC1	mediator of DNA-damage checkpoint 1	0.884
MSH6	mutS homolog 6 (E. coli)	0.867
PCNA	proliferating cell nuclear antigen	0.864
RBL1	retinoblastoma-like 1 (p107)	0.858	Fly
COPS6	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	0.841	Fly
TOPBP1	topoisomerase (DNA) II binding protein 1	0.837	Fly
MCM2	minichromosome maintenance complex component 2	0.833
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.832	Fly
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.803
CDT1	chromatin licensing and DNA replication factor 1	0.799
CLSPN	claspin	0.787
COPS3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	0.785	Fly
EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.772
CUL1	cullin 1	0.768	Fly
RBBP8	retinoblastoma binding protein 8	0.761
BRCC3	BRCA1/BRCA2-containing complex, subunit 3	0.760
SIRT2	sirtuin 2	0.756
BLM	Bloom syndrome, RecQ helicase-like	0.755
BABAM1	BRISC and BRCA1 A complex member 1	0.754
SKP2	S-phase kinase-associated protein 2 (p45)	0.712
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.689	Fly
GFER	growth factor, augmenter of liver regeneration	0.664
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.646
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.645
BTG1	B-cell translocation gene 1, anti-proliferative	0.599
BRE	brain and reproductive organ-expressed (TNFRSF1A modulator)	0.572
MCM6	minichromosome maintenance complex component 6	0.563
CUL4A	cullin 4A	0.562
COPS8	COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)	0.562
UBXN7	UBX domain protein 7	0.548
ORC1	origin recognition complex, subunit 1	0.532
MCM7	minichromosome maintenance complex component 7	0.480	Fly
FAM175A	family with sequence similarity 175, member A	0.478
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.462
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.448
FANCA	Fanconi anemia, complementation group A	0.445
ATM	ataxia telangiectasia mutated	0.440
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.426
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.420
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.390
MED29	mediator complex subunit 29	0.375
WRN	Werner syndrome, RecQ helicase-like	0.366
COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)	0.329	Fly
CDK1	cyclin-dependent kinase 1	0.323	Mouse Fly
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.304
MED10	mediator complex subunit 10	0.300
CSNK2B	casein kinase 2, beta polypeptide	0.300
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.287
COPS2	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	0.271	Fly
CDK8	cyclin-dependent kinase 8	0.257	Fly
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.255
UIMC1	ubiquitin interaction motif containing 1	0.255
MED1	mediator complex subunit 1	0.254
RBL2	retinoblastoma-like 2 (p130)	0.253	Fly
MED23	mediator complex subunit 23	0.239
MED13	mediator complex subunit 13	0.231
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.221
CUL2	cullin 2	0.215
SMC1A	structural maintenance of chromosomes 1A	0.211
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.207
BRCA2	breast cancer 2, early onset	0.200
NEK9	NIMA (never in mitosis gene a)- related kinase 9	0.193	Human
ATR	ataxia telangiectasia and Rad3 related	0.192	Fly
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.191
EXO1	exonuclease 1	0.184
RPA1	replication protein A1, 70kDa	0.182	Fly
MAPK14	mitogen-activated protein kinase 14	0.181
PRNP	prion protein	0.180
HSF1	heat shock transcription factor 1	0.174
PKM2	pyruvate kinase, muscle	0.171
HDGF	hepatoma-derived growth factor	0.156
RPA2	replication protein A2, 32kDa	0.149
TOP1	topoisomerase (DNA) I	0.142
HSPB1	heat shock 27kDa protein 1	0.142
UBA1	ubiquitin-like modifier activating enzyme 1	0.132
CCNE1	cyclin E1	0.129
BARD1	BRCA1 associated RING domain 1	0.129
TFDP1	transcription factor Dp-1	0.128
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.122
RBBP4	retinoblastoma binding protein 4	0.118
MCM5	minichromosome maintenance complex component 5	0.118
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.116
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.116
CNOT8	CCR4-NOT transcription complex, subunit 8	0.115	Fly
CNOT1	CCR4-NOT transcription complex, subunit 1	0.115
CDCA2	cell division cycle associated 2	0.108
BBS1	Bardet-Biedl syndrome 1	0.102
TP53BP1	tumor protein p53 binding protein 1	0.099
HDAC1	histone deacetylase 1	0.095
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.092
TDG	thymine-DNA glycosylase	0.089
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.083
MAP2K3	mitogen-activated protein kinase kinase 3	0.083
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.081
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.078
MCM10	minichromosome maintenance complex component 10	0.075
MED14	mediator complex subunit 14	0.075
MED18	mediator complex subunit 18	0.072
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.071	Fly
SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	0.071
ANKRD28	ankyrin repeat domain 28	0.067
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.067
E2F5	E2F transcription factor 5, p130-binding	0.066
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.063
TK1	thymidine kinase 1, soluble	0.061
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.060
SSRP1	structure specific recognition protein 1	0.059
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.057
MCM4	minichromosome maintenance complex component 4	0.057
ORC2	origin recognition complex, subunit 2	0.057
CNOT6	CCR4-NOT transcription complex, subunit 6	0.054
AGXT2	alanine--glyoxylate aminotransferase 2	0.052
KPNA4	karyopherin alpha 4 (importin alpha 3)	0.050	Fly
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.050
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.050
MED26	mediator complex subunit 26	0.047
TPI1	triosephosphate isomerase 1	0.047
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.047
DDB1	damage-specific DNA binding protein 1, 127kDa	0.045
POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	0.045
MED6	mediator complex subunit 6	0.044
NCL	nucleolin	0.044
MED4	mediator complex subunit 4	0.044
RBBP7	retinoblastoma binding protein 7	0.043
RFWD2	ring finger and WD repeat domain 2	0.042
RECQL	RecQ protein-like (DNA helicase Q1-like)	0.041
USP42	ubiquitin specific peptidase 42	0.039
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.039
BRAP	BRCA1 associated protein	0.039
MED28	mediator complex subunit 28	0.038
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.037
CUL5	cullin 5	0.036
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	0.034
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.034
CDK19	cyclin-dependent kinase 19	0.034	Fly
E2F4	E2F transcription factor 4, p107/p130-binding	0.034
ORC3	origin recognition complex, subunit 3	0.033
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	0.033
CBX5	chromobox homolog 5	0.033
CARD11	caspase recruitment domain family, member 11	0.032
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.032
ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	0.031
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.030
HABP4	hyaluronan binding protein 4	0.030
ACACA	acetyl-CoA carboxylase alpha	0.029
TNRC6B	trinucleotide repeat containing 6B	0.029
MSH3	mutS homolog 3 (E. coli)	0.029
CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	0.028
CCNB1	cyclin B1	0.027
CHUK	conserved helix-loop-helix ubiquitous kinase	0.027
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.027
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.025
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.025
GPI	glucose-6-phosphate isomerase	0.025
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.025
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.024
CNOT7	CCR4-NOT transcription complex, subunit 7	0.024	Fly
FAM175B	family with sequence similarity 175, member B	0.024	Human
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.024
COPS7B	COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)	0.024
MYST1	MYST histone acetyltransferase 1	0.024
EXOC7	exocyst complex component 7	0.024
PMF1	polyamine-modulated factor 1	0.024
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.023
RPL39	ribosomal protein L39	0.023
PLK1	polo-like kinase 1	0.023
CCNB2	cyclin B2	0.023
E2F2	E2F transcription factor 2	0.022
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.022
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.022
SAE1	SUMO1 activating enzyme subunit 1	0.022
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.022
HDAC2	histone deacetylase 2	0.021
PXN	paxillin	0.021
BCAT2	branched chain amino-acid transaminase 2, mitochondrial	0.021
YBX1	Y box binding protein 1	0.021
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.021
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.020
TERF2	telomeric repeat binding factor 2	0.020
SIRT1	sirtuin 1	0.020
RFC5	replication factor C (activator 1) 5, 36.5kDa	0.020
MAK	male germ cell-associated kinase	0.020
CREBBP	CREB binding protein	0.020
CCDC6	coiled-coil domain containing 6	0.019
PALB2	partner and localizer of BRCA2	0.019
BBS2	Bardet-Biedl syndrome 2	0.019
DTL	denticleless homolog (Drosophila)	0.019
ERI3	ERI1 exoribonuclease family member 3	0.019
FANCG	Fanconi anemia, complementation group G	0.019
POLR2J	polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa	0.019
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.018
RBM8A	RNA binding motif protein 8A	0.018
MED19	mediator complex subunit 19	0.018
USP16	ubiquitin specific peptidase 16	0.018
MBD1	methyl-CpG binding domain protein 1	0.017
POLR1A	polymerase (RNA) I polypeptide A, 194kDa	0.017
POLR2E	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	0.017	Fly
WDR48	WD repeat domain 48	0.017
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.017
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.017
MED20	mediator complex subunit 20	0.017
STK4	serine/threonine kinase 4	0.017
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.017
FYN	FYN oncogene related to SRC, FGR, YES	0.017
HDAC4	histone deacetylase 4	0.017
MYO1C	myosin IC	0.017
CAPN7	calpain 7	0.017
MYCBP	c-myc binding protein	0.017
MED13L	mediator complex subunit 13-like	0.016
SBNO2	strawberry notch homolog 2 (Drosophila)	0.016
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.016
CCNE2	cyclin E2	0.016
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.016
SGOL1	shugoshin-like 1 (S. pombe)	0.016
PIAS4	protein inhibitor of activated STAT, 4	0.016	Fly
FEN1	flap structure-specific endonuclease 1	0.016
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.016
CTBP1	C-terminal binding protein 1	0.015
BTG2	BTG family, member 2	0.015
RAD9A	RAD9 homolog A (S. pombe)	0.015
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.015
C16orf53	chromosome 16 open reading frame 53	0.015
EHD1	EH-domain containing 1	0.015
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.015
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.015
GPS1	G protein pathway suppressor 1	0.015	Fly
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.014
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.014
EGR1	early growth response 1	0.014
CNOT3	CCR4-NOT transcription complex, subunit 3	0.014
USPL1	ubiquitin specific peptidase like 1	0.014
TRIM27	tripartite motif containing 27	0.014
TDGF1	teratocarcinoma-derived growth factor 1	0.014
ZBTB11	zinc finger and BTB domain containing 11	0.014
SUDS3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.014
NIPBL	Nipped-B homolog (Drosophila)	0.014
PHC2	polyhomeotic homolog 2 (Drosophila)	0.014
POLR2B	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	0.013
IGF1R	insulin-like growth factor 1 receptor	0.013
NFYA	nuclear transcription factor Y, alpha	0.013
RBBP5	retinoblastoma binding protein 5	0.013
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.013
EP300	E1A binding protein p300	0.013
C12orf10	chromosome 12 open reading frame 10	0.013
GSG2	germ cell associated 2 (haspin)	0.013
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.013
RAD18	RAD18 homolog (S. cerevisiae)	0.013
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.013
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.012
TOR1A	torsin family 1, member A (torsin A)	0.012
CCND1	cyclin D1	0.012
BBS4	Bardet-Biedl syndrome 4	0.012
HUWE1	HECT, UBA and WWE domain containing 1	0.012
STX5	syntaxin 5	0.012
H2AFY	H2A histone family, member Y	0.012
LIMK1	LIM domain kinase 1	0.012
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.012
SEPT7	septin 7	0.012
UBE2K	ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)	0.012
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.012
NONO	non-POU domain containing, octamer-binding	0.012
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.012
UBE2G1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.011
MCPH1	microcephalin 1	0.011
CAND1	cullin-associated and neddylation-dissociated 1	0.011
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.011
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.011
RNF126	ring finger protein 126	0.011
PIH1D1	PIH1 domain containing 1	0.011
HELZ	helicase with zinc finger	0.011
GTF2I	general transcription factor IIi	0.011
BCL10	B-cell CLL/lymphoma 10	0.011
PIAS2	protein inhibitor of activated STAT, 2	0.010
CDC37L1	cell division cycle 37 homolog (S. cerevisiae)-like 1	0.010
FOSL1	FOS-like antigen 1	0.010
CDK6	cyclin-dependent kinase 6	0.010
FANCE	Fanconi anemia, complementation group E	0.010
ERCC8	excision repair cross-complementing rodent repair deficiency, complementation group 8	0.010
FBXO11	F-box protein 11	0.010
ARID4A	AT rich interactive domain 4A (RBP1-like)	0.010
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.010
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.010